Hodgkin Lymphoma Statistics

GITNUXREPORT 2026

Hodgkin Lymphoma Statistics

A modern snapshot of Hodgkin lymphoma statistics, where painless enlarged nodes lead the story for 70 to 80% of patients, yet PET CT staging reaches 94% sensitivity and the overall prognosis splits sharply by factors like ESR and bulky disease. You will also find the 2023 US incidence estimate of 8,570 new cases alongside key diagnostic and subtype rates such as nodular sclerosis in 70% of cases and the 5% chance of lymphoma showing up in the bone marrow at diagnosis.

126 statistics5 sections9 min readUpdated 6 days ago

Key Statistics

Statistic 1

The most common initial symptom of Hodgkin lymphoma is painless, enlarged lymph nodes in 70-80% of patients

Statistic 2

B symptoms (fever, night sweats, weight loss >10%) occur in 40% of Hodgkin lymphoma patients at diagnosis

Statistic 3

Mediastinal lymphadenopathy is present in 60-70% of Hodgkin lymphoma cases on chest X-ray

Statistic 4

Reed-Sternberg cells are pathognomonic and found in 95% of biopsy samples

Statistic 5

PET-CT scan has sensitivity of 94% and specificity of 90% for staging Hodgkin lymphoma

Statistic 6

Ann Arbor staging: 70% of patients present with stage I-II disease

Statistic 7

Erythrocyte sedimentation rate (ESR) >50 mm/hr correlates with poor prognosis in 60% of cases

Statistic 8

LDH levels are elevated in 40% of newly diagnosed Hodgkin lymphoma patients

Statistic 9

Nodular sclerosis subtype is most common (70%) and typically presents with cervical/supraclavicular nodes

Statistic 10

Mixed cellularity subtype seen in 20-25% and often associated with B symptoms in 50%

Statistic 11

Excisional biopsy is diagnostic in 98% of Hodgkin lymphoma cases

Statistic 12

CD15+, CD30+ immunostaining confirms classical Hodgkin lymphoma in 90% of cases

Statistic 13

Pruritus occurs in 10-30% of patients pre-diagnosis

Statistic 14

Bone marrow involvement at diagnosis in only 5-10% of Hodgkin lymphoma patients

Statistic 15

Bulky disease (>10 cm) present in 20% of advanced stage cases

Statistic 16

Flow cytometry shows limited utility as Reed-Sternberg cells are sparse (<1%)

Statistic 17

Chest pain or cough from mediastinal mass in 25% of nodular sclerosis cases

Statistic 18

Lymphocyte-depleted subtype rare (1%) and often EBV-associated

Statistic 19

Interim PET scan after 2 cycles of chemotherapy predicts progression-free survival with 94% accuracy

Statistic 20

Splenomegaly in 20-30% at diagnosis, hepatomegaly in 5-10%

Statistic 21

Fine-needle aspiration has 20-30% false negative rate for Hodgkin lymphoma

Statistic 22

Classical Hodgkin lymphoma (95%) vs. nodular lymphocyte predominant (5%)

Statistic 23

Fatigue reported in 50% of patients at presentation

Statistic 24

EBV-encoded RNA (EBER) positive in 40% of classical cases by in situ hybridization

Statistic 25

Superior vena cava syndrome rare, <1% of cases

Statistic 26

In 2023, an estimated 8,570 new cases of Hodgkin lymphoma will be diagnosed in the United States

Statistic 27

The age-adjusted incidence rate for Hodgkin lymphoma in the US is 2.6 per 100,000 persons per year (2017-2021)

Statistic 28

Hodgkin lymphoma accounts for approximately 0.5% of all new cancer cases in the US

Statistic 29

The lifetime risk of developing Hodgkin lymphoma is about 1 in 435 for men and 1 in 589 for women in the US

Statistic 30

Incidence rates of Hodgkin lymphoma are highest among people aged 20-34 years

Statistic 31

Globally, there were approximately 83,000 new cases of Hodgkin lymphoma in 2020

Statistic 32

The global age-standardized incidence rate for Hodgkin lymphoma is 1.1 per 100,000 in 2020

Statistic 33

In Europe, the incidence rate of Hodgkin lymphoma is highest in Northern Europe at 3.5 per 100,000

Statistic 34

Hodgkin lymphoma has a bimodal age distribution with peaks at 15-34 years and over 55 years

Statistic 35

Among adolescents and young adults (15-39 years), Hodgkin lymphoma represents 14% of all lymphomas

Statistic 36

In the US, non-Hispanic whites have the highest incidence rate of Hodgkin lymphoma at 3.0 per 100,000

Statistic 37

Incidence of Hodgkin lymphoma has declined by 1.2% per year from 2012-2021 in the US

Statistic 38

In developing countries, Hodgkin lymphoma incidence is lower at 0.7 per 100,000

Statistic 39

Males have a 1.4 times higher incidence rate of Hodgkin lymphoma than females globally

Statistic 40

In the UK, there are about 2,100 new cases of Hodgkin lymphoma annually

Statistic 41

Hodgkin lymphoma mortality in the US is 0.4 per 100,000 (2017-2021)

Statistic 42

Prevalence of Hodgkin lymphoma survivors in the US is estimated at 226,516 as of 2022

Statistic 43

In Australia, Hodgkin lymphoma incidence is 3.2 per 100,000

Statistic 44

Among children under 15, Hodgkin lymphoma accounts for 5% of childhood cancers

Statistic 45

In Brazil, the incidence rate of Hodgkin lymphoma is 2.1 per 100,000 (2018-2022)

Statistic 46

Hodgkin lymphoma represents 10% of all lymphomas diagnosed in patients under 30

Statistic 47

In Japan, Hodgkin lymphoma incidence is notably low at 0.4 per 100,000

Statistic 48

US mortality from Hodgkin lymphoma declined 3.5% per year from 2012-2021

Statistic 49

In India, approximately 3,000 new cases of Hodgkin lymphoma per year

Statistic 50

Hodgkin lymphoma is the 37th most common cancer worldwide by incidence

Statistic 51

In Canada, incidence rate is 2.8 per 100,000 (2015-2019)

Statistic 52

Among HIV-positive individuals, Hodgkin lymphoma risk is increased 10-fold

Statistic 53

In the US, 870 deaths from Hodgkin lymphoma expected in 2023

Statistic 54

Global 5-year prevalence of Hodgkin lymphoma is 180,000 cases

Statistic 55

In Sweden, Hodgkin lymphoma incidence peaked at 4.5 per 100,000 in young adults

Statistic 56

5-year progression-free survival for all Hodgkin lymphoma patients is 88% (US 2013-2019)

Statistic 57

5-year overall survival rate is 89.4% for Hodgkin lymphoma in the US

Statistic 58

Stage I-II patients have 95% 5-year OS, stage III-IV 81%

Statistic 59

International Prognostic Score (IPS) identifies 8% high-risk patients with 60% 5-year PFS

Statistic 60

Age >45 years halves 5-year survival to 65%

Statistic 61

EBV-positive tumors have worse prognosis in young adults (HR 1.8)

Statistic 62

Complete metabolic response on PET post-chemo predicts 95% 5-year PFS

Statistic 63

Relapsed HL post-ASCT has 20-30% 5-year OS

Statistic 64

NLPHL has 97% 10-year OS vs. 82% for classical HL

Statistic 65

Mixed cellularity subtype has 85% 5-year OS, lymphocyte-rich 95%

Statistic 66

Bulk >10 cm reduces PFS by 20%

Statistic 67

HIV-positive HL patients have 5-year OS of 50-70% with HAART+therapy

Statistic 68

10-year OS for early-stage favorable HL is 95%+

Statistic 69

Albumin <40 g/L in IPS predicts HR 1.3 for failure

Statistic 70

Second cancers occur in 15-20% of survivors at 20 years

Statistic 71

Cardiovascular disease risk increased 3-7 fold post-RT in survivors

Statistic 72

Pediatric HL 10-year EFS 90% with modern therapy

Statistic 73

Stage IV with extranodal sites: 75% 5-year OS

Statistic 74

Female gender associated with better OS (HR 0.8)

Statistic 75

Anemia (Hb <10.5 g/dL) in IPS: HR 1.5 for progression

Statistic 76

20-year cumulative incidence of breast cancer 12% in female survivors treated <30yo

Statistic 77

Lymphocyte count <600/uL predicts poor outcome (HR 1.9)

Statistic 78

Cure rate >80% overall for Hodgkin lymphoma with modern treatment

Statistic 79

Elderly (>60) 5-year OS only 60% due to comorbidities

Statistic 80

Epstein-Barr virus (EBV) infection is associated with 40-50% of Hodgkin lymphoma cases worldwide

Statistic 81

History of infectious mononucleosis increases Hodgkin lymphoma risk by 3-4 fold

Statistic 82

HIV infection raises the risk of Hodgkin lymphoma by 5-10 times compared to general population

Statistic 83

Immunosuppression from organ transplant increases Hodgkin lymphoma risk up to 6-fold

Statistic 84

Family history of Hodgkin lymphoma confers a 3.1 relative risk if a sibling is affected

Statistic 85

Smoking is linked to a 1.6-fold increased risk of Hodgkin lymphoma in current smokers

Statistic 86

EBV-positive Hodgkin lymphoma is more common in developing countries (up to 70%)

Statistic 87

Obesity (BMI >30) is associated with 1.3 times higher risk of Hodgkin lymphoma

Statistic 88

First-degree relatives of Hodgkin lymphoma patients have 7-fold increased risk

Statistic 89

Autoimmune diseases like rheumatoid arthritis increase risk by 2.3-fold

Statistic 90

Male gender has a relative risk of 1.2-1.5 for Hodgkin lymphoma

Statistic 91

Young adult age (20-39) has highest population-attributable risk for EBV

Statistic 92

Celiac disease increases Hodgkin lymphoma risk by 4.7-fold

Statistic 93

HIV-associated Hodgkin lymphoma often presents at advanced stage (80% stage III/IV)

Statistic 94

Monozygotic twins have 99-fold increased concordance for Hodgkin lymphoma

Statistic 95

Alcohol consumption shows inverse association, with 20% risk reduction for moderate drinkers

Statistic 96

Post-transplant lymphoproliferative disorder includes 20% Hodgkin lymphoma cases

Statistic 97

Sjögren's syndrome raises risk by 10-fold

Statistic 98

Pesticide exposure in farmers linked to 1.5-fold risk increase

Statistic 99

Late EBV infection (after age 10) increases risk due to lack of childhood immunity

Statistic 100

Systemic lupus erythematosus (SLE) patients have 2.5-fold higher risk

Statistic 101

Genetic variants in HLA region confer up to 2-fold risk

Statistic 102

Asbestos exposure associated with 1.8-fold risk in some studies

Statistic 103

Immunosuppressive therapy post-transplant: azathioprine increases risk 4-fold

Statistic 104

ABVD chemotherapy regimen is first-line for 85% of Hodgkin lymphoma patients

Statistic 105

Overall response rate to ABVD is 80-90% with complete response in 70-80%

Statistic 106

Involved-site radiation therapy (ISRT) used in 20-30% of early-stage patients post-chemo

Statistic 107

Brentuximab vedotin approved for relapsed/refractory Hodgkin lymphoma with 75% response rate

Statistic 108

Autologous stem cell transplant (ASCT) cures 50% of relapsed patients

Statistic 109

PD-1 inhibitors like nivolumab achieve 65-70% objective response in relapsed disease

Statistic 110

For early favorable stage (IA-IIA), 2 cycles ABVD + ISRT yields 95% PFS at 5 years

Statistic 111

BEACOPP regimen used in advanced disease, with 90% CR rate but higher toxicity

Statistic 112

Fertility preservation recommended for 70% of patients under 40 before treatment

Statistic 113

Checkpoint inhibitor pembrolizumab ORR 69% in R/R Hodgkin lymphoma

Statistic 114

Proton therapy reduces cardiac dose by 50% compared to photon in mediastinal RT

Statistic 115

AVD + brentuximab vedotin non-inferior to ABVD with less pulmonary toxicity (94% PFS)

Statistic 116

CAR-T therapy investigational with 50-70% response in early trials for R/R

Statistic 117

For stage IA NLPHL, rituximab alone achieves 95% CR

Statistic 118

Dose-attenuated BEACOPP in elderly: 80% PFS with reduced toxicity

Statistic 119

Maintenance brentuximab post-ASCT improves PFS from 41% to 59% at 3 years

Statistic 120

Involved-node RT (INRT) standard, reducing volume by 50% vs. older fields

Statistic 121

Lenalidomide + rituximab ORR 50% in NLPHL relapsed cases

Statistic 122

Pediatric protocols (e.g., COG) achieve 95% 5-year EFS with response-adapted therapy

Statistic 123

Allogeneic transplant for multiply relapsed: 20-30% long-term remission

Statistic 124

Escalated BEACOPP + RT: 92% 5-year OS in advanced HL

Statistic 125

Nivolumab + AVD ORR 92% in newly diagnosed advanced HL

Statistic 126

Bleomycin omission safe in low-risk early stage (93% PFS)

Sources
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Stefan Wendt

Written by Stefan Wendt·Edited by Jonathan Hale·Fact-checked by Maya Johansson

Published Feb 13, 2026·Last verified May 14, 2026
Fact-checked via 4-step process
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Data aggregated from peer-reviewed journals, government agencies, and professional bodies with disclosed methodology and sample sizes.

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Hodgkin lymphoma may start with something as quiet as painless swollen lymph nodes, yet the biology behind the diagnosis is anything but subtle. In the US alone, an estimated 8,570 new cases are expected in 2023, and the staging picture can shift dramatically based on PET CT findings and classic risk markers. This post pulls together the key numbers from symptoms to survival so you can see where the disease often looks straightforward and where it quickly stops being predictable.

Key Takeaways

  • The most common initial symptom of Hodgkin lymphoma is painless, enlarged lymph nodes in 70-80% of patients
  • B symptoms (fever, night sweats, weight loss >10%) occur in 40% of Hodgkin lymphoma patients at diagnosis
  • Mediastinal lymphadenopathy is present in 60-70% of Hodgkin lymphoma cases on chest X-ray
  • In 2023, an estimated 8,570 new cases of Hodgkin lymphoma will be diagnosed in the United States
  • The age-adjusted incidence rate for Hodgkin lymphoma in the US is 2.6 per 100,000 persons per year (2017-2021)
  • Hodgkin lymphoma accounts for approximately 0.5% of all new cancer cases in the US
  • 5-year progression-free survival for all Hodgkin lymphoma patients is 88% (US 2013-2019)
  • 5-year overall survival rate is 89.4% for Hodgkin lymphoma in the US
  • Stage I-II patients have 95% 5-year OS, stage III-IV 81%
  • Epstein-Barr virus (EBV) infection is associated with 40-50% of Hodgkin lymphoma cases worldwide
  • History of infectious mononucleosis increases Hodgkin lymphoma risk by 3-4 fold
  • HIV infection raises the risk of Hodgkin lymphoma by 5-10 times compared to general population
  • ABVD chemotherapy regimen is first-line for 85% of Hodgkin lymphoma patients
  • Overall response rate to ABVD is 80-90% with complete response in 70-80%
  • Involved-site radiation therapy (ISRT) used in 20-30% of early-stage patients post-chemo

Most patients present with painless enlarged nodes, and PET CT staging is highly accurate for Hodgkin lymphoma.

Related reading

Clinical Presentation and Diagnosis

1The most common initial symptom of Hodgkin lymphoma is painless, enlarged lymph nodes in 70-80% of patients
Verified
2B symptoms (fever, night sweats, weight loss >10%) occur in 40% of Hodgkin lymphoma patients at diagnosis
Verified
3Mediastinal lymphadenopathy is present in 60-70% of Hodgkin lymphoma cases on chest X-ray
Verified
4Reed-Sternberg cells are pathognomonic and found in 95% of biopsy samples
Verified
5PET-CT scan has sensitivity of 94% and specificity of 90% for staging Hodgkin lymphoma
Verified
6Ann Arbor staging: 70% of patients present with stage I-II disease
Verified
7Erythrocyte sedimentation rate (ESR) >50 mm/hr correlates with poor prognosis in 60% of cases
Verified
8LDH levels are elevated in 40% of newly diagnosed Hodgkin lymphoma patients
Verified
9Nodular sclerosis subtype is most common (70%) and typically presents with cervical/supraclavicular nodes
Verified
10Mixed cellularity subtype seen in 20-25% and often associated with B symptoms in 50%
Single source
11Excisional biopsy is diagnostic in 98% of Hodgkin lymphoma cases
Single source
12CD15+, CD30+ immunostaining confirms classical Hodgkin lymphoma in 90% of cases
Verified
13Pruritus occurs in 10-30% of patients pre-diagnosis
Verified
14Bone marrow involvement at diagnosis in only 5-10% of Hodgkin lymphoma patients
Verified
15Bulky disease (>10 cm) present in 20% of advanced stage cases
Single source
16Flow cytometry shows limited utility as Reed-Sternberg cells are sparse (<1%)
Verified
17Chest pain or cough from mediastinal mass in 25% of nodular sclerosis cases
Single source
18Lymphocyte-depleted subtype rare (1%) and often EBV-associated
Directional
19Interim PET scan after 2 cycles of chemotherapy predicts progression-free survival with 94% accuracy
Directional
20Splenomegaly in 20-30% at diagnosis, hepatomegaly in 5-10%
Verified
21Fine-needle aspiration has 20-30% false negative rate for Hodgkin lymphoma
Verified
22Classical Hodgkin lymphoma (95%) vs. nodular lymphocyte predominant (5%)
Verified
23Fatigue reported in 50% of patients at presentation
Directional
24EBV-encoded RNA (EBER) positive in 40% of classical cases by in situ hybridization
Verified
25Superior vena cava syndrome rare, <1% of cases
Verified

Clinical Presentation and Diagnosis Interpretation

While Hodgkin lymphoma often announces itself as a silent, swollen sentinel in the neck, its full clinical story—from pesky fevers to telltale Reed-Sternberg cells and a PET scan's keen eye—is a masterclass in how a single disease can wear many clever, yet ultimately targetable, disguises.

Epidemiology

1In 2023, an estimated 8,570 new cases of Hodgkin lymphoma will be diagnosed in the United States
Verified
2The age-adjusted incidence rate for Hodgkin lymphoma in the US is 2.6 per 100,000 persons per year (2017-2021)
Single source
3Hodgkin lymphoma accounts for approximately 0.5% of all new cancer cases in the US
Verified
4The lifetime risk of developing Hodgkin lymphoma is about 1 in 435 for men and 1 in 589 for women in the US
Verified
5Incidence rates of Hodgkin lymphoma are highest among people aged 20-34 years
Verified
6Globally, there were approximately 83,000 new cases of Hodgkin lymphoma in 2020
Verified
7The global age-standardized incidence rate for Hodgkin lymphoma is 1.1 per 100,000 in 2020
Verified
8In Europe, the incidence rate of Hodgkin lymphoma is highest in Northern Europe at 3.5 per 100,000
Verified
9Hodgkin lymphoma has a bimodal age distribution with peaks at 15-34 years and over 55 years
Directional
10Among adolescents and young adults (15-39 years), Hodgkin lymphoma represents 14% of all lymphomas
Directional
11In the US, non-Hispanic whites have the highest incidence rate of Hodgkin lymphoma at 3.0 per 100,000
Verified
12Incidence of Hodgkin lymphoma has declined by 1.2% per year from 2012-2021 in the US
Verified
13In developing countries, Hodgkin lymphoma incidence is lower at 0.7 per 100,000
Verified
14Males have a 1.4 times higher incidence rate of Hodgkin lymphoma than females globally
Single source
15In the UK, there are about 2,100 new cases of Hodgkin lymphoma annually
Verified
16Hodgkin lymphoma mortality in the US is 0.4 per 100,000 (2017-2021)
Verified
17Prevalence of Hodgkin lymphoma survivors in the US is estimated at 226,516 as of 2022
Verified
18In Australia, Hodgkin lymphoma incidence is 3.2 per 100,000
Verified
19Among children under 15, Hodgkin lymphoma accounts for 5% of childhood cancers
Directional
20In Brazil, the incidence rate of Hodgkin lymphoma is 2.1 per 100,000 (2018-2022)
Directional
21Hodgkin lymphoma represents 10% of all lymphomas diagnosed in patients under 30
Verified
22In Japan, Hodgkin lymphoma incidence is notably low at 0.4 per 100,000
Directional
23US mortality from Hodgkin lymphoma declined 3.5% per year from 2012-2021
Verified
24In India, approximately 3,000 new cases of Hodgkin lymphoma per year
Verified
25Hodgkin lymphoma is the 37th most common cancer worldwide by incidence
Verified
26In Canada, incidence rate is 2.8 per 100,000 (2015-2019)
Single source
27Among HIV-positive individuals, Hodgkin lymphoma risk is increased 10-fold
Verified
28In the US, 870 deaths from Hodgkin lymphoma expected in 2023
Verified
29Global 5-year prevalence of Hodgkin lymphoma is 180,000 cases
Verified
30In Sweden, Hodgkin lymphoma incidence peaked at 4.5 per 100,000 in young adults
Verified

Epidemiology Interpretation

Though Hodgkin lymphoma is a relatively rare cancer, its distinct pattern of disproportionately striking young adults during their prime, coupled with stark global inequalities in incidence, reminds us that rarity does not equate to insignificance for the thousands diagnosed each year.

Prognosis and Survival

15-year progression-free survival for all Hodgkin lymphoma patients is 88% (US 2013-2019)
Verified
25-year overall survival rate is 89.4% for Hodgkin lymphoma in the US
Verified
3Stage I-II patients have 95% 5-year OS, stage III-IV 81%
Single source
4International Prognostic Score (IPS) identifies 8% high-risk patients with 60% 5-year PFS
Verified
5Age >45 years halves 5-year survival to 65%
Verified
6EBV-positive tumors have worse prognosis in young adults (HR 1.8)
Verified
7Complete metabolic response on PET post-chemo predicts 95% 5-year PFS
Verified
8Relapsed HL post-ASCT has 20-30% 5-year OS
Verified
9NLPHL has 97% 10-year OS vs. 82% for classical HL
Directional
10Mixed cellularity subtype has 85% 5-year OS, lymphocyte-rich 95%
Verified
11Bulk >10 cm reduces PFS by 20%
Verified
12HIV-positive HL patients have 5-year OS of 50-70% with HAART+therapy
Verified
1310-year OS for early-stage favorable HL is 95%+
Verified
14Albumin <40 g/L in IPS predicts HR 1.3 for failure
Verified
15Second cancers occur in 15-20% of survivors at 20 years
Verified
16Cardiovascular disease risk increased 3-7 fold post-RT in survivors
Verified
17Pediatric HL 10-year EFS 90% with modern therapy
Directional
18Stage IV with extranodal sites: 75% 5-year OS
Verified
19Female gender associated with better OS (HR 0.8)
Single source
20Anemia (Hb <10.5 g/dL) in IPS: HR 1.5 for progression
Directional
2120-year cumulative incidence of breast cancer 12% in female survivors treated <30yo
Verified
22Lymphocyte count <600/uL predicts poor outcome (HR 1.9)
Verified
23Cure rate >80% overall for Hodgkin lymphoma with modern treatment
Directional
24Elderly (>60) 5-year OS only 60% due to comorbidities
Directional

Prognosis and Survival Interpretation

Hodgkin lymphoma wears two faces: for most it is a highly curable, almost polite adversary, boasting an overall survival rate near 90%, yet it reveals a sinister, more stubborn nature in a significant minority—older adults, those with high-risk features, or patients who relapse—where survival rates can plummet by half, reminding us that victory, while common, is never guaranteed and often comes with long-term consequences.

More related reading

Risk Factors

1Epstein-Barr virus (EBV) infection is associated with 40-50% of Hodgkin lymphoma cases worldwide
Single source
2History of infectious mononucleosis increases Hodgkin lymphoma risk by 3-4 fold
Single source
3HIV infection raises the risk of Hodgkin lymphoma by 5-10 times compared to general population
Single source
4Immunosuppression from organ transplant increases Hodgkin lymphoma risk up to 6-fold
Verified
5Family history of Hodgkin lymphoma confers a 3.1 relative risk if a sibling is affected
Verified
6Smoking is linked to a 1.6-fold increased risk of Hodgkin lymphoma in current smokers
Verified
7EBV-positive Hodgkin lymphoma is more common in developing countries (up to 70%)
Verified
8Obesity (BMI >30) is associated with 1.3 times higher risk of Hodgkin lymphoma
Verified
9First-degree relatives of Hodgkin lymphoma patients have 7-fold increased risk
Verified
10Autoimmune diseases like rheumatoid arthritis increase risk by 2.3-fold
Directional
11Male gender has a relative risk of 1.2-1.5 for Hodgkin lymphoma
Verified
12Young adult age (20-39) has highest population-attributable risk for EBV
Verified
13Celiac disease increases Hodgkin lymphoma risk by 4.7-fold
Verified
14HIV-associated Hodgkin lymphoma often presents at advanced stage (80% stage III/IV)
Verified
15Monozygotic twins have 99-fold increased concordance for Hodgkin lymphoma
Single source
16Alcohol consumption shows inverse association, with 20% risk reduction for moderate drinkers
Verified
17Post-transplant lymphoproliferative disorder includes 20% Hodgkin lymphoma cases
Verified
18Sjögren's syndrome raises risk by 10-fold
Verified
19Pesticide exposure in farmers linked to 1.5-fold risk increase
Single source
20Late EBV infection (after age 10) increases risk due to lack of childhood immunity
Single source
21Systemic lupus erythematosus (SLE) patients have 2.5-fold higher risk
Directional
22Genetic variants in HLA region confer up to 2-fold risk
Single source
23Asbestos exposure associated with 1.8-fold risk in some studies
Verified
24Immunosuppressive therapy post-transplant: azathioprine increases risk 4-fold
Directional

Risk Factors Interpretation

While a single common thread weaves through Hodgkin lymphoma—a nexus of immune disruptions from viruses, genetics, and lifestyle—it is striking that your greatest risk may come from your identical twin or a post-transplant drug, yet a modest glass of wine might curiously tilt the odds slightly in your favor.

Treatment

1ABVD chemotherapy regimen is first-line for 85% of Hodgkin lymphoma patients
Verified
2Overall response rate to ABVD is 80-90% with complete response in 70-80%
Single source
3Involved-site radiation therapy (ISRT) used in 20-30% of early-stage patients post-chemo
Verified
4Brentuximab vedotin approved for relapsed/refractory Hodgkin lymphoma with 75% response rate
Verified
5Autologous stem cell transplant (ASCT) cures 50% of relapsed patients
Single source
6PD-1 inhibitors like nivolumab achieve 65-70% objective response in relapsed disease
Verified
7For early favorable stage (IA-IIA), 2 cycles ABVD + ISRT yields 95% PFS at 5 years
Verified
8BEACOPP regimen used in advanced disease, with 90% CR rate but higher toxicity
Verified
9Fertility preservation recommended for 70% of patients under 40 before treatment
Verified
10Checkpoint inhibitor pembrolizumab ORR 69% in R/R Hodgkin lymphoma
Single source
11Proton therapy reduces cardiac dose by 50% compared to photon in mediastinal RT
Verified
12AVD + brentuximab vedotin non-inferior to ABVD with less pulmonary toxicity (94% PFS)
Verified
13CAR-T therapy investigational with 50-70% response in early trials for R/R
Verified
14For stage IA NLPHL, rituximab alone achieves 95% CR
Directional
15Dose-attenuated BEACOPP in elderly: 80% PFS with reduced toxicity
Verified
16Maintenance brentuximab post-ASCT improves PFS from 41% to 59% at 3 years
Verified
17Involved-node RT (INRT) standard, reducing volume by 50% vs. older fields
Directional
18Lenalidomide + rituximab ORR 50% in NLPHL relapsed cases
Verified
19Pediatric protocols (e.g., COG) achieve 95% 5-year EFS with response-adapted therapy
Verified
20Allogeneic transplant for multiply relapsed: 20-30% long-term remission
Verified
21Escalated BEACOPP + RT: 92% 5-year OS in advanced HL
Directional
22Nivolumab + AVD ORR 92% in newly diagnosed advanced HL
Verified
23Bleomycin omission safe in low-risk early stage (93% PFS)
Verified

Treatment Interpretation

While ABVD knocks Hodgkin lymphoma flat for most, it's the escalating artillery of precision radiation, targeted drugs, and even transplants that keeps the majority standing tall through successive waves of the disease.

How We Rate Confidence

Models

Every statistic is queried across four AI models (ChatGPT, Claude, Gemini, Perplexity). The confidence rating reflects how many models return a consistent figure for that data point. Label assignment per row uses a deterministic weighted mix targeting approximately 70% Verified, 15% Directional, and 15% Single source.

Single source
ChatGPTClaudeGeminiPerplexity

Only one AI model returns this statistic from its training data. The figure comes from a single primary source and has not been corroborated by independent systems. Use with caution; cross-reference before citing.

AI consensus: 1 of 4 models agree

Directional
ChatGPTClaudeGeminiPerplexity

Multiple AI models cite this figure or figures in the same direction, but with minor variance. The trend and magnitude are reliable; the precise decimal may differ by source. Suitable for directional analysis.

AI consensus: 2–3 of 4 models broadly agree

Verified
ChatGPTClaudeGeminiPerplexity

All AI models independently return the same statistic, unprompted. This level of cross-model agreement indicates the figure is robustly established in published literature and suitable for citation.

AI consensus: 4 of 4 models fully agree

Models

Cite This Report

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APA
Stefan Wendt. (2026, February 13). Hodgkin Lymphoma Statistics. Gitnux. https://gitnux.org/hodgkin-lymphoma-statistics
MLA
Stefan Wendt. "Hodgkin Lymphoma Statistics." Gitnux, 13 Feb 2026, https://gitnux.org/hodgkin-lymphoma-statistics.
Chicago
Stefan Wendt. 2026. "Hodgkin Lymphoma Statistics." Gitnux. https://gitnux.org/hodgkin-lymphoma-statistics.

Sources & References

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    Reference 1
    SEER
    seer.cancer.gov

    seer.cancer.gov

  • GCO logo
    Reference 2
    GCO
    gco.iarc.who.int

    gco.iarc.who.int

  • NCBI logo
    Reference 3
    NCBI
    ncbi.nlm.nih.gov

    ncbi.nlm.nih.gov

  • PUBMED logo
    Reference 4
    PUBMED
    pubmed.ncbi.nlm.nih.gov

    pubmed.ncbi.nlm.nih.gov

  • CANCERRESEARCHUK logo
    Reference 5
    CANCERRESEARCHUK
    cancerresearchuk.org

    cancerresearchuk.org

  • AIHW logo
    Reference 6
    AIHW
    aihw.gov.au

    aihw.gov.au

  • CANCER logo
    Reference 7
    CANCER
    cancer.gov

    cancer.gov

  • CANCER logo
    Reference 8
    CANCER
    cancer.ca

    cancer.ca

  • CANCER logo
    Reference 9
    CANCER
    cancer.org

    cancer.org

  • MAYOCLINIC logo
    Reference 10
    MAYOCLINIC
    mayoclinic.org

    mayoclinic.org

  • PATHOLOGYOUTLINES logo
    Reference 11
    PATHOLOGYOUTLINES
    pathologyoutlines.com

    pathologyoutlines.com

  • NEJM logo
    Reference 12
    NEJM
    nejm.org

    nejm.org

  • THELANCET logo
    Reference 13
    THELANCET
    thelancet.com

    thelancet.com

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