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Top 10 Best Oncology Emr Software of 2026

Find the best oncology EMR software to optimize your practice—compare features, rankings, and choose the right solution today.

Gitnux Team

Feb 11, 2026

10 tools comparedExpert reviewed
Independent evaluation · Unbiased commentary · Updated regularly
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Oncology practices rely on specialized electronic medical record (EMR) software to navigate complex care workflows, from chemotherapy protocols to survivorship planning. With a diverse array of tools designed for this niche, selecting the right solution—tailored to integration, usability, and clinical needs—can transform efficiency and patient outcomes. This guide highlights the top 10 options, from cloud-based platforms to radiation therapy systems, to empower practices in their choice.

Quick Overview

  1. 1#1: OncoEMR - Cloud-based electronic medical record system tailored specifically for oncology practices with integrated treatment planning and clinical decision support.
  2. 2#2: Epic - Enterprise EHR platform with advanced oncology modules for comprehensive patient management, chemotherapy ordering, and survivorship care.
  3. 3#3: Oracle Cerner - Integrated health IT suite featuring oncology-specific workflows for multispecialty cancer care and data interoperability.
  4. 4#4: iKnowMed - Oncology-focused EHR designed for community practices with protocol management, infusion tracking, and quality reporting.
  5. 5#5: Varian ARIA - Oncology information system optimizing radiation therapy workflows, treatment planning, and patient data management.
  6. 6#6: Elekta MOSAIQ - Platinum-rated oncology information system supporting clinical, administrative, and billing processes across cancer care.
  7. 7#7: Flatiron Health - Oncology learning health network platform aggregating real-world data for clinical insights and EMR integration.
  8. 8#8: athenahealth - Cloud-based EHR with oncology templates for practice management, e-prescribing, and revenue cycle optimization.
  9. 9#9: Veradigm - EHR solution with oncology modules supporting specialty workflows, population health, and interoperability standards.
  10. 10#10: eClinicalWorks - Specialty EHR offering oncology features like infusion management, patient portals, and telehealth integration.

Tools were ranked based on alignment with oncology-specific requirements (treatment planning, interoperability, workflow optimization), user experience, clinical decision support capabilities, and overall value, ensuring they meet the unique demands of cancer care.

Comparison Table

Oncology electronic medical record (EMR) software is essential for managing specialized care workflows, and this comparison table evaluates top tools including OncoEMR, Epic, Oracle Cerner, iKnowMed, Varian ARIA, and more. Readers will discover key features, usability, integration abilities, and tailored support, enabling them to match software to their practice's specific needs.

1OncoEMR logo9.8/10

Cloud-based electronic medical record system tailored specifically for oncology practices with integrated treatment planning and clinical decision support.

Features
9.9/10
Ease
9.4/10
Value
9.6/10
2Epic logo9.2/10

Enterprise EHR platform with advanced oncology modules for comprehensive patient management, chemotherapy ordering, and survivorship care.

Features
9.5/10
Ease
7.8/10
Value
8.1/10

Integrated health IT suite featuring oncology-specific workflows for multispecialty cancer care and data interoperability.

Features
9.2/10
Ease
7.4/10
Value
7.8/10
4iKnowMed logo8.7/10

Oncology-focused EHR designed for community practices with protocol management, infusion tracking, and quality reporting.

Features
9.2/10
Ease
7.8/10
Value
8.4/10

Oncology information system optimizing radiation therapy workflows, treatment planning, and patient data management.

Features
9.2/10
Ease
7.1/10
Value
7.8/10

Platinum-rated oncology information system supporting clinical, administrative, and billing processes across cancer care.

Features
9.1/10
Ease
6.8/10
Value
7.5/10

Oncology learning health network platform aggregating real-world data for clinical insights and EMR integration.

Features
9.1/10
Ease
7.6/10
Value
8.0/10

Cloud-based EHR with oncology templates for practice management, e-prescribing, and revenue cycle optimization.

Features
8.5/10
Ease
7.7/10
Value
7.9/10
9Veradigm logo7.6/10

EHR solution with oncology modules supporting specialty workflows, population health, and interoperability standards.

Features
8.1/10
Ease
6.9/10
Value
7.4/10

Specialty EHR offering oncology features like infusion management, patient portals, and telehealth integration.

Features
7.5/10
Ease
6.8/10
Value
7.8/10
1
OncoEMR logo

OncoEMR

specialized

Cloud-based electronic medical record system tailored specifically for oncology practices with integrated treatment planning and clinical decision support.

Overall Rating9.8/10
Features
9.9/10
Ease of Use
9.4/10
Value
9.6/10
Standout Feature

Vast, physician-curated library of 1,500+ evidence-based chemotherapy protocols and treatment plans

OncoEMR is a leading, oncology-specific Electronic Medical Records (EMR) software designed exclusively for cancer care practices, providing end-to-end workflow management from diagnosis to survivorship. It features specialized tools for staging, chemotherapy planning, treatment tracking, and clinical trial integration, all within a secure, cloud-based platform certified for ONC standards. The system also includes built-in practice management, billing, and analytics to optimize oncology operations and improve patient outcomes.

Pros

  • Oncology-tailored workflows with 1,500+ chemotherapy regimens and staging tools
  • Seamless integration with labs, pharmacies, and EHRs like Epic
  • Robust reporting, analytics, and regulatory compliance features

Cons

  • Initial setup and training require time investment
  • Pricing is custom and can be premium for smaller practices
  • Less flexibility for non-oncology modules compared to general EMRs

Best For

Oncology practices of any size seeking a specialized EMR with comprehensive cancer care tools.

Pricing

Custom subscription pricing based on practice size and users; typically starts at $500/user/month with implementation fees—contact vendor for quote.

Visit OncoEMRoncoemr.com
2
Epic logo

Epic

enterprise

Enterprise EHR platform with advanced oncology modules for comprehensive patient management, chemotherapy ordering, and survivorship care.

Overall Rating9.2/10
Features
9.5/10
Ease of Use
7.8/10
Value
8.1/10
Standout Feature

Beacon Oncology module's intelligent regimen engine for building, validating, and scaling treatment protocols with built-in safety checks

Epic is a comprehensive electronic health record (EHR) system with its Beacon module specifically tailored for oncology, enabling streamlined workflows for treatment planning, regimen building, infusion management, and survivorship care. It integrates patient data across multidisciplinary teams, supports clinical trials matching, and provides advanced analytics for oncology outcomes. Widely adopted in large health systems, Epic facilitates regulatory compliance and interoperability with other healthcare technologies.

Pros

  • Robust Beacon oncology module with protocol libraries and automated regimen support
  • Seamless integration with hospital-wide EHR for multidisciplinary care coordination
  • Powerful analytics and reporting for oncology quality metrics and clinical trials

Cons

  • Steep learning curve and lengthy implementation process
  • High upfront and ongoing costs unsuitable for small practices
  • Customization requires significant IT resources

Best For

Large hospitals and academic medical centers with complex, high-volume oncology programs needing enterprise-scale integration.

Pricing

Custom enterprise pricing negotiated per organization; typically involves multimillion-dollar implementation fees plus annual subscriptions based on user count or bed size.

Visit Epicepic.com
3
Oracle Cerner logo

Oracle Cerner

enterprise

Integrated health IT suite featuring oncology-specific workflows for multispecialty cancer care and data interoperability.

Overall Rating8.5/10
Features
9.2/10
Ease of Use
7.4/10
Value
7.8/10
Standout Feature

Oncology Clinical Pathways with embedded evidence-based protocols and real-time variance tracking for standardized, high-quality care delivery

Oracle Cerner, now part of Oracle Health, offers a robust enterprise-grade electronic medical record (EMR) system with specialized oncology modules designed for comprehensive cancer care management. It supports end-to-end workflows including patient intake, treatment planning, chemotherapy and radiation therapy documentation, multidisciplinary team coordination, and survivorship care. The platform integrates advanced tools like clinical pathways, genomics data handling, and analytics to drive evidence-based oncology decisions and improve patient outcomes.

Pros

  • Extensive oncology-specific features like automated treatment protocols and clinical decision support
  • Seamless scalability and integration with hospital-wide systems and third-party oncology tools
  • Strong data analytics for population health management and research in oncology

Cons

  • Complex user interface with a steep learning curve for new users
  • High upfront implementation and customization costs
  • Slower deployment timelines due to enterprise-scale configuration needs

Best For

Large hospitals, academic medical centers, and comprehensive cancer institutes requiring a fully integrated, scalable EMR for complex oncology workflows.

Pricing

Enterprise custom pricing; implementation often exceeds $1M with annual subscriptions scaling by beds/users, typically $500K+ yearly for mid-large deployments.

4
iKnowMed logo

iKnowMed

specialized

Oncology-focused EHR designed for community practices with protocol management, infusion tracking, and quality reporting.

Overall Rating8.7/10
Features
9.2/10
Ease of Use
7.8/10
Value
8.4/10
Standout Feature

Built-in oncology treatment pathways and protocols with automated regimen support

iKnowMed, offered by OneOncology, is a cloud-based electronic medical record (EMR) system specifically designed for oncology practices to manage complex cancer care workflows. It provides oncology-tailored tools for treatment planning, chemotherapy ordering, infusion management, and clinical trial enrollment. The platform emphasizes interoperability with EHRs, pharmacies, and labs, supporting value-based care and regulatory compliance in oncology settings.

Pros

  • Highly specialized oncology workflows including treatment pathways and infusion management
  • Strong interoperability with pharmacies, labs, and other EMRs like Epic
  • Robust analytics and reporting for quality metrics and clinical trials

Cons

  • Steep learning curve due to oncology-specific complexity
  • High implementation costs and custom pricing
  • Limited flexibility for non-oncology specialties

Best For

Mid-sized to large oncology practices needing a dedicated EMR for streamlined cancer care and compliance.

Pricing

Custom enterprise pricing based on practice size and users; typically quote-based starting around $500-$1,000 per provider/month.

Visit iKnowMedoneoncology.com
5
Varian ARIA logo

Varian ARIA

specialized

Oncology information system optimizing radiation therapy workflows, treatment planning, and patient data management.

Overall Rating8.4/10
Features
9.2/10
Ease of Use
7.1/10
Value
7.8/10
Standout Feature

Deep integration with Varian TrueBeam systems for real-time, adaptive radiation delivery and automated quality assurance

Varian ARIA is a comprehensive Oncology Information System (OIS) tailored for radiation oncology, managing the full patient lifecycle from treatment planning and simulation to delivery, charting, billing, and outcomes analysis. It integrates deeply with Varian's ecosystem, including Eclipse treatment planning and TrueBeam linear accelerators, enabling paperless workflows and real-time data exchange. ARIA supports regulatory compliance, image management, and advanced analytics to optimize cancer care delivery in specialized oncology settings.

Pros

  • Seamless integration with Varian hardware and Eclipse for end-to-end radiation therapy workflows
  • Robust regulatory compliance, billing automation, and oncology-specific analytics
  • Scalable for high-volume centers with strong data security and interoperability standards support

Cons

  • Steep learning curve and complex interface requiring extensive training
  • High upfront costs and lengthy implementation timelines
  • Less flexible for non-Varian equipment or comprehensive medical oncology beyond radiation

Best For

Large radiation oncology departments heavily invested in Varian hardware seeking integrated, high-volume treatment management.

Pricing

Enterprise custom pricing; initial implementation often exceeds $500,000 with annual maintenance fees around 15-20% of license cost.

6
Elekta MOSAIQ logo

Elekta MOSAIQ

specialized

Platinum-rated oncology information system supporting clinical, administrative, and billing processes across cancer care.

Overall Rating8.2/10
Features
9.1/10
Ease of Use
6.8/10
Value
7.5/10
Standout Feature

Seamless real-time integration with linear accelerators for automated treatment verification and delivery control

Elekta MOSAIQ is a comprehensive Oncology Information System (OIS) tailored for radiation oncology departments, managing the full patient lifecycle from diagnosis and treatment planning to delivery, billing, and follow-up. It integrates seamlessly with Elekta's linear accelerators and other hardware for real-time data exchange and workflow automation. MOSAIQ supports electronic charting, dosimetry calculations, and quality assurance, making it a robust EMR solution for oncology practices focused on radiation therapy.

Pros

  • Deep integration with Elekta hardware for streamlined treatment delivery
  • Comprehensive oncology-specific workflows including treatment planning and QA
  • Strong compliance tools for regulatory standards like Meaningful Use and oncology billing

Cons

  • Steep learning curve due to complex interface
  • Outdated UI in some modules, less intuitive than modern cloud-based EMRs
  • High implementation and maintenance costs

Best For

Large radiation oncology centers with Elekta equipment seeking an integrated, hardware-agnostic OIS.

Pricing

Enterprise licensing with custom quotes; typically $100K+ annually per site, plus implementation fees.

7
Flatiron Health logo

Flatiron Health

specialized

Oncology learning health network platform aggregating real-world data for clinical insights and EMR integration.

Overall Rating8.4/10
Features
9.1/10
Ease of Use
7.6/10
Value
8.0/10
Standout Feature

Real-World Evidence (RWE) platform that abstracts and analyzes structured oncology data for clinical trials, publications, and value-based care

Flatiron Health's OncoEMR is a cloud-based electronic medical record (EMR) system tailored specifically for oncology practices, offering specialized workflows for cancer patient management, treatment planning, and survivorship care. It integrates clinical documentation with advanced data analytics to capture real-world evidence from patient records, supporting research, quality reporting, and population health initiatives. The platform connects with over 800 sites, enabling benchmarking and insights across a vast oncology dataset.

Pros

  • Oncology-specific templates and workflows streamline complex cancer care documentation
  • Powerful real-world data platform for research, outcomes analysis, and regulatory reporting
  • Seamless integration with EHRs, labs, and genomic data for comprehensive patient views

Cons

  • Steep learning curve due to specialized oncology features and data entry requirements
  • High implementation costs and custom pricing can strain smaller practices
  • Limited flexibility for non-oncology modules or general practice customization

Best For

Mid-to-large oncology practices or networks focused on data-driven care, research, and real-world evidence generation.

Pricing

Custom enterprise subscription pricing, typically starting at $500+ per provider/month with implementation fees; quotes required.

8
athenahealth logo

athenahealth

enterprise

Cloud-based EHR with oncology templates for practice management, e-prescribing, and revenue cycle optimization.

Overall Rating8.1/10
Features
8.5/10
Ease of Use
7.7/10
Value
7.9/10
Standout Feature

Advanced chemotherapy infusion management with real-time protocol adherence and automated documentation

athenahealth's athenaOne Oncology is a cloud-based EMR solution tailored for oncology practices, offering specialized workflows for chemotherapy regimens, infusion management, survivorship care planning, and integration with radiation oncology systems. It combines EHR functionality with robust revenue cycle management to streamline billing for complex oncology treatments. The platform emphasizes interoperability with labs, imaging, and registries, supporting comprehensive patient care coordination in oncology settings.

Pros

  • Specialized oncology templates and regimen builders for efficient treatment planning
  • Strong interoperability and cloud accessibility for multi-location practices
  • Integrated revenue cycle management optimized for oncology billing complexities

Cons

  • Higher pricing with additional fees for oncology modules and implementation
  • Steep learning curve for advanced customization and workflows
  • Occasional reports of slower support response times during peak issues

Best For

Mid-sized oncology practices needing an integrated EMR with strong billing and interoperability features.

Pricing

Subscription-based at $400-$700 per provider/month, plus one-time implementation fees ($10K-$50K) and add-ons for oncology-specific tools.

Visit athenahealthathenahealth.com
9
Veradigm logo

Veradigm

enterprise

EHR solution with oncology modules supporting specialty workflows, population health, and interoperability standards.

Overall Rating7.6/10
Features
8.1/10
Ease of Use
6.9/10
Value
7.4/10
Standout Feature

Veradigm Network for real-time data sharing and oncology-specific population health insights

Veradigm, formerly Allscripts, offers a comprehensive EHR platform with oncology-specific modules for managing cancer patient workflows, including chemotherapy regimens, treatment planning, and survivorship care. It integrates seamlessly with practice management, revenue cycle tools, and population health analytics to support oncology practices. The solution emphasizes interoperability through its Veradigm Network, enabling data sharing across providers for coordinated cancer care.

Pros

  • Excellent interoperability and data exchange via Veradigm Network
  • Robust analytics and reporting for oncology outcomes and quality metrics
  • Scalable for multi-specialty oncology groups with strong customization options

Cons

  • Steep learning curve and complex interface requiring extensive training
  • High implementation costs and ongoing fees
  • Limited native support for advanced radiation oncology planning compared to specialized tools

Best For

Mid-sized to large oncology practices or networks seeking integrated EHR with strong analytics and payer connectivity.

Pricing

Custom enterprise pricing, typically $400-$700 per provider/month plus implementation fees; contact for quote.

Visit Veradigmveradigm.com
10
eClinicalWorks logo

eClinicalWorks

enterprise

Specialty EHR offering oncology features like infusion management, patient portals, and telehealth integration.

Overall Rating7.2/10
Features
7.5/10
Ease of Use
6.8/10
Value
7.8/10
Standout Feature

Advanced chemotherapy regimen builder with built-in dosing calculators and protocol adherence checks

eClinicalWorks is a cloud-based EHR and practice management platform that supports oncology practices with specialized modules for chemotherapy regimen building, treatment planning, infusion management, and toxicity tracking. It integrates patient portals, telehealth via Healow, and AI-driven documentation tools to enhance workflow efficiency. While versatile for ambulatory settings, it provides robust data analytics and interoperability for oncology-specific needs like survivorship care planning.

Pros

  • Comprehensive oncology modules including chemo order entry and toxicity management
  • Integrated telehealth and patient engagement via Healow app
  • Scalable pricing and strong interoperability with ONC certification

Cons

  • Steep learning curve and dated user interface
  • Reported performance lags during peak usage
  • Customer support response times can be inconsistent

Best For

Small to mid-sized oncology practices seeking an affordable, all-in-one EHR with solid specialty tools.

Pricing

Subscription-based starting at ~$449/user/month for core EHR, plus add-ons for oncology modules; custom quotes required.

Visit eClinicalWorkseclinicalworks.com

Conclusion

The reviewed oncology EMR tools showcase diverse strengths, with OncoEMR leading as the top choice, offering specialized integration for treatment planning and clinical support. Epic and Oracle Cerner stand out as robust alternatives, respectively excelling in enterprise-level management and multispecialty interoperability, catering to varied practice needs. Together, these solutions redefine efficiency in cancer care, each bringing unique value to streamline workflows and enhance patient outcomes.

OncoEMR logo
Our Top Pick
OncoEMR

Take the first step toward optimizing your practice—experience the tailored power of OncoEMR and discover how it can transform your daily operations and patient care delivery.