Beyond its life-saving purpose, the global blood plasma industry—a complex and vital network valued at over $30 billion and growing nearly 8% annually—is built on astonishing statistics, from the U.S. supplying 70% of the world's plasma to immunoglobulins alone driving 42% of market revenue.
Key Takeaways
- The global blood plasma products market size was valued at USD 32.47 billion in 2022 and is expected to grow at a CAGR of 7.8% from 2023 to 2030.
- The plasma fractionation market is projected to reach USD 42.5 billion by 2028, growing at a CAGR of 8.2% from 2023.
- North America dominated the blood plasma market with a 45% share in 2022, driven by high collection volumes.
- In 2022, over 100 million plasma donations occurred worldwide.
- U.S. centers collected 110 liters of plasma per 1000 people in 2022.
- Europe collects 5.5 million liters of plasma annually from whole blood.
- CSL Behring leads with 25% global plasma fractionation market share in 2023.
- Grifols SA revenue from plasma products: €5.2 billion in 2022.
- Takeda Pharmaceutical's plasma division (Shire) generated $6.5B in 2022 sales.
- U.S. represents 70% of global plasma supply, with 900+ FDA-licensed centers.
- Europe collects only 25% of source plasma needed, imports 75% from U.S.
- China 25% of global plasma, but mostly for domestic use.
- Immunoglobulins treat primary immunodeficiency in 1 in 10,000 people worldwide.
- Albumin used in 50 million infusions annually for hypoalbuminemia.
- Factor VIII from plasma treats 400,000 hemophilia A patients globally.
The plasma industry is rapidly growing due to global demand for its lifesaving therapies.
Applications and Products
- Immunoglobulins treat primary immunodeficiency in 1 in 10,000 people worldwide.
- Albumin used in 50 million infusions annually for hypoalbuminemia.
- Factor VIII from plasma treats 400,000 hemophilia A patients globally.
- IVIG market driven by autoimmune diseases, 60% usage.
- Alpha-1 antitrypsin deficiency affects 100,000 in U.S., treated by plasma Prolastin.
- Rhophylac (anti-D) prevents hemolytic disease in 1M pregnancies/year.
- C1 esterase inhibitor for hereditary angioedema, 10,000 patients EU.
- Fibrinogen concentrates for congenital afibrinogenemia, rare 1:1M.
- Protein C concentrate for thrombosis prevention, 500 patients global.
- Von Willebrand factor plasma-derived for 1% population VWD.
- Hyperimmune globulins like HBIG prevent hepatitis B in 1M newborns Asia.
- Cytomegalovirus IG for transplant patients, 200,000/year.
- Antithrombin III for hereditary deficiency, 1:5000 prevalence.
- Plasma cryoprecipitate used in 20% trauma cases for fibrinogen.
- Fresh frozen plasma transfused 10M units globally for coagulopathy.
- Convalescent plasma efficacy 20% mortality reduction in early COVID trials.
- Solvent-detergent plasma safer, reduces viral risk 1:10M.
Applications and Products Interpretation
These statistics are a humbling mosaic, proving that from a single liter of donor plasma we can wage countless quiet wars—from saving a rare child with a one-in-a-million disorder to protecting a million newborns each year—making this vast industry profoundly personal.
Geographic Distribution
- U.S. represents 70% of global plasma supply, with 900+ FDA-licensed centers.
- Europe collects only 25% of source plasma needed, imports 75% from U.S.
- China 25% of global plasma, but mostly for domestic use.
- EU plasma self-sufficiency rate: 42% for source plasma in 2022.
- U.S. plasma donations per capita: 42 liters/1000 people vs EU 6.5.
- Australia 100% self-sufficient in plasma products via imports processing.
- Japan imports 70% plasma from U.S., domestic bans on paid collection.
- Canada 95% reliant on U.S. imports for fractionated plasma.
- Brazil exports 40% of collected plasma to Europe.
- Germany highest EU collection: 15 liters/1000 pop.
- India plasma fractionation capacity: 5M liters but utilization 40%.
- Russia self-sufficient, exports to CIS countries.
- Mexico 80% plasma processed locally, exports to U.S.
- UK imports 100% plasma for fractionation from U.S./Spain.
- South Africa collects 0.4M liters, imports most IVIG.
- Austria high per capita: 20 liters/1000, exports surplus.
- Czech Republic fractionation hub for CEE, 0.6M liters.
- Hungary exports plasma to Grifols network.
- Poland growing collections to 1M liters by 2025 target.
- UAE imports all plasma, new centers planned.
- Saudi Arabia collects 0.3M liters domestically.
Geographic Distribution Interpretation
The United States operates as the world's hyper-efficient, paid-plasma pharmacy, leaving Europe in a chronic supply deficit and countries like Canada and Japan utterly dependent, while nations with the capacity, like China and Russia, guard their stockpiles domestically.
Major Companies
- CSL Behring leads with 25% global plasma fractionation market share in 2023.
- Grifols SA revenue from plasma products: €5.2 billion in 2022.
- Takeda Pharmaceutical's plasma division (Shire) generated $6.5B in 2022 sales.
- Octapharma AG operates 180 collection centers, revenue €3.8B in 2022.
- Sanofi (via Bioverativ) plasma revenue: $2.1B in 2023.
- Kedrion Biopharma Italian firm with €1.2B revenue, 10% market share.
- LFB (France) produces 4 million liters fractionated plasma yearly.
- Biotest AG German plasma specialist, revenue €0.7B in 2022.
- Haema AG (CSL subsidiary) 50 centers in Germany, key EU supplier.
- Talecris Biotherapeutics (acquired by Grifols) historic 15% share.
- ADMA Biologics emerging player, revenue $0.3B in 2023, 100% growth.
- China Biologic Products (acquired by Grifols) 12M liters capacity.
- Emergent BioSolutions plasma contracts $1.5B government deals.
- Kamada Ltd Israeli firm, $0.2B revenue from plasma hyperimmunes.
- BPL (UK) supplies NHS, revenue £0.4B, fractionation leader.
- Hualan Biological China, 4M liters collection, state-owned.
- GC Biopharma Korea, $1B revenue, growing exports.
- Intas Pharmaceuticals India plasma arm, $0.5B.
- NatiLife Argentina, exports to 20 countries, 1M liters.
- VivoKey (Grifols) Hungary center expansions.
- SK Plasma Korea, new $300M facility for 5M liters.
Major Companies Interpretation
While CSL Behring holds a quarter of the global market by volume, the plasma industry is a fiercely competitive and surprisingly fragmented ecosystem where giants like Grifols and Takeda count their revenue in billions, yet niche players from Argentina to South Korea still carve out vital, lucrative roles in this life-saving supply chain.
Market Size and Growth
- The global blood plasma products market size was valued at USD 32.47 billion in 2022 and is expected to grow at a CAGR of 7.8% from 2023 to 2030.
- The plasma fractionation market is projected to reach USD 42.5 billion by 2028, growing at a CAGR of 8.2% from 2023.
- North America dominated the blood plasma market with a 45% share in 2022, driven by high collection volumes.
- The immunoglobulin segment accounted for 42% of the plasma derivatives market revenue in 2023.
- Global plasma collection volume reached 55 million liters in 2022, supporting a market valued at over $30 billion.
- The U.S. plasma industry generated $28.6 billion in economic output in 2021.
- Asia-Pacific plasma market is expected to grow fastest at 9.5% CAGR through 2030 due to rising healthcare investments.
- Protease inhibitors segment held 25% market share in plasma fractionation in 2022.
- Europe plasma products market was USD 8.9 billion in 2022.
- By 2030, the global plasma therapy market could exceed $50 billion amid rising chronic disease prevalence.
- U.S. accounted for 68% of global source plasma collection in 2022.
- Albumin segment revenue reached $7.2 billion globally in 2023.
- The convalescent plasma market surged 300% during COVID-19 peak in 2020.
- Plasma-derived therapeutics market CAGR projected at 6.5% to 2027.
- Latin America plasma market valued at $1.8 billion in 2022, growing at 7% CAGR.
- Factor VIII market within plasma products hit $10.5 billion in 2022.
- Global plasma supply chain market valued at $15 billion in logistics segment alone in 2023.
- Immunoglobulin market to grow from $13.5B in 2022 to $22B by 2030.
- U.S. plasma exports reached $4.2 billion in 2022.
- Plasma fractionation capacity utilization averaged 75% globally in 2022.
- Middle East & Africa plasma market smallest at $0.9B in 2022, but growing 8% CAGR.
- Coagulation factor concentrates segment 35% of plasma market in 2023.
Market Size and Growth Interpretation
It appears our civilization has engineered a remarkably efficient, multi-billion dollar system for bottling human vitality, where a single liter of plasma quietly sustains an enormous and fiercely growing global enterprise focused on fending off mortality.
Production and Volume
- In 2022, over 100 million plasma donations occurred worldwide.
- U.S. centers collected 110 liters of plasma per 1000 people in 2022.
- Europe collects 5.5 million liters of plasma annually from whole blood.
- Global source plasma volume grew 5% YoY to 55 million liters in 2022.
- CSL Plasma operates over 300 collection centers worldwide, collecting 15 million liters yearly.
- Recovered plasma from whole blood donations: 12 million liters in EU in 2021.
- U.S. plasma donation frequency averages 40 times per donor per year.
- China plasma collection volume: 14 million liters in 2022, up 10%.
- Australia collects 1.2 million liters of plasma annually from 50,000 donors.
- Grifols collects 20% of global plasma, approx 11 million liters in 2022.
- Japan plasma fractionation uses 80% imported plasma, domestic 1.5M liters.
- India plasma collection: 3 million liters in 2022, mostly recovered plasma.
- Octapharma's 80 global centers yield 8 million liters annually.
- Brazil national plasma collection: 2.8 million liters from 1.2M donations.
- Germany leads EU with 4.5 million liters source plasma in 2022.
- Canada collects 1.1 million units of plasma yearly via Canadian Blood Services.
- World plasma yield per 1000 population: 7.2 liters average in 2022.
- UK plasma collection banned for fractionation since 1999, relies on imports.
- South Korea plasma volume: 1.8 million liters, 90% imported.
- Mexico plasma collection centers: 150, yielding 2.5M liters/year.
- Russia domestic plasma: 4 million liters in 2022.
- New Zealand plasma from 60,000 donors: 0.8M liters annually.
- Argentina plasma exports: 1.2M liters, key supplier to Latin America.
- Turkey collection: 1.5M liters, growing 12% YoY.
- Vietnam plasma volume doubled to 0.9M liters in 2022.
- Thailand 1.1M liters from 200 centers.
Production and Volume Interpretation
The global blood plasma industry reveals a world profoundly interconnected yet starkly unequal, where life-saving liquid is mined, traded, and consumed in a colossal and geopolitically charged marketplace that treats human plasma not just as a gift, but as a strategic commodity.
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