Top 10 Best Medical Invoice Software of 2026

Kareo is a cloud-based medical billing and revenue cycle management platform designed specifically for independent medical practices. It automates claims submission to thousands of payers, handles payment posting, patient invoicing, and denial management to maximize reimbursements. Integrated with EHR and practice management, it provides end-to-end invoicing workflows with real-time analytics and eligibility verification.

AdvancedMD is a cloud-based medical practice management platform with robust invoicing and billing capabilities, including automated claims processing, denial management, and patient payment collection. It integrates seamlessly with EHR and practice management tools to streamline the entire revenue cycle for healthcare providers. Ideal for handling complex medical billing workflows while ensuring HIPAA compliance and regulatory adherence.

athenaOne by athenahealth is a comprehensive cloud-based EHR and practice management platform with advanced revenue cycle management (RCM) tools tailored for medical invoicing and billing. It automates claims submission, eligibility verification, denial management, and patient payment processing to streamline revenue workflows. Leveraging data from a nationwide network of providers, it offers benchmarking insights and predictive analytics to optimize financial performance for healthcare practices.

DrChrono is a cloud-based EHR and practice management platform with integrated medical invoicing and billing tools designed for healthcare providers. It enables electronic claims submission to over 3,000 payers, patient statement generation, payment processing via integrated gateways, and real-time eligibility verification. The system streamlines revenue cycle management by automating coding, superbills, and AR tracking directly from clinical documentation.

eClinicalWorks is a comprehensive EHR and practice management platform with integrated medical invoicing and billing features designed for healthcare providers. It automates claims processing, eligibility verification, payment posting, and denial management to streamline revenue cycles. The software supports electronic remittance advice (ERA) and offers tools for patient statements and collections.

CureMD is a cloud-based EHR and practice management platform with robust medical invoicing and billing capabilities, automating claims submission, payment posting, and revenue cycle management. It supports electronic eligibility verification, denial management, and AR reporting to help practices maximize reimbursements. Integrated with its full EHR suite, it streamlines workflows for healthcare providers handling complex billing needs.

NextGen Healthcare offers a robust revenue cycle management (RCM) solution integrated into its flagship EHR platform, streamlining medical invoicing from charge capture and claims submission to payment posting and denial management. It automates billing processes, ensures HIPAA compliance, and provides analytics for revenue optimization across specialties. Ideal for practices seeking an all-in-one system, it handles complex workflows like eligibility verification and patient statements efficiently.

Practice Fusion is a cloud-based electronic health record (EHR) platform that includes integrated medical invoicing and billing tools designed for small to medium-sized practices. It enables users to generate superbills, submit electronic claims to clearinghouses, track payments, and manage denial workflows directly within the EHR interface. While not a standalone billing solution, its invoicing features streamline revenue cycle management alongside clinical documentation and scheduling.

SimplePractice is a comprehensive practice management platform tailored for behavioral health and wellness professionals, offering robust medical invoicing and billing tools integrated with scheduling, EHR, and telehealth. It automates insurance claims submission, generates customizable superbills, and supports secure online payments via a client portal. The software simplifies revenue cycle management for solo practitioners and small practices by handling both cash-pay and insurance billing efficiently.

TherapyNotes is a practice management software tailored for behavioral health professionals, providing integrated medical invoicing tools like superbill generation, electronic claims submission, and payment processing. It streamlines billing workflows by automating insurance eligibility checks, patient statements, and ERA posting directly within the EHR system. While robust for therapy practices, its invoicing features are specialized for mental health CPT codes and lack broader medical customization.