Top 10 Best Medical Invoicing Software of 2026

Kareo is a cloud-based medical billing and revenue cycle management platform designed specifically for independent healthcare practices, offering end-to-end invoicing solutions including electronic claims submission, patient payments, and AR management. It integrates seamlessly with EHR systems to automate workflows, track reimbursements, and minimize denials through advanced analytics and scrubbing tools. With robust reporting and compliance features, Kareo helps practices maximize revenue while reducing administrative overhead.

AdvancedMD is a comprehensive cloud-based platform offering robust medical invoicing and revenue cycle management solutions for healthcare practices. It automates claims submission, eligibility verification, denial management, and patient statements while integrating seamlessly with EHR and practice management tools. Designed for efficiency, it helps providers maximize reimbursements and reduce administrative burdens through advanced coding and AR tracking features.

athenaOne by athenahealth is a cloud-based electronic health record (EHR) and practice management platform with robust revenue cycle management (RCM) capabilities, specializing in medical invoicing, claims processing, and payment optimization. It automates eligibility verification, electronic claims submission, denial management, and patient statements to maximize revenue capture for healthcare providers. The system integrates seamlessly with EHR workflows, providing real-time analytics and reporting to support financial performance across various medical specialties.

DrChrono is a cloud-based EHR and practice management platform with integrated medical invoicing tools designed for ambulatory care providers. It streamlines the revenue cycle by automating charge capture, claims submission to major payers, payment posting, and patient statement generation directly from patient encounters. The software supports eligibility verification, denial management, and reporting to optimize cash flow for medical practices.

eClinicalWorks is a comprehensive EHR and practice management platform with robust medical invoicing and revenue cycle management tools. It automates claims submission, scrubbing, payment posting, denial management, and eligibility verification to optimize billing workflows. The system integrates billing seamlessly with clinical documentation, reducing errors and improving cash flow for healthcare providers.

NextGen Office is a comprehensive cloud-based EHR and practice management platform from NextGen Healthcare, with robust medical invoicing and revenue cycle management (RCM) capabilities tailored for ambulatory practices. It automates claims submission, eligibility verification, payment posting, and denial management, integrating seamlessly with its EHR for streamlined workflows. The software supports specialty-specific billing rules and provides detailed financial reporting to optimize reimbursements.

Practice Fusion is a free, cloud-based Electronic Health Record (EHR) system with integrated medical invoicing and billing features designed for small to mid-sized practices. It enables users to generate superbills, submit electronic claims to payers, manage patient statements, and track payments directly from patient charts. While primarily an EHR, its invoicing tools streamline revenue cycle management by embedding billing workflows within clinical documentation.

CureMD is a cloud-based EHR and practice management platform with robust medical invoicing features, enabling automated claims submission, eligibility verification, and revenue cycle management. It supports electronic remittance posting, denial management, and customizable patient statements to streamline billing workflows. Ideal for specialty practices, it integrates billing seamlessly with clinical documentation for efficient financial operations.

Greenway Health offers Prime Suite, an integrated EHR and practice management platform with comprehensive medical invoicing features tailored for ambulatory care practices. It streamlines revenue cycle management, including claims scrubbing, electronic submission to payers, denial management, and patient payment collections. The software ensures HIPAA compliance and interoperability with other healthcare systems for efficient billing workflows.

Allscripts, now part of Veradigm, offers comprehensive revenue cycle management (RCM) solutions integrated with its electronic health records (EHR) platform, streamlining medical invoicing, claims submission, and payment processing for healthcare providers. The software automates billing workflows, handles complex payer rules, and provides tools for denial management and patient collections. It is particularly suited for larger practices and hospitals seeking an all-in-one healthcare IT ecosystem.