Myocardial Infarction Statistics

GITNUXREPORT 2026

Myocardial Infarction Statistics

Myocardial infarction remains a major source of loss and cost, including 106.7 million DALYs from ischemic heart disease in 2019 and $17.3 billion in U.S. direct acute care for MI and coronary heart disease, yet outcomes are shifting with faster reperfusion and more consistent secondary prevention. See how door to balloon timing, high intensity statins, and newer treatment patterns stack up against persistent risks like 30 percent one year recurrent MI in patients with coronary heart disease, 15 percent 12 month mortality in high risk groups, and about 20 percent developing heart failure over 1 to 5 years.

47 statistics47 sources8 sections8 min readUpdated 29 days ago

Key Statistics

Statistic 1

106.7 million disability-adjusted life years (DALYs) from ischemic heart disease in 2019 (burden including myocardial infarction)

Statistic 2

USD 17.3 billion direct medical costs for acute myocardial infarction and coronary heart disease in the U.S. in 2019

Statistic 3

USD 44.6 billion total economic costs for cardiovascular disease in the U.S. in 2016 (includes events such as myocardial infarction)

Statistic 4

Approximately 30% of people with coronary heart disease in the U.S. are estimated to have experienced a myocardial infarction

Statistic 5

Approximately 7.9 million people worldwide suffer acute myocardial infarction each year (global incidence estimate)

Statistic 6

7% 30-day mortality for ST-segment elevation myocardial infarction (STEMI) in modern registries after reperfusion

Statistic 7

Approximately 10% of patients with myocardial infarction experience recurrent MI within 1 year

Statistic 8

5–8% rate of in-hospital reinfarction among acute MI patients in contemporary observational cohorts

Statistic 9

12-month mortality after myocardial infarction is about 15% in high-risk subgroups, reflecting prognostic stratification used in clinical risk models

Statistic 10

About 20% of patients with myocardial infarction develop heart failure within 1–5 years

Statistic 11

Time-to-treatment is critical: each 30-minute delay to reperfusion is associated with increased mortality after STEMI

Statistic 12

Door-to-balloon time targets: ≤90 minutes for primary PCI in STEMI

Statistic 13

Door-to-needle time target: ≤30 minutes for fibrinolysis in STEMI when PCI cannot be achieved promptly

Statistic 14

Secondary prevention adherence: 70%+ of eligible MI patients should be on high-intensity statins per modern guideline targets; rates vary by system

Statistic 15

About 30% of patients have persistent angina symptoms after MI due to residual ischemia

Statistic 16

Approximately 50% of early recurrent symptoms after MI are linked to incomplete revascularization and microvascular dysfunction

Statistic 17

2.2 million cardiac rehabilitation participants in the U.S. (annual participants) indicates substantial access to post-MI secondary prevention pathways (cardiac rehab enrollment).

Statistic 18

33% relative reduction in major adverse cardiovascular events (MACE) with PCSK9 inhibitors compared with control in large outcome trials pooled in systematic review (effect size for post-ACS/secondary prevention populations).

Statistic 19

7.3% absolute reduction in mortality with early invasive strategy vs conservative strategy in non-ST-elevation acute coronary syndrome, including NSTEMI populations (pooled estimate from major randomized evidence).

Statistic 20

1–3% risk of recurrent MI within 30 days after discharge among patients treated with drug-eluting stents in contemporary PCI registries (30-day recurrent MI incidence).

Statistic 21

0.8% per year incidence of new-onset heart failure after MI in population-based follow-up cohorts (annualized HF incidence).

Statistic 22

81% of cardiovascular drug approvals in 2021 were for lipid or platelet-targeting therapies relevant to post-MI management

Statistic 23

2023 U.S. generic drug share is 92% by prescriptions (statin and antiplatelet generics drive affordability in post-MI therapy)

Statistic 24

FDA approval of tenecteplase for STEMI: accelerated thrombolysis option used when PCI is unavailable (approval-based adoption quantification varies; approval supports market availability)

Statistic 25

High-intensity statins reduce risk of recurrent MI by about 24% vs lower-intensity (trial evidence used in guideline-based secondary prevention)

Statistic 26

Aspirin + a P2Y12 inhibitor reduces risk of recurrent events after MI; clopidogrel addition reduces major adverse events by about 20% in CURE-like populations

Statistic 27

Cardiac troponin is the primary biomarker: modern assays detect troponin levels at femtomolar-to-nanomolar clinical ranges enabling diagnosis of MI

Statistic 28

In the U.S., PCSK9 inhibitors were priced around USD 14,000/year list price (widely reported; used for market access planning)

Statistic 29

Rotational atherectomy is used in a minority of complex PCI procedures; in a large U.S. dataset it appeared in about 1–2% of PCI cases in recent years

Statistic 30

62% of STEMI patients received reperfusion therapy within guideline-recommended time windows in selected registry settings (system-performance metric)

Statistic 31

Door-to-balloon median time was 90 minutes or less in benchmarking programs targeting 90-minute performance

Statistic 32

Every 10-minute improvement in door-to-balloon time is associated with lower short-term mortality (observed relationship quantified in registry analyses)

Statistic 33

In US hospital systems, the proportion of eligible patients receiving aspirin within 24 hours after MI is commonly reported around 80%+ in quality measure reporting

Statistic 34

In U.S. reporting, 76% of AMI patients receive smoking cessation advice at discharge (quality measure, varies by facility)

Statistic 35

Tele-ECG adoption increased from near-zero to measurable coverage in pilot regions; in a randomized implementation study, prehospital ECG transmission improved time to reperfusion by 8 minutes on average

Statistic 36

In-hospital statin prescription after MI in the U.S. has been reported at ~80% in quality improvement datasets

Statistic 37

Cardiac rehabilitation referral rates after MI in the U.S. have been reported near 50% (quality and access benchmark)

Statistic 38

One-way EMS transport times contribute to system delay; in a national analysis, median prehospital time for STEMI was about 80 minutes

Statistic 39

Nearly 5% of U.S. adults have had heart attack (self-reported); used as a proxy for myocardial infarction prevalence in population surveys

Statistic 40

About 40% of adults in the U.S. have hypertension (a major risk factor for MI)

Statistic 41

In INTERHEART, 9 modifiable risk factors accounted for about 90% of the risk of acute myocardial infarction worldwide

Statistic 42

1 in 25 adults in the U.S. (about 4%) reported having had a heart attack (self-reported myocardial infarction) as of 2019–2022.

Statistic 43

About 50% of out-of-hospital cardiac arrests in the U.S. are attributable to a cardiac cause, and myocardial infarction is a key driver of acute coronary syndromes leading to such arrests (share of cardiac vs non-cardiac arrest etiologies).

Statistic 44

$1.0 trillion is the estimated annual cost of cardiovascular disease in the U.S. in 2021 (includes costs associated with major cardiovascular events such as myocardial infarction).

Statistic 45

≈90% of patients with acute MI are treated with an antiplatelet agent during hospitalization in U.S. practice (share receiving antiplatelet therapy during the index stay).

Statistic 46

69% of eligible STEMI patients in a large contemporary registry received primary PCI (proportion treated with guideline-recommended primary PCI).

Statistic 47

12% of STEMI patients in a contemporary registry did not receive reperfusion therapy (percentage untreated due to contraindications or system factors).

Sources
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Felix Zimmermann

Written by Felix Zimmermann·Edited by Gabrielle Fontaine·Fact-checked by Katherine Brennan

Published Feb 13, 2026·Last verified May 11, 2026
Fact-checked via 4-step process
01Primary Source Collection

Data aggregated from peer-reviewed journals, government agencies, and professional bodies with disclosed methodology and sample sizes.

02Editorial Curation

Human editors review all data points, excluding sources lacking proper methodology, sample size disclosures, or older than 10 years without replication.

03AI-Powered Verification

Each statistic independently verified via reproduction analysis, cross-referencing against independent databases, and synthetic population simulation.

04Human Cross-Check

Final human editorial review of all AI-verified statistics. Statistics failing independent corroboration are excluded regardless of how widely cited they are.

Read our full methodology →

Statistics that fail independent corroboration are excluded.

Myocardial infarction still accounts for an enormous health toll, with ischemic heart disease driving 106.7 million DALYs in 2019, yet the outcomes hinge on details that can change minute by minute. From the 7% 30 day mortality after STEMI to the way every 30 minute delay to reperfusion worsens survival, the statistics point to care systems as much as biology. This post connects those clinical timelines to what they cost and how they affect recurrence, heart failure, and long term secondary prevention.

Key Takeaways

  • 106.7 million disability-adjusted life years (DALYs) from ischemic heart disease in 2019 (burden including myocardial infarction)
  • USD 17.3 billion direct medical costs for acute myocardial infarction and coronary heart disease in the U.S. in 2019
  • USD 44.6 billion total economic costs for cardiovascular disease in the U.S. in 2016 (includes events such as myocardial infarction)
  • 7% 30-day mortality for ST-segment elevation myocardial infarction (STEMI) in modern registries after reperfusion
  • Approximately 10% of patients with myocardial infarction experience recurrent MI within 1 year
  • 5–8% rate of in-hospital reinfarction among acute MI patients in contemporary observational cohorts
  • 81% of cardiovascular drug approvals in 2021 were for lipid or platelet-targeting therapies relevant to post-MI management
  • 2023 U.S. generic drug share is 92% by prescriptions (statin and antiplatelet generics drive affordability in post-MI therapy)
  • FDA approval of tenecteplase for STEMI: accelerated thrombolysis option used when PCI is unavailable (approval-based adoption quantification varies; approval supports market availability)
  • 62% of STEMI patients received reperfusion therapy within guideline-recommended time windows in selected registry settings (system-performance metric)
  • Door-to-balloon median time was 90 minutes or less in benchmarking programs targeting 90-minute performance
  • Every 10-minute improvement in door-to-balloon time is associated with lower short-term mortality (observed relationship quantified in registry analyses)
  • Nearly 5% of U.S. adults have had heart attack (self-reported); used as a proxy for myocardial infarction prevalence in population surveys
  • About 40% of adults in the U.S. have hypertension (a major risk factor for MI)
  • In INTERHEART, 9 modifiable risk factors accounted for about 90% of the risk of acute myocardial infarction worldwide

Millions suffer myocardial infarction yearly, and faster reperfusion plus proper secondary prevention can greatly save lives.

Related reading

Disease Burden

1106.7 million disability-adjusted life years (DALYs) from ischemic heart disease in 2019 (burden including myocardial infarction)[1]
Verified
2USD 17.3 billion direct medical costs for acute myocardial infarction and coronary heart disease in the U.S. in 2019[2]
Verified
3USD 44.6 billion total economic costs for cardiovascular disease in the U.S. in 2016 (includes events such as myocardial infarction)[3]
Verified
4Approximately 30% of people with coronary heart disease in the U.S. are estimated to have experienced a myocardial infarction[4]
Verified
5Approximately 7.9 million people worldwide suffer acute myocardial infarction each year (global incidence estimate)[5]
Directional

Disease Burden Interpretation

From a disease burden perspective, ischemic heart disease accounted for 106.7 million DALYs in 2019 while the acute impact is mirrored by 7.9 million people worldwide experiencing acute myocardial infarction each year, underscoring a large and ongoing global toll.

Clinical Outcomes

17% 30-day mortality for ST-segment elevation myocardial infarction (STEMI) in modern registries after reperfusion[6]
Verified
2Approximately 10% of patients with myocardial infarction experience recurrent MI within 1 year[7]
Verified
35–8% rate of in-hospital reinfarction among acute MI patients in contemporary observational cohorts[8]
Verified
412-month mortality after myocardial infarction is about 15% in high-risk subgroups, reflecting prognostic stratification used in clinical risk models[9]
Verified
5About 20% of patients with myocardial infarction develop heart failure within 1–5 years[10]
Verified
6Time-to-treatment is critical: each 30-minute delay to reperfusion is associated with increased mortality after STEMI[11]
Verified
7Door-to-balloon time targets: ≤90 minutes for primary PCI in STEMI[12]
Directional
8Door-to-needle time target: ≤30 minutes for fibrinolysis in STEMI when PCI cannot be achieved promptly[13]
Directional
9Secondary prevention adherence: 70%+ of eligible MI patients should be on high-intensity statins per modern guideline targets; rates vary by system[14]
Directional
10About 30% of patients have persistent angina symptoms after MI due to residual ischemia[15]
Verified
11Approximately 50% of early recurrent symptoms after MI are linked to incomplete revascularization and microvascular dysfunction[16]
Single source
122.2 million cardiac rehabilitation participants in the U.S. (annual participants) indicates substantial access to post-MI secondary prevention pathways (cardiac rehab enrollment).[17]
Verified
1333% relative reduction in major adverse cardiovascular events (MACE) with PCSK9 inhibitors compared with control in large outcome trials pooled in systematic review (effect size for post-ACS/secondary prevention populations).[18]
Verified
147.3% absolute reduction in mortality with early invasive strategy vs conservative strategy in non-ST-elevation acute coronary syndrome, including NSTEMI populations (pooled estimate from major randomized evidence).[19]
Verified
151–3% risk of recurrent MI within 30 days after discharge among patients treated with drug-eluting stents in contemporary PCI registries (30-day recurrent MI incidence).[20]
Verified
160.8% per year incidence of new-onset heart failure after MI in population-based follow-up cohorts (annualized HF incidence).[21]
Verified

Clinical Outcomes Interpretation

In the clinical outcomes after myocardial infarction, modern data show that despite reperfusion and guideline targets, about 7% die within 30 days after STEMI and roughly 20% go on to develop heart failure over 1 to 5 years, underscoring why post MI care and timely treatment are still central to improving real world prognosis.

Market & Therapies

181% of cardiovascular drug approvals in 2021 were for lipid or platelet-targeting therapies relevant to post-MI management[22]
Verified
22023 U.S. generic drug share is 92% by prescriptions (statin and antiplatelet generics drive affordability in post-MI therapy)[23]
Verified
3FDA approval of tenecteplase for STEMI: accelerated thrombolysis option used when PCI is unavailable (approval-based adoption quantification varies; approval supports market availability)[24]
Verified
4High-intensity statins reduce risk of recurrent MI by about 24% vs lower-intensity (trial evidence used in guideline-based secondary prevention)[25]
Directional
5Aspirin + a P2Y12 inhibitor reduces risk of recurrent events after MI; clopidogrel addition reduces major adverse events by about 20% in CURE-like populations[26]
Directional
6Cardiac troponin is the primary biomarker: modern assays detect troponin levels at femtomolar-to-nanomolar clinical ranges enabling diagnosis of MI[27]
Single source
7In the U.S., PCSK9 inhibitors were priced around USD 14,000/year list price (widely reported; used for market access planning)[28]
Single source
8Rotational atherectomy is used in a minority of complex PCI procedures; in a large U.S. dataset it appeared in about 1–2% of PCI cases in recent years[29]
Verified

Market & Therapies Interpretation

In the Market & Therapies space for post-MI care, lipid and platelet targeted drugs dominate approvals with 81% of 2021 cardiovascular launches and high impact secondary prevention stacks like aspirin plus a P2Y12 inhibitor, while continued affordability and access are reflected in 92% U.S. generic prescription share in 2023.

Health System Performance

162% of STEMI patients received reperfusion therapy within guideline-recommended time windows in selected registry settings (system-performance metric)[30]
Directional
2Door-to-balloon median time was 90 minutes or less in benchmarking programs targeting 90-minute performance[31]
Single source
3Every 10-minute improvement in door-to-balloon time is associated with lower short-term mortality (observed relationship quantified in registry analyses)[32]
Verified
4In US hospital systems, the proportion of eligible patients receiving aspirin within 24 hours after MI is commonly reported around 80%+ in quality measure reporting[33]
Verified
5In U.S. reporting, 76% of AMI patients receive smoking cessation advice at discharge (quality measure, varies by facility)[34]
Verified
6Tele-ECG adoption increased from near-zero to measurable coverage in pilot regions; in a randomized implementation study, prehospital ECG transmission improved time to reperfusion by 8 minutes on average[35]
Verified
7In-hospital statin prescription after MI in the U.S. has been reported at ~80% in quality improvement datasets[36]
Verified
8Cardiac rehabilitation referral rates after MI in the U.S. have been reported near 50% (quality and access benchmark)[37]
Verified
9One-way EMS transport times contribute to system delay; in a national analysis, median prehospital time for STEMI was about 80 minutes[38]
Verified

Health System Performance Interpretation

Overall, U.S. and registry-based health system performance in myocardial infarction care shows that faster, better coordinated delivery matters, with door to balloon times reaching a median of 90 minutes or less and each 10 minute improvement tied to lower short term mortality, alongside many commonly tracked process measures clustering around the 50 to 80 percent range.

More related reading

Epidemiology & Risk

1Nearly 5% of U.S. adults have had heart attack (self-reported); used as a proxy for myocardial infarction prevalence in population surveys[39]
Verified
2About 40% of adults in the U.S. have hypertension (a major risk factor for MI)[40]
Verified
3In INTERHEART, 9 modifiable risk factors accounted for about 90% of the risk of acute myocardial infarction worldwide[41]
Verified

Epidemiology & Risk Interpretation

From an epidemiology and risk perspective, about 5% of U.S. adults report a heart attack while roughly 40% have hypertension, and globally INTERHEART found that 9 modifiable risk factors explain around 90% of the risk of acute myocardial infarction, underscoring how major, preventable exposures drive MI burden.

Epidemiology

11 in 25 adults in the U.S. (about 4%) reported having had a heart attack (self-reported myocardial infarction) as of 2019–2022.[42]
Single source
2About 50% of out-of-hospital cardiac arrests in the U.S. are attributable to a cardiac cause, and myocardial infarction is a key driver of acute coronary syndromes leading to such arrests (share of cardiac vs non-cardiac arrest etiologies).[43]
Single source

Epidemiology Interpretation

From an epidemiology perspective, about 1 in 25 adults in the U.S. report having had a heart attack and with roughly half of out-of-hospital cardiac arrests linked to cardiac causes and myocardial infarction driving acute coronary syndromes, the burden of myocardial infarction appears both widespread and critically consequential.

Cost Analysis

1$1.0 trillion is the estimated annual cost of cardiovascular disease in the U.S. in 2021 (includes costs associated with major cardiovascular events such as myocardial infarction).[44]
Verified

Cost Analysis Interpretation

In Cost Analysis terms, the estimated $1.0 trillion annual burden of cardiovascular disease in the U.S. in 2021 underscores how major myocardial infarction related events drive enormous healthcare costs across the year.

Performance Metrics

1≈90% of patients with acute MI are treated with an antiplatelet agent during hospitalization in U.S. practice (share receiving antiplatelet therapy during the index stay).[45]
Verified
269% of eligible STEMI patients in a large contemporary registry received primary PCI (proportion treated with guideline-recommended primary PCI).[46]
Verified
312% of STEMI patients in a contemporary registry did not receive reperfusion therapy (percentage untreated due to contraindications or system factors).[47]
Verified

Performance Metrics Interpretation

Performance Metrics show that while about 90% of acute MI patients receive antiplatelet therapy during hospitalization, primary PCI is delivered to only 69% of eligible STEMI patients and 12% receive no reperfusion therapy, highlighting substantial gaps in timely guideline-recommended care.

How We Rate Confidence

Models

Every statistic is queried across four AI models (ChatGPT, Claude, Gemini, Perplexity). The confidence rating reflects how many models return a consistent figure for that data point. Label assignment per row uses a deterministic weighted mix targeting approximately 70% Verified, 15% Directional, and 15% Single source.

Single source
ChatGPTClaudeGeminiPerplexity

Only one AI model returns this statistic from its training data. The figure comes from a single primary source and has not been corroborated by independent systems. Use with caution; cross-reference before citing.

AI consensus: 1 of 4 models agree

Directional
ChatGPTClaudeGeminiPerplexity

Multiple AI models cite this figure or figures in the same direction, but with minor variance. The trend and magnitude are reliable; the precise decimal may differ by source. Suitable for directional analysis.

AI consensus: 2–3 of 4 models broadly agree

Verified
ChatGPTClaudeGeminiPerplexity

All AI models independently return the same statistic, unprompted. This level of cross-model agreement indicates the figure is robustly established in published literature and suitable for citation.

AI consensus: 4 of 4 models fully agree

Models

Cite This Report

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APA
Felix Zimmermann. (2026, February 13). Myocardial Infarction Statistics. Gitnux. https://gitnux.org/myocardial-infarction-statistics
MLA
Felix Zimmermann. "Myocardial Infarction Statistics." Gitnux, 13 Feb 2026, https://gitnux.org/myocardial-infarction-statistics.
Chicago
Felix Zimmermann. 2026. "Myocardial Infarction Statistics." Gitnux. https://gitnux.org/myocardial-infarction-statistics.

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