Top 10 Best Pathology Management Software of 2026

Sunquest PowerPath is a leading anatomic pathology laboratory information system (LIS) from Oracle Health that manages the full spectrum of pathology workflows, from specimen accessioning and grossing to microscopic review, reporting, and archiving. It supports high-volume labs with advanced automation, digital pathology integration, and synoptic reporting compliant with CAP and College of American Pathologists standards. PowerPath enhances pathologist productivity through voice recognition, customizable templates, and seamless EMR interoperability.

Epic Beaker Anatomic Pathology is a robust module within Epic's Beaker laboratory information system, designed to streamline anatomic pathology workflows from specimen accessioning to final sign-out. It supports comprehensive processes including grossing, microscopy, tumor board integration, and synoptic reporting with multimedia capabilities. Deeply integrated with Epic's EHR, it enables seamless data exchange across clinical and laboratory domains, enhancing efficiency in high-volume pathology labs.

Oracle Health CoPathPlus is a robust anatomic pathology laboratory information system (LIS) that manages the full workflow from specimen accessioning to case reporting for surgical pathology, cytology, and molecular diagnostics. It integrates seamlessly with Oracle Health EHRs and other systems, supporting synoptic reporting, quality assurance, and compliance with CAP and CLIA standards. The platform enhances pathologist productivity through automation, barcode tracking, and advanced querying tools for large-scale labs.

SCC SoftPath Dx is a robust anatomic pathology laboratory information system (AP-LIS) from SCC Soft Computer, designed to manage the full pathology workflow from specimen accessioning to case sign-out and reporting. It supports surgical pathology, cytology, histopathology, and molecular testing, with features for case tracking, quality assurance, and compliance with CAP, CLIA, and HIPAA standards. The software excels in integrating with EMRs, LIS systems, digital pathology scanners, and billing platforms to enable efficient, paperless operations in busy labs.

NovoPath 360 is a robust anatomic pathology laboratory information system (LIS) that manages the full spectrum of pathology workflows, from accessioning and grossing to reporting and archiving. It supports surgical pathology, cytology, autopsy, and research cases with automation tools, customizable templates, and integration with EMRs, digital pathology scanners, and instruments. Designed for multi-site labs, it ensures compliance with CAP, CLIA, and HIPAA standards while providing real-time case tracking and quality assurance features.

Psyche Systems APEX is a web-based laboratory information system (LIS) designed specifically for pathology labs, streamlining workflows from specimen accessioning and grossing to microscopic review, synoptic reporting, and final sign-out. It supports anatomic pathology, cytology, surgical pathology, and molecular diagnostics with integrated image management and voice productivity tools. APEX emphasizes regulatory compliance (HIPAA, CLIA) and seamless integration with EMRs, billing systems, and instruments, making it a robust solution for high-volume pathology operations.

Orchard Pathology, from Orchard Software, is a comprehensive laboratory information system (LIS) designed specifically for pathology labs, handling anatomic, clinical, molecular, and cytology workflows. It streamlines accessioning, case management, grossing, sign-out, reporting, and billing while supporting digital pathology imaging and voice dictation. The platform integrates seamlessly with EHRs, analyzers, and middleware, ensuring HIPAA compliance and regulatory adherence for high-volume labs.

Xifin LIS is a robust, cloud-based laboratory information system tailored for anatomic pathology and clinical labs, managing the full workflow from specimen accessioning and testing to result reporting and billing. It stands out with deep integration into revenue cycle management (RCM), using AI and machine learning to optimize claims, reduce denials, and maximize reimbursements. Designed for high-volume operations, it supports complex workflows, instrument integrations, and compliance with standards like HIPAA and CLIA.

Proscia Concentriq is a cloud-based digital pathology platform designed to manage whole slide images, streamline workflows, and integrate AI-driven tools for pathology labs. It provides case management, image viewing, collaboration features, and an open ecosystem for AI apps via the Concentriq Apps marketplace. The software supports primary diagnostics, research, and telepathology, enabling scalable operations from small labs to large enterprises.

Sectra Pathology is an enterprise-grade digital pathology platform that provides whole-slide imaging, secure storage, and advanced workflow management for pathology labs. It enables high-resolution scanning of slides, AI-assisted analysis, and seamless integration with LIS, PACS, and other healthcare systems. The solution supports remote collaboration, diagnostics reporting, and compliance with standards like DICOM and HL7 to optimize pathologists' efficiency.