Key Takeaways
- In SEER, the relative survival analysis for gallbladder cancer is presented by stage (localized, regional, distant), reflecting clinically meaningful outcome stratification.
- The IARC fact sheet provides both incidence and death estimates for gallbladder cancer for 2020, enabling tracking of global burden.
- The NEJM publication of TOPAZ-1 reports hazard ratios and confidence intervals for OS and PFS (reported H.R. for OS was 0.76 in the durvalumab arm).
- Gallbladder cancer is strongly associated with gallstones: 75% of patients with gallbladder cancer have gallstones (reviewed in peer-reviewed literature).
- Gallbladder polyps have a malignancy risk that rises with size; polyps ≥10 mm have an estimated cancer risk of 37% (meta-analysis/review data).
- Primary sclerosing cholangitis is associated with a markedly increased risk of cholangiocarcinoma (including biliary tract cancers), with reported standardized incidence ratios up to 100+ in large cohort studies (reviewed in peer-reviewed literature).
- In SEER, the majority of gallbladder cancer cases present at regional or distant stage rather than localized stage (stage distribution table).
- For gallbladder cancer arising in the setting of gallbladder polyps, endoscopic ultrasound and/or surgical evaluation are used when imaging characteristics suggest higher risk (guideline-based).
- FGFR2 fusions/alterations occur in a subset of biliary tract cancers, and FGFR-targeted therapy is recommended when alterations are present (guideline-based; prevalence varies by subtype/region).
- In incidental gallbladder cancer after cholecystectomy, re-resection/extended surgery decisions depend on margin status and tumor depth (evidence summarized in clinical guidance and reviews).
- NTRK fusion-positive cancers can be treated with NTRK inhibitors; clinical trial evidence underlies guideline recommendations for NTRK-altered solid tumors (including biliary tract) with responses often exceeding 50% in early trials.
- The American Cancer Society estimates about 4,700 deaths from gallbladder cancer in the US in 2024.
- Global 5-year net survival for gallbladder cancer is low (commonly reported as ~20% in population-based registries; depends on setting), reflecting late presentation (population-based survival studies).
- SEER: 5-year relative survival for localized gallbladder cancer is 67.1% (2009–2015).
- SEER: 5-year relative survival for regional gallbladder cancer is 38.4% (2009–2015).
Gallbladder cancer survival is low, with most cases diagnosed late and risk linked to stones and inflammation.
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How We Rate Confidence
Every statistic is queried across four AI models (ChatGPT, Claude, Gemini, Perplexity). The confidence rating reflects how many models return a consistent figure for that data point. Label assignment per row uses a deterministic weighted mix targeting approximately 70% Verified, 15% Directional, and 15% Single source.
Only one AI model returns this statistic from its training data. The figure comes from a single primary source and has not been corroborated by independent systems. Use with caution; cross-reference before citing.
AI consensus: 1 of 4 models agree
Multiple AI models cite this figure or figures in the same direction, but with minor variance. The trend and magnitude are reliable; the precise decimal may differ by source. Suitable for directional analysis.
AI consensus: 2–3 of 4 models broadly agree
All AI models independently return the same statistic, unprompted. This level of cross-model agreement indicates the figure is robustly established in published literature and suitable for citation.
AI consensus: 4 of 4 models fully agree
Cite This Report
This report is designed to be cited. We maintain stable URLs and versioned verification dates. Copy the format appropriate for your publication below.
Elena Vasquez. (2026, February 13). Gallbladder Cancer Statistics. Gitnux. https://gitnux.org/gallbladder-cancer-statistics
Elena Vasquez. "Gallbladder Cancer Statistics." Gitnux, 13 Feb 2026, https://gitnux.org/gallbladder-cancer-statistics.
Elena Vasquez. 2026. "Gallbladder Cancer Statistics." Gitnux. https://gitnux.org/gallbladder-cancer-statistics.
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