Top 10 Best Drug Testing Software of 2026

eScreen is a leading cloud-based drug testing software platform that streamlines the entire occupational drug screening process for employers, clinics, and testing facilities. It enables electronic ordering, real-time result delivery, compliance reporting, and integration with a vast network of certified collection sites and labs. The platform supports rapid testing, electronic chain of custody (eCCF), and customizable panels for pre-employment, random, and post-accident screenings.

Psyche Systems offers Psyche LIS, a robust laboratory information system (LIS) tailored for toxicology labs specializing in drug testing and screening. It manages the full workflow, including sample accessioning, chain-of-custody tracking, instrument integration for analyzers like LC-MS/GC-MS, and generation of certified reports. The platform ensures compliance with regulations such as CLIA, CAP, and SAMHSA, supporting panels for employment testing, pain management, and forensic applications.

First Advantage provides a comprehensive drug testing management platform that handles ordering, scheduling, and result delivery for urine, hair, oral fluid, and other testing methods. It integrates with HRIS systems and offers real-time dashboards for tracking compliance and turnaround times. Designed for employers, it supports DOT-regulated and non-regulated programs with a focus on accuracy and speed through a vast network of collection sites.

Sterling (sterlingcheck.com) offers a comprehensive drug testing management platform integrated with its extensive background screening services, enabling employers to order tests, track results in real-time, and ensure compliance with federal and state regulations. The software supports various testing methods including urine, hair, oral fluid, and DOT-compliant panels, with features like automated scheduling, candidate portals, and integration with HRIS/ATS systems. It leverages Sterling's nationwide network of over 10,000 collection sites for rapid turnaround times, typically 24-48 hours for negative results.

HireRight is a comprehensive background screening platform that includes robust drug testing services for pre-employment, random, and post-accident screening. Employers can order tests via an online portal, track results in real-time, and integrate with ATS systems for seamless workflows. It supports various testing methods like urine, hair follicle, and oral fluid, leveraging a global network of certified labs and collection sites.

Accurate (accurate.com) provides a comprehensive drug testing platform as part of its background screening services, enabling employers to order, track, and manage drug screens including urine, hair, oral fluid, and DOT-compliant tests. The software offers a user-friendly client portal for real-time result viewing, compliance reporting, and integration with popular ATS systems like Workday and iCIMS. It supports pre-employment, random, and post-accident testing with Medical Review Officer (MRO) verification to ensure regulatory compliance.

Cisive provides a web-based platform for managing drug testing as part of its broader background screening and compliance solutions. It enables employers to order tests (urine, hair, oral fluid), schedule collections at a vast network of sites, track results in real-time, and receive certified Medical Review Officer (MRO) interpretations. The software integrates with major labs like Quest Diagnostics and LabCorp, offering electronic chain-of-custody and compliance reporting for pre-employment, random, and post-accident testing.

ClearStar is a comprehensive background screening platform with specialized drug testing software that enables employers to order, track, and manage pre-employment, random, and post-accident drug screens through an intuitive online portal. It integrates with a nationwide network of collection sites and certified labs, supporting urine, hair, oral fluid, and DOT-compliant testing methods. The platform emphasizes compliance with FCRA and DOT regulations, providing electronic results delivery and medical review officer (MRO) services for accurate interpretation.

PreCheck is a comprehensive background screening platform with integrated drug testing software that enables employers to order, track, and manage drug screens efficiently. It supports multiple testing methods like urine, hair follicle, and oral fluid tests through a vast network of collection sites. The platform ensures FCRA compliance, real-time result delivery, and seamless integration with ATS and HRIS systems for streamlined workflows.

Matrix Technology (matrixpls.com) is a specialized software platform for managing drug and alcohol testing programs, primarily for DOT-compliant employers and consortia. It handles random pool selection, scheduling, electronic custody and control forms (eCCF), lab result integration, and compliance reporting. The tool focuses on streamlining regulatory requirements while supporting both DOT and non-DOT testing workflows.