Key Takeaways
- In 2022, approximately 52.5 million people aged 12 or older in the United States reported using cannabis in the past year, representing 18.7% of the population in that age group
- A 2023 study found that 22.0% of U.S. adults aged 18-25 used cannabis in the past month, the highest rate among age groups
- Globally, an estimated 219 million people used cannabis in 2022, making it the most widely used drug worldwide
- A clinical trial showed that cannabis with 10mg THC reduced chronic pain by 30% in 73% of patients vs placebo
- Epidiolex (CBD) reduced seizure frequency by 39% in Dravet syndrome patients in Phase 3 trials
- In a 2020 meta-analysis, medical cannabis reduced opioid use by 64% in chronic pain patients
- In 2023, U.S. cannabis sales reached $28.9 billion, up 10.4% from 2022
- Colorado collected $423 million in cannabis taxes in 2023, funding schools and infrastructure
- California's legal cannabis market generated $5.3 billion in 2023 sales
- As of 2024, 24 U.S. states have legalized recreational cannabis, covering 54% of population
- Canada fully legalized recreational cannabis on October 17, 2018, under Cannabis Act
- Uruguay became first country to legalize recreational cannabis in 2013
- Heavy cannabis use associated with 2.1-fold increased risk of schizophrenia in men
- Daily cannabis use linked to 34% higher risk of heart attack per 2024 study
- Adolescent cannabis use increases depression risk by 37% in adulthood
Cannabis is now widely used and studied for both its medical benefits and potential health risks.
Economic Aspects
- In 2023, U.S. cannabis sales reached $28.9 billion, up 10.4% from 2022
- Colorado collected $423 million in cannabis taxes in 2023, funding schools and infrastructure
- California's legal cannabis market generated $5.3 billion in 2023 sales
- Global legal cannabis market projected to hit $57.2 billion by 2026, CAGR 24.3%
- Canada’s legal cannabis sales were CAD 4.5 billion in 2023
- U.S. cannabis industry employed 428,000 full-time workers in 2023
- Illinois cannabis taxes yielded $1.5 billion since 2020 launch
- Germany’s medical cannabis imports cost €1.2 billion in 2023
- Michigan’s recreational cannabis sales hit $3.1 billion in 2023
- Hemp-derived CBD market in U.S. valued at $5.3 billion in 2022
- Nevada cannabis revenue topped $55 million monthly in 2023
- Israel exported $500 million in medical cannabis products in 2023
- Washington state cannabis taxes generated $466 million in 2023
- U.S. ancillary cannabis businesses generated $2.5 billion in 2023
- Oklahoma medical cannabis sales reached $1 billion in first year post-2018
- Global cannabis beverage market expected to grow to $2.9 billion by 2028
- Florida medical cannabis revenue was $1.8 billion in 2023
- U.K. medical cannabis prescriptions rose 400% to 50,000 in 2023
- Arizona recreational cannabis sales debuted with $30 million in first month 2021
- In 2023, U.S. cannabis industry paid $3.5 billion in taxes
- Oregon cannabis sales $1.7 billion since 2015
- New Jersey first-year rec sales $700 million 2022
- Global med cannabis market $14.9 billion in 2023
- 440,000 U.S. cannabis jobs projected by end 2023
- New York rec sales $1.2 billion in first 2 years
- Hemp fiber market $1.2 billion globally 2023
- Connecticut cannabis taxes $250 million FY2023
- Australia med cannabis $300 million AUD 2023
- Virginia med sales $1 billion by 2023
- Cannabis tourism generated $2 billion in Colorado 2023
- Ohio med sales $400 million 2023
- UK med cannabis market £100 million 2023
- Massachusetts rec sales $5 billion cumulative 2016-2023
Economic Aspects Interpretation
Health Benefits
- A clinical trial showed that cannabis with 10mg THC reduced chronic pain by 30% in 73% of patients vs placebo
- Epidiolex (CBD) reduced seizure frequency by 39% in Dravet syndrome patients in Phase 3 trials
- In a 2020 meta-analysis, medical cannabis reduced opioid use by 64% in chronic pain patients
- Sativex (THC/CBD spray) improved spasticity scores by 20% in MS patients per 2019 review
- Cannabis-based treatments alleviated chemotherapy-induced nausea in 70% of patients vs 10% placebo
- A 2022 study found inhaled cannabis reduced PTSD symptoms by 50% in veterans over 8 weeks
- CBD oil at 300mg daily reduced anxiety scores by 79% in 57 patients
- Medical cannabis users reported 40% improvement in sleep quality in a 2021 Israeli study of 1,164 patients
- In glaucoma patients, THC lowered intraocular pressure by 30-45% for 3-4 hours
- Cannabis flower with 24% THC improved appetite by 75% in HIV/AIDS patients
- A Phase 2 trial showed nabiximols reduced cancer pain by 1.37 points on NRS scale
- In Crohn's disease, 10 patients achieved remission with inhaled cannabis vs 4 on placebo
- Low-dose CBD (25mg) enhanced fear extinction in PTSD models by 65%
- Medical cannabis reduced fibromyalgia pain by 2.5 points on VAS in 128 patients
- THC:CBD 1:1 ratio improved bladder control in MS by 30%
- In epilepsy, CBD adjunct therapy cut seizures by 50% in 43% of Lennox-Gastaut patients
- Cannabis terpenes like myrcene enhanced anti-inflammatory effects by 40% in arthritis models
- Vaping CBD reduced social anxiety by 60% in public speaking test
- A randomized trial with 95 FM patients showed cannabis oil reduced pain by 1.7/10
- In 128 cancer patients, MC improved sleep in 66% and appetite in 53%
- THC/CBD oromucosal spray reduced MS spasticity by 0.8 points on 0-10 scale
- In 30 HIV patients, dronabinol increased caloric intake by 600 kcal/day
- CBD 600mg reduced anxiety in SAD patients during speech test
- In 47 epilepsy patients, CBD reduced seizures by median 36.5%
- Inhaled cannabis eased neuropathic pain by 3.3/10 reduction in 21 patients
- MC registry data: 90% Parkinson's patients improved motor symptoms
- Low-dose THC improved Alzheimer’s agitation in 9/10 patients
- Cannabis reduced IBS symptoms in 50% of 19 patients over 8 weeks
Health Benefits Interpretation
Legal and Policy
- As of 2024, 24 U.S. states have legalized recreational cannabis, covering 54% of population
- Canada fully legalized recreational cannabis on October 17, 2018, under Cannabis Act
- Uruguay became first country to legalize recreational cannabis in 2013
- Germany legalized recreational cannabis possession up to 25g in public from April 2024
- U.S. federal law still classifies cannabis as Schedule I under Controlled Substances Act
- Malta legalized recreational cannabis clubs in 2021, allowing up to 500 members per club
- Thailand decriminalized cannabis in June 2022, leading to 8,000+ dispensaries
- 38 U.S. states allow medical cannabis as of 2024
- Luxembourg legalized home cultivation of up to 4 plants per household in 2023
- Mexico legalized recreational use up to 28g possession in June 2021
- New Zealand rejected recreational legalization in 2020 referendum by 50.7%
- Australia allows medical cannabis since 2016, but recreational illegal federally
- U.K. rescheduled cannabis to Class B in 2009, medical access since 2018
- Switzerland permits cannabis possession under 10g since 2013
- Czech Republic allows home grow up to 5 plants since 2010
- South Africa legalized private use and home grow up to 4 plants in 2018
- U.S. DEA proposed rescheduling to Schedule III in May 2024
- Brazil approved medical cannabis in 2015, first recreational bill in 2023
- Netherlands tolerates sales up to 5g in coffeeshops since 1976
- Spain medical cannabis bill passed 2022, coffeeshops tolerated
- Georgia allows low-THC oil <5% since 2015
- Jamaica decriminalized possession up to 2oz in 2015, Rastafari sacrament
- Armenia legalized med cannabis 2023, first in region
- Ohio legalized rec cannabis Issue 2 in Nov 2023
- Kentucky med cannabis effective 2025 after 2023 law
- Missouri legalized rec 2022, sales started Feb 2023
- Philippines med cannabis pilot 2023 for 23 conditions
- Colombia legalized med 2016, rec decrim 2023 SC ruling
- Portugal decriminalized all drugs 2001, cannabis possession <25g admin offense
Legal and Policy Interpretation
Prevalence and Usage
- In 2022, approximately 52.5 million people aged 12 or older in the United States reported using cannabis in the past year, representing 18.7% of the population in that age group
- A 2023 study found that 22.0% of U.S. adults aged 18-25 used cannabis in the past month, the highest rate among age groups
- Globally, an estimated 219 million people used cannabis in 2022, making it the most widely used drug worldwide
- In Canada, cannabis use among young adults aged 20-24 reached 39% in the past year following legalization in 2018
- The 2021 European Drug Report indicated that 8% of young adults (15-34) in the EU had used cannabis in the past year
- In Australia, lifetime cannabis use among people aged 14+ was 31.6% in 2022-2023
- U.S. past-month cannabis use among adults rose from 7.5% in 2015 to 15.3% in 2021
- In 2023, 48% of New Zealand adults reported lifetime cannabis use
- Among U.S. high school students, 15.8% reported past-year cannabis use in 2023, down from previous years
- In the UK, 16.7% of adults aged 16-59 used cannabis in the last year per 2022 Crime Survey
- Mexico saw 5.4% past-month cannabis use among adults in 2022
- In 2021, 29.6 million Americans aged 12+ used cannabis in the past 30 days
- Brazil's 2019 survey showed 8.4% lifetime prevalence among those 12-65
- South Africa's 2019 data indicated 15% past-year use among 15-64 year olds
- In Japan, lifetime cannabis use is only 1.8% due to strict laws, per 2020 survey
- Germany's 2021 data showed 7.7% past-year use among 18-64 year olds
- In 2023, 42% of U.S. college students reported lifetime cannabis use
- Israel's medical cannabis patient registry grew to 130,000 by 2023
- Past-day cannabis use in U.S. adults tripled from 0.9% in 2015 to 2.8% in 2022
- In Uruguay, post-legalization, 16% of adults used cannabis in past year by 2022
- Chronic daily cannabis use in U.S. adults reached 10.3 million in 2021
- In 2022, 61.9 million Americans aged 12+ used cannabis past year, up from 47 million in 2019
- Past 30-day use among U.S. 12th graders dropped to 15.8% in 2023
- In Europe, 22 million used cannabis past year in 2022
- Daily or near-daily use in U.S. adults reached 6.5 million in 2022
- Women’s past-year cannabis use increased 4.3% to 19.6% from 2019-2022
- In 2023, 28 states plus DC had recreational sales
- Black Americans past-year use at 19.5% matching whites in 2022
- Edible cannabis use past year 4.5 million U.S. adults 2021
- Concentrate/dabs use past year 11% among young adults 2023
Prevalence and Usage Interpretation
Risks and Adverse Effects
- Heavy cannabis use associated with 2.1-fold increased risk of schizophrenia in men
- Daily cannabis use linked to 34% higher risk of heart attack per 2024 study
- Adolescent cannabis use increases depression risk by 37% in adulthood
- THC impairs driving, doubling crash risk equivalent to 0.08% BAC alcohol
- Cannabis use disorder affects 22-30% of users, per NIDA
- Vaping cannabis causes EVALI in 2,800 cases with 68 deaths by 2020
- Prenatal cannabis exposure linked to 2.4x low birth weight risk
- Chronic use reduces lung function by 8% in FEV1 measures
- High-potency cannabis (>10% THC) raises psychosis risk 5-fold
- Emergency room visits for cannabis rose 15% annually 2015-2020
- Cannabis smoke contains 20x more ammonia than tobacco smoke
- Youth users show 8 IQ point decline persisting to adulthood
- Cannabinoid hyperemesis syndrome cases increased 25x since 2000s
- Mixing cannabis with tobacco raises dependence risk by 40%
- Acute cannabis use impairs memory consolidation by 50% for 24 hours
- Long-term use linked to gum disease in 3x more users
- Pediatric cannabis ingestions via edibles rose 1500% 2017-2021
- High-THC strains cause paranoia in 28% of users
- Cannabis withdrawal symptoms affect 47% of daily users
- Regular use increases testicular cancer risk by 20%
- Cannabis use during pregnancy linked to 50% preterm birth increase
- Daily use raises stroke risk 25% in young adults
- Impaired cognition lasts 28 days post-abstinence in heavy users
- Edible overdoses cause hospitalization in 1/6 child cases
- Chronic bronchitis 20% higher in smokers
- Psychotic episodes 4x more likely with daily high-potency use
- Motivation syndrome in 34% young users
- Tar in cannabis smoke 4x higher than tobacco per gram
- Bipolar disorder risk doubles with adolescent onset use
- CUD treatment success only 12% without intervention
Risks and Adverse Effects Interpretation
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