Top 10 Best Hipaa Compliant Help Desk Software of 2026

Zendesk is a comprehensive cloud-based customer service platform designed for help desk operations, offering ticketing, omnichannel support, AI-driven automation, and analytics. For HIPAA compliance, it provides a Business Associate Agreement (BAA) on Professional and Enterprise plans, enabling secure handling of protected health information (PHI) with features like data encryption, audit logs, and role-based access controls. It excels in scaling support for healthcare organizations while integrating with EHR systems and other tools.

Freshservice is a cloud-based IT service management (ITSM) platform designed for help desk operations, offering ticketing, asset management, automation, and self-service portals. It provides a HIPAA-compliant edition with features like data encryption at rest and in transit, detailed audit trails, role-based access controls, and a Business Associate Agreement (BAA), making it suitable for healthcare organizations handling PHI. The tool excels in streamlining IT support workflows while ensuring regulatory compliance for sensitive environments.

ServiceNow is a leading enterprise IT service management (ITSM) platform that provides robust help desk capabilities through its Incident Management, Service Request, and Knowledge Management modules. It enables efficient ticketing, workflow automation, and resolution tracking while supporting HIPAA compliance via configurable encrypted instances, audit trails, and Business Associate Agreements (BAAs). Ideal for healthcare organizations, it integrates AI-driven analytics and self-service portals to streamline support for sensitive patient data handling.

Salesforce Service Cloud is a robust customer service platform designed for managing support tickets, cases, and customer interactions across multiple channels. It supports HIPAA compliance through Salesforce Shield, which provides encryption, event monitoring, and a Business Associate Agreement (BAA) for handling protected health information (PHI) in healthcare environments. As a help desk solution, it excels in enterprise-scale deployments with AI-driven automation and deep CRM integrations, making it suitable for complex healthcare support operations.

SysAI d is a comprehensive IT service management (ITSM) platform offering robust help desk ticketing, automation, asset management, and self-service portals designed for enterprise use. It supports HIPAA compliance through its cloud deployment with a signed Business Associate Agreement (BAA), data encryption at rest and in transit, detailed audit logs, and role-based access controls to safeguard PHI. The software excels in streamlining IT support workflows while ensuring regulatory adherence for healthcare environments.

Zoho Desk is a versatile omnichannel help desk software that centralizes customer support tickets from email, chat, social media, and phone. For HIPAA compliance, it offers enterprise-grade features like AES-256 encryption, audit logs, role-based access controls, and a Business Associate Agreement (BAA) on higher plans, making it suitable for healthcare support teams. It excels in automation, AI-driven insights, and scalability for growing organizations handling sensitive patient data.

ManageEngine ServiceDesk Plus is a robust IT service management (ITSM) platform designed for help desk ticketing, asset management, change management, and incident resolution. It includes HIPAA-compliant features such as AES-256 encryption for data at rest and in transit, comprehensive audit trails, role-based access controls, and customizable workflows to safeguard protected health information (PHI). As a versatile solution ranked #7, it supports self-service portals, automation rules, and integrations, making it suitable for healthcare organizations managing IT support securely.

Vision Helpdesk is an omnichannel helpdesk software platform that manages support tickets from email, chat, phone, social media, and portals. It offers HIPAA-compliant cloud hosting on secure AWS infrastructure, ensuring data encryption, audit logs, and role-based access controls for handling protected health information (PHI). The solution includes asset management, SLA tracking, knowledge base, and reporting features suitable for healthcare support teams.

Microsoft Dynamics 365 Customer Service is an enterprise-grade CRM platform offering omnichannel ticketing, case management, knowledge bases, and AI-driven automation for customer support operations. It supports HIPAA compliance through Microsoft's Business Associate Agreement (BAA), advanced encryption, audit logs, and role-based access controls, making it viable for healthcare help desks handling protected health information (PHI). The solution integrates deeply with the Microsoft ecosystem, including Teams, Power BI, and Outlook, enabling streamlined workflows for large-scale deployments.

Ivanti Service Manager is a robust IT service management (ITSM) platform designed for help desk operations, incident tracking, asset management, and service catalog fulfillment. It supports ITIL best practices with automation, self-service portals, and reporting tools tailored for enterprise environments. For HIPAA compliance, it offers configurable features like role-based access control, audit logging, data encryption, and integration with secure identity providers, though full compliance often requires custom setup and a Business Associate Agreement.