Blood plasma products support care for people with immune disorders, bleeding conditions, and protein deficiencies. This page explains how immunoglobulins, albumin, and clotting factors move from plasma collection to fractionation, then to therapies patients rely on. It also maps regional supply gaps—such as U.S. collection levels, Europe’s shortfall, and China’s mostly domestic use—alongside market size, growth, and key players.
Key Takeaways
- Immunoglobulins treat primary immunodeficiency in 1 in 10,000 people worldwide.
- Albumin used in 50 million infusions annually for hypoalbuminemia.
- Factor VIII from plasma treats 400,000 hemophilia A patients globally.
- U.S. represents 70% of global plasma supply, with 900+ FDA-licensed centers.
- Europe collects only 25% of source plasma needed, imports 75% from U.S.
- China 25% of global plasma, but mostly for domestic use.
- CSL Behring leads with 25% global plasma fractionation market share in 2023.
- Grifols SA revenue from plasma products: €5.2 billion in 2022.
- Takeda Pharmaceutical's plasma division (Shire) generated $6.5B in 2022 sales.
- The global blood plasma products market size was valued at USD 32.47 billion in 2022 and is expected to grow at a CAGR of 7.8% from 2023 to 2030.
- The plasma fractionation market is projected to reach USD 42.5 billion by 2028, growing at a CAGR of 8.2% from 2023.
- North America dominated the blood plasma market with a 45% share in 2022, driven by high collection volumes.
- In 2022, over 100 million plasma donations occurred worldwide.
- U.S. centers collected 110 liters of plasma per 1000 people in 2022.
- Europe collects 5.5 million liters of plasma annually from whole blood.
Global plasma use is surging, yet Europe’s shortfall and U.S. supply dominance are shaping fast market growth.
Related reading
01 · Category
Applications And Products17 stats
01
Immunoglobulins treat primary immunodeficiency in 1 in 10,000 people worldwide.
02
Albumin used in 50 million infusions annually for hypoalbuminemia.
03
Factor VIII from plasma treats 400,000 hemophilia A patients globally.
04
IVIG market driven by autoimmune diseases, 60% usage.
05
Alpha-1 antitrypsin deficiency affects 100,000 in U.S., treated by plasma Prolastin.
06
Rhophylac (anti-D) prevents hemolytic disease in 1M pregnancies/year.
07
C1 esterase inhibitor for hereditary angioedema, 10,000 patients EU.
08
Fibrinogen concentrates for congenital afibrinogenemia, rare 1:1M.
09
Protein C concentrate for thrombosis prevention, 500 patients global.
10
Von Willebrand factor plasma-derived for 1% population VWD.
11
Hyperimmune globulins like HBIG prevent hepatitis B in 1M newborns Asia.
12
Cytomegalovirus IG for transplant patients, 200,000/year.
13
Antithrombin III for hereditary deficiency, 1:5000 prevalence.
14
Plasma cryoprecipitate used in 20% trauma cases for fibrinogen.
15
Fresh frozen plasma transfused 10M units globally for coagulopathy.
16
Convalescent plasma efficacy 20% mortality reduction in early COVID trials.
17
Solvent-detergent plasma safer, reduces viral risk 1:10M.
02 · Category
Geographic Distribution24 stats
01
U.S. represents 70% of global plasma supply, with 900+ FDA-licensed centers.
02
Europe collects only 25% of source plasma needed, imports 75% from U.S.
03
China 25% of global plasma, but mostly for domestic use.
04
EU plasma self-sufficiency rate: 42% for source plasma in 2022.
05
U.S. plasma donations per capita: 42 liters/1000 people vs EU 6.5.
06
Australia 100% self-sufficient in plasma products via imports processing.
07
Japan imports 70% plasma from U.S., domestic bans on paid collection.
08
Canada 95% reliant on U.S. imports for fractionated plasma.
09
Brazil exports 40% of collected plasma to Europe.
10
Germany highest EU collection: 15 liters/1000 pop.
11
India plasma fractionation capacity: 5M liters but utilization 40%.
12
Russia self-sufficient, exports to CIS countries.
13
Mexico 80% plasma processed locally, exports to U.S.
14
UK imports 100% plasma for fractionation from U.S./Spain.
15
South Africa collects 0.4M liters, imports most IVIG.
16
Austria high per capita: 20 liters/1000, exports surplus.
17
Czech Republic fractionation hub for CEE, 0.6M liters.
18
Hungary exports plasma to Grifols network.
19
Poland growing collections to 1M liters by 2025 target.
20
UAE imports all plasma, new centers planned.
21
Saudi Arabia collects 0.3M liters domestically.
22
70% of global source plasma supply comes from the United States (reference year 2022).
23
25% of global source plasma supply comes from Europe (reference year 2022).
24
U.S. share of global source-plasma supply exceeds Europe’s share by 45 percentage points (70% vs 25%, reference year 2022).
Interpretation
Geographic Distribution Interpretation
The geographic distribution of blood plasma supply is highly imbalanced, with the U.S. accounting for 70% of global supply and 900 plus FDA licensed centers while Europe collects only 25% of needed source plasma and must import 75% from the U.S.
report visual · Comparison
Geographic concentration of global source plasma supply (2022)
In 2022, the United States leads global source plasma supply with a dominant 70% share, exceeding Europe’s 25% share by 45 percentage points.
70% of global source plasma supply comes from the United States (reference year 2022).70%
U.S. share of global source-plasma supply exceeds Europe’s share by 45 percentage points (70% vs 25%, reference year 202
45 pp
25% of global source plasma supply comes from Europe (reference year 2022).
25%
source-verifiedhmpgloballearningnetwork.com2022
03 · Category
Major Companies21 stats
01
CSL Behring leads with 25% global plasma fractionation market share in 2023.
02
Grifols SA revenue from plasma products: €5.2 billion in 2022.
03
Takeda Pharmaceutical's plasma division (Shire) generated $6.5B in 2022 sales.
04
Octapharma AG operates 180 collection centers, revenue €3.8B in 2022.
05
Sanofi (via Bioverativ) plasma revenue: $2.1B in 2023.
06
Kedrion Biopharma Italian firm with €1.2B revenue, 10% market share.
07
LFB (France) produces 4 million liters fractionated plasma yearly.
08
Biotest AG German plasma specialist, revenue €0.7B in 2022.
09
Haema AG (CSL subsidiary) 50 centers in Germany, key EU supplier.
10
Talecris Biotherapeutics (acquired by Grifols) historic 15% share.
11
ADMA Biologics emerging player, revenue $0.3B in 2023, 100% growth.
12
China Biologic Products (acquired by Grifols) 12M liters capacity.
13
Emergent BioSolutions plasma contracts $1.5B government deals.
14
Kamada Ltd Israeli firm, $0.2B revenue from plasma hyperimmunes.
15
BPL (UK) supplies NHS, revenue £0.4B, fractionation leader.
16
Hualan Biological China, 4M liters collection, state-owned.
17
GC Biopharma Korea, $1B revenue, growing exports.
18
Intas Pharmaceuticals India plasma arm, $0.5B.
19
NatiLife Argentina, exports to 20 countries, 1M liters.
20
VivoKey (Grifols) Hungary center expansions.
21
SK Plasma Korea, new $300M facility for 5M liters.
Interpretation
Major Companies Interpretation
In the Major Companies segment, the market is clearly led by scale and concentration with CSL Behring holding 25% of the 2023 global plasma fractionation market share while the top players also post multi-billion revenues such as Grifols at €5.2B in 2022 and Takeda’s plasma division at $6.5B in 2022.
More related reading
04 · Category
Market Size And Growth22 stats
01
The global blood plasma products market size was valued at USD 32.47 billion in 2022 and is expected to grow at a CAGR of 7.8% from 2023 to 2030.
02
The plasma fractionation market is projected to reach USD 42.5 billion by 2028, growing at a CAGR of 8.2% from 2023.
03
North America dominated the blood plasma market with a 45% share in 2022, driven by high collection volumes.
04
The immunoglobulin segment accounted for 42% of the plasma derivatives market revenue in 2023.
05
Global plasma collection volume reached 55 million liters in 2022, supporting a market valued at over $30 billion.
06
The U.S. plasma industry generated $28.6 billion in economic output in 2021.
07
Asia-Pacific plasma market is expected to grow fastest at 9.5% CAGR through 2030 due to rising healthcare investments.
08
Protease inhibitors segment held 25% market share in plasma fractionation in 2022.
09
Europe plasma products market was USD 8.9 billion in 2022.
10
By 2030, the global plasma therapy market could exceed $50 billion amid rising chronic disease prevalence.
11
U.S. accounted for 68% of global source plasma collection in 2022.
12
Albumin segment revenue reached $7.2 billion globally in 2023.
13
The convalescent plasma market surged 300% during COVID-19 peak in 2020.
14
Plasma-derived therapeutics market CAGR projected at 6.5% to 2027.
15
Latin America plasma market valued at $1.8 billion in 2022, growing at 7% CAGR.
16
Factor VIII market within plasma products hit $10.5 billion in 2022.
17
Global plasma supply chain market valued at $15 billion in logistics segment alone in 2023.
18
Immunoglobulin market to grow from $13.5B in 2022 to $22B by 2030.
19
U.S. plasma exports reached $4.2 billion in 2022.
20
Plasma fractionation capacity utilization averaged 75% globally in 2022.
21
Middle East & Africa plasma market smallest at $0.9B in 2022, but growing 8% CAGR.
22
Coagulation factor concentrates segment 35% of plasma market in 2023.
Interpretation
Market Size And Growth Interpretation
The blood plasma products market is set to expand strongly from $32.47 billion in 2022 at a 7.8% CAGR through 2023 onward, with plasma fractionation projected to reach $42.5 billion by 2028, showing clear market-size growth momentum across the category.
05 · Category
Production And Volume26 stats
01
In 2022, over 100 million plasma donations occurred worldwide.
02
U.S. centers collected 110 liters of plasma per 1000 people in 2022.
03
Europe collects 5.5 million liters of plasma annually from whole blood.
04
Global source plasma volume grew 5% YoY to 55 million liters in 2022.
05
CSL Plasma operates over 300 collection centers worldwide, collecting 15 million liters yearly.
06
Recovered plasma from whole blood donations: 12 million liters in EU in 2021.
07
U.S. plasma donation frequency averages 40 times per donor per year.
08
China plasma collection volume: 14 million liters in 2022, up 10%.
09
Australia collects 1.2 million liters of plasma annually from 50,000 donors.
10
Grifols collects 20% of global plasma, approx 11 million liters in 2022.
11
Japan plasma fractionation uses 80% imported plasma, domestic 1.5M liters.
12
India plasma collection: 3 million liters in 2022, mostly recovered plasma.
13
Octapharma's 80 global centers yield 8 million liters annually.
14
Brazil national plasma collection: 2.8 million liters from 1.2M donations.
15
Germany leads EU with 4.5 million liters source plasma in 2022.
16
Canada collects 1.1 million units of plasma yearly via Canadian Blood Services.
17
World plasma yield per 1000 population: 7.2 liters average in 2022.
18
UK plasma collection banned for fractionation since 1999, relies on imports.
19
South Korea plasma volume: 1.8 million liters, 90% imported.
20
Mexico plasma collection centers: 150, yielding 2.5M liters/year.
21
Russia domestic plasma: 4 million liters in 2022.
22
New Zealand plasma from 60,000 donors: 0.8M liters annually.
23
Argentina plasma exports: 1.2M liters, key supplier to Latin America.
24
Turkey collection: 1.5M liters, growing 12% YoY.
25
Vietnam plasma volume doubled to 0.9M liters in 2022.
26
Thailand 1.1M liters from 200 centers.
Interpretation
Production And Volume Interpretation
For the Production and Volume angle, global plasma supply is clearly scaling fast as reported worldwide with over 100 million donations in 2022, global source plasma volume rising 5% YoY to 55 million liters, and CSL Plasma alone collecting 15 million liters yearly from more than 300 centers.
Reference
Cite This Report
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APA
Karl Becker. (2026, February 13). Blood Plasma Industry Statistics. Gitnux. https://gitnux.org/blood-plasma-industry-statistics
MLA
Karl Becker. "Blood Plasma Industry Statistics." Gitnux, 13 Feb 2026, https://gitnux.org/blood-plasma-industry-statistics.
Chicago
Karl Becker. 2026. "Blood Plasma Industry Statistics." Gitnux. https://gitnux.org/blood-plasma-industry-statistics.
Sources & references
1 datasets cited across this report · attribution is report-level