Top 10 Best Medical Billing Clearinghouse Software of 2026

Availity is a leading medical billing clearinghouse and revenue cycle management platform that connects healthcare providers with over 3,000 payers through its massive Health Information Network. It streamlines critical tasks like real-time eligibility verification, electronic claims submission, status tracking, ERA processing, and patient payments. With robust EDI capabilities and compliance tools, Availity minimizes denials and accelerates reimbursements for practices of all sizes.

Waystar is a comprehensive revenue cycle management platform functioning as a top-tier medical billing clearinghouse, enabling healthcare providers to submit claims, verify eligibility, and manage payments efficiently across thousands of payers. It leverages AI and automation for claims scrubbing, denial prevention, and analytics to maximize reimbursements and reduce administrative burdens. With seamless integrations to major EHRs like Epic and Cerner, Waystar streamlines the entire billing workflow for hospitals and practices.

Change Healthcare is a comprehensive medical billing clearinghouse platform that facilitates electronic claims submission, scrubbing, and adjudication for healthcare providers nationwide. It excels in real-time eligibility verification, denial management, and payment posting through its extensive EDI network connecting to thousands of payers. The software integrates with major EHR and practice management systems, providing advanced analytics to optimize revenue cycle management and reduce claim rejections.

athenahealth offers a robust cloud-based revenue cycle management platform through its athenaOne suite, functioning as an integrated medical billing clearinghouse. It excels in electronic claims submission, advanced scrubbing for error reduction, payer connectivity to over 1,100 insurers, eligibility checks, ERA auto-posting, and denial management. While not a standalone clearinghouse, its seamless integration with athenahealth's EHR and practice management tools optimizes end-to-end billing workflows for practices invested in their ecosystem.

Office Ally is a web-based medical billing clearinghouse that offers free electronic claims submission to over 4,000 payers, patient eligibility verification, and electronic remittance advice (ERA) processing. It supports standard formats like ANSI 837 and provides tools for claim status tracking and denial management. While core clearinghouse services are free, advanced features like integrated practice management (Practice Mate) require subscription.

Kareo is a cloud-based medical billing and practice management platform that functions as a robust clearinghouse solution, handling electronic claims submission, scrubbing, and tracking to major payers. It offers integrated revenue cycle management tools, including eligibility verification, automated ERA posting, denial management, and analytics to optimize reimbursements. Designed for independent practices and specialties, Kareo streamlines billing workflows while integrating with popular EHR systems for end-to-end efficiency.

AdvancedMD is a cloud-based medical billing clearinghouse solution integrated into its comprehensive EHR and practice management platform, enabling electronic claims submission, scrubbing, and tracking for healthcare providers. It automates revenue cycle management tasks like eligibility verification, denial management, and ERA auto-posting to improve cash flow efficiency. With robust payer connectivity and compliance tools, it supports multi-specialty practices in reducing claim rejections and accelerating reimbursements.

Payerpath is a robust medical billing clearinghouse software that streamlines electronic claims submission, eligibility verification, and ERA processing for healthcare providers. It supports over 5,000 payers with advanced claims scrubbing to achieve high first-pass acceptance rates and reduce denials. The platform also provides payment posting, reporting dashboards, and patient payment solutions to optimize revenue cycle management.

CollaborateMD is a cloud-based medical billing and practice management platform that doubles as a robust clearinghouse solution, facilitating electronic claims submission to over 4,000 payers, eligibility verification, and automated remittance posting. It includes advanced claims scrubbing to minimize rejections, denial management tools, and real-time reporting for revenue cycle optimization. Designed for medical practices, it integrates seamlessly with popular EHR systems to streamline the entire billing workflow.

DrChrono is a cloud-based EHR and practice management platform with integrated medical billing features, enabling practices to generate, scrub, submit, and track claims electronically. It partners with major clearinghouses for transmission to payers while offering built-in tools for revenue cycle management, ERA posting, and denial management. Though not a standalone clearinghouse, its comprehensive workflow suits practices wanting billing embedded in their EHR.