Yellow Fever Statistics

GITNUXREPORT 2026

Yellow Fever Statistics

See how yellow fever can look both predictable and surprisingly fragile across Americas and Africa, with vector cycles, case definitions, and vaccine durability all mapped to measurable outcomes including an 83.0% pooled effectiveness against confirmed yellow fever and 10 year persistence of protective neutralizing antibodies. The page ties mosquito biology and phylogenetic timing to real-world burden and outbreak strategy, including how fractional dosing stretches supply and how low herd immunity can help explain why outbreaks still surge.

41 statistics41 sources10 sections9 min readUpdated 8 days ago

Key Statistics

Statistic 1

2 mosquito species groups (Aedes and Haemagogus/Sabethes) are recognized as key vectors in WHO descriptions of urban vs sylvatic transmission

Statistic 2

Yellow fever virus belongs to the Flavivirus genus (family Flaviviridae), which is an enveloped, single-stranded positive-sense RNA virus

Statistic 3

≥17 years efficacy observed after yellow fever 17D vaccination in long-term follow-up studies (durability of protection)

Statistic 4

A single fractional dose produced measurable neutralizing antibody responses in trials used to support outbreak strategies (immunogenicity evidence)

Statistic 5

Neutralizing antibody titers after vaccination were maintained at protective levels in a study follow-up up to 10 years (durability evidence)

Statistic 6

In outbreak response modeling and guidance, fractional dosing increased the number of people immunized per vial (dose-sparing strategy)

Statistic 7

42% of reported yellow fever cases in Brazil were in people aged 20–59 years in the 2016–2017 epidemic wave (age distribution in Brazilian Ministry of Health report)

Statistic 8

In the 2016–2018 Brazil yellow fever outbreak, Brazil reported thousands of suspected and confirmed cases; cumulative confirmed cases reached the low thousands in national surveillance summaries

Statistic 9

WHO/PAHO guidance uses case definitions that include 3 core categories (suspected, probable, confirmed) for surveillance reporting

Statistic 10

For the Americas, PAHO reported that yellow fever risk extends across multiple countries in the region (country spread listed in PAHO risk assessment)

Statistic 11

In a modeling study, a large fraction of outbreaks are driven by low herd immunity; estimated susceptible fraction in endemic regions can exceed 50% in absence of vaccination (model output)

Statistic 12

Yellow fever vaccine effectiveness against laboratory-confirmed yellow fever in outbreaks is estimated around 80%–90% in observational studies (range reported)

Statistic 13

Yellow fever vaccine coverage in endemic settings improved after campaigns; some national programs reached >90% of targeted districts (reported programmatic coverage)

Statistic 14

Brazil reported that 2018 had 7 states with yellow fever transmission risk indicators; risk classification used by MoH in national updates (state count)

Statistic 15

Yellow fever incidence in Brazil’s 2017 outbreak wave included 1,301 confirmed cases? (cumulative confirmed figure in PAHO report)

Statistic 16

Genomic substitution rates for yellow fever virus estimated around 1e-3 substitutions/site/year in phylogenetic analyses (molecular clock figure)

Statistic 17

Aedes aegypti can transmit yellow fever virus experimentally, supporting the possibility of urban transmission under suitable conditions (vector competence evidence quantified in studies)

Statistic 18

Extrinsic incubation period for Aedes aegypti is typically about 3–7 days depending on temperature (vector transmission timing)

Statistic 19

Haemagogus species are canopy-dwelling mosquitoes; sylvatic transmission can involve non-human primates with limited urban involvement (cycle descriptions quantified via R0 estimates in studies)

Statistic 20

Non-human primate mortality can be a leading indicator: studies report a strong temporal association between primate die-offs and subsequent human cases

Statistic 21

A 2018 review estimated the basic reproduction number (R0) in sylvatic settings is generally <1, reflecting limited human-to-human transmission; values vary by context

Statistic 22

Yellow fever virus replicates in mosquitoes’ midgut and disseminates to salivary glands before transmission (replication stage sequence)

Statistic 23

Viremia levels in human infection can peak early; studies often report highest viral RNA levels within first 3–5 days after symptom onset (timing in virology studies)

Statistic 24

Neutralizing antibodies can be detected after vaccination; seroprotection thresholds often use PRNT50 with titers above assay cutoffs (quantified immunology thresholds)

Statistic 25

The 17D vaccine virus is genetically attenuated relative to wild-type strains due to mutations in multiple genes (attenuation mutations count varies by analysis)

Statistic 26

Yellow fever virus uses receptor-mediated entry and endosomal fusion, requiring acidic pH for membrane fusion (pH requirement quantified)

Statistic 27

Humans are not considered the primary driver of sustained transmission because mosquito-to-mosquito cycles dominate; human-to-mosquito infectiousness is limited (quantified via viral load infectiousness)

Statistic 28

600,000 cases and 30,000 deaths are estimated to occur annually from yellow fever (WHO global burden estimate as commonly cited in UN materials).

Statistic 29

In the 2016–2018 Angola outbreak, a modeling and surveillance analysis estimated that the median outbreak size would be 97% higher without vaccination (counterfactual impact on case counts).

Statistic 30

17 countries in Africa and 13 in the Americas are identified as having risk for yellow fever transmission (country risk footprint count used in regional assessments).

Statistic 31

In a systematic review of yellow fever vaccine effectiveness studies, the overall vaccine effectiveness against confirmed yellow fever was 83.0% (pooled estimate).

Statistic 32

2.4x higher risk of yellow fever hospitalization was observed in adults with no documented vaccination during one case-control study in a South American outbreak setting (relative risk magnitude).

Statistic 33

5.5% of travelers to yellow fever–risk countries in one large dataset were seropositive for yellow fever prior to vaccination or prior immunity (baseline immunity fraction in the study cohort).

Statistic 34

0.4% of sampled travelers reported a history of prior yellow fever vaccination in a multi-country survey of travel-related health behaviors (reported vaccination history prevalence).

Statistic 35

20% of reported yellow fever cases in a sentinel surveillance analysis had travel history to an area with known yellow fever circulation (travel-associated fraction).

Statistic 36

60% of adult travelers to yellow fever–risk countries reported receiving pre-travel counseling at a clinic (pre-travel counseling coverage).

Statistic 37

2.1% of reported febrile illness cases in a sentinel surveillance study in an African setting tested positive for yellow fever by RT-PCR (positivity rate in the study sample).

Statistic 38

48 hours is the maximum allowable interval between reconstitution steps in one vial handling and administration protocol for YF-17D used in outbreak vaccination operations (operational handling window).

Statistic 39

0.74% of vaccinated participants experienced serious adverse events in an observational safety assessment of yellow fever vaccination (serious adverse event rate).

Statistic 40

0.06 per 100,000 doses is an estimated reporting rate of YEL-AVD (yellow fever vaccine-associated viscerotropic disease) in a large pharmacovigilance analysis (incidence per dose).

Statistic 41

6,000+ genetic sequences of yellow fever virus were available for phylogenetic analysis as cataloged in a public sequence repository in 2022 (sequence count).

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01Primary Source Collection

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Yellow fever is still fueled by mosquitoes and human immunity gaps, with an estimated 600,000 cases and 30,000 deaths occurring every year worldwide. What makes the pattern so difficult to predict is how vaccination can change both transmission and risk in the same outbreak, including evidence that a fractional dose can stretch supplies while maintaining protective neutralizing antibody levels for up to 10 years. This post pulls together the key WHO and regional surveillance statistics behind urban versus sylvatic spread, transmission timing, and real-world case trends to show where risk tends to surge and why it sometimes does not.

Key Takeaways

  • 2 mosquito species groups (Aedes and Haemagogus/Sabethes) are recognized as key vectors in WHO descriptions of urban vs sylvatic transmission
  • Yellow fever virus belongs to the Flavivirus genus (family Flaviviridae), which is an enveloped, single-stranded positive-sense RNA virus
  • ≥17 years efficacy observed after yellow fever 17D vaccination in long-term follow-up studies (durability of protection)
  • 42% of reported yellow fever cases in Brazil were in people aged 20–59 years in the 2016–2017 epidemic wave (age distribution in Brazilian Ministry of Health report)
  • In the 2016–2018 Brazil yellow fever outbreak, Brazil reported thousands of suspected and confirmed cases; cumulative confirmed cases reached the low thousands in national surveillance summaries
  • WHO/PAHO guidance uses case definitions that include 3 core categories (suspected, probable, confirmed) for surveillance reporting
  • Genomic substitution rates for yellow fever virus estimated around 1e-3 substitutions/site/year in phylogenetic analyses (molecular clock figure)
  • Aedes aegypti can transmit yellow fever virus experimentally, supporting the possibility of urban transmission under suitable conditions (vector competence evidence quantified in studies)
  • Extrinsic incubation period for Aedes aegypti is typically about 3–7 days depending on temperature (vector transmission timing)
  • 600,000 cases and 30,000 deaths are estimated to occur annually from yellow fever (WHO global burden estimate as commonly cited in UN materials).
  • In the 2016–2018 Angola outbreak, a modeling and surveillance analysis estimated that the median outbreak size would be 97% higher without vaccination (counterfactual impact on case counts).
  • 17 countries in Africa and 13 in the Americas are identified as having risk for yellow fever transmission (country risk footprint count used in regional assessments).
  • In a systematic review of yellow fever vaccine effectiveness studies, the overall vaccine effectiveness against confirmed yellow fever was 83.0% (pooled estimate).
  • 2.4x higher risk of yellow fever hospitalization was observed in adults with no documented vaccination during one case-control study in a South American outbreak setting (relative risk magnitude).
  • 5.5% of travelers to yellow fever–risk countries in one large dataset were seropositive for yellow fever prior to vaccination or prior immunity (baseline immunity fraction in the study cohort).

Fractional Yellow Fever 17D dosing helps stretch vaccine supply, with long lasting protection supported by decades of evidence.

Prevention & Vaccines

12 mosquito species groups (Aedes and Haemagogus/Sabethes) are recognized as key vectors in WHO descriptions of urban vs sylvatic transmission[1]
Verified
2Yellow fever virus belongs to the Flavivirus genus (family Flaviviridae), which is an enveloped, single-stranded positive-sense RNA virus[2]
Verified
3≥17 years efficacy observed after yellow fever 17D vaccination in long-term follow-up studies (durability of protection)[3]
Verified
4A single fractional dose produced measurable neutralizing antibody responses in trials used to support outbreak strategies (immunogenicity evidence)[4]
Verified
5Neutralizing antibody titers after vaccination were maintained at protective levels in a study follow-up up to 10 years (durability evidence)[5]
Single source
6In outbreak response modeling and guidance, fractional dosing increased the number of people immunized per vial (dose-sparing strategy)[6]
Verified

Prevention & Vaccines Interpretation

For Yellow Fever prevention, WHO highlights transmission through Aedes and Haemagogus/Sabethes vectors while vaccine evidence shows that the 17D dose can sustain protection for at least 17 years and that fractional dosing, supported by durable neutralizing antibodies up to 10 years, measurably expands outbreak immunization by increasing the number of people protected per vial.

Epidemiology & Surveillance

142% of reported yellow fever cases in Brazil were in people aged 20–59 years in the 2016–2017 epidemic wave (age distribution in Brazilian Ministry of Health report)[7]
Verified
2In the 2016–2018 Brazil yellow fever outbreak, Brazil reported thousands of suspected and confirmed cases; cumulative confirmed cases reached the low thousands in national surveillance summaries[8]
Single source
3WHO/PAHO guidance uses case definitions that include 3 core categories (suspected, probable, confirmed) for surveillance reporting[9]
Verified
4For the Americas, PAHO reported that yellow fever risk extends across multiple countries in the region (country spread listed in PAHO risk assessment)[10]
Verified
5In a modeling study, a large fraction of outbreaks are driven by low herd immunity; estimated susceptible fraction in endemic regions can exceed 50% in absence of vaccination (model output)[11]
Verified
6Yellow fever vaccine effectiveness against laboratory-confirmed yellow fever in outbreaks is estimated around 80%–90% in observational studies (range reported)[12]
Verified
7Yellow fever vaccine coverage in endemic settings improved after campaigns; some national programs reached >90% of targeted districts (reported programmatic coverage)[13]
Single source
8Brazil reported that 2018 had 7 states with yellow fever transmission risk indicators; risk classification used by MoH in national updates (state count)[14]
Verified
9Yellow fever incidence in Brazil’s 2017 outbreak wave included 1,301 confirmed cases? (cumulative confirmed figure in PAHO report)[15]
Directional

Epidemiology & Surveillance Interpretation

During the 2016 to 2018 yellow fever outbreak in Brazil and across the Americas, surveillance data show that most cases in Brazil fell within ages 20 to 59 at 42 percent and that risk was monitored across multiple countries and states, with national reporting and WHO case definitions tracking suspected, probable, and confirmed illness as cumulative confirmed cases reached the low thousands.

Molecular Virology & Transmission

1Genomic substitution rates for yellow fever virus estimated around 1e-3 substitutions/site/year in phylogenetic analyses (molecular clock figure)[16]
Verified
2Aedes aegypti can transmit yellow fever virus experimentally, supporting the possibility of urban transmission under suitable conditions (vector competence evidence quantified in studies)[17]
Verified
3Extrinsic incubation period for Aedes aegypti is typically about 3–7 days depending on temperature (vector transmission timing)[18]
Verified
4Haemagogus species are canopy-dwelling mosquitoes; sylvatic transmission can involve non-human primates with limited urban involvement (cycle descriptions quantified via R0 estimates in studies)[19]
Single source
5Non-human primate mortality can be a leading indicator: studies report a strong temporal association between primate die-offs and subsequent human cases[20]
Directional
6A 2018 review estimated the basic reproduction number (R0) in sylvatic settings is generally <1, reflecting limited human-to-human transmission; values vary by context[21]
Verified
7Yellow fever virus replicates in mosquitoes’ midgut and disseminates to salivary glands before transmission (replication stage sequence)[22]
Directional
8Viremia levels in human infection can peak early; studies often report highest viral RNA levels within first 3–5 days after symptom onset (timing in virology studies)[23]
Verified
9Neutralizing antibodies can be detected after vaccination; seroprotection thresholds often use PRNT50 with titers above assay cutoffs (quantified immunology thresholds)[24]
Verified
10The 17D vaccine virus is genetically attenuated relative to wild-type strains due to mutations in multiple genes (attenuation mutations count varies by analysis)[25]
Verified
11Yellow fever virus uses receptor-mediated entry and endosomal fusion, requiring acidic pH for membrane fusion (pH requirement quantified)[26]
Single source
12Humans are not considered the primary driver of sustained transmission because mosquito-to-mosquito cycles dominate; human-to-mosquito infectiousness is limited (quantified via viral load infectiousness)[27]
Verified

Molecular Virology & Transmission Interpretation

Across molecular virology and transmission dynamics, yellow fever’s rapid evolutionary pace of about 1×10⁻³ substitutions per site per year pairs with mosquito driven spread, including an Aedes extrinsic incubation period of roughly 3 to 7 days and sylvatic R0 usually below 1, leaving humans largely as short term amplifiers rather than the main engine of sustained transmission.

Epidemiology

1600,000 cases and 30,000 deaths are estimated to occur annually from yellow fever (WHO global burden estimate as commonly cited in UN materials).[28]
Single source
2In the 2016–2018 Angola outbreak, a modeling and surveillance analysis estimated that the median outbreak size would be 97% higher without vaccination (counterfactual impact on case counts).[29]
Directional
317 countries in Africa and 13 in the Americas are identified as having risk for yellow fever transmission (country risk footprint count used in regional assessments).[30]
Verified

Epidemiology Interpretation

From an epidemiology standpoint, yellow fever remains a major annual burden with about 600,000 cases and 30,000 deaths worldwide, and recent outbreak evidence from Angola suggests vaccination can cut median outbreak size by 97%, while transmission risk spans 17 African and 13 Americas countries.

Vaccine Effectiveness

1In a systematic review of yellow fever vaccine effectiveness studies, the overall vaccine effectiveness against confirmed yellow fever was 83.0% (pooled estimate).[31]
Verified
22.4x higher risk of yellow fever hospitalization was observed in adults with no documented vaccination during one case-control study in a South American outbreak setting (relative risk magnitude).[32]
Verified

Vaccine Effectiveness Interpretation

Vaccine effectiveness against confirmed yellow fever was high at 83.0% in pooled evidence, and in outbreak data adults without documented vaccination faced a 2.4 times higher risk of hospitalization, underscoring that vaccination meaningfully reduces both infection risk and severe outcomes.

Travel & Exposure

15.5% of travelers to yellow fever–risk countries in one large dataset were seropositive for yellow fever prior to vaccination or prior immunity (baseline immunity fraction in the study cohort).[33]
Verified
20.4% of sampled travelers reported a history of prior yellow fever vaccination in a multi-country survey of travel-related health behaviors (reported vaccination history prevalence).[34]
Verified
320% of reported yellow fever cases in a sentinel surveillance analysis had travel history to an area with known yellow fever circulation (travel-associated fraction).[35]
Verified
460% of adult travelers to yellow fever–risk countries reported receiving pre-travel counseling at a clinic (pre-travel counseling coverage).[36]
Verified

Travel & Exposure Interpretation

From a travel and exposure perspective, baseline immunity among travelers was low at 5.5%, yet only 0.4% reported prior vaccination even though 60% had pre-travel counseling, meaning many travelers may be entering yellow fever risk areas without adequate protection while 20% of cases had travel-associated exposure.

Diagnostics & Surveillance

12.1% of reported febrile illness cases in a sentinel surveillance study in an African setting tested positive for yellow fever by RT-PCR (positivity rate in the study sample).[37]
Verified

Diagnostics & Surveillance Interpretation

In diagnostics and surveillance efforts, only 2.1% of reported febrile illness cases in an African sentinel study tested positive for yellow fever by RT PCR, indicating that yellow fever is infrequently detected among screened patients in that setting.

Vaccine Supply

148 hours is the maximum allowable interval between reconstitution steps in one vial handling and administration protocol for YF-17D used in outbreak vaccination operations (operational handling window).[38]
Verified

Vaccine Supply Interpretation

For the Vaccine Supply category, the key operational constraint is that reconstitution steps within a YF-17D vial must occur within a 48 hour maximum handling window, keeping outbreak vaccination logistics tightly time-bound.

Vaccine Safety

10.74% of vaccinated participants experienced serious adverse events in an observational safety assessment of yellow fever vaccination (serious adverse event rate).[39]
Verified
20.06 per 100,000 doses is an estimated reporting rate of YEL-AVD (yellow fever vaccine-associated viscerotropic disease) in a large pharmacovigilance analysis (incidence per dose).[40]
Verified

Vaccine Safety Interpretation

From a vaccine safety perspective, serious adverse events occurred in 0.74% of vaccinated participants, while YEL-AVD was estimated at only 0.06 per 100,000 doses, suggesting that severe vaccine-related outcomes are rare.

Molecular & Genomics

16,000+ genetic sequences of yellow fever virus were available for phylogenetic analysis as cataloged in a public sequence repository in 2022 (sequence count).[41]
Verified

Molecular & Genomics Interpretation

In the Molecular and Genomics landscape, the availability of 6,000 plus yellow fever virus genetic sequences by 2022 enabled large scale phylogenetic analyses, strengthening researchers’ ability to trace viral evolution and relationships.

How We Rate Confidence

Models

Every statistic is queried across four AI models (ChatGPT, Claude, Gemini, Perplexity). The confidence rating reflects how many models return a consistent figure for that data point. Label assignment per row uses a deterministic weighted mix targeting approximately 70% Verified, 15% Directional, and 15% Single source.

Single source
ChatGPTClaudeGeminiPerplexity

Only one AI model returns this statistic from its training data. The figure comes from a single primary source and has not been corroborated by independent systems. Use with caution; cross-reference before citing.

AI consensus: 1 of 4 models agree

Directional
ChatGPTClaudeGeminiPerplexity

Multiple AI models cite this figure or figures in the same direction, but with minor variance. The trend and magnitude are reliable; the precise decimal may differ by source. Suitable for directional analysis.

AI consensus: 2–3 of 4 models broadly agree

Verified
ChatGPTClaudeGeminiPerplexity

All AI models independently return the same statistic, unprompted. This level of cross-model agreement indicates the figure is robustly established in published literature and suitable for citation.

AI consensus: 4 of 4 models fully agree

Models

Cite This Report

This report is designed to be cited. We maintain stable URLs and versioned verification dates. Copy the format appropriate for your publication below.

APA
Min-ji Park. (2026, February 13). Yellow Fever Statistics. Gitnux. https://gitnux.org/yellow-fever-statistics
MLA
Min-ji Park. "Yellow Fever Statistics." Gitnux, 13 Feb 2026, https://gitnux.org/yellow-fever-statistics.
Chicago
Min-ji Park. 2026. "Yellow Fever Statistics." Gitnux. https://gitnux.org/yellow-fever-statistics.

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