Quick Overview
- 1#1: DrFirst Rcopia - Provides secure, compliant electronic prescribing with EPCS for controlled substances, formulary checks, and broad EHR integrations.
- 2#2: athenahealth - Delivers cloud-based EHR with advanced e-prescribing, prior authorizations, and real-time eligibility verification.
- 3#3: eClinicalWorks - Offers comprehensive EHR platform featuring robust e-prescribing, telehealth integration, and patient portal connectivity.
- 4#4: Epic Systems - Powers enterprise-grade EHR with sophisticated e-prescribing, clinical decision support, and interoperability features.
- 5#5: Oracle Health (Cerner) - Provides enterprise health IT solutions including secure e-prescribing and medication management across care settings.
- 6#6: Kareo - Combines practice management, billing, and e-prescribing in a user-friendly platform for independent practices.
- 7#7: RXNT - Offers affordable cloud-based e-prescribing with EPCS, scheduling, and billing for small to mid-sized practices.
- 8#8: Practice Fusion - Free web-based EHR with integrated e-prescribing, charting, and Surescripts connectivity for solo providers.
- 9#9: Veradigm - Delivers healthcare analytics and EHR tools with e-prescribing, revenue cycle management, and population health features.
- 10#10: NextGen Healthcare - Provides ambulatory EHR with e-prescribing, specialty-specific templates, and interoperability standards compliance.
We ranked these tools based on key factors including feature depth (such as EPCS capability and EHR integrations), user-friendliness, regulatory compliance, and overall value, ensuring relevance for diverse clinical settings and practice sizes.
Comparison Table
E Prescribing Software simplifies medication ordering, boosting accuracy and patient safety in healthcare settings. This comparison table features tools like DrFirst Rcopia, athenahealth, eClinicalWorks, Epic Systems, Oracle Health (Cerner) and more, guiding readers to identify the right solution based on usability, integrations, and key functionalities.
| # | Tool | Category | Overall | Features | Ease of Use | Value |
|---|---|---|---|---|---|---|
| 1 | DrFirst Rcopia Provides secure, compliant electronic prescribing with EPCS for controlled substances, formulary checks, and broad EHR integrations. | specialized | 9.7/10 | 9.8/10 | 9.5/10 | 9.4/10 |
| 2 | athenahealth Delivers cloud-based EHR with advanced e-prescribing, prior authorizations, and real-time eligibility verification. | enterprise | 9.1/10 | 9.4/10 | 8.7/10 | 8.9/10 |
| 3 | eClinicalWorks Offers comprehensive EHR platform featuring robust e-prescribing, telehealth integration, and patient portal connectivity. | enterprise | 8.4/10 | 9.1/10 | 7.6/10 | 8.0/10 |
| 4 | Epic Systems Powers enterprise-grade EHR with sophisticated e-prescribing, clinical decision support, and interoperability features. | enterprise | 8.4/10 | 9.6/10 | 7.1/10 | 6.8/10 |
| 5 | Oracle Health (Cerner) Provides enterprise health IT solutions including secure e-prescribing and medication management across care settings. | enterprise | 8.2/10 | 9.1/10 | 7.0/10 | 7.4/10 |
| 6 | Kareo Combines practice management, billing, and e-prescribing in a user-friendly platform for independent practices. | enterprise | 8.1/10 | 8.4/10 | 7.7/10 | 7.9/10 |
| 7 | RXNT Offers affordable cloud-based e-prescribing with EPCS, scheduling, and billing for small to mid-sized practices. | specialized | 8.4/10 | 8.2/10 | 9.1/10 | 9.0/10 |
| 8 | Practice Fusion Free web-based EHR with integrated e-prescribing, charting, and Surescripts connectivity for solo providers. | other | 7.8/10 | 7.5/10 | 8.2/10 | 9.2/10 |
| 9 | Veradigm Delivers healthcare analytics and EHR tools with e-prescribing, revenue cycle management, and population health features. | enterprise | 7.4/10 | 8.2/10 | 6.8/10 | 7.0/10 |
| 10 | NextGen Healthcare Provides ambulatory EHR with e-prescribing, specialty-specific templates, and interoperability standards compliance. | enterprise | 8.2/10 | 8.7/10 | 7.4/10 | 7.9/10 |
Provides secure, compliant electronic prescribing with EPCS for controlled substances, formulary checks, and broad EHR integrations.
Delivers cloud-based EHR with advanced e-prescribing, prior authorizations, and real-time eligibility verification.
Offers comprehensive EHR platform featuring robust e-prescribing, telehealth integration, and patient portal connectivity.
Powers enterprise-grade EHR with sophisticated e-prescribing, clinical decision support, and interoperability features.
Provides enterprise health IT solutions including secure e-prescribing and medication management across care settings.
Combines practice management, billing, and e-prescribing in a user-friendly platform for independent practices.
Offers affordable cloud-based e-prescribing with EPCS, scheduling, and billing for small to mid-sized practices.
Free web-based EHR with integrated e-prescribing, charting, and Surescripts connectivity for solo providers.
Delivers healthcare analytics and EHR tools with e-prescribing, revenue cycle management, and population health features.
Provides ambulatory EHR with e-prescribing, specialty-specific templates, and interoperability standards compliance.
DrFirst Rcopia
specializedProvides secure, compliant electronic prescribing with EPCS for controlled substances, formulary checks, and broad EHR integrations.
Integrated electronic prior authorization (ePA) with real-time payer responses, reducing approval times from days to minutes
DrFirst Rcopia is a leading cloud-based e-prescribing platform that enables healthcare providers to electronically transmit prescriptions to pharmacies with robust safety checks, including drug-allergy interactions, formulary verification, and duplicate therapy alerts. It seamlessly integrates with over 100 EHR/EMR systems and supports EPCS for controlled substances, medication history retrieval, and electronic prior authorizations. Widely used by hospitals, clinics, and independent providers, Rcopia ensures compliance with DEA, ONC, and state regulations while optimizing workflow efficiency.
Pros
- Seamless integration with major EHRs like Epic, Cerner, and athenahealth
- Comprehensive safety features including real-time formulary checks and EPCS support
- Advanced tools like MedHx for patient medication history and ePA for prior authorizations
Cons
- Higher pricing may be prohibitive for very small practices
- Occasional reports of integration delays during peak times
- Steeper initial learning curve for non-integrated standalone use
Best For
Large practices, hospitals, and multi-provider organizations needing a scalable, fully compliant e-prescribing solution with deep EHR integrations.
Pricing
Subscription-based starting at ~$150/provider/month, with tiered pricing and discounts for volume users or bundled services.
athenahealth
enterpriseDelivers cloud-based EHR with advanced e-prescribing, prior authorizations, and real-time eligibility verification.
AI-powered clinical decision support that provides predictive insights and prior authorization assistance during prescribing
Athenahealth's e-prescribing solution, integrated within its athenaOne cloud-based EHR platform, allows healthcare providers to electronically transmit prescriptions to pharmacies securely and efficiently. It features comprehensive drug interaction checks, allergy warnings, formulary verification, and support for controlled substances via EPCS certification. The system streamlines workflows by integrating with patient records, eligibility verification, and payer systems, reducing errors and improving compliance.
Pros
- Seamless integration with full EHR and practice management for unified workflows
- Advanced safety features including real-time drug-allergy checks and formulary management
- Mobile accessibility via athenaOne app for prescribing on the go
Cons
- High subscription costs better suited for larger practices
- Steep learning curve during initial onboarding and customization
- Relies heavily on stable internet connectivity
Best For
Mid-sized to large medical practices needing integrated EHR with robust e-prescribing and compliance tools.
Pricing
Custom subscription pricing; typically $419+ per provider per month for athenaOne suite including e-prescribing.
eClinicalWorks
enterpriseOffers comprehensive EHR platform featuring robust e-prescribing, telehealth integration, and patient portal connectivity.
Integrated electronic prior authorization (ePA) workflow that automates approvals directly within the prescribing process
eClinicalWorks is a comprehensive EHR platform with integrated e-prescribing functionality designed for ambulatory care providers. It enables secure electronic transmission of prescriptions to pharmacies via Surescripts, including support for controlled substances (EPCS), real-time drug interaction checks, formulary verification, and electronic prior authorizations. The system streamlines prescribing workflows by integrating seamlessly with patient records, allergies, and practice management tools.
Pros
- Robust integration with EHR for seamless prescribing from patient charts
- Full EPCS compliance for controlled substances with PDMP checks
- Advanced tools like ePA and real-time eligibility verification
Cons
- Steep learning curve due to complex interface
- Reported occasional system slowdowns during peak usage
- Higher cost structure for smaller practices
Best For
Mid-sized ambulatory practices seeking an all-in-one EHR with advanced e-prescribing capabilities.
Pricing
Custom pricing starting at around $449 per provider per month, plus one-time implementation fees and add-ons for advanced features.
Epic Systems
enterprisePowers enterprise-grade EHR with sophisticated e-prescribing, clinical decision support, and interoperability features.
Epic's Hyperspace module with predictive analytics and AI-driven formulary optimization for proactive prescribing decisions
Epic Systems, through its EpicCare EHR platform, offers advanced e-prescribing capabilities integrated seamlessly with comprehensive electronic health records. Providers can transmit prescriptions electronically to pharmacies via Surescripts, perform real-time formulary checks, insurance verification, and controlled substance e-prescribing (EPCS). It includes robust clinical decision support for drug interactions, allergies, and dosing, ensuring compliance and safety in large-scale healthcare environments.
Pros
- Seamless integration with full EHR for complete patient context and medication reconciliation
- Advanced clinical decision support including real-time benefits, interactions, and allergy alerts
- High reliability and scalability for enterprise-level use with full regulatory compliance (DEA EPCS, Surescripts)
Cons
- Extremely high implementation costs and long deployment timelines (often 2+ years)
- Steep learning curve due to complex interface not ideal for standalone e-prescribing
- Not cost-effective or practical for small practices or solo providers
Best For
Large hospitals, health systems, and multi-site organizations requiring fully integrated e-prescribing within a comprehensive EHR ecosystem.
Pricing
Custom enterprise pricing with multi-million-dollar implementation fees, annual licensing based on users/beds, and ongoing support costs.
Oracle Health (Cerner)
enterpriseProvides enterprise health IT solutions including secure e-prescribing and medication management across care settings.
AI-enhanced clinical decision support with predictive analytics for drug interactions and personalized recommendations
Oracle Health (formerly Cerner) offers robust e-prescribing capabilities integrated within its comprehensive EHR platform, allowing providers to electronically transmit prescriptions to pharmacies with real-time drug interaction, allergy, and formulary checks. It supports EPCS for controlled substances, prior authorizations, and seamless connectivity via Surescripts. Designed for enterprise-scale use, it ensures compliance with regulations like DEA and MIPS while leveraging Oracle's infrastructure for high reliability and data security.
Pros
- Deep integration with EHR for contextual prescribing
- Advanced clinical decision support including AI-driven alerts
- Proven scalability for large hospitals and health systems
Cons
- Steep learning curve and complex interface
- High implementation and ongoing costs
- Less flexible for small practices or standalone use
Best For
Large hospitals, health systems, and enterprise organizations seeking fully integrated EHR e-prescribing.
Pricing
Custom enterprise pricing via subscription, often $50,000+ annually depending on user count and modules, with significant upfront implementation fees.
Kareo
enterpriseCombines practice management, billing, and e-prescribing in a user-friendly platform for independent practices.
Built-in EPCS for secure electronic prescribing of controlled substances without external hardware
Kareo is a cloud-based medical practice management and EHR platform that includes integrated e-prescribing functionality, allowing providers to send electronic prescriptions directly to pharmacies from any device. It supports advanced features like drug interaction checks, formulary verification, and secure prescribing of controlled substances via EPCS compliance. Designed primarily for independent practices, Kareo streamlines prescribing workflows while integrating with billing and patient records for efficiency.
Pros
- Seamless integration with EHR and practice management for unified workflows
- EPCS support for controlled substances with two-factor authentication
- Real-time drug interaction and allergy alerts to enhance patient safety
Cons
- Interface can feel cluttered for users focused solely on e-prescribing
- Pricing scales up quickly for multi-provider practices
- Occasional delays in pharmacy connectivity reported by users
Best For
Independent medical practices needing integrated e-prescribing within a full practice management suite.
Pricing
Subscription starts at $144/provider/month for core features including e-prescribing, with higher tiers up to $300+/month for full EHR integration; pay-per-claim options available.
RXNT
specializedOffers affordable cloud-based e-prescribing with EPCS, scheduling, and billing for small to mid-sized practices.
Lightning-fast EPCS implementation, enabling controlled substance e-prescribing in all 50 states within days
RXNT is a cloud-based e-prescribing platform designed for healthcare providers to send secure electronic prescriptions to pharmacies, including support for controlled substances via EPCS certification. It integrates seamlessly with its own EHR and practice management tools, offering features like formulary checks, drug interaction alerts, and mobile access. Ideal for streamlining prescribing workflows, RXNT emphasizes quick setup and compliance with HIPAA and DEA regulations.
Pros
- Affordable pricing with scalable plans
- Intuitive interface and mobile app support
- Rapid setup, often live in days with EPCS
Cons
- Limited third-party integrations compared to larger EHRs
- Customer support response times can vary
- Fewer advanced reporting and analytics tools
Best For
Small to medium-sized practices seeking a straightforward, cost-effective e-prescribing solution with quick implementation.
Pricing
Starts at $59/provider/month for eRx Pro; full EHR + PM bundle at $249/provider/month (billed annually).
Practice Fusion
otherFree web-based EHR with integrated e-prescribing, charting, and Surescripts connectivity for solo providers.
100% free, fully certified e-prescribing with no upfront or ongoing costs for essential functionality
Practice Fusion is a cloud-based electronic health record (EHR) platform that provides integrated e-prescribing capabilities for healthcare providers. It enables secure electronic transmission of prescriptions to pharmacies, formulary checks, drug interaction alerts, and support for controlled substances via EPCS compliance. Primarily targeted at small to medium-sized practices, it combines eRx with charting, scheduling, and patient portal features in a web-accessible interface.
Pros
- Completely free core e-prescribing and EHR functionality with no subscription fees
- Surescripts-certified with robust safety checks like drug allergies and interactions
- Seamless integration with EHR workflow for quick prescribing from patient charts
Cons
- Limited customer support primarily through forums and self-help resources
- Interface can feel dated and occasionally cluttered for advanced users
- Some integrations (e.g., labs, billing) require paid add-ons or partnerships
Best For
Ideal for solo practitioners and small primary care clinics seeking a cost-free, straightforward e-prescribing solution integrated with basic EHR tools.
Pricing
Free for core EHR and e-prescribing features; optional paid add-ons for advanced integrations starting at $100+/month per provider.
Veradigm
enterpriseDelivers healthcare analytics and EHR tools with e-prescribing, revenue cycle management, and population health features.
Advanced electronic prior authorization capabilities with real-time payer responses
Veradigm, formerly Allscripts, offers a robust e-prescribing solution integrated within its comprehensive EHR and practice management platforms, enabling healthcare providers to send electronic prescriptions securely to pharmacies nationwide. It supports key features like formulary checks, drug interaction alerts, and electronic prior authorizations through partnerships with Surescripts. The software is designed for seamless workflow integration in clinical settings, particularly for specialty practices.
Pros
- Strong integration with EHR and practice management systems
- Comprehensive support for controlled substances (EPCS) and prior authorizations
- Nationwide pharmacy network connectivity via Surescripts
Cons
- Steep learning curve for new users due to complex interface
- Reported occasional system downtimes and slower customer support
- Higher costs make it less ideal for solo or small practices
Best For
Mid-sized to large medical practices or specialties needing fully integrated EHR-e-prescribing workflows.
Pricing
Custom enterprise pricing, typically $150-$400 per provider/month depending on practice size and modules.
NextGen Healthcare
enterpriseProvides ambulatory EHR with e-prescribing, specialty-specific templates, and interoperability standards compliance.
Seamless EPCS for controlled substances with built-in DEA compliance and two-factor authentication
NextGen Healthcare provides a robust electronic health record (EHR) platform with integrated e-prescribing functionality, enabling providers to transmit prescriptions electronically to pharmacies nationwide via the Surescripts network. It includes features like drug interaction checks, formulary verification, and access to patient medication history to enhance safety and efficiency. Designed primarily for ambulatory practices, it supports controlled substance e-prescribing (EPCS) and integrates seamlessly with other clinical workflows.
Pros
- Strong integration with full EHR for streamlined workflows
- Comprehensive drug interaction and allergy alerts
- Support for EPCS and real-time pharmacy connectivity
Cons
- Steep learning curve for new users
- Custom pricing can be expensive for smaller practices
- Occasional interface lag during peak usage
Best For
Mid-sized ambulatory practices and specialty groups needing integrated EHR and e-prescribing with advanced compliance features.
Pricing
Custom enterprise pricing, typically $300-$600 per provider/month depending on practice size and modules.
Conclusion
Among the reviewed e-prescribing software, DrFirst Rcopia leads as the top choice, distinguished by its secure, compliant e-prescribing with EPCS and broad EHR integrations. athenahealth and eClinicalWorks follow closely, with athenahealth offering cloud-based EHR and real-time eligibility verification, and eClinicalWorks impressing with comprehensive platform features including telehealth and patient portal connectivity. Each of the top three addresses specific practice needs, but Rcopia’s focus on security and integration sets it apart.
Don’t miss out on the top-ranked solution—explore DrFirst Rcopia to streamline your e-prescribing process and elevate patient care.
Tools Reviewed
All tools were independently evaluated for this comparison