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Healthcare Medicine

Top 10 Best General Practice Software of 2026

Discover the top 10 general practice software to streamline clinic operations. Compare features, read reviews, find the best fit—start optimizing today.

Min-ji Park

Min-ji Park

Feb 11, 2026

10 tools comparedExpert reviewed
Independent evaluation · Unbiased commentary · Updated regularly
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In today's fast-paced healthcare landscape, general practice software is indispensable for optimizing workflows, enhancing patient care, and managing administrative tasks effectively. With a range of solutions—from cloud-based EHR platforms to beginner-friendly web tools—the options below cater to diverse practice needs, making selecting the right software a key driver of operational success.

Quick Overview

  1. 1#1: athenaOne - Cloud-based EHR and practice management platform that streamlines workflows, billing, and patient engagement for general practices.
  2. 2#2: Practice Fusion - Free web-based EHR software offering charting, e-prescribing, scheduling, and lab integrations for small general practices.
  3. 3#3: Kareo - Integrated billing, EHR, and practice management platform designed for independent primary care providers.
  4. 4#4: AdvancedMD - All-in-one EHR, practice management, and revenue cycle solution tailored for ambulatory general practices.
  5. 5#5: eClinicalWorks - Comprehensive EHR system with telehealth, patient portal, and population health tools for general practitioners.
  6. 6#6: DrChrono - Mobile-first EHR and practice management software with scheduling, billing, and telehealth for efficient general practice.
  7. 7#7: NextGen Healthcare - Ambulatory EHR platform providing clinical decision support and interoperability for primary care practices.
  8. 8#8: Greenway Health - Interoperable EHR and revenue management software focused on usability for general practice settings.
  9. 9#9: Amazing Charts - Physician-designed EHR with customizable templates and strong usability for solo and small general practices.
  10. 10#10: ChartLogic - EHR software featuring voice dictation and dynamic charting to enhance productivity in general practice.

Tools were chosen based on their ability to deliver robust clinical and business features, intuitive usability, seamless integration, and strong support, ensuring they meet the evolving demands of general practices while providing lasting value.

Comparison Table

This comparison table explores key general practice software tools, including athenaOne, Practice Fusion, Kareo, AdvancedMD, eClinicalWorks, and more, to help identify the best fit for your practice. Readers will learn about features, usability, and practical considerations to streamline workflows and improve patient care.

1athenaOne logo9.5/10

Cloud-based EHR and practice management platform that streamlines workflows, billing, and patient engagement for general practices.

Features
9.7/10
Ease
9.2/10
Value
9.0/10

Free web-based EHR software offering charting, e-prescribing, scheduling, and lab integrations for small general practices.

Features
8.2/10
Ease
9.1/10
Value
9.8/10
3Kareo logo8.6/10

Integrated billing, EHR, and practice management platform designed for independent primary care providers.

Features
8.8/10
Ease
8.5/10
Value
8.3/10
4AdvancedMD logo8.6/10

All-in-one EHR, practice management, and revenue cycle solution tailored for ambulatory general practices.

Features
9.1/10
Ease
7.9/10
Value
8.2/10

Comprehensive EHR system with telehealth, patient portal, and population health tools for general practitioners.

Features
8.5/10
Ease
6.5/10
Value
7.2/10
6DrChrono logo8.4/10

Mobile-first EHR and practice management software with scheduling, billing, and telehealth for efficient general practice.

Features
9.0/10
Ease
8.2/10
Value
7.8/10

Ambulatory EHR platform providing clinical decision support and interoperability for primary care practices.

Features
9.0/10
Ease
7.2/10
Value
7.8/10

Interoperable EHR and revenue management software focused on usability for general practice settings.

Features
8.2/10
Ease
6.8/10
Value
7.1/10

Physician-designed EHR with customizable templates and strong usability for solo and small general practices.

Features
7.5/10
Ease
8.5/10
Value
8.0/10
10ChartLogic logo7.6/10

EHR software featuring voice dictation and dynamic charting to enhance productivity in general practice.

Features
8.1/10
Ease
7.2/10
Value
7.0/10
1
athenaOne logo

athenaOne

enterprise

Cloud-based EHR and practice management platform that streamlines workflows, billing, and patient engagement for general practices.

Overall Rating9.5/10
Features
9.7/10
Ease of Use
9.2/10
Value
9.0/10
Standout Feature

AI-driven athenaOne Intelligence for predictive revenue insights, automated coding, and workflow optimization

athenaOne by athenahealth is a cloud-based, all-in-one electronic health record (EHR) and practice management platform tailored for ambulatory care, including general practices. It integrates clinical documentation, scheduling, billing, patient engagement, telehealth, and revenue cycle management to streamline workflows and improve financial performance. With AI-driven tools and robust interoperability, it supports population health management and regulatory compliance, making it a top choice for efficient practice operations.

Pros

  • Comprehensive EHR with AI-powered clinical documentation and coding assistance
  • Superior revenue cycle management with high clean claim rates and denial prevention
  • Strong interoperability via nationwide network and patient engagement portal

Cons

  • High subscription costs may strain small practices
  • Initial implementation and training require significant time investment
  • Limited customization options compared to some modular competitors

Best For

Mid-sized to large general practices prioritizing integrated EHR, billing efficiency, and scalability over budget constraints.

Pricing

Subscription-based at $140-$450 per provider per month (depending on practice size and features), plus one-time implementation fees of $5,000+.

Visit athenaOneathenahealth.com
2
Practice Fusion logo

Practice Fusion

specialized

Free web-based EHR software offering charting, e-prescribing, scheduling, and lab integrations for small general practices.

Overall Rating8.4/10
Features
8.2/10
Ease of Use
9.1/10
Value
9.8/10
Standout Feature

Fully free, ONC-certified EHR with unlimited e-prescribing, eliminating common subscription barriers for small practices

Practice Fusion is a cloud-based electronic health record (EHR) and practice management software tailored for general practices, offering charting, e-prescribing, scheduling, billing, and patient engagement tools. It supports Meaningful Use certification and integrates seamlessly with labs, pharmacies, and imaging centers. As one of the few free EHR options, it enables small practices to digitize records without upfront costs, though it includes some ads and optional paid add-ons.

Pros

  • Completely free core EHR with e-prescribing and scheduling
  • Intuitive, web-based interface requiring minimal training
  • Strong integration with labs, pharmacies, and patient portals

Cons

  • Intrusive ads within the interface
  • Limited customization and advanced reporting options
  • Customer support primarily email-based with variable response times

Best For

Solo practitioners or small general practices seeking a no-cost, user-friendly EHR to streamline daily operations.

Pricing

Free for core features; paid add-ons for premium support, clearinghouse billing (~$150/month), and advanced tools.

Visit Practice Fusionpracticefusion.com
3
Kareo logo

Kareo

specialized

Integrated billing, EHR, and practice management platform designed for independent primary care providers.

Overall Rating8.6/10
Features
8.8/10
Ease of Use
8.5/10
Value
8.3/10
Standout Feature

AI-powered denial prevention and revenue cycle intelligence that maximizes reimbursements

Kareo is a cloud-based medical software platform tailored for independent practices, providing integrated electronic health records (EHR), practice management, billing, and patient engagement tools. It excels in streamlining revenue cycle management, appointment scheduling, and claims processing to reduce administrative burdens. Designed for general practices, Kareo helps optimize cash flow and improve operational efficiency through automation and analytics.

Pros

  • Robust revenue cycle management with high claim approval rates
  • Intuitive cloud-based interface accessible from anywhere
  • Comprehensive patient portal and telehealth integration

Cons

  • Pricing can be steep for very small practices
  • Some advanced customizations require additional fees
  • Customer support response times vary

Best For

Small to medium-sized general practices focused on efficient billing and practice management without needing extensive customization.

Pricing

Starts at $110/provider/month for billing; full EHR and practice management suites range from $300-$600/month based on providers and features (quote-based).

Visit Kareokareo.com
4
AdvancedMD logo

AdvancedMD

enterprise

All-in-one EHR, practice management, and revenue cycle solution tailored for ambulatory general practices.

Overall Rating8.6/10
Features
9.1/10
Ease of Use
7.9/10
Value
8.2/10
Standout Feature

Advanced Revenue Cycle Management with AI-driven denial prevention and automated claims scrubbing

AdvancedMD is a comprehensive cloud-based EHR and practice management platform tailored for medical practices, including general practitioners, offering integrated tools for scheduling, billing, patient records, and telehealth. It streamlines workflows with features like automated claims processing, patient engagement portals, and analytics for revenue cycle management. Designed for scalability, it supports solo providers to multi-location practices while ensuring HIPAA compliance and interoperability.

Pros

  • Robust revenue cycle management with denial prevention tools
  • Seamless integration of EHR, PM, and patient portal
  • Scalable for growing practices with strong reporting and analytics

Cons

  • Steep learning curve for new users
  • Higher pricing that may strain smaller practices
  • Mixed customer support experiences

Best For

Mid-sized general practices seeking an all-in-one solution for efficient billing and patient management.

Pricing

Custom subscription pricing starts at around $400-$700 per provider per month, with tiers for EHR, PM, and advanced features; implementation fees apply.

Visit AdvancedMDadvancedmd.com
5
eClinicalWorks logo

eClinicalWorks

enterprise

Comprehensive EHR system with telehealth, patient portal, and population health tools for general practitioners.

Overall Rating7.8/10
Features
8.5/10
Ease of Use
6.5/10
Value
7.2/10
Standout Feature

Healow patient engagement ecosystem with open-access portal, app, and automated messaging for improved patient communication

eClinicalWorks is a comprehensive electronic health record (EHR) and practice management platform tailored for general practices and ambulatory care settings. It offers integrated tools for charting, scheduling, billing, e-prescribing, telehealth, and patient engagement through its Healow portal. With strong interoperability support via standards like HL7 and FHIR, it enables seamless data exchange with labs, hospitals, and other systems, making it suitable for practices of varying sizes.

Pros

  • Extensive feature set including EHR, practice management, and telehealth in one platform
  • Strong interoperability and customization options for general practice workflows
  • Scalable for solo practitioners to large multi-site practices

Cons

  • Outdated and clunky user interface with a steep learning curve
  • Frequent complaints about slow customer support and implementation delays
  • High ongoing costs that may not justify value for smaller practices

Best For

Mid-sized general practices seeking an all-in-one EHR with robust telehealth and interoperability features.

Pricing

Custom quote-based pricing; typically $400-$600 per provider/month for core EHR and PM features, plus add-ons.

Visit eClinicalWorkseclinicalworks.com
6
DrChrono logo

DrChrono

specialized

Mobile-first EHR and practice management software with scheduling, billing, and telehealth for efficient general practice.

Overall Rating8.4/10
Features
9.0/10
Ease of Use
8.2/10
Value
7.8/10
Standout Feature

Native iPad app providing full EHR functionality for charting, prescribing, and patient management directly from tablets

DrChrono is a cloud-based electronic health record (EHR) and practice management software designed for medical practices, including general practitioners. It offers tools for scheduling, billing, e-prescribing, telehealth, patient portals, and customizable charting to streamline daily operations. The platform emphasizes mobility with a robust iPad app, enabling providers to manage patient care on the go while ensuring HIPAA compliance and interoperability with labs and pharmacies.

Pros

  • Highly customizable templates and workflows for general practice needs
  • Seamless telehealth integration with video visits and mobile accessibility
  • Strong revenue cycle management including automated billing and claims

Cons

  • Pricing can be expensive for solo or small practices
  • Initial setup and customization require significant time investment
  • Customer support response times can vary

Best For

Small to medium-sized general practices seeking a mobile-optimized EHR with comprehensive practice management and telehealth features.

Pricing

Custom quote-based pricing; typically starts at $199 per provider per month, with additional fees for advanced features and implementation.

Visit DrChronodrchrono.com
7
NextGen Healthcare logo

NextGen Healthcare

enterprise

Ambulatory EHR platform providing clinical decision support and interoperability for primary care practices.

Overall Rating8.2/10
Features
9.0/10
Ease of Use
7.2/10
Value
7.8/10
Standout Feature

NextGen Population Health platform for proactive patient risk stratification and care management

NextGen Healthcare is a comprehensive electronic health record (EHR) and practice management platform tailored for ambulatory care, including general practices. It streamlines clinical workflows with features like patient scheduling, billing, e-prescribing, telehealth, and population health analytics. The software excels in interoperability, enabling seamless data exchange across systems to support value-based care.

Pros

  • Extensive feature set with strong population health and analytics tools
  • Excellent interoperability and compliance with standards like FHIR
  • Scalable for multi-location practices with customizable templates

Cons

  • Steep learning curve and complex interface for new users
  • High implementation costs and lengthy onboarding process
  • Reported occasional downtime and slower performance in high-volume settings

Best For

Mid-sized to large general practices needing robust enterprise-level EHR with advanced analytics and interoperability.

Pricing

Quote-based subscription model, typically $400-$700 per provider per month, plus one-time implementation fees starting at $10,000+.

8
Greenway Health logo

Greenway Health

enterprise

Interoperable EHR and revenue management software focused on usability for general practice settings.

Overall Rating7.6/10
Features
8.2/10
Ease of Use
6.8/10
Value
7.1/10
Standout Feature

Unified single-database architecture for seamless clinical and financial data flow

Greenway Health offers Prime Suite, a comprehensive EHR and practice management software designed for ambulatory practices including general practitioners. It integrates clinical documentation, scheduling, billing, e-prescribing, and patient engagement tools into a single platform to streamline operations. The solution is ONC-certified for meaningful use and emphasizes revenue cycle management with robust analytics.

Pros

  • Strong integration of EHR, billing, and practice management
  • Advanced revenue cycle tools with denial management
  • Reliable interoperability with labs, pharmacies, and payers

Cons

  • Steep learning curve and outdated interface
  • High upfront implementation costs and training requirements
  • Limited customization and mobile app functionality

Best For

Mid-sized general practices prioritizing billing efficiency and regulatory compliance over intuitive usability.

Pricing

Quote-based pricing starting at $400-$700 per provider/month, plus one-time implementation fees of $5,000-$20,000 depending on practice size.

Visit Greenway Healthgreenwayhealth.com
9
Amazing Charts logo

Amazing Charts

specialized

Physician-designed EHR with customizable templates and strong usability for solo and small general practices.

Overall Rating7.8/10
Features
7.5/10
Ease of Use
8.5/10
Value
8.0/10
Standout Feature

Patented dot-click charting system that builds SOAP notes rapidly by selecting predefined clinical dots

Amazing Charts is an EHR system designed specifically for primary care physicians, featuring a unique 'chartless' dot-clicking interface for rapid documentation of patient encounters. It supports essential general practice functions like scheduling, e-prescribing, billing, and population health management, with a focus on solo and small practices. Certified for MACRA and MIPS, it emphasizes workflow efficiency to minimize administrative time while maintaining comprehensive clinical records.

Pros

  • Ultra-fast dot-click charting enables notes in seconds
  • Strong primary care templates and workflows
  • Affordable pricing for small practices

Cons

  • Dated interface feels less modern
  • Limited integrations with third-party apps
  • Less scalable for larger practices

Best For

Solo or small primary care practices seeking quick, intuitive documentation without complex setups.

Pricing

Per-provider subscription starting at $395/month (billed annually), including core features; one-time implementation fees around $2,000-$5,000.

Visit Amazing Chartsamazingcharts.com
10
ChartLogic logo

ChartLogic

specialized

EHR software featuring voice dictation and dynamic charting to enhance productivity in general practice.

Overall Rating7.6/10
Features
8.1/10
Ease of Use
7.2/10
Value
7.0/10
Standout Feature

Proprietary voice-enabled charting with Dragon Medical One integration for seamless, hands-free note creation during patient encounters

ChartLogic is an electronic health record (EHR) and practice management software primarily designed for specialty practices like ENT, ophthalmology, and dermatology, but adaptable for general practice workflows. It excels in voice-enabled charting, allowing physicians to dictate notes hands-free using advanced speech recognition integrated with Dragon Medical One. The platform also includes scheduling, billing, e-prescribing, patient portals, and customizable templates to streamline clinical documentation and operations.

Pros

  • Highly accurate voice-to-text charting reduces documentation time significantly
  • Customizable templates and intuitive exam screen for efficient workflows
  • Strong integration with practice management for billing and scheduling

Cons

  • Steeper learning curve for voice features and customization
  • Higher pricing compared to general-purpose EHRs
  • Less optimized for broad general practice needs outside specialties

Best For

General practices with tech-savvy providers who prioritize hands-free documentation and are willing to invest in specialty-grade tools.

Pricing

Custom quote-based pricing; typically $500–$1,000 per provider/month including EHR, PM, and voice features.

Visit ChartLogicchartlogic.com

Conclusion

The top 10 general practice software options present diverse, effective solutions, with the top three standing out: athenaOne leads as the top choice, excelling in streamlining workflows, billing, and patient engagement. Practice Fusion and Kareo follow as strong alternatives—Practice Fusion offers a free, web-based platform with comprehensive charting and integrations, while Kareo provides integrated billing, EHR, and management tailored for independent providers. Together, these tools highlight the breadth of options available, ensuring practices can find the right fit for their unique needs.

athenaOne logo
Our Top Pick
athenaOne

Don’t miss out on athenaOne’s transformative approach to practice management—explore its features today, or consider Practice Fusion or Kareo to align with your specific requirements, and take the first step toward enhancing your practice operations.