Quick Overview
- 1#1: Epic Beacon - Enterprise-grade oncology module for comprehensive treatment planning, infusion management, and survivorship within the Epic EHR platform.
- 2#2: Cerner Oncology - Integrated oncology workflows in the Millennium EHR for managing complex cancer care, protocols, and multidisciplinary teams.
- 3#3: Flatiron OncoEMR - Specialized oncology EHR for community practices with real-world data analytics and evidence-based treatment support.
- 4#4: MOSAIQ - Oncology information system optimizing radiation, medical, and surgical oncology workflows and patient management.
- 5#5: ARIA Oncology Information System - Robust OIS for radiation oncology, streamlining treatment planning, delivery, and quality assurance.
- 6#6: Allscripts Oncology - EHR solution with oncology-specific tools for regimen building, clinical documentation, and revenue cycle optimization.
- 7#7: athenaOne Oncology - Cloud-based EHR tailored for oncology practices with automated workflows, MIPS reporting, and patient engagement.
- 8#8: NextGen Oncology - Specialty EHR offering oncology regimen support, e-prescribing, and interoperability for efficient cancer care.
- 9#9: eClinicalWorks Oncology - Integrated EHR platform with oncology modules for telehealth, population health, and chemotherapy management.
- 10#10: CureMD Oncology EHR - Affordable cloud EHR focused on oncology with chemotherapy ordering, patient portals, and practice analytics.
These tools were selected based on oncology-specific functionality, usability, integration strength, and overall value, with a focus on supporting complex care pathways, clinical documentation, and practice efficiency.
Comparison Table
Oncology electronic health record (EHR) software is essential for optimizing cancer care workflows, and comparing leading tools helps identify the right fit. This table details key features, integration capabilities, and user experiences of platforms like Epic Beacon, Cerner Oncology, Flatiron OncoEMR, MOSAIQ, and ARIA, equipping readers to make informed decisions for their practice or facility.
| # | Tool | Category | Overall | Features | Ease of Use | Value |
|---|---|---|---|---|---|---|
| 1 | Epic Beacon Enterprise-grade oncology module for comprehensive treatment planning, infusion management, and survivorship within the Epic EHR platform. | enterprise | 9.6/10 | 9.8/10 | 8.2/10 | 9.0/10 |
| 2 | Cerner Oncology Integrated oncology workflows in the Millennium EHR for managing complex cancer care, protocols, and multidisciplinary teams. | enterprise | 8.7/10 | 9.2/10 | 7.4/10 | 8.1/10 |
| 3 | Flatiron OncoEMR Specialized oncology EHR for community practices with real-world data analytics and evidence-based treatment support. | specialized | 8.7/10 | 9.3/10 | 7.9/10 | 8.4/10 |
| 4 | MOSAIQ Oncology information system optimizing radiation, medical, and surgical oncology workflows and patient management. | specialized | 8.6/10 | 9.3/10 | 7.4/10 | 8.1/10 |
| 5 | ARIA Oncology Information System Robust OIS for radiation oncology, streamlining treatment planning, delivery, and quality assurance. | specialized | 8.7/10 | 9.2/10 | 7.4/10 | 8.1/10 |
| 6 | Allscripts Oncology EHR solution with oncology-specific tools for regimen building, clinical documentation, and revenue cycle optimization. | enterprise | 7.8/10 | 8.3/10 | 7.1/10 | 7.4/10 |
| 7 | athenaOne Oncology Cloud-based EHR tailored for oncology practices with automated workflows, MIPS reporting, and patient engagement. | enterprise | 8.2/10 | 8.5/10 | 8.8/10 | 7.7/10 |
| 8 | NextGen Oncology Specialty EHR offering oncology regimen support, e-prescribing, and interoperability for efficient cancer care. | enterprise | 8.1/10 | 8.7/10 | 7.6/10 | 7.9/10 |
| 9 | eClinicalWorks Oncology Integrated EHR platform with oncology modules for telehealth, population health, and chemotherapy management. | enterprise | 7.8/10 | 8.1/10 | 7.2/10 | 7.5/10 |
| 10 | CureMD Oncology EHR Affordable cloud EHR focused on oncology with chemotherapy ordering, patient portals, and practice analytics. | specialized | 7.6/10 | 8.2/10 | 7.4/10 | 7.3/10 |
Enterprise-grade oncology module for comprehensive treatment planning, infusion management, and survivorship within the Epic EHR platform.
Integrated oncology workflows in the Millennium EHR for managing complex cancer care, protocols, and multidisciplinary teams.
Specialized oncology EHR for community practices with real-world data analytics and evidence-based treatment support.
Oncology information system optimizing radiation, medical, and surgical oncology workflows and patient management.
Robust OIS for radiation oncology, streamlining treatment planning, delivery, and quality assurance.
EHR solution with oncology-specific tools for regimen building, clinical documentation, and revenue cycle optimization.
Cloud-based EHR tailored for oncology practices with automated workflows, MIPS reporting, and patient engagement.
Specialty EHR offering oncology regimen support, e-prescribing, and interoperability for efficient cancer care.
Integrated EHR platform with oncology modules for telehealth, population health, and chemotherapy management.
Affordable cloud EHR focused on oncology with chemotherapy ordering, patient portals, and practice analytics.
Epic Beacon
enterpriseEnterprise-grade oncology module for comprehensive treatment planning, infusion management, and survivorship within the Epic EHR platform.
Beacon Protocol Engine for building, validating, and automating evidence-based chemotherapy regimens with embedded clinical decision support
Epic Beacon is the oncology-specific module of the Epic EHR platform, providing end-to-end support for cancer care from diagnosis through treatment, survivorship, and palliative care. It excels in managing complex chemotherapy regimens, radiation therapy planning, symptom management, and genomic data integration. With robust decision support tools and interoperability, it streamlines workflows for multidisciplinary oncology teams while ensuring regulatory compliance.
Pros
- Comprehensive oncology workflows with protocol-driven order entry and toxicity grading
- Seamless integration with Epic's broader EHR ecosystem and interoperability standards like FHIR
- Advanced analytics, reporting, and clinical trial matching capabilities
Cons
- Steep learning curve and complex interface requiring extensive training
- High upfront implementation costs and long deployment timelines
- Less suitable for small practices due to scalability focused on enterprises
Best For
Large oncology practices, academic cancer centers, and health systems needing scalable, integrated enterprise EHR for complex multidisciplinary care.
Pricing
Custom enterprise licensing with negotiated pricing; typically millions annually plus significant implementation fees based on organization size.
Cerner Oncology
enterpriseIntegrated oncology workflows in the Millennium EHR for managing complex cancer care, protocols, and multidisciplinary teams.
Integrated multidisciplinary care plans with embedded NCCN guidelines and real-time decision support for chemotherapy and radiation oncology
Cerner Oncology, part of the Oracle Health (formerly Cerner) EHR platform, is a robust solution designed specifically for oncology practices, offering integrated tools for treatment planning, chemotherapy management, and patient monitoring. It supports multidisciplinary care coordination, guideline-based protocols, and advanced analytics to improve clinical outcomes. The system integrates seamlessly with broader Cerner Millennium EHR for comprehensive patient data across specialties.
Pros
- Comprehensive oncology workflows including regimen support, toxicity management, and survivorship care
- Strong interoperability with standards like HL7 FHIR and ONC certification for data exchange
- Advanced analytics and AI-driven insights for personalized treatment planning
Cons
- Steep learning curve and complex interface requiring extensive user training
- High implementation costs and lengthy deployment timelines for enterprise setups
- Customization often needed for smaller practices, increasing overall expense
Best For
Large hospitals, academic medical centers, and multispecialty oncology groups needing enterprise-grade integration and scalability.
Pricing
Enterprise-level pricing upon request; typically subscription-based starting at $500+ per user/month plus significant one-time implementation fees ($100K+).
Flatiron OncoEMR
specializedSpecialized oncology EHR for community practices with real-world data analytics and evidence-based treatment support.
Real-World Evidence (RWE) platform that aggregates de-identified clinical data from thousands of patients for actionable oncology insights and trial recruitment.
Flatiron OncoEMR is a specialized electronic health record (EHR) platform tailored for oncology practices, enabling efficient capture of structured clinical data during patient encounters. It supports comprehensive workflows for treatment planning, chemotherapy management, and survivorship care while integrating real-world evidence (RWE) generation for research and quality improvement. The system connects practices to a vast oncology dataset, facilitating clinical trial matching and population-level analytics.
Pros
- Oncology-specific workflows and templates that streamline complex cancer care documentation
- Powerful real-world evidence tools for research, trial matching, and benchmarking
- Seamless integration with lab systems, registries, and Flatiron's analytics platform
Cons
- Steep learning curve for providers new to specialized oncology EHRs
- High implementation and customization costs for smaller practices
- Limited flexibility for non-oncology specialties or general practice needs
Best For
Mid-to-large oncology practices focused on data-driven care, clinical research, and real-world evidence generation.
Pricing
Enterprise-level subscription pricing starting at $500+ per provider/month, plus one-time implementation fees; custom quotes based on practice size.
MOSAIQ
specializedOncology information system optimizing radiation, medical, and surgical oncology workflows and patient management.
MOSAIQ Record & Verify with real-time linac integration for error-proof treatment delivery
MOSAIQ by Elekta is a comprehensive Oncology Information System (OIS) tailored for radiation oncology, managing the full patient lifecycle from consultation and treatment planning to delivery, verification, and billing. It integrates electronic health records (EHR) with imaging, dosimetry, and linear accelerator controls for streamlined workflows. Widely used in hospitals and cancer centers, it supports multi-site operations and regulatory compliance like Meaningful Use.
Pros
- Deep integration with Elekta hardware for precise treatment delivery and verification
- Robust workflow automation for complex radiation oncology processes
- Comprehensive reporting, analytics, and billing modules
Cons
- Steep learning curve due to dense interface and customization needs
- Outdated UI in some modules compared to modern EHRs
- High implementation and maintenance costs for smaller practices
Best For
Large radiation oncology departments in hospitals with Elekta equipment needing an integrated OIS for high-volume treatments.
Pricing
Enterprise licensing with custom quotes; typically $50,000–$200,000+ annually based on department size, users, and modules.
ARIA Oncology Information System
specializedRobust OIS for radiation oncology, streamlining treatment planning, delivery, and quality assurance.
Native integration with Varian linear accelerators and Eclipse for automated, end-to-end treatment planning to delivery
ARIA Oncology Information System by Varian is a comprehensive oncology-specific EHR and information system tailored for radiation oncology practices. It manages the full patient lifecycle, including electronic medical records, treatment planning integration, image management, dosimetry calculations, billing, and compliance reporting. ARIA excels in streamlining workflows for radiation therapy delivery, particularly when paired with Varian hardware like linear accelerators and the Eclipse planning system.
Pros
- Deep integration with Varian hardware and Eclipse TPS for seamless treatment delivery
- Robust oncology-specific workflows, including advanced dosimetry and QA tools
- Strong regulatory compliance and revenue cycle management capabilities
Cons
- Steep learning curve and complex interface for new users
- High implementation and ongoing costs
- Limited native support for non-radiation oncology or non-Varian ecosystems
Best For
Large radiation oncology departments or networks heavily invested in Varian equipment needing an all-in-one OIS.
Pricing
Enterprise-level custom pricing; typically $500K+ initial setup plus annual maintenance/subscription fees scaling with practice size.
Allscripts Oncology
enterpriseEHR solution with oncology-specific tools for regimen building, clinical documentation, and revenue cycle optimization.
Advanced Beacon protocol engine for evidence-based treatment planning and automation
Allscripts Oncology is a robust EHR solution tailored for oncology practices, providing integrated tools for patient records, treatment planning, chemotherapy management, and survivorship care. It streamlines clinical workflows with evidence-based protocols, infusion center management, and seamless integration with lab, pharmacy, and imaging systems. The platform supports regulatory compliance and revenue cycle management, making it suitable for specialized cancer care delivery.
Pros
- Specialized oncology workflows including regimen building and protocol adherence
- Strong interoperability with external systems like labs and pharmacies
- Comprehensive compliance tools for ONC certification and MIPS reporting
Cons
- Steep learning curve due to complex interface
- High implementation costs and lengthy setup time
- Occasional performance issues in high-volume environments
Best For
Mid-to-large oncology practices needing integrated EHR with advanced treatment planning and revenue cycle capabilities.
Pricing
Custom enterprise pricing; typically $400-$700 per user/month plus one-time implementation fees starting at $50,000+.
athenaOne Oncology
enterpriseCloud-based EHR tailored for oncology practices with automated workflows, MIPS reporting, and patient engagement.
Intelligent chemotherapy protocol builder with embedded clinical pathways and real-time decision support
athenaOne Oncology is a cloud-based electronic health record (EHR) solution from athenahealth, tailored for oncology practices to streamline patient management, treatment planning, and administrative workflows. It offers specialized tools for chemotherapy regimen building, infusion management, survivorship care planning, and interoperability with labs, imaging, and payer systems. The platform integrates EHR with revenue cycle management, helping oncology providers focus more on care delivery while optimizing billing for complex oncology codes.
Pros
- Intuitive, user-friendly interface reduces training time for clinical staff
- Robust oncology-specific features like regimen support and infusion documentation
- Strong revenue cycle management with automated claims and denial handling
Cons
- Pricing can be steep for smaller practices without volume discounts
- Limited customization compared to larger enterprise systems like Epic
- Occasional performance issues in high-volume infusion centers
Best For
Mid-sized oncology practices seeking an integrated, cloud-based EHR with excellent usability and revenue optimization.
Pricing
Subscription-based, typically $500-$800 per provider per month plus implementation fees and add-ons for oncology modules.
NextGen Oncology
enterpriseSpecialty EHR offering oncology regimen support, e-prescribing, and interoperability for efficient cancer care.
Advanced chemotherapy management module with protocol-driven ordering, dose calculations, and real-time infusion tracking
NextGen Oncology, from NextGen Healthcare, is a comprehensive EHR solution tailored for oncology practices, offering specialized workflows for cancer care including treatment planning, chemotherapy management, and survivorship care. It integrates clinical documentation, infusion center operations, billing, and quality reporting to streamline operations in oncology settings. The platform supports interoperability with labs, imaging systems, and oncology information systems like MOSAIQ, enabling efficient data exchange and compliance with ONC standards.
Pros
- Specialized oncology templates and chemotherapy order entry with built-in safety protocols
- Seamless integration with practice management, billing, and external systems for end-to-end workflows
- Advanced analytics and registry reporting for MIPS and oncology quality measures
Cons
- Steep learning curve due to complex interface and extensive customization needs
- High upfront implementation costs and ongoing subscription fees
- Limited native mobile functionality compared to newer cloud-first competitors
Best For
Mid-sized to large oncology practices needing robust, integrated EHR with strong billing and compliance features.
Pricing
Custom enterprise pricing, typically $400-$700 per provider/month plus one-time implementation fees starting at $50,000+
eClinicalWorks Oncology
enterpriseIntegrated EHR platform with oncology modules for telehealth, population health, and chemotherapy management.
Chemotherapy management with built-in clinical decision support and automated safety checks like the Sunset Protocol
eClinicalWorks Oncology is a specialized EHR module within the eClinicalWorks platform, designed for oncology practices to streamline cancer patient management from diagnosis through treatment and survivorship. It offers oncology-specific workflows, including chemotherapy ordering, infusion management, treatment planning, and integration with lab, pathology, and imaging results. The solution supports regulatory compliance, such as ONC certification, and includes tools for multidisciplinary care coordination and patient engagement via portals.
Pros
- Oncology-specific templates and workflows for chemotherapy and treatment planning
- Strong interoperability with labs, imaging, and other EHR systems
- Integrated practice management and billing to reduce administrative burden
Cons
- User interface feels dated compared to modern EHRs
- Steep learning curve during implementation and training
- Customizations can be limited without additional vendor support
Best For
Mid-sized oncology practices seeking a comprehensive, integrated EHR with solid administrative and clinical tools.
Pricing
Subscription-based, typically $450-$650 per provider per month including oncology modules; custom quotes required for full implementation.
CureMD Oncology EHR
specializedAffordable cloud EHR focused on oncology with chemotherapy ordering, patient portals, and practice analytics.
Advanced chemotherapy management with customizable protocol builders and infusion tracking
CureMD Oncology EHR is a cloud-based electronic health record system designed specifically for oncology practices, offering tools for patient management, treatment planning, and chemotherapy administration. It includes features like protocol builders, infusion management, survivorship care planning, and integration with oncology information systems for streamlined workflows. The platform supports regulatory compliance, interoperability via HL7/FHIR, and analytics for practice efficiency.
Pros
- Specialized oncology workflows including chemotherapy regimen builders and NCCN guideline integration
- Strong interoperability and cloud scalability for growing practices
- Robust reporting and analytics for treatment outcomes and billing
Cons
- User interface feels somewhat dated compared to modern competitors
- Implementation and customization process can be time-consuming
- Customer support response times vary, especially for smaller practices
Best For
Mid-sized oncology clinics needing affordable, specialty-focused EHR with solid treatment planning tools.
Pricing
Quote-based pricing, typically $300-$600 per provider/month based on practice size and modules.
Conclusion
The review of leading oncology EHR solutions highlights specialized tools designed to enhance efficiency and patient care, with Epic Beacon emerging as the top choice for its enterprise-grade integration of treatment planning, infusion management, and survivorship features. Close contenders Cerner Oncology and Flatiron OncoEMR offer distinct strengths—Cerner's focus on complex care coordination and Flatiron's emphasis on community practice analytics—making them strong alternatives for specific needs. Together, these tools elevate oncology workflows, underscoring the importance of specialized software in modern cancer care.
Explore Epic Beacon to experience a comprehensive oncology EHR that combines power, integration, and support to streamline care delivery and improve outcomes.
Tools Reviewed
All tools were independently evaluated for this comparison