Quick Overview
- 1#1: Practice Fusion - Free cloud-based EHR platform offering certified electronic prescribing integrated with full practice management.
- 2#2: OpenEMR - Open-source EHR and practice management system with built-in e-prescribing module for cost-free deployment.
- 3#3: CharmHealth - Affordable cloud EHR with low-cost e-prescribing starting free for solos and scaling with usage.
- 4#4: RXNT - Budget-friendly e-prescribing, EHR, and billing suite with plans starting under $100 per month.
- 5#5: MD Toolbox - Web-based e-prescribing service with pay-per-prescription pricing as low as $0.99 each.
- 6#6: ScriptWorkflow - Standalone low-cost e-prescribing platform for rapid electronic prescription delivery starting at $49 monthly.
- 7#7: SimplePractice - All-in-one practice management for therapists with e-prescribing included from $29 per month.
- 8#8: Kareo - EHR and billing platform with integrated e-prescribing optimized for small practices at competitive rates.
- 9#9: DrChrono - Mobile-first EHR with e-prescribing features starting around $200 monthly for comprehensive tools.
- 10#10: TherapyNotes - Behavioral health EHR with secure e-prescribing available from $49 per user per month.
These tools were selected based on robust e-prescribing features, seamless integration with practice management, user-friendly design, and exceptional value, ensuring they deliver reliable performance at competitive price points
Comparison Table
E-prescribing software is a critical tool for modern healthcare, but costs and features differ significantly across platforms. This comparison table breaks down top options like Practice Fusion, OpenEMR, CharmHealth, RXNT, MD Toolbox, and more, guiding readers to find the most budget-friendly solution that aligns with their practice needs.
| # | Tool | Category | Overall | Features | Ease of Use | Value |
|---|---|---|---|---|---|---|
| 1 | Practice Fusion Free cloud-based EHR platform offering certified electronic prescribing integrated with full practice management. | enterprise | 8.7/10 | 8.5/10 | 8.8/10 | 9.8/10 |
| 2 | OpenEMR Open-source EHR and practice management system with built-in e-prescribing module for cost-free deployment. | enterprise | 8.1/10 | 8.4/10 | 6.7/10 | 9.6/10 |
| 3 | CharmHealth Affordable cloud EHR with low-cost e-prescribing starting free for solos and scaling with usage. | enterprise | 8.4/10 | 8.2/10 | 8.6/10 | 9.1/10 |
| 4 | RXNT Budget-friendly e-prescribing, EHR, and billing suite with plans starting under $100 per month. | enterprise | 8.3/10 | 8.1/10 | 8.6/10 | 9.2/10 |
| 5 | MD Toolbox Web-based e-prescribing service with pay-per-prescription pricing as low as $0.99 each. | specialized | 8.2/10 | 7.8/10 | 8.5/10 | 9.5/10 |
| 6 | ScriptWorkflow Standalone low-cost e-prescribing platform for rapid electronic prescription delivery starting at $49 monthly. | specialized | 7.4/10 | 6.9/10 | 8.3/10 | 9.6/10 |
| 7 | SimplePractice All-in-one practice management for therapists with e-prescribing included from $29 per month. | enterprise | 7.8/10 | 8.2/10 | 8.7/10 | 6.9/10 |
| 8 | Kareo EHR and billing platform with integrated e-prescribing optimized for small practices at competitive rates. | enterprise | 7.8/10 | 8.2/10 | 8.0/10 | 7.5/10 |
| 9 | DrChrono Mobile-first EHR with e-prescribing features starting around $200 monthly for comprehensive tools. | enterprise | 8.1/10 | 8.4/10 | 8.7/10 | 7.6/10 |
| 10 | TherapyNotes Behavioral health EHR with secure e-prescribing available from $49 per user per month. | enterprise | 8.1/10 | 7.9/10 | 8.6/10 | 9.2/10 |
Free cloud-based EHR platform offering certified electronic prescribing integrated with full practice management.
Open-source EHR and practice management system with built-in e-prescribing module for cost-free deployment.
Affordable cloud EHR with low-cost e-prescribing starting free for solos and scaling with usage.
Budget-friendly e-prescribing, EHR, and billing suite with plans starting under $100 per month.
Web-based e-prescribing service with pay-per-prescription pricing as low as $0.99 each.
Standalone low-cost e-prescribing platform for rapid electronic prescription delivery starting at $49 monthly.
All-in-one practice management for therapists with e-prescribing included from $29 per month.
EHR and billing platform with integrated e-prescribing optimized for small practices at competitive rates.
Mobile-first EHR with e-prescribing features starting around $200 monthly for comprehensive tools.
Behavioral health EHR with secure e-prescribing available from $49 per user per month.
Practice Fusion
enterpriseFree cloud-based EHR platform offering certified electronic prescribing integrated with full practice management.
100% free e-prescribing for unlimited prescriptions, including controlled substances, with no usage caps
Practice Fusion is a cloud-based electronic health record (EHR) platform that provides free e-prescribing functionality as part of its core offerings, enabling healthcare providers to send electronic prescriptions securely to pharmacies nationwide, including Schedule II-V controlled substances with proper certification. The software integrates e-prescribing directly into patient charts, supporting formulary checks, allergy alerts, and real-time eligibility verification to streamline workflows and reduce errors. As a completely free solution for basic use, it stands out in the e-prescribing market for small practices seeking zero-cost entry without sacrificing essential features.
Pros
- Completely free e-prescribing with no subscription fees for core features
- Seamless integration with EHR for quick prescription management
- Supports controlled substances and includes safety checks like drug interactions
Cons
- Intrusive ads in the interface unless upgraded
- Limited advanced customization without partnerships or add-ons
- Customer support is basic and community-driven for free users
Best For
Solo practitioners and small clinics prioritizing zero-cost e-prescribing with reliable basic functionality.
Pricing
Free for core EHR and e-prescribing; optional paid services for advanced features or ad removal via partnerships.
OpenEMR
enterpriseOpen-source EHR and practice management system with built-in e-prescribing module for cost-free deployment.
Zero licensing fees for a full-featured open-source EHR with integrated e-prescribing
OpenEMR is a free, open-source electronic health records (EHR) and practice management software that includes integrated e-prescribing functionality for sending electronic prescriptions directly from patient charts. It supports connectivity with services like NewCrop and Surescripts for compliant eRx, including controlled substances with proper setup. Ideal for cost-conscious practices, it provides a full suite of clinical tools without licensing fees, though self-hosting and maintenance are required.
Pros
- Completely free open-source software with no licensing costs
- Comprehensive EHR features including robust e-prescribing integration
- Highly customizable to fit specific practice needs
Cons
- Steep learning curve and technical setup required for installation and eRx configuration
- Dated user interface that feels clunky compared to modern SaaS options
- Potential additional fees for e-prescribing gateways or hosting services
Best For
Small practices or solo providers with IT resources seeking a no-cost, customizable EHR with e-prescribing capabilities.
Pricing
Free open-source; self-hosting costs vary ($0-$500+/year), e-prescribing services may add $0.25-$1 per prescription or subscription fees.
CharmHealth
enterpriseAffordable cloud EHR with low-cost e-prescribing starting free for solos and scaling with usage.
Integrated EPCS e-prescribing with zero per-Rx costs, included in all plans for small practices
CharmHealth is a cloud-based electronic health record (EHR) and practice management platform that includes robust e-prescribing functionality for sending prescriptions electronically to pharmacies. It supports EPCS for controlled substances, formulary checks, and integration with Surescripts for real-time eligibility and cost information. Ideal for small practices, it combines e-prescribing with patient engagement tools and telehealth at a competitive price point.
Pros
- Highly affordable pricing for integrated e-prescribing and EHR
- User-friendly interface with mobile app support
- No per-prescription fees and supports controlled substances
Cons
- Limited advanced customization options
- Customer support response times can vary
- Reporting features are basic compared to enterprise solutions
Best For
Solo practitioners and small medical offices seeking the cheapest reliable e-prescribing integrated with essential EHR tools.
Pricing
Starts at $299/month per provider for the Essentials plan including unlimited e-prescribing; higher tiers up to $599/month with more features.
RXNT
enterpriseBudget-friendly e-prescribing, EHR, and billing suite with plans starting under $100 per month.
Low-cost EPCS certification with instant activation and no hidden setup fees
RXNT (rxnt.com) is a cloud-based e-prescribing software that enables healthcare providers to send electronic prescriptions securely, including controlled substances via EPCS certification. It offers formulary checks, allergy alerts, and integration with EHR and practice management systems for streamlined workflows. As one of the more affordable options, it's designed for small practices prioritizing cost without sacrificing core functionality.
Pros
- Highly affordable pricing for EPCS and basic e-prescribing
- Quick setup and activation process
- Seamless integration with major EHR platforms
Cons
- Limited advanced analytics and reporting
- Occasional customer support delays
- Fewer customization options compared to premium tools
Best For
Solo providers and small practices seeking the cheapest reliable e-prescribing solution with EPCS support.
Pricing
Starts at $39/provider/month for basic e-prescribing; full EPCS suite from $99/provider/month with no long-term contracts.
MD Toolbox
specializedWeb-based e-prescribing service with pay-per-prescription pricing as low as $0.99 each.
Free lifetime e-prescribing access for eligible users with no per-prescription fees
MD Toolbox is a cost-effective e-prescribing platform that enables secure electronic prescriptions, access to patient medication history, and formulary checks via Surescripts certification. It integrates seamlessly with popular practice management systems and offers EHR capabilities for small practices. Designed for affordability, it supports controlled substances prescribing and complies with federal eRx mandates without high costs.
Pros
- Exceptionally low pricing with free basic e-prescribing option
- Quick integration with existing PM and EHR systems
- Comprehensive drug interaction and allergy alerts included
Cons
- Fewer advanced analytics and reporting tools
- Interface appears somewhat dated compared to modern competitors
- Limited customization options for larger practices
Best For
Budget-conscious solo practitioners or small clinics needing reliable, no-frills e-prescribing without subscription fees.
Pricing
Free for basic e-prescribing; premium plans start at $99/user/month including EHR and billing.
ScriptWorkflow
specializedStandalone low-cost e-prescribing platform for rapid electronic prescription delivery starting at $49 monthly.
Free tier providing unlimited e-prescriptions with no usage fees
ScriptWorkflow is an affordable e-prescribing platform that enables healthcare providers to send electronic prescriptions securely via the Surescripts network, supporting both controlled and non-controlled substances. It offers essential features like prescription history, refill requests, and basic patient communication tools. Designed for small practices, it emphasizes simplicity and low cost over advanced enterprise capabilities.
Pros
- Extremely low pricing makes it accessible for budget-conscious users
- Straightforward setup and intuitive interface for quick adoption
- Reliable integration with major pharmacy networks like Surescripts
Cons
- Limited advanced features compared to premium competitors
- Fewer EHR/EMR integrations available
- Basic reporting and analytics tools
Best For
Solo practitioners and small independent clinics seeking the most economical e-prescribing solution without needing extensive features.
Pricing
Free basic plan for core e-prescribing; Pro plan at $25/month per provider.
SimplePractice
enterpriseAll-in-one practice management for therapists with e-prescribing included from $29 per month.
Seamless e-prescribing integration directly from client charts, notes, and telehealth sessions
SimplePractice is an all-in-one practice management platform tailored for behavioral health professionals, featuring secure e-prescribing for medications including controlled substances via EPCS compliance. It integrates e-prescribing with scheduling, electronic health records, billing, and telehealth for streamlined workflows. While not a standalone e-prescribing tool, it provides reliable prescription management within a comprehensive suite.
Pros
- Integrated e-prescribing with full practice management tools like scheduling and billing
- Supports EPCS for controlled substances with secure transmission
- User-friendly interface with mobile app for on-the-go prescribing
Cons
- E-prescribing requires Professional plan ($69/month) or higher, not available in basic tier
- Additional setup costs and time for EPCS certification and integrations
- Overkill and pricier for users needing only e-prescribing without full practice management
Best For
Behavioral health solo practitioners or small groups seeking an integrated platform with reliable e-prescribing.
Pricing
Essential $29/mo, Professional $69/mo, Enterprise $99/mo (annual billing per provider); e-prescribing included in Professional+ with extra EPCS fees.
Kareo
enterpriseEHR and billing platform with integrated e-prescribing optimized for small practices at competitive rates.
Revenue cycle management integration that ties e-prescribing directly to billing and claims for faster reimbursements.
Kareo is a cloud-based platform designed for independent medical practices, offering integrated electronic health records (EHR), practice management, medical billing, and e-prescribing solutions. Its e-prescribing module enables secure electronic prescriptions, including support for controlled substances via EPCS, drug interaction checks, and formulary management. AI med at streamlining clinical and administrative workflows, it helps small practices reduce costs and improve efficiency without needing expensive on-premise hardware.
Pros
- Integrated e-prescribing with EHR and billing for seamless workflows
- Supports EPCS for controlled substances at no extra per-Rx fee
- Cloud-based with mobile access, ideal for small practices
Cons
- Not the absolute cheapest standalone e-prescribing option
- Subscription pricing can add up for larger teams
- Full features require higher-tier plans
Best For
Small to mid-sized independent practices seeking affordable, all-in-one e-prescribing integrated with practice management.
Pricing
Starts at $110/provider/month for Billing + e-prescribing; Clinical plans from $160/provider/month; custom enterprise pricing available.
DrChrono
enterpriseMobile-first EHR with e-prescribing features starting around $200 monthly for comprehensive tools.
Fully mobile e-prescribing app with voice-to-text and real-time pharmacy connectivity
DrChrono is a cloud-based electronic health record (EHR) platform that offers integrated e-prescribing capabilities, enabling providers to send secure electronic prescriptions to pharmacies via Surescripts integration. It supports both standard medications and controlled substances through EPCS compliance, with features like real-time formulary checks, drug interaction alerts, and eligibility verification. Designed for solo practitioners and small practices, it combines e-prescribing with practice management, scheduling, and patient engagement tools for streamlined workflows.
Pros
- Integrated e-prescribing with no additional per-prescription fees
- Mobile app supports on-the-go prescribing with voice dictation
- Strong compliance features including EPCS and PDMP integration
Cons
- Higher cost compared to standalone e-prescribing tools
- Full platform pricing may be overkill for eRx-only needs
- Custom pricing requires sales quote, lacking transparency
Best For
Solo providers or small practices needing affordable, all-in-one EHR with reliable e-prescribing.
Pricing
Starts at around $199-$329 per provider per month (billed annually) including e-prescribing; custom quotes for advanced features.
TherapyNotes
enterpriseBehavioral health EHR with secure e-prescribing available from $49 per user per month.
Therapy-specific integration of e-prescribing with customizable progress notes and billing
TherapyNotes is an all-in-one practice management platform tailored for behavioral health professionals, featuring electronic health records, scheduling, billing, and integrated e-prescribing. Its e-prescribing tool enables secure electronic prescriptions, including controlled substances via Surescripts integration, directly within patient charts. While not a standalone e-prescribing solution, it offers reliable eRx functionality at a competitive price as part of its comprehensive suite.
Pros
- Affordable all-inclusive pricing with e-prescribing at no extra cost
- Intuitive interface designed for mental health workflows
- Strong HIPAA compliance and support for controlled substances
Cons
- Limited customization for non-behavioral health specialties
- eRx setup requires certification and fees through third-party networks
- No free tier or standalone e-prescribing option
Best For
Mental health providers looking for cost-effective e-prescribing integrated with EHR and practice management.
Pricing
$49 per clinician per month (billed annually), includes unlimited e-prescribing; additional network fees may apply.
Conclusion
The top three cheapest e-prescribing tools excel in balancing cost and functionality, with Practice Fusion leading as the clear winner—offering a free cloud-based EHR integrated with robust e-prescribing and practice management features. OpenEMR follows as a strong open-source alternative, perfect for those prioritizing cost-free deployment, while CharmHealth stands out for its scalable pricing, starting free for solos and growing with usage. Together, these tools demonstrate that quality and affordability can coexist, with options tailored to diverse practice needs.
Seize the opportunity to try the top-ranked Practice Fusion today and discover seamless, budget-friendly electronic prescribing for your practice.
Tools Reviewed
All tools were independently evaluated for this comparison