Top 10 Best Medical Lab Billing Software of 2026

Xifin is a cloud-based revenue cycle management (RCM) platform designed specifically for medical laboratories, pathology groups, and diagnostics providers. It automates complex lab billing processes, including claims scrubbing, coding optimization, denial management, and payment posting using advanced AI-driven rules engines. The software also offers robust analytics, patient collections tools, and compliance features to maximize reimbursements and streamline financial operations.

SCC Soft Computer's SoftLab is a comprehensive laboratory information system (LIS) with advanced medical lab billing capabilities, designed for high-volume clinical labs. It automates revenue cycle management, including claims submission, eligibility checks, denial management, and payment posting via EDI and ERA integration. The platform ensures HIPAA compliance and seamless connectivity with EHRs, practice management systems, and payer portals, streamlining end-to-end lab billing workflows.

Orchard Software offers comprehensive laboratory information systems (LIS) like Orchard Harvest and Orchard Enterprise, with integrated billing modules designed specifically for medical laboratories. It streamlines the entire revenue cycle, from automated charge capture and claim generation to electronic remittance processing and denial management. The platform ensures HIPAA compliance and supports seamless integration with EHRs, practice management systems, and clearinghouses via HL7 and other standards.

Psyche Systems provides a comprehensive Laboratory Information System (LIS) with integrated billing software designed specifically for clinical, anatomic pathology, and molecular diagnostics labs. It automates complex billing processes including charge capture, claims submission to payers, denial management, and accounts receivable tracking. The platform ensures HIPAA compliance and supports high-volume lab workflows, reducing errors in reimbursement for specialized lab services.

NovoPath is a comprehensive anatomic pathology laboratory information system (LIS) with an integrated billing module tailored for medical labs focused on pathology workflows. It automates claims generation, submission to payers like Medicare and private insurers, denial management, and revenue cycle tracking directly from case accessioning to payment posting. The software supports HL7 integrations, electronic remittance advice (ERA), and compliance with HIPAA and billing standards such as CPT, ICD-10, and SNOMED coding.

TruBridge TruLab is a comprehensive revenue cycle management solution tailored for medical laboratories, handling everything from patient eligibility verification and claims scrubbing to denial management and payment posting. It supports lab-specific billing for anatomic pathology, molecular diagnostics, and high-volume testing with seamless integration to LIS and EHR systems. The software emphasizes compliance, accuracy, and cash flow optimization through automated workflows and real-time reporting.

Epic Beaker is a comprehensive laboratory information system (LIS) from Epic Systems that manages end-to-end lab workflows, including test ordering, result reporting, and integrated billing for medical laboratories. It excels in charge capture, claims submission, and revenue cycle management through seamless integration with Epic's EHR platform. Designed for high-volume environments, it automates complex billing rules and ensures regulatory compliance like HIPAA and CMS standards.

Oracle Health Laboratory is an enterprise-grade laboratory information management system (LIMS) from Oracle Health (formerly Cerner) that supports end-to-end lab operations, including robust medical lab billing functionalities like claims processing, eligibility verification, and revenue cycle management. It excels in handling high-volume lab billing with support for complex CPT/ICD coding, electronic remittance advice (ERA), and integration with major payers. Tailored for large-scale healthcare organizations, it ensures compliance with HIPAA and other regulations while optimizing reimbursement rates.

Kareo is a cloud-based revenue cycle management (RCM) platform designed primarily for independent medical practices, offering integrated billing, practice management, and EHR functionalities. For medical lab billing, it excels in electronic claims submission (EDI 837), automated ERA posting, denial management, and eligibility verification, supporting lab-specific CPT/HCPCS codes and payer contracts. While versatile for general healthcare billing, it provides solid tools for labs handling high-volume claims but lacks deep native integration with lab information systems (LIS).

AdvancedMD is a comprehensive cloud-based EHR and practice management platform that includes robust medical billing capabilities suitable for medical labs handling claims for diagnostic tests and services. It streamlines revenue cycle management with features like automated claims scrubbing, electronic remittance advice (ERA) posting, and denial management tailored to high-volume lab billing. While not exclusively a lab-focused solution, it integrates lab results with billing workflows to ensure accurate coding and reimbursement from payers like Medicare and private insurers.