Top 10 Best Denial Management Software of 2026

Waystar is a comprehensive revenue cycle management platform with advanced denial management capabilities designed for healthcare providers. It leverages AI and machine learning to predict, prevent, and resolve claim denials through automated workflows, intelligent appeals management, and detailed analytics. The software integrates seamlessly with EHRs and practice management systems to streamline the entire denial lifecycle, significantly reducing revenue leakage.

Experian Health provides a robust denial management platform that uses AI-driven analytics and predictive intelligence to prevent, identify, and resolve claim denials across the revenue cycle. The solution offers tools like Denial Intelligence and automated workflows for appeals, trend analysis, and root cause identification, integrating seamlessly with EHRs and billing systems. It helps healthcare providers reduce denial rates, accelerate reimbursements, and optimize financial performance through data from billions of processed claims.

Availity is a leading health information network that connects healthcare providers with over 3,000 payers and organizations for streamlined administrative transactions. As a denial management solution, it provides tools for real-time claim status tracking, denial analysis, root cause identification, and automated appeal workflows to reduce revenue leakage. Its analytics dashboard helps practices identify denial trends and implement preventive strategies across high-volume claims processing.

Optum Revenue Cycle is a comprehensive revenue cycle management platform from Optum, specializing in denial management for healthcare providers. It uses advanced analytics, AI-driven insights, and automated workflows to identify denial patterns, prevent future denials, and streamline appeals processes. The solution integrates seamlessly with EHRs and billing systems to optimize reimbursements and reduce revenue leakage.

Athenahealth's athenaOne platform offers comprehensive denial management within its integrated revenue cycle management (RCM) suite, helping healthcare providers prevent, track, and resolve claim denials efficiently. Key features include automated denial workflows, advanced analytics for root cause analysis, and AI-driven insights to predict and reduce future denials. Seamlessly integrated with its EHR and practice management tools, it streamlines the entire revenue cycle from claims submission to appeals management.

nThrive is a comprehensive revenue cycle management (RCM) platform tailored for healthcare providers, with robust denial management capabilities that leverage AI-driven analytics to identify, prevent, and resolve claim denials efficiently. It automates workflows for appeals, tracks denial trends, and integrates with EHR systems to streamline reimbursements. The solution emphasizes data intelligence to reduce denial rates and accelerate cash flow for hospitals and health systems.

Quadax provides a comprehensive revenue cycle management (RCM) platform with specialized denial management tools tailored for healthcare providers. Its Q-Denials module automates the tracking, analysis, and resolution of claim denials, including root cause identification and automated appeals workflows. The software leverages analytics and AI to prevent future denials, integrating seamlessly with existing EHR and practice management systems to streamline revenue recovery.

MedeAnalytics ClaimGuardian is an AI-driven denial management platform tailored for healthcare revenue cycle teams, focusing on preventing claim denials through predictive analytics and risk scoring before submission. It provides real-time dashboards, automated workflows for appeals, and trend analysis to identify root causes of denials and improve recovery rates. The solution integrates with major EHR and practice management systems to streamline denial prevention and resolution processes.

AKASA is an AI-powered revenue cycle management platform designed specifically for healthcare providers to tackle denial management. It leverages machine learning to predict, prevent, and resolve claim denials by automating appeals, analyzing payer trends, and optimizing workflows. The software integrates with EHRs and billing systems to deliver actionable insights and improve reimbursement rates.

Cirius is an AI-powered revenue cycle management platform specializing in denial management for healthcare providers, using machine learning to identify denial patterns, automate appeals, and predict future denials. It integrates with EHR and billing systems to provide real-time analytics and workflows that streamline AR management and reduce write-offs. The tool focuses on proactive denial prevention through data-driven insights and automated remediation processes.