Top 10 Best Hipaa Compliant Billing Software of 2026

Kareo is a leading cloud-based medical billing software platform designed specifically for independent healthcare practices, offering end-to-end revenue cycle management. It handles claims processing, denial management, patient payments, and analytics while maintaining full HIPAA compliance through robust security features like encryption and audit trails. Kareo integrates seamlessly with EHR systems to streamline workflows and maximize reimbursements, making it a top choice for efficient billing operations.

AdvancedMD is a cloud-based, all-in-one practice management and EHR platform with robust medical billing capabilities, fully HIPAA compliant for secure handling of protected health information. It streamlines revenue cycle management through automated claims processing, eligibility verification, and denial management tools. Designed for specialty and multi-location practices, it integrates billing seamlessly with patient engagement and analytics features.

athenahealth is a comprehensive cloud-based platform providing integrated electronic health records (EHR), practice management, and revenue cycle management (RCM) solutions tailored for healthcare providers. It specializes in HIPAA-compliant medical billing, featuring automated claims submission, scrubbing, denial management, and analytics to maximize reimbursements. The software supports seamless interoperability and offers robust security measures to protect patient data.

DrChrono is a comprehensive cloud-based EHR and practice management platform with integrated medical billing software designed for healthcare providers. It supports HIPAA-compliant electronic claims submission to over 3,000 payers, automated ERA posting, denial management, and eligibility verification to streamline revenue cycle management. The platform combines patient scheduling, charting, and billing in a mobile-accessible interface, reducing administrative burdens while ensuring data security and compliance.

SimplePractice is a comprehensive practice management platform tailored for mental health and wellness professionals, providing HIPAA-compliant tools for scheduling, EHR documentation, telehealth, and billing. Its billing module supports electronic claims submission to multiple clearinghouses, automated superbills, ERA posting, and patient invoicing with secure payment processing. Designed for ease of use, it streamlines revenue cycle management while maintaining strict HIPAA standards through encrypted data and BAAs.

TherapyNotes is a comprehensive, cloud-based practice management software tailored for mental health professionals, offering HIPAA-compliant tools for progress notes, scheduling, billing, and telehealth. Its billing module automates electronic claims submission to over 700 payers, handles ERA posting, superbills, and patient statements seamlessly within the same platform. Designed specifically for behavioral health, it ensures secure handling of sensitive PHI while streamlining revenue cycle management.

eClinicalWorks is a comprehensive EHR and practice management platform with integrated HIPAA-compliant billing software designed for medical practices. It handles the full revenue cycle, including electronic claims submission, real-time eligibility verification, denial management, and payment posting. The solution ensures secure data handling and compliance with HIPAA standards while integrating billing seamlessly with patient records to minimize errors and accelerate reimbursements.

NextGen Healthcare provides an integrated electronic health records (EHR) and practice management platform with robust HIPAA-compliant billing software designed for medical practices. It automates revenue cycle management, including claims submission, scrubbing, denial management, and patient payments. The solution supports specialty-specific billing workflows and ensures secure handling of protected health information (PHI) in compliance with HIPAA regulations.

CureMD is a cloud-based EHR and practice management platform with integrated HIPAA-compliant medical billing software, designed to handle the full revenue cycle from claims submission to payment reconciliation. It supports electronic claims processing, insurance verification, denial management, and detailed financial reporting, all while maintaining strict data security standards. Ideal for specialty practices, it integrates with major clearinghouses and offers tools for AR management and compliance auditing.

Practice Fusion is a cloud-based electronic health record (EHR) platform that offers HIPAA-compliant billing features integrated into its core system for managing patient records, e-prescribing, and claim submissions. It supports electronic claims processing through a built-in clearinghouse, scheduling, and basic revenue cycle management tailored for small practices. While not a standalone billing solution, it provides essential billing tools within a free EHR environment, certified for HIPAA security and Meaningful Use.