Top 10 Best Medical Billing Electronic Claims Software of 2026

Kareo is a leading cloud-based medical billing platform specializing in electronic claims submission, revenue cycle management, and practice optimization for healthcare providers. It automates claims scrubbing, eligibility verification, and denial management to minimize rejections and accelerate reimbursements. Integrated with EHR systems, it offers end-to-end billing workflows, patient payments, and analytics to enhance financial performance.

AdvancedMD is a comprehensive cloud-based practice management and EHR platform with robust medical billing capabilities, specializing in electronic claims submission and revenue cycle management. It automates claim scrubbing, batch processing, electronic remittance advice (ERA) posting, and denial management to streamline reimbursements from payers. Ideal for medical practices, it integrates billing seamlessly with patient records for efficient workflows.

athenahealth's athenaOne platform is a cloud-based electronic health record and revenue cycle management solution with robust medical billing and electronic claims capabilities. It automates claims scrubbing, submission, and tracking across major payers, achieving high first-pass acceptance rates often exceeding 95%. The software integrates eligibility verification, denial management, and payment posting to streamline the entire billing workflow for healthcare practices.

Waystar is a comprehensive revenue cycle management platform focused on electronic claims submission, processing, and payment optimization for healthcare providers. It automates claims scrubbing, submission to payers, denial management, and analytics to improve first-pass acceptance rates and cash flow. Designed for scalability, it integrates seamlessly with major EHR systems and offers real-time visibility into billing workflows.

DrChrono is a cloud-based EHR and practice management platform with integrated medical billing and electronic claims submission tools, enabling seamless claims processing, eligibility verification, and payment posting. It supports HIPAA-compliant electronic claims to major clearinghouses, handles ICD-10 and CPT coding, and includes features like automated scrubbing and ERA reconciliation. Designed for modern practices, it offers mobile accessibility via native iOS apps, making it suitable for on-the-go billing workflows.

Office Ally is a web-based clearinghouse platform that provides free electronic claims submission for professional (CMS-1500) and institutional (UB-04) claims to thousands of payers. It offers eligibility verification, real-time claim status tracking, Electronic Remittance Advice (ERA) posting, and patient statement generation. Designed for healthcare providers, it streamlines medical billing processes without requiring expensive software installations.

eClinicalWorks is a comprehensive EHR and practice management platform with integrated medical billing and electronic claims processing designed for healthcare providers. It enables seamless submission of ANSI 837 claims, processes ERA 835 remittances, tracks claim status, manages denials, and supports eligibility verification to streamline revenue cycle management. The software integrates patient clinical data with billing workflows, reducing errors and improving reimbursement rates while ensuring HIPAA compliance.

NextGen Healthcare offers a comprehensive practice management and EHR platform with robust medical billing and electronic claims submission capabilities tailored for healthcare providers. Its RCM module automates claims processing, including scrubbing, eligibility verification, and electronic remittance advice (ERA) posting. The software integrates seamlessly with major payers and clearinghouses to minimize denials and accelerate reimbursements.

CollaborateMD is a cloud-based medical billing software focused on electronic claims submission, revenue cycle management, and practice efficiency for healthcare providers. It automates claims scrubbing, eligibility checks, payment posting, and denial management to reduce errors and speed up reimbursements. The platform integrates with EHRs and offers reporting tools tailored for small to mid-sized practices handling high-volume claims.

Availity is a comprehensive healthcare connectivity platform that enables providers to submit electronic claims, verify patient eligibility, post remittances, and manage prior authorizations through a single secure portal. It leverages the largest neutral health information network in the U.S., connecting to virtually all major payers for seamless EDI transactions. Designed for medical billing, it supports end-to-end revenue cycle management with tools for claims editing, scrubbing, and status tracking to improve acceptance rates and reimbursements.