Top 10 Best Medical Claims Billing Software of 2026

Kareo is a leading cloud-based medical billing software that specializes in revenue cycle management for healthcare providers. It automates claims submission, scrubbing, denial management, and patient payments while integrating seamlessly with EHR and practice management systems. Designed to maximize reimbursements and minimize administrative overhead, Kareo delivers high first-pass claim acceptance rates and comprehensive reporting tools.

AdvancedMD is a comprehensive cloud-based medical billing and revenue cycle management (RCM) solution designed for healthcare practices, offering automated claims creation, scrubbing, and electronic submission to over 2,500 payers. It includes denial management, AR tracking, patient payment processing, and real-time eligibility verification to optimize cash flow. Integrated with its EHR and practice management suite, it provides end-to-end billing workflows with advanced analytics for performance insights.

athenaOne by athenahealth is a comprehensive cloud-based EHR and practice management platform with robust medical claims billing capabilities integrated into its revenue cycle management suite. It automates claims creation, submission, scrubbing, and denial management while providing real-time eligibility verification and payer analytics to maximize reimbursements. Designed for ambulatory care, it supports high-volume billing with compliance tools for HIPAA and other regulations, achieving industry-leading first-pass acceptance rates.

DrChrono is a cloud-based electronic health record (EHR) and practice management platform with integrated medical claims billing capabilities, enabling seamless workflows from patient charting to claims submission. It supports electronic claims processing for over 3,000 payers, real-time eligibility verification, automated scrubbing, and payment posting directly within the EHR interface. Designed for ambulatory practices, it streamlines revenue cycle management while ensuring HIPAA compliance and mobile accessibility via iOS and web apps.

Waystar is a leading cloud-based revenue cycle management platform focused on medical claims billing for healthcare providers. It automates claims scrubbing, submission, eligibility verification, and denial management to accelerate reimbursements and reduce errors. With advanced analytics and AI-driven insights, it integrates seamlessly with EHRs and practice management systems to optimize financial performance across large-scale operations.

eClinicalWorks is a comprehensive EHR and practice management platform with integrated medical claims billing software that automates the revenue cycle from charge entry to payment reconciliation. It features claims scrubbing, electronic submission to major payers, denial management, and ERA auto-posting to minimize errors and accelerate reimbursements. The system supports eligibility checks, superbilling, and customizable reporting for efficient financial oversight in medical practices.

NextGen Healthcare offers a comprehensive EHR and practice management platform with robust medical claims billing features, automating the entire revenue cycle from charge capture to payment posting. It excels in claims scrubbing, electronic submission to major payers, denial management, and AR analytics to optimize reimbursements. Ideal for ambulatory and specialty practices, it ensures HIPAA compliance and interoperability with clearinghouses.

Practice Fusion is a free, cloud-based electronic health record (EHR) platform that includes integrated basic medical claims billing functionalities for small practices. It enables users to generate superbills, CMS-1500 forms, patient statements, and track payments within the same interface as clinical documentation. While it supports claims export and integration with third-party clearinghouses for electronic submission, it is not a dedicated revenue cycle management solution and focuses more on EHR capabilities.

CharmHealth is a cloud-based EHR and practice management platform with integrated medical claims billing features, enabling electronic claims submission to major payers like Medicare, Medicaid, and commercial insurers. It streamlines revenue cycle management through automated scrubbing, denial tracking, ERA auto-posting, and patient payment portals. Designed primarily for small to mid-sized practices, it combines clinical documentation with billing workflows to minimize errors and improve cash flow.

CureMD is a comprehensive cloud-based EHR and practice management platform with integrated medical claims billing software designed for healthcare providers. It automates electronic claims submission for CMS-1500 and UB-04 forms, supports real-time eligibility verification across major payers, and includes advanced tools for AR management, denial scrubbing, and payment posting. The solution emphasizes seamless integration between clinical documentation and billing workflows to reduce errors and accelerate reimbursements.