Quick Overview
- 1#1: DocuSign - Provides secure, legally binding e-signatures with full HIPAA compliance and Business Associate Agreement for handling protected health information.
- 2#2: Adobe Acrobat Sign - Offers cloud-based electronic signatures compliant with HIPAA for secure signing of medical and healthcare documents.
- 3#3: OneSpan Sign - Delivers enterprise-grade digital signatures with advanced HIPAA compliance, audit trails, and identity verification for healthcare.
- 4#4: RightSignature - Secure e-signature platform by Citrix providing HIPAA Business Associate Agreement and tamper-proof audit logs for PHI.
- 5#5: Dropbox Sign - User-friendly e-signature tool offering HIPAA-compliant signing with encryption and BAA for healthcare workflows.
- 6#6: SignNow - Versatile e-signature solution with HIPAA compliance, unlimited templates, and integrations for medical practices.
- 7#7: PandaDoc - Document automation and e-signature platform with HIPAA BAA support for healthcare proposals and consents.
- 8#8: SignWell - Affordable, unlimited electronic signature software fully compliant with HIPAA for small to mid-sized healthcare providers.
- 9#9: BoldSign - API-first e-signature platform with built-in HIPAA compliance, encryption, and audit trails for developers and healthcare apps.
- 10#10: Jotform Sign - Integrated form and e-signature tool providing HIPAA-compliant digital signing for patient intake and consents.
Tools were selected based on robust HIPAA compliance—including verified Business Associate Agreements—alongside key features like encryption, audit trails, and user-friendliness, prioritizing value and effectiveness for healthcare applications.
Comparison Table
For healthcare providers seeking secure, compliant e-signature solutions, this comparison table breaks down top HIPAA-compliant tools like DocuSign, Adobe Acrobat Sign, OneSpan Sign, RightSignature, Dropbox Sign, and more. Readers will discover features, pricing, and usability to find the best fit for their practice or facility.
| # | Tool | Category | Overall | Features | Ease of Use | Value |
|---|---|---|---|---|---|---|
| 1 | DocuSign Provides secure, legally binding e-signatures with full HIPAA compliance and Business Associate Agreement for handling protected health information. | enterprise | 9.5/10 | 9.7/10 | 9.3/10 | 8.9/10 |
| 2 | Adobe Acrobat Sign Offers cloud-based electronic signatures compliant with HIPAA for secure signing of medical and healthcare documents. | enterprise | 9.1/10 | 9.5/10 | 8.4/10 | 8.2/10 |
| 3 | OneSpan Sign Delivers enterprise-grade digital signatures with advanced HIPAA compliance, audit trails, and identity verification for healthcare. | enterprise | 8.4/10 | 9.1/10 | 7.6/10 | 7.9/10 |
| 4 | RightSignature Secure e-signature platform by Citrix providing HIPAA Business Associate Agreement and tamper-proof audit logs for PHI. | enterprise | 8.3/10 | 8.7/10 | 7.9/10 | 8.0/10 |
| 5 | Dropbox Sign User-friendly e-signature tool offering HIPAA-compliant signing with encryption and BAA for healthcare workflows. | enterprise | 8.2/10 | 8.0/10 | 9.2/10 | 7.5/10 |
| 6 | SignNow Versatile e-signature solution with HIPAA compliance, unlimited templates, and integrations for medical practices. | enterprise | 8.1/10 | 8.0/10 | 9.0/10 | 8.5/10 |
| 7 | PandaDoc Document automation and e-signature platform with HIPAA BAA support for healthcare proposals and consents. | enterprise | 7.4/10 | 7.8/10 | 8.9/10 | 6.5/10 |
| 8 | SignWell Affordable, unlimited electronic signature software fully compliant with HIPAA for small to mid-sized healthcare providers. | specialized | 8.2/10 | 7.9/10 | 9.4/10 | 9.1/10 |
| 9 | BoldSign API-first e-signature platform with built-in HIPAA compliance, encryption, and audit trails for developers and healthcare apps. | specialized | 8.3/10 | 8.0/10 | 8.7/10 | 9.2/10 |
| 10 | Jotform Sign Integrated form and e-signature tool providing HIPAA-compliant digital signing for patient intake and consents. | specialized | 7.8/10 | 7.5/10 | 9.2/10 | 8.4/10 |
Provides secure, legally binding e-signatures with full HIPAA compliance and Business Associate Agreement for handling protected health information.
Offers cloud-based electronic signatures compliant with HIPAA for secure signing of medical and healthcare documents.
Delivers enterprise-grade digital signatures with advanced HIPAA compliance, audit trails, and identity verification for healthcare.
Secure e-signature platform by Citrix providing HIPAA Business Associate Agreement and tamper-proof audit logs for PHI.
User-friendly e-signature tool offering HIPAA-compliant signing with encryption and BAA for healthcare workflows.
Versatile e-signature solution with HIPAA compliance, unlimited templates, and integrations for medical practices.
Document automation and e-signature platform with HIPAA BAA support for healthcare proposals and consents.
Affordable, unlimited electronic signature software fully compliant with HIPAA for small to mid-sized healthcare providers.
API-first e-signature platform with built-in HIPAA compliance, encryption, and audit trails for developers and healthcare apps.
Integrated form and e-signature tool providing HIPAA-compliant digital signing for patient intake and consents.
DocuSign
enterpriseProvides secure, legally binding e-signatures with full HIPAA compliance and Business Associate Agreement for handling protected health information.
Automated BAA execution and PHI-safe signing rooms with granular permissions and tamper-evident audit trails
DocuSign is a premier electronic signature platform that provides secure, legally binding digital signatures for documents across industries, with specialized HIPAA compliance features for healthcare. It supports encrypted document storage, comprehensive audit trails, and Business Associate Agreements (BAAs) to protect PHI under HIPAA regulations. The platform integrates seamlessly with EHR systems, CRM tools, and productivity apps, enabling efficient workflows for signing patient consents, medical forms, and contracts.
Pros
- Gold-standard HIPAA compliance with HITRUST certification, BAAs, and advanced encryption
- Extensive integrations with EHRs like Epic and Cerner, plus 1,000+ apps
- Robust automation, templates, and AI-powered insights for streamlined workflows
Cons
- Premium pricing for HIPAA-enabled Enterprise plans
- Steeper learning curve for complex workflows
- Some advanced features require add-ons
Best For
Healthcare providers, hospitals, and telehealth services requiring secure, scalable HIPAA-compliant e-signatures for high-volume patient documentation.
Pricing
Starts at $10/user/month for standard plans; HIPAA compliance via Enterprise custom pricing from $25+/user/month including BAA.
Adobe Acrobat Sign
enterpriseOffers cloud-based electronic signatures compliant with HIPAA for secure signing of medical and healthcare documents.
Native PDF integration with Document Cloud for seamless editing, signing, and HIPAA-secure storage in one ecosystem
Adobe Acrobat Sign is a robust e-signature platform integrated with Adobe's Document Cloud, enabling secure digital signing, workflow automation, and document management. It supports HIPAA compliance through a signed Business Associate Agreement (BAA), encryption of protected health information (PHI), and detailed audit trails to meet healthcare regulatory requirements. Ideal for healthcare providers, it offers templates, multi-party signing, and integrations with EHR systems like Epic and Cerner.
Pros
- Enterprise-grade HIPAA compliance with BAA, PHI encryption, and compliant audit logs
- Deep integrations with Adobe Acrobat, Microsoft 365, Salesforce, and healthcare EHRs
- Advanced workflow automation, templates, and mobile signing capabilities
Cons
- Higher pricing tiers for full HIPAA features require enterprise plans
- Interface can feel complex for non-Adobe users with a steeper learning curve
- Limited customization in basic plans compared to specialized HIPAA tools
Best For
Mid-to-large healthcare organizations and enterprises requiring scalable, compliant e-signatures with strong integrations and PDF-native workflows.
Pricing
Starts at $9.99/user/month for Standard (billed annually), $24.99 for Plus; HIPAA-compliant enterprise plans via custom quote (typically $30+/user/month).
OneSpan Sign
enterpriseDelivers enterprise-grade digital signatures with advanced HIPAA compliance, audit trails, and identity verification for healthcare.
HIPAA-specific compliance toolkit with automated BAA management and healthcare workflow templates
OneSpan Sign is an enterprise-grade electronic signature platform that enables secure document signing, workflow automation, and compliance management for regulated industries. It supports HIPAA compliance through Business Associate Agreements (BAA), encrypted data handling, and detailed audit trails to meet healthcare requirements. The software integrates with CRM systems like Salesforce and offers mobile signing, templates, and identity verification to streamline e-signature processes while prioritizing security.
Pros
- Strong HIPAA compliance with BAA, encryption, and audit logs tailored for healthcare
- Advanced security features like biometric authentication and PKI-based signatures
- Seamless integrations with enterprise tools such as Salesforce, Microsoft Dynamics, and EHR systems
Cons
- Complex interface and setup for non-enterprise users, requiring training
- Custom enterprise pricing can be expensive for small practices
- Limited free tier or trial options compared to consumer-focused competitors
Best For
Large healthcare organizations and enterprises needing robust, HIPAA-compliant e-signatures with high-security identity verification.
Pricing
Custom enterprise pricing starting at around $25-40/user/month for business plans; volume discounts and quotes required for HIPAA-compliant setups.
RightSignature
enterpriseSecure e-signature platform by Citrix providing HIPAA Business Associate Agreement and tamper-proof audit logs for PHI.
Secure Signing Rooms for real-time, collaborative signing with controlled access and activity logging
RightSignature is a secure electronic signature platform specializing in compliant document workflows, particularly for healthcare with HIPAA Business Associate Agreement (BAA) support. It enables users to send, sign, track, and store documents with robust encryption, audit trails, and tamper-evident seals compliant with ESIGN, UETA, and HIPAA standards. The software offers customizable templates, automated reminders, and integrations with EHR systems and productivity tools for streamlined operations.
Pros
- Strong HIPAA compliance via BAA and PHI encryption
- Detailed audit trails and signer authentication options like KBA
- Flexible templates and workflow automation
Cons
- Dated user interface compared to newer competitors
- Higher pricing for small teams or low-volume users
- Limited advanced mobile editing capabilities
Best For
Mid-sized healthcare practices and organizations needing reliable HIPAA-compliant e-signatures with enterprise-grade security.
Pricing
Starts at $15/user/month (Essentials), $30/user/month (Pro), with custom Enterprise pricing including unlimited envelopes.
Dropbox Sign
enterpriseUser-friendly e-signature tool offering HIPAA-compliant signing with encryption and BAA for healthcare workflows.
Seamless Dropbox integration for automatic secure storage and sharing of signed HIPAA documents
Dropbox Sign, formerly HelloSign, is a cloud-based e-signature platform that enables users to send, sign, track, and manage documents securely from anywhere. It integrates seamlessly with Dropbox, Google Drive, and other tools, streamlining workflows for teams. For HIPAA compliance, it provides a Business Associate Agreement (BAA), encryption for data at rest and in transit, and audit logs, making it suitable for healthcare organizations handling protected health information (PHI), though full compliance requires Enterprise plans.
Pros
- Intuitive interface with mobile app support for quick signing
- Strong integrations with Dropbox and popular productivity tools
- HIPAA compliance via BAA, SOC 2 Type II, and detailed audit trails
Cons
- HIPAA features and BAA limited to costly Enterprise plans
- Lacks deep healthcare-specific integrations like EMR systems
- Template limits on lower tiers restrict scalability for high-volume use
Best For
Small to mid-sized healthcare practices already using Dropbox that need simple, compliant e-signatures without complex setups.
Pricing
Essentials at $15/user/month (annual); Business at $25/user/month; HIPAA-compliant Enterprise plans custom-priced with BAA.
SignNow
enterpriseVersatile e-signature solution with HIPAA compliance, unlimited templates, and integrations for medical practices.
Built-in workflow automation with conditional logic and reusable templates for streamlined HIPAA-compliant document processes.
SignNow is a versatile cloud-based e-signature platform that allows users to create, send, sign, and track documents securely online. It supports HIPAA compliance through a Business Associate Agreement (BAA), encrypted storage, and audit trails, making it viable for healthcare organizations handling PHI. Additional features include customizable templates, multi-party workflows, mobile signing, and integrations with tools like Google Workspace and Salesforce.
Pros
- Intuitive drag-and-drop interface for quick setup
- Strong mobile app for on-the-go signing
- Affordable pricing with HIPAA BAA included in higher tiers
Cons
- Limited advanced compliance reporting compared to enterprise leaders
- Customer support response times can vary
- Fewer native integrations than top competitors like DocuSign
Best For
Small to mid-sized healthcare practices needing an easy, cost-effective HIPAA-compliant e-signature tool without complex enterprise requirements.
Pricing
Business plan at $8/user/month (annual billing); Enterprise with HIPAA BAA is custom-priced, starting around $15/user/month; 14-day free trial available.
PandaDoc
enterpriseDocument automation and e-signature platform with HIPAA BAA support for healthcare proposals and consents.
Interactive content blocks and live previews for dynamic, engaging documents during the e-signing process
PandaDoc is a versatile document automation platform that combines professional document creation, e-signatures, and analytics, suitable for sales, proposals, and contracts. It achieves HIPAA compliance via a Business Associate Agreement (BAA) on its Enterprise plan, enabling secure handling of protected health information (PHI) for healthcare users. While not exclusively designed for healthcare, it streamlines workflows with templates, real-time tracking, and legally binding signatures.
Pros
- Intuitive drag-and-drop document builder with reusable templates
- Real-time document analytics and engagement tracking
- Strong integrations with CRMs like Salesforce and HubSpot
Cons
- HIPAA compliance (BAA) restricted to expensive Enterprise plan
- Limited healthcare-specific workflows or PHI-focused tools
- Pricing escalates quickly for advanced features needed in compliance
Best For
Healthcare sales and marketing teams needing document automation with compliant e-signatures.
Pricing
Essentials: $19/user/mo; Business: $49/user/mo (billed annually); Enterprise: Custom pricing with HIPAA BAA.
SignWell
specializedAffordable, unlimited electronic signature software fully compliant with HIPAA for small to mid-sized healthcare providers.
Unlimited templates and signers on all paid plans, ideal for repetitive healthcare forms
SignWell is a user-friendly e-signature platform designed for quick and secure document signing, tracking, and storage, with specific support for HIPAA compliance through a Business Associate Agreement (BAA) and encrypted handling of protected health information. It offers features like unlimited templates, automated reminders, and audit trails essential for healthcare workflows. Suitable for small to mid-sized practices seeking an affordable alternative to enterprise solutions.
Pros
- Intuitive drag-and-drop interface simplifies setup
- Affordable pricing with unlimited documents on paid plans
- Reliable HIPAA compliance including BAA and PHI encryption
Cons
- Limited advanced integrations compared to enterprise tools
- No dedicated mobile app (web-responsive only)
- Support primarily via email without phone option
Best For
Small healthcare practices and solo providers needing simple, cost-effective HIPAA-compliant e-signatures.
Pricing
Free plan (3 docs/month); Pro at $15/month (unlimited docs); Business at $30/month (teams); HIPAA compliance via BAA on paid plans starting at Pro.
BoldSign
specializedAPI-first e-signature platform with built-in HIPAA compliance, encryption, and audit trails for developers and healthcare apps.
HIPAA-compliant e-signatures with automatic BAA provision and dedicated secure infrastructure for PHI
BoldSign is a cloud-based e-signature platform designed for secure, legally binding electronic signatures with HIPAA compliance tailored for healthcare providers. It supports features like drag-and-drop document preparation, reusable templates, automated workflows, bulk sending, and mobile signing capabilities. As an affordable solution from Syncfusion, it emphasizes ease of use and API integrations while offering a Business Associate Agreement (BAA) for protected health information (PHI) handling.
Pros
- Highly affordable pricing with unlimited envelopes on paid plans
- Full HIPAA compliance including BAA and PHI encryption
- Intuitive drag-and-drop interface for quick setup
Cons
- Limited advanced workflow automation compared to leaders like DocuSign
- Fewer native integrations with healthcare-specific tools
- Support primarily via email and tickets, no live chat
Best For
Small to mid-sized healthcare practices and clinics seeking a budget-friendly, HIPAA-compliant e-signature tool without complex enterprise needs.
Pricing
Free plan available; Essentials at $10/user/month, Business (HIPAA-enabled) at $30/user/month, Enterprise custom with volume discounts.
Jotform Sign
specializedIntegrated form and e-signature tool providing HIPAA-compliant digital signing for patient intake and consents.
Seamless embedding of e-signatures directly into customizable, HIPAA-secure forms without needing separate tools.
Jotform Sign is an e-signature tool integrated into the Jotform form-building platform, enabling users to create, send, and collect legally binding signatures on documents and forms. It offers HIPAA compliance through a Business Associate Agreement (BAA) on eligible paid plans, making it suitable for healthcare workflows involving protected health information (PHI). The solution emphasizes ease of use with drag-and-drop customization, automations, and integrations, though it is more form-centric than a dedicated enterprise e-signature platform.
Pros
- Intuitive drag-and-drop builder for forms and signatures
- HIPAA compliance with BAA on paid plans
- Extensive integrations and automation options
Cons
- Limited advanced audit trails and compliance reporting compared to leaders
- HIPAA features locked behind higher-tier plans
- Less suited for complex, high-volume enterprise workflows
Best For
Small to mid-sized healthcare practices seeking an affordable, user-friendly e-signature solution integrated with form automation.
Pricing
Starts at $34/month (Starter plan); HIPAA compliance requires Gold ($99/month) or higher, with Enterprise custom pricing.
Conclusion
Evaluating the reviewed tools, DocuSign emerges as the top choice, offering robust security, legally binding e-signatures, and seamless handling of protected health information. Adobe Acrobat Sign follows with a user-friendly cloud platform ideal for healthcare workflows, while OneSpan Sign stands out with advanced features like audit trails and identity verification, catering to enterprise needs. Together, these options highlight the breadth of solutions available, ensuring healthcare providers can find a fit that matches their unique requirements, whether prioritizing simplicity, security, or integration. The top-ranked tools deliver the compliance and reliability essential for managing sensitive patient data.
Secure your healthcare document processes today—try the leading e-signature solution DocuSign to experience industry-leading security, ease of use, and confidence in protecting protected health information.
Tools Reviewed
All tools were independently evaluated for this comparison