Quick Overview
- 1#1: Medidata Rave RTSM - Provides advanced randomization, trial supply management, inventory tracking, and real-time visibility for global clinical trials.
- 2#2: Oracle Clinical One Supply - Integrated supply chain platform within Clinical One for planning, forecasting, and managing clinical trial materials end-to-end.
- 3#3: Calyx IRT - Robust interactive response technology system for patient randomization, drug accountability, and automated resupply in clinical trials.
- 4#4: Almac ONE - End-to-end clinical supply chain platform covering demand forecasting, packaging, labeling, distribution, and returns management.
- 5#5: Suvoda RTSM - Cloud-based, patient-centric RTSM solution with rapid deployment, dynamic resupply, and enhanced usability for complex trials.
- 6#6: Clario RTSM - Unified RTSM integrated with eCOA, imaging, and eConsent for optimized trial supply and patient-centric outcomes.
- 7#7: Signant Health RTSM - Flexible IRT/RTSM platform emphasizing patient engagement, supply optimization, and integration with clinical assessments.
- 8#8: Veeva Vault CTMS - Cloud CTMS with embedded supply planning, visibility, and collaboration tools for clinical trial operations.
- 9#9: Anju eClinical - Unified eClinical platform with RTSM modules for supply chain visibility, forecasting, and regulatory compliance.
- 10#10: Viedoc - eClinical platform with integrated RTSM for EDC, randomization, and trial supply management in a user-friendly interface.
These tools were ranked based on key attributes including advanced functionality (such as real-time inventory tracking and automated resupply), integration capabilities (with EDC, eCOA, and other trial systems), ease of deployment, and value for sponsors and CROs. Quality and reliability were prioritized to ensure solutions meet the complexities of modern clinical research.
Comparison Table
Effective clinical trial supply management is pivotal for modern drug development, and selecting the right software requires evaluating key tools to align with operational needs. This comparison table dives into solutions like Medidata Rave RTSM, Oracle Clinical One Supply, Calyx IRT, Almac ONE, Suvoda RTSM, and more, examining their features, integration, and suitability for diverse trials. Readers will gain clarity on each tool’s strengths to make informed decisions that enhance efficiency and compliance.
| # | Tool | Category | Overall | Features | Ease of Use | Value |
|---|---|---|---|---|---|---|
| 1 | Medidata Rave RTSM Provides advanced randomization, trial supply management, inventory tracking, and real-time visibility for global clinical trials. | enterprise | 9.4/10 | 9.7/10 | 8.6/10 | 8.9/10 |
| 2 | Oracle Clinical One Supply Integrated supply chain platform within Clinical One for planning, forecasting, and managing clinical trial materials end-to-end. | enterprise | 9.1/10 | 9.5/10 | 8.7/10 | 8.9/10 |
| 3 | Calyx IRT Robust interactive response technology system for patient randomization, drug accountability, and automated resupply in clinical trials. | specialized | 9.2/10 | 9.5/10 | 8.7/10 | 9.0/10 |
| 4 | Almac ONE End-to-end clinical supply chain platform covering demand forecasting, packaging, labeling, distribution, and returns management. | enterprise | 8.6/10 | 9.1/10 | 7.9/10 | 8.3/10 |
| 5 | Suvoda RTSM Cloud-based, patient-centric RTSM solution with rapid deployment, dynamic resupply, and enhanced usability for complex trials. | specialized | 8.7/10 | 8.9/10 | 9.2/10 | 8.4/10 |
| 6 | Clario RTSM Unified RTSM integrated with eCOA, imaging, and eConsent for optimized trial supply and patient-centric outcomes. | enterprise | 8.3/10 | 8.7/10 | 7.9/10 | 8.1/10 |
| 7 | Signant Health RTSM Flexible IRT/RTSM platform emphasizing patient engagement, supply optimization, and integration with clinical assessments. | specialized | 8.1/10 | 8.5/10 | 7.6/10 | 7.9/10 |
| 8 | Veeva Vault CTMS Cloud CTMS with embedded supply planning, visibility, and collaboration tools for clinical trial operations. | enterprise | 8.4/10 | 9.1/10 | 7.6/10 | 8.0/10 |
| 9 | Anju eClinical Unified eClinical platform with RTSM modules for supply chain visibility, forecasting, and regulatory compliance. | enterprise | 8.1/10 | 8.5/10 | 7.7/10 | 7.9/10 |
| 10 | Viedoc eClinical platform with integrated RTSM for EDC, randomization, and trial supply management in a user-friendly interface. | specialized | 7.8/10 | 7.6/10 | 9.1/10 | 7.9/10 |
Provides advanced randomization, trial supply management, inventory tracking, and real-time visibility for global clinical trials.
Integrated supply chain platform within Clinical One for planning, forecasting, and managing clinical trial materials end-to-end.
Robust interactive response technology system for patient randomization, drug accountability, and automated resupply in clinical trials.
End-to-end clinical supply chain platform covering demand forecasting, packaging, labeling, distribution, and returns management.
Cloud-based, patient-centric RTSM solution with rapid deployment, dynamic resupply, and enhanced usability for complex trials.
Unified RTSM integrated with eCOA, imaging, and eConsent for optimized trial supply and patient-centric outcomes.
Flexible IRT/RTSM platform emphasizing patient engagement, supply optimization, and integration with clinical assessments.
Cloud CTMS with embedded supply planning, visibility, and collaboration tools for clinical trial operations.
Unified eClinical platform with RTSM modules for supply chain visibility, forecasting, and regulatory compliance.
eClinical platform with integrated RTSM for EDC, randomization, and trial supply management in a user-friendly interface.
Medidata Rave RTSM
enterpriseProvides advanced randomization, trial supply management, inventory tracking, and real-time visibility for global clinical trials.
AI-driven real-time supply simulations that predict and automate resupply needs across global depots
Medidata Rave RTSM is a leading cloud-based Randomized Trial Supply Management (RTSM) solution designed for clinical trials, offering real-time inventory tracking, dynamic randomization, and automated supply chain optimization. It integrates seamlessly with the Medidata Rave EDC and broader Clinical Cloud platform, enabling precise kit assignments, forecasting, and resupply decisions to minimize waste and ensure patient compliance. With advanced AI-driven simulations, it supports complex, global trials while maintaining regulatory compliance like 21 CFR Part 11.
Pros
- Seamless integration with Medidata's unified Clinical Cloud for end-to-end trial data visibility
- AI-powered real-time forecasting and dynamic supply modeling to optimize inventory and reduce over/under-supply
- Robust randomization engine supporting adaptive trials, blinding, and stratified randomization
Cons
- High implementation costs and lengthy setup for custom configurations
- Steep learning curve for non-expert users due to extensive customization options
- Vendor lock-in for organizations heavily invested in the Medidata ecosystem
Best For
Large pharmaceutical companies, biotech firms, and CROs managing complex, multi-site global clinical trials requiring advanced supply chain precision.
Pricing
Custom enterprise pricing via quote; typically $200K+ annually based on trial scale, users, and integrations.
Oracle Clinical One Supply
enterpriseIntegrated supply chain platform within Clinical One for planning, forecasting, and managing clinical trial materials end-to-end.
End-to-end real-time supply visibility integrated with patient-level data for dynamic, just-in-time resupply
Oracle Clinical One Supply is a cloud-native solution for clinical trial supply chain management, providing end-to-end visibility from manufacturing and packaging to site distribution and patient dosing. It leverages AI-driven forecasting, scenario planning, and automated workflows to optimize inventory, reduce waste, and ensure timely supply availability. Seamlessly integrated with the Oracle Clinical One platform, it synchronizes supply activities with study design, patient enrollment, and electronic data capture for enhanced efficiency and compliance.
Pros
- AI-powered demand forecasting and scenario planning for precise supply optimization
- Seamless integration with Oracle Clinical One for unified trial management
- Real-time visibility and compliance tools including temperature excursion management
Cons
- Enterprise-level pricing with no public tiers
- Steep implementation and customization timeline
- Optimized for larger organizations within Oracle ecosystem
Best For
Large pharmaceutical companies and CROs managing complex, global clinical trials with high-volume supply needs.
Pricing
Custom enterprise licensing; quote-based, typically starting in the high six figures annually depending on scope and users.
Calyx IRT
specializedRobust interactive response technology system for patient randomization, drug accountability, and automated resupply in clinical trials.
Proprietary Dynamic Resupply Engine that uses predictive analytics for automated, just-in-time shipments tailored to enrollment rates
Calyx IRT is a leading Interactive Response Technology (IRT) platform specialized in clinical trial supply management, enabling randomization, patient enrollment, and real-time inventory tracking. It optimizes investigational product distribution through advanced forecasting algorithms, ensuring sites receive just-in-time resupplies to minimize waste and stockouts. The solution supports complex, global trials with full regulatory compliance, including 21 CFR Part 11, and integrates seamlessly with EDC and CTMS systems.
Pros
- Advanced resupply optimization algorithms reduce drug waste by up to 30%
- Robust scalability for multi-site, global trials with 99.9% uptime
- Strong integration capabilities with major EDC and ERP systems
Cons
- Steep learning curve for non-expert administrators
- Custom pricing can be prohibitive for small Phase I trials
- Implementation timelines may extend for highly customized protocols
Best For
Large pharmaceutical companies and CROs conducting complex, multi-center Phase II-IV trials requiring precise supply chain visibility and automation.
Pricing
Custom per-trial pricing starting at $50,000+ for setup, plus per-enrollment fees; volume discounts for enterprise contracts.
Almac ONE
enterpriseEnd-to-end clinical supply chain platform covering demand forecasting, packaging, labeling, distribution, and returns management.
Supply Chain Control Tower for unified, real-time monitoring and proactive scenario-based planning across the entire clinical supply lifecycle
Almac ONE is a comprehensive clinical trial supply chain management platform from Almac Group that provides end-to-end visibility and control across demand forecasting, packaging, labeling, distribution, and returns. It integrates seamlessly with IRT systems, ERP, and other clinical technologies to optimize inventory, reduce waste, and ensure compliance in global trials. The solution leverages real-time analytics and scenario planning to mitigate supply risks and enhance decision-making.
Pros
- End-to-end supply chain integration with real-time visibility
- Advanced forecasting and simulation tools for risk mitigation
- Robust compliance features for global regulatory standards
Cons
- Complex interface requiring significant training for new users
- Pricing tailored for large-scale operations, less ideal for small trials
- Limited public documentation and community resources
Best For
Mid-to-large pharmaceutical companies and CROs managing complex, multi-site global clinical trials with high supply chain demands.
Pricing
Custom enterprise pricing based on trial scale, modules, and services; typically starts in the high six figures annually—contact Almac for quotes.
Suvoda RTSM
specializedCloud-based, patient-centric RTSM solution with rapid deployment, dynamic resupply, and enhanced usability for complex trials.
Industry-leading study build speed with configurable launches in as little as 4 weeks
Suvoda RTSM is a cloud-based Randomization and Trial Supply Management (RTSM) platform tailored for clinical trials, particularly complex ones like oncology and cell/gene therapies. It provides real-time inventory visibility, automated resupply forecasting, integrated randomization, and supply chain optimization to minimize waste and delays. The software emphasizes rapid deployment, with studies often going live in 4-6 weeks, and supports depotless direct-to-site supply models for enhanced efficiency.
Pros
- Rapid study build times (4-6 weeks to live)
- Intuitive user interface favored by clinical staff
- Advanced real-time forecasting and simulation tools
Cons
- Premium pricing for smaller trials
- Limited native integrations with some EDC systems
- Primarily optimized for depotless models
Best For
Sponsor and CRO teams running complex, decentralized trials who need fast deployment and clinician-friendly tools.
Pricing
Custom subscription pricing based on trial size and complexity; typically starts at $100K+ annually per study—contact for quote.
Clario RTSM
enterpriseUnified RTSM integrated with eCOA, imaging, and eConsent for optimized trial supply and patient-centric outcomes.
AI-powered real-time supply optimization that dynamically adjusts resupply based on enrollment and site performance data
Clario RTSM is a robust real-time supply management platform for clinical trials, providing randomization, dynamic inventory forecasting, and automated resupply to optimize supply chain efficiency. It offers global visibility into temperature-controlled logistics and integrates with Clario's broader eClinical suite for seamless data flow. The solution minimizes stockouts, reduces waste, and ensures regulatory compliance across complex, multinational trials.
Pros
- Advanced AI-driven forecasting for precise demand prediction
- Seamless integration with Clario's imaging, ePRO, and eConsent tools
- Global scalability with real-time visibility and compliance features
Cons
- Steep learning curve and complex initial setup
- Premium pricing may not suit smaller trials
- Full benefits require adoption of Clario ecosystem
Best For
Large pharmaceutical companies managing complex, multinational Phase II-III trials with integrated eClinical needs.
Pricing
Custom enterprise pricing based on trial scale and modules; typically starts at $100K+ annually, requires sales quote.
Signant Health RTSM
specializedFlexible IRT/RTSM platform emphasizing patient engagement, supply optimization, and integration with clinical assessments.
Unified randomization and dynamic resupply engine that simulates scenarios in real-time for proactive supply adjustments
Signant Health RTSM is a unified platform for Randomization and Trial Supply Management (RTSM) in clinical trials, providing real-time inventory tracking, demand forecasting, and automated resupply to optimize drug distribution. It integrates seamlessly with eClinical technologies for enhanced visibility across the supply chain, supporting complex protocols and temperature-controlled logistics. The solution helps reduce waste, ensure compliance, and adapt to dynamic trial needs in decentralized and global studies.
Pros
- Advanced AI-driven forecasting minimizes stockouts and overages
- Strong integration with ePRO, EDC, and other Signant tools
- Robust compliance features for global regulatory standards
Cons
- Steep learning curve for non-expert users
- Enterprise pricing can be prohibitive for smaller trials
- Limited flexibility for highly customized workflows
Best For
Large pharma sponsors and CROs managing complex, multi-site global clinical trials requiring integrated RTSM.
Pricing
Custom enterprise pricing upon request, typically starting at $100K+ annually based on trial scale and modules.
Veeva Vault CTMS
enterpriseCloud CTMS with embedded supply planning, visibility, and collaboration tools for clinical trial operations.
Unified Vault platform data model providing real-time, single-source supply forecasting tied directly to trial planning and enrollment data
Veeva Vault CTMS is a cloud-based clinical trial management system that provides integrated oversight for clinical trial supply management within the broader Veeva Vault platform. It enables supply forecasting, demand planning, and real-time visibility into investigational product distribution aligned with trial enrollment and site activities. While not a standalone supply chain tool, it excels in unifying supply data with study timelines, compliance tracking, and automated resupply triggers for global trials.
Pros
- Seamless integration with Veeva Vault ecosystem for unified clinical data and supply visibility
- Robust regulatory compliance and validation tools tailored for pharma
- Advanced forecasting and automation for supply chain aligned with trial milestones
Cons
- High implementation complexity and timeline for customization
- Steep learning curve for non-enterprise users
- Premium pricing may not suit smaller organizations
Best For
Large pharmaceutical and biotech companies managing complex, global clinical trials with integrated supply needs.
Pricing
Custom enterprise subscription pricing, typically starting at $200,000+ annually based on users, modules, and deployment scope.
Anju eClinical
enterpriseUnified eClinical platform with RTSM modules for supply chain visibility, forecasting, and regulatory compliance.
AI-powered demand forecasting that dynamically adjusts supply plans based on enrollment rates and site performance data
Anju eClinical is a comprehensive eClinical platform from Anju Software that includes robust Clinical Trial Supply Management (CTSM) capabilities, enabling efficient forecasting, inventory management, and distribution of investigational products across global trials. It integrates supply chain data with trial operations for real-time visibility, automated resupply triggers, and compliance with regulatory standards like FDA 21 CFR Part 11. The solution supports temperature-controlled logistics and site-level inventory tracking to minimize stockouts and waste in complex, multi-site studies.
Pros
- Seamless integration with broader eClinical suite for end-to-end trial management
- Advanced forecasting and real-time analytics reduce supply disruptions
- Strong compliance tools and customizable workflows for global trials
Cons
- Steep learning curve for non-technical users due to extensive customization options
- Higher cost structure suited more for enterprise-level organizations
- Limited visibility into mobile accessibility for field teams
Best For
Mid-to-large pharmaceutical companies and CROs managing complex, multi-site clinical trials with stringent supply chain requirements.
Pricing
Enterprise licensing model with custom pricing starting at approximately $50,000 annually, based on user count and modules; contact sales for quotes.
Viedoc
specializedeClinical platform with integrated RTSM for EDC, randomization, and trial supply management in a user-friendly interface.
Dynamic, real-time resupply forecasting that adapts to enrollment rates and site demands
Viedoc is a cloud-based eClinical platform offering integrated Randomization and Trial Supply Management (RTSM) capabilities for clinical trials. It provides real-time inventory tracking, dynamic resupply forecasting, kit assignment, and randomization to optimize supply chain efficiency. The solution emphasizes seamless integration with EDC, ePRO, and other modules for end-to-end trial management.
Pros
- Intuitive, user-friendly interface with minimal training required
- Real-time visibility and automated resupply to reduce waste
- Strong integration with other eClinical tools for unified workflows
Cons
- Limited depth in advanced supply chain simulations for complex global trials
- Pricing is quote-based and not transparent
- Fewer customization options compared to enterprise-level competitors
Best For
Mid-sized biopharma companies and CROs needing an agile, integrated RTSM solution without heavy IT overhead.
Pricing
Custom enterprise pricing via quote, typically subscription-based per study or user; starts around €50K+ annually for standard deployments.
Conclusion
The reviewed tools showcase diverse strengths in clinical trial supply management, with the top three leading the pack. Medidata Rave RTSM emerges as the clear top choice, offering advanced randomization, real-time global visibility, and comprehensive trial supply oversight. Oracle Clinical One Supply follows closely with its integrated end-to-end platform for planning and forecasting, while Calyx IRT stands out for robust randomization and automated resupply capabilities, each proving invaluable for different trial needs.
Don’t miss out on optimizing your clinical trial supply management—begin exploring Medidata Rave RTSM today to unlock its potential for streamlined operations and improved outcomes.
Tools Reviewed
All tools were independently evaluated for this comparison