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Science Research

Top 10 Best Biorepository Management Software of 2026

Discover the top 10 biorepository management software tools to streamline lab operations. Explore now for expert insights.

Sarah Mitchell

Sarah Mitchell

Feb 11, 2026

10 tools comparedExpert reviewed
Independent evaluation · Unbiased commentary · Updated regularly
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Biorepository management software is essential for efficient handling of biological sample lifecycles, compliance, and collaboration, as modern labs and biobanks manage increasingly complex workflows. With a spectrum of options—from comprehensive enterprise platforms to specialized tools and open-source solutions—selecting the right software impacts operational success and data integrity, as showcased in this curated list.

Quick Overview

  1. 1#1: Freezerworks - Comprehensive biorepository management software for tracking, storing, and managing biological samples across freezers and inventories.
  2. 2#2: Azenta FreezerPro - Web-based sample tracking and inventory management system designed for biobanks and biorepositories.
  3. 3#3: Titian Mosaic - Enterprise sample management platform integrating request, tracking, and workflow automation for biorepositories.
  4. 4#4: LabVantage - Flexible LIMS platform with specialized biorepository modules for sample lifecycle management and compliance.
  5. 5#5: STARLIMS - Robust LIMS solution supporting biobanking operations, sample accessioning, and regulatory compliance.
  6. 6#6: Thermo Fisher SampleManager - Advanced LIMS for managing complex biorepository workflows, storage, and data integration.
  7. 7#7: CloudLIMS - Cloud-based LIMS tailored for biorepositories with sample tracking, chain-of-custody, and reporting features.
  8. 8#8: LabKey Server - Data management platform with biorepository tools for sample tracking, assays, and collaboration.
  9. 9#9: OpenSpecimen - Open-source biospecimen management software for collecting, storing, and distributing samples in research.
  10. 10#10: QBench - Cloud LIMS platform offering biorepository inventory, workflow automation, and analytics for labs.

Tools were chosen based on rigorous assessment of core features (sample tracking, workflow automation, and compliance support), operational reliability, user-friendliness, and overall value, ensuring relevance across diverse biorepository needs.

Comparison Table

Efficient biorepository management is vital for ensuring sample integrity and operational efficiency, with specialized software streamlining workflows. This comparison table examines key tools including Freezerworks, Azenta FreezerPro, Titian Mosaic, LabVantage, STARLIMS, and more, equipping readers to evaluate features, scalability, and fit for their specific requirements.

Comprehensive biorepository management software for tracking, storing, and managing biological samples across freezers and inventories.

Features
9.8/10
Ease
8.2/10
Value
9.0/10

Web-based sample tracking and inventory management system designed for biobanks and biorepositories.

Features
9.5/10
Ease
8.2/10
Value
8.7/10

Enterprise sample management platform integrating request, tracking, and workflow automation for biorepositories.

Features
9.2/10
Ease
7.8/10
Value
8.1/10
4LabVantage logo8.7/10

Flexible LIMS platform with specialized biorepository modules for sample lifecycle management and compliance.

Features
9.3/10
Ease
7.8/10
Value
8.2/10
5STARLIMS logo8.2/10

Robust LIMS solution supporting biobanking operations, sample accessioning, and regulatory compliance.

Features
9.1/10
Ease
7.4/10
Value
7.7/10

Advanced LIMS for managing complex biorepository workflows, storage, and data integration.

Features
9.1/10
Ease
7.0/10
Value
7.4/10
7CloudLIMS logo8.1/10

Cloud-based LIMS tailored for biorepositories with sample tracking, chain-of-custody, and reporting features.

Features
8.4/10
Ease
7.7/10
Value
8.0/10

Data management platform with biorepository tools for sample tracking, assays, and collaboration.

Features
9.2/10
Ease
6.8/10
Value
7.5/10

Open-source biospecimen management software for collecting, storing, and distributing samples in research.

Features
8.7/10
Ease
7.0/10
Value
9.2/10
10QBench logo8.0/10

Cloud LIMS platform offering biorepository inventory, workflow automation, and analytics for labs.

Features
8.5/10
Ease
7.5/10
Value
7.8/10
1
Freezerworks logo

Freezerworks

enterprise

Comprehensive biorepository management software for tracking, storing, and managing biological samples across freezers and inventories.

Overall Rating9.5/10
Features
9.8/10
Ease of Use
8.2/10
Value
9.0/10
Standout Feature

Advanced pedigree tracking that visually maps sample lineages, derivatives, and chain-of-custody from collection to analysis

Freezerworks is a specialized Laboratory Information Management System (LIMS) designed for biorepository management, providing comprehensive tracking of biological samples, aliquots, and reagents across freezers and storage systems. It excels in inventory control, barcode generation, workflow automation, and regulatory compliance, including 21 CFR Part 11 validation. The software supports customizable modules for patient data, pedigrees, and chain-of-custody documentation, making it a robust solution for research labs and biobanks handling complex sample lifecycles.

Pros

  • Superior sample tracking with pedigree and aliquot management
  • Strong regulatory compliance tools and audit trails
  • Highly customizable workflows and scalable architecture
  • Visual freezer mapping for efficient inventory management

Cons

  • Steep learning curve for advanced customization
  • Primarily on-premise deployment with limited cloud options
  • Higher pricing suitable for larger organizations

Best For

Large biorepositories, clinical research labs, and biobanks managing high volumes of samples with strict compliance needs.

Pricing

Quote-based pricing for Basic, Standard, and Enterprise editions; typically starts at $15,000+ for perpetual licenses with annual maintenance fees.

Visit Freezerworksfreezerworks.com
2
Azenta FreezerPro logo

Azenta FreezerPro

enterprise

Web-based sample tracking and inventory management system designed for biobanks and biorepositories.

Overall Rating9.2/10
Features
9.5/10
Ease of Use
8.2/10
Value
8.7/10
Standout Feature

Interactive graphical freezer mapping for visual sample navigation and location

Azenta FreezerPro is a robust web-based biorepository management software that enables precise tracking and management of biological samples across freezers, liquid nitrogen tanks, and other storage systems. It supports barcode, RFID, and QR code technologies for inventory control, chain-of-custody documentation, and regulatory compliance including 21 CFR Part 11. The platform offers visual mapping of storage layouts, workflow automation, and integration with LIMS and lab instruments for seamless operations in research and biobanking environments.

Pros

  • Comprehensive sample tracking with real-time visibility and audit trails
  • Scalable for multi-site enterprises with strong compliance features
  • Advanced integrations and customizable workflows

Cons

  • Steep learning curve for complex configurations
  • High implementation costs for smaller labs
  • Limited native mobile app capabilities

Best For

Large biorepositories and research institutions requiring enterprise-grade sample management with regulatory compliance.

Pricing

Quote-based enterprise pricing, typically starting at $20,000+ annually depending on users, sites, and modules.

3
Titian Mosaic logo

Titian Mosaic

enterprise

Enterprise sample management platform integrating request, tracking, and workflow automation for biorepositories.

Overall Rating8.7/10
Features
9.2/10
Ease of Use
7.8/10
Value
8.1/10
Standout Feature

Mosaic Live: Web-based real-time inventory dashboard for instant access to sample status across global sites.

Titian Mosaic is a comprehensive sample management platform tailored for biorepositories in life sciences, enabling precise tracking of biological samples throughout their lifecycle from intake to disposal. It excels in inventory management, automated workflows, aliquoting, and storage optimization across multiple sites. The software integrates with LIMS, robotics, and analytical instruments while providing robust audit trails for regulatory compliance such as GLP and GxP.

Pros

  • Advanced sample tracking with barcode/RFID support and chain-of-custody auditing
  • Seamless integrations with lab instruments, LIMS, and ELNs
  • Scalable architecture for multi-site biorepositories with real-time visibility

Cons

  • Steep learning curve and complex initial configuration
  • High upfront implementation and customization costs
  • Overkill for small-scale labs with basic needs

Best For

Large pharmaceutical, biotech, or academic biorepositories managing high-volume, complex sample inventories with strict compliance requirements.

Pricing

Custom enterprise pricing based on modules, users, and scale; typically starts at $50,000+ annually with implementation fees.

Visit Titian Mosaictitian-software.com
4
LabVantage logo

LabVantage

enterprise

Flexible LIMS platform with specialized biorepository modules for sample lifecycle management and compliance.

Overall Rating8.7/10
Features
9.3/10
Ease of Use
7.8/10
Value
8.2/10
Standout Feature

Advanced pedigree and lineage tracking that visualizes full sample history and relationships for unparalleled chain-of-custody assurance.

LabVantage is a comprehensive Laboratory Information Management System (LIMS) with specialized modules for biorepository management, enabling end-to-end tracking of biological samples from accessioning through storage, processing, and distribution. It supports advanced inventory control, automated aliquoting, pedigree tracking, and compliance with regulations like 21 CFR Part 11 and ISO standards. The platform excels in scalability for multi-site operations and integrates with lab instruments, ELNs, and ERP systems for seamless data flow.

Pros

  • Highly configurable no-code/low-code workflows tailored to biorepository needs
  • Robust sample lineage, chain-of-custody, and inventory management
  • Strong regulatory compliance and audit trail capabilities

Cons

  • Steep learning curve and complex initial setup requiring IT expertise
  • High implementation time and costs for customization
  • Interface can feel dated compared to modern SaaS alternatives

Best For

Large pharmaceutical, biotech, or academic biorepositories managing high-volume, complex sample collections across multiple sites.

Pricing

Enterprise quote-based pricing; typically $100K+ annually depending on modules, users, and deployment scale.

Visit LabVantagelabvantage.com
5
STARLIMS logo

STARLIMS

enterprise

Robust LIMS solution supporting biobanking operations, sample accessioning, and regulatory compliance.

Overall Rating8.2/10
Features
9.1/10
Ease of Use
7.4/10
Value
7.7/10
Standout Feature

Advanced Biorepository module with dynamic sample lineage tracking for parent-derivative relationships and automated aliquoting protocols

STARLIMS is a comprehensive Laboratory Information Management System (LIMS) from Abbott Informatics, offering specialized modules for biorepository management that enable end-to-end tracking of biological samples, including collection, processing, storage, and distribution. It excels in inventory control, aliquot tracking, and managing complex sample hierarchies with derivatives and parent-child relationships. The platform ensures regulatory compliance (e.g., CAP, FDA 21 CFR Part 11) through audit trails, chain of custody, and automated workflows, making it suitable for high-volume research and clinical environments.

Pros

  • Robust sample tracking and inventory management with support for freeze-thaw cycles and storage optimization
  • Strong compliance tools and audit trails for regulated biorepositories
  • Highly configurable workflows and seamless integration with lab instruments and ELNs

Cons

  • Steep learning curve due to extensive customization options
  • High implementation costs and time for enterprise deployments
  • Pricing is opaque and typically requires custom quotes

Best For

Large pharmaceutical companies, academic medical centers, and biobanks handling high volumes of complex biological samples requiring strict regulatory compliance.

Pricing

Enterprise-level custom pricing; typically starts at $100K+ annually for mid-sized deployments, with subscription or perpetual license models plus implementation fees.

Visit STARLIMSstarlims.com
6
Thermo Fisher SampleManager logo

Thermo Fisher SampleManager

enterprise

Advanced LIMS for managing complex biorepository workflows, storage, and data integration.

Overall Rating8.2/10
Features
9.1/10
Ease of Use
7.0/10
Value
7.4/10
Standout Feature

Seamless instrument integration and automated aliquoting workflows for high-throughput biorepository operations

Thermo Fisher SampleManager is a comprehensive Laboratory Information Management System (LIMS) tailored for biorepository management, enabling end-to-end tracking of biospecimens from collection to disposal. It supports inventory control, aliquoting, chain-of-custody documentation, and compliance with regulations like 21 CFR Part 11 and ISO standards. The software excels in integrating with lab instruments and automating workflows for high-volume sample handling in research and clinical environments.

Pros

  • Robust sample tracking with barcode/RFID support and full audit trails
  • Extensive integrations with lab instruments, ELNs, and ERP systems
  • Advanced compliance tools and customizable workflows for regulated environments

Cons

  • High implementation costs and lengthy setup process
  • Steep learning curve due to complex, highly customizable interface
  • Limited out-of-the-box usability for smaller labs without IT support

Best For

Large-scale biobanks, pharmaceutical companies, and research institutions handling complex, regulated biospecimen collections.

Pricing

Enterprise quote-based pricing, typically starting at $50,000+ annually depending on modules and users.

7
CloudLIMS logo

CloudLIMS

enterprise

Cloud-based LIMS tailored for biorepositories with sample tracking, chain-of-custody, and reporting features.

Overall Rating8.1/10
Features
8.4/10
Ease of Use
7.7/10
Value
8.0/10
Standout Feature

Hierarchical storage management that tracks samples across freezers, racks, boxes, and vials with real-time capacity monitoring.

CloudLIMS is a cloud-based Laboratory Information Management System (LIMS) tailored for biorepositories, enabling comprehensive management of biological samples from accessioning to long-term storage and disposal. It supports inventory tracking across hierarchical storage locations, automated workflows for aliquoting and processing, and ensures compliance with regulations like 21 CFR Part 11, ISO 17025, and GLP. The platform also offers customizable dashboards, reporting, and integrations for seamless lab operations.

Pros

  • Robust sample lifecycle management with chain-of-custody tracking
  • Scalable cloud architecture with strong regulatory compliance tools
  • Customizable workflows and hierarchical inventory for complex storage needs

Cons

  • Steep learning curve for advanced customizations
  • Limited native integrations with some niche biorepository instruments
  • Pricing lacks transparency and can escalate with add-ons

Best For

Mid-sized biorepositories and research labs seeking a compliant, cloud-native solution for sample and inventory management.

Pricing

Subscription-based with custom quotes; starts around $500-$1,500/month depending on users, storage volume, and modules (contact sales for details).

Visit CloudLIMScloudlims.com
8
LabKey Server logo

LabKey Server

specialized

Data management platform with biorepository tools for sample tracking, assays, and collaboration.

Overall Rating8.1/10
Features
9.2/10
Ease of Use
6.8/10
Value
7.5/10
Standout Feature

Schema-driven extensibility for building custom biorepository schemas without custom coding

LabKey Server is a flexible, web-based platform for life sciences data management, with dedicated modules for biorepository management including sample tracking, inventory control, and chain-of-custody workflows. It integrates assay results, study data, and instrument outputs into a unified system, supporting compliance standards like 21 CFR Part 11. Designed for research organizations, it enables advanced querying, reporting, and collaboration across distributed teams.

Pros

  • Highly customizable sample management and workflows
  • Seamless integration with lab instruments and ELNs
  • Strong compliance and audit trail features

Cons

  • Steep learning curve for setup and configuration
  • High cost requires enterprise-scale justification
  • Heavy reliance on admin expertise for optimal use

Best For

Large research institutions and biopharma companies handling complex, high-volume biorepositories with integrated data analysis needs.

Pricing

Enterprise subscription starting at ~$50,000/year; custom pricing based on users, modules, and hosting.

9
OpenSpecimen logo

OpenSpecimen

specialized

Open-source biospecimen management software for collecting, storing, and distributing samples in research.

Overall Rating8.2/10
Features
8.7/10
Ease of Use
7.0/10
Value
9.2/10
Standout Feature

Advanced rules engine for automating complex, institution-specific workflows like conditional aliquoting and distribution protocols

OpenSpecimen is an open-source biorepository management system designed for biobanks, research institutions, and clinical trial organizations to track biospecimens throughout their lifecycle. It handles participant registration, sample collection, processing, aliquoting, storage, distribution, and reporting, with support for complex workflows and regulatory compliance. The platform enables multi-site collaboration and integrates with EHRs, lab information systems, and standards like HL7 and DICOM.

Pros

  • Comprehensive biospecimen lifecycle management with advanced aliquoting and tracking
  • Open-source with no licensing fees and high customizability
  • Strong integrations with clinical systems and support for regulatory compliance

Cons

  • Steep learning curve and complex initial setup requiring technical expertise
  • User interface feels dated compared to modern SaaS alternatives
  • Relies on community support; enterprise features need paid add-ons

Best For

Cost-conscious research institutions and biobanks needing a highly customizable, scalable open-source solution for multi-site specimen management.

Pricing

Core open-source version is free; enterprise support, hosting, and advanced modules available via paid subscriptions starting around $5,000/year depending on scale.

Visit OpenSpecimenopenspecimen.org
10
QBench logo

QBench

enterprise

Cloud LIMS platform offering biorepository inventory, workflow automation, and analytics for labs.

Overall Rating8.0/10
Features
8.5/10
Ease of Use
7.5/10
Value
7.8/10
Standout Feature

No-code workflow studio for building tailored biorepository processes without programming

QBench is a cloud-based Laboratory Information Management System (LIMS) designed for biorepositories and labs, offering comprehensive sample tracking, inventory management, and workflow automation from accessioning to distribution. It supports hierarchical storage organization, chain-of-custody logging, and compliance with standards like CAP and ISO. The platform enables real-time dashboards, QC/QA processes, and integrations with instruments for efficient biorepository operations.

Pros

  • Flexible no-code workflow builder for custom biorepository processes
  • Strong sample tracking and multi-level inventory management
  • Real-time analytics and instrument integrations

Cons

  • Custom pricing can be expensive for small biorepositories
  • Initial configuration has a learning curve
  • Less specialized biorepository templates compared to niche tools

Best For

Mid-sized research or clinical biorepositories needing scalable, customizable sample lifecycle management.

Pricing

Quote-based, modular pricing starting around $500/month for basic plans, scaling with users and features.

Visit QBenchqbench.net

Conclusion

The review highlights the critical role of advanced software in optimizing biorepository operations, with top tools distinguished by features like comprehensive tracking, automation, and compliance support. Leading the rankings, Freezerworks sets the standard with its robust management of sample storage and inventory across systems. Azenta FreezerPro and Titian Mosaic follow closely, offering tailored solutions—web-based flexibility and workflow integration respectively—ensuring options for diverse needs.

Freezerworks logo
Our Top Pick
Freezerworks

Ready to enhance your biorepository efficiency? Start with Freezerworks, the top choice, to streamline sample tracking and management. For different needs, explore Azenta FreezerPro or Titian Mosaic—each brings unique strengths to excel in your operations.