Top 10 Best Hipaa Compliant Electronic Signature Software of 2026

DocuSign is a leading cloud-based electronic signature platform that allows users to send, sign, track, and manage agreements securely from any device. It excels in HIPAA compliance through its dedicated Business Associate Agreement (BAA), advanced encryption, audit trails, and features tailored for healthcare like secure signer authentication and PHI protection. Widely trusted by enterprises, it integrates seamlessly with EHR systems such as Epic and Cerner, streamlining workflows while ensuring regulatory adherence.

Adobe Acrobat Sign is a robust electronic signature platform integrated with Adobe's Document Cloud, enabling users to send, sign, track, and manage legally binding documents securely. It supports advanced workflows, templates, and integrations with tools like Microsoft 365 and Salesforce. For HIPAA compliance, it provides a Business Associate Agreement (BAA), end-to-end encryption, tamper-evident audit trails, and secure storage for protected health information (PHI), making it suitable for healthcare environments.

OneSpan Sign is an enterprise-grade electronic signature platform that delivers secure, legally binding digital signatures with a strong emphasis on compliance, particularly HIPAA for healthcare workflows. It offers features like tamper-evident audit trails, advanced authentication methods including biometrics, and seamless integrations with EHR systems and CRM tools. Designed for high-security environments, it enables organizations to manage consents, treatment plans, and patient agreements while maintaining data privacy and regulatory adherence.

Dropbox Sign, formerly HelloSign, is a cloud-based electronic signature platform that enables users to request signatures, track document status, and manage workflows securely. It offers HIPAA compliance through its Business and Enterprise plans, including a signed Business Associate Agreement (BAA), encryption, and audit trails tailored for healthcare providers handling protected health information. Integrated deeply with Dropbox, it streamlines document storage, sharing, and collaboration while supporting templates, reminders, and mobile signing.

RightSignature is a secure electronic signature platform owned by Citrix, specializing in legally binding e-signatures with robust compliance features tailored for regulated industries. It offers HIPAA-compliant solutions through a Business Associate Agreement (BAA), end-to-end encryption, and detailed audit trails to protect PHI during document signing and storage. Key functionalities include customizable templates, sequential routing, mobile signing, and integrations with tools like Salesforce and Microsoft Office.

SignNow is a versatile cloud-based electronic signature platform that allows users to create, send, sign, and track documents securely from any device. It achieves HIPAA compliance through a Business Associate Agreement (BAA) available on Enterprise plans, enabling secure handling of protected health information (PHI) with robust encryption, audit trails, and access controls. Ideal for streamlining workflows in healthcare, it supports templates, conditional fields, and integrations with tools like Google Workspace and Microsoft 365.

PandaDoc is a versatile document automation platform that streamlines the creation, collaboration, tracking, and electronic signing of proposals, contracts, and other business documents. It supports HIPAA compliance through a Business Associate Agreement (BAA), enabling secure handling of protected health information in healthcare settings. Key features include customizable templates, real-time analytics, and audit trails for e-signatures, making it suitable for regulated industries beyond just basic signing.

Zoho Sign is a versatile cloud-based electronic signature platform that allows users to create, send, sign, and manage documents securely from any device. It supports HIPAA compliance through features like advanced encryption, tamper-proof audit trails, and a Business Associate Agreement (BAA), making it suitable for healthcare organizations handling protected health information. Integrated with the Zoho ecosystem and popular third-party apps, it streamlines workflows while ensuring regulatory adherence.

Formstack Sign is a secure electronic signature platform that enables users to create, send, and manage legally binding signatures on documents with robust compliance features. It is fully HIPAA compliant, offering a Business Associate Agreement (BAA) for healthcare organizations handling protected health information (PHI). The software integrates seamlessly with Formstack Forms, allowing for automated workflows from data collection to signing and beyond.

Jotform Sign is an electronic signature tool embedded within the Jotform form-building platform, enabling users to create, send, and collect legally binding signatures on documents and forms. It offers HIPAA compliance via a Business Associate Agreement (BAA) on Enterprise plans, with features like encrypted storage and audit trails for handling protected health information (PHI). While versatile for general workflows, it shines in scenarios combining data collection forms with e-signatures, though it lacks some advanced enterprise-grade security of dedicated e-signature platforms.