Quick Overview
- 1#1: Omnicell 340B - Comprehensive 340B compliance platform with advanced split-billing, inventory tracking, and contract pharmacy management.
- 2#2: Parata Proxy - Automated proxy solution for managing 340B contract pharmacies with real-time dispensing and eligibility verification.
- 3#3: ScriptPro 340B - Integrated robotic dispensing system with 340B compliance tools for accurate inventory diversion and auditing.
- 4#4: QS/1 340B - Pharmacy workflow software featuring robust 340B third-party administration and claims processing capabilities.
- 5#5: RedSail 340B - Full-suite 340B management for retail and specialty pharmacies including duplicate discount prevention.
- 6#6: MacroHelix 340B - Cloud-based platform for 340B split-billing, analytics, and regulatory compliance reporting.
- 7#7: BD Pyxis 340B - Hospital automation software with 340B inventory management and diversion tracking for inpatient use.
- 8#8: 340B Complete - End-to-end 340B program oversight tool with auditing, reporting, and virtual TPA services.
- 9#9: CertiPath 340B - Analytics-driven 340B compliance monitoring and optimization platform for covered entities.
- 10#10: DataMill 340B - Inventory and claims management software focused on 340B eligibility and reimbursement accuracy.
Tools were selected based on key factors including compliance capabilities, feature breadth, user experience, and value, ensuring they meet the diverse needs of 340B program management
Comparison Table
This comparison table outlines key features of popular 340B software tools, including Omnicell 340B, Parata Proxy, ScriptPro 340B, QS/1 340B, RedSail 340B, and additional options, to guide healthcare organizations in evaluating their needs. Readers will discover details on functionality, usability, and best-fit scenarios, empowering informed choices for efficient 340B program management.
| # | Tool | Category | Overall | Features | Ease of Use | Value |
|---|---|---|---|---|---|---|
| 1 | Omnicell 340B Comprehensive 340B compliance platform with advanced split-billing, inventory tracking, and contract pharmacy management. | enterprise | 9.6/10 | 9.8/10 | 8.9/10 | 9.3/10 |
| 2 | Parata Proxy Automated proxy solution for managing 340B contract pharmacies with real-time dispensing and eligibility verification. | specialized | 9.1/10 | 9.4/10 | 8.7/10 | 8.9/10 |
| 3 | ScriptPro 340B Integrated robotic dispensing system with 340B compliance tools for accurate inventory diversion and auditing. | enterprise | 8.4/10 | 8.8/10 | 8.0/10 | 8.1/10 |
| 4 | QS/1 340B Pharmacy workflow software featuring robust 340B third-party administration and claims processing capabilities. | enterprise | 8.2/10 | 8.7/10 | 7.9/10 | 7.8/10 |
| 5 | RedSail 340B Full-suite 340B management for retail and specialty pharmacies including duplicate discount prevention. | specialized | 8.4/10 | 9.1/10 | 7.6/10 | 8.2/10 |
| 6 | MacroHelix 340B Cloud-based platform for 340B split-billing, analytics, and regulatory compliance reporting. | specialized | 7.8/10 | 8.2/10 | 7.5/10 | 7.6/10 |
| 7 | BD Pyxis 340B Hospital automation software with 340B inventory management and diversion tracking for inpatient use. | enterprise | 7.8/10 | 8.5/10 | 7.2/10 | 7.0/10 |
| 8 | 340B Complete End-to-end 340B program oversight tool with auditing, reporting, and virtual TPA services. | specialized | 7.6/10 | 8.0/10 | 7.4/10 | 7.5/10 |
| 9 | CertiPath 340B Analytics-driven 340B compliance monitoring and optimization platform for covered entities. | specialized | 7.9/10 | 8.3/10 | 7.6/10 | 7.7/10 |
| 10 | DataMill 340B Inventory and claims management software focused on 340B eligibility and reimbursement accuracy. | specialized | 7.8/10 | 8.2/10 | 7.4/10 | 7.6/10 |
Comprehensive 340B compliance platform with advanced split-billing, inventory tracking, and contract pharmacy management.
Automated proxy solution for managing 340B contract pharmacies with real-time dispensing and eligibility verification.
Integrated robotic dispensing system with 340B compliance tools for accurate inventory diversion and auditing.
Pharmacy workflow software featuring robust 340B third-party administration and claims processing capabilities.
Full-suite 340B management for retail and specialty pharmacies including duplicate discount prevention.
Cloud-based platform for 340B split-billing, analytics, and regulatory compliance reporting.
Hospital automation software with 340B inventory management and diversion tracking for inpatient use.
End-to-end 340B program oversight tool with auditing, reporting, and virtual TPA services.
Analytics-driven 340B compliance monitoring and optimization platform for covered entities.
Inventory and claims management software focused on 340B eligibility and reimbursement accuracy.
Omnicell 340B
enterpriseComprehensive 340B compliance platform with advanced split-billing, inventory tracking, and contract pharmacy management.
Virtual binning and automated split-billing engine for 99.9%+ accuracy in 340B/TPA diversion without manual intervention
Omnicell 340B is a leading enterprise-grade software platform tailored for 340B compliance, offering end-to-end automation for inventory management, split-billing, dispensing verification, and regulatory reporting in healthcare settings. It integrates seamlessly with Omnicell's XT automated dispensing cabinets and electronic health records (EHRs) to enable precise 340B/340B-TPA diversion tracking and virtual binning. The solution minimizes compliance risks through robust audit trails, real-time analytics, and customizable workflows, making it ideal for complex hospital and health system environments.
Pros
- Comprehensive 340B compliance automation with proven audit-pass rates
- Seamless integration with dispensing hardware and EHR systems
- Advanced analytics and real-time diversion prevention tools
Cons
- Steep initial setup and training requirements
- Premium pricing may strain smaller organizations
- Occasional customization needs for unique workflows
Best For
Large hospitals and health systems with high-volume 340B programs requiring robust, scalable compliance solutions.
Pricing
Custom enterprise pricing starting at $100K+ annually, including software subscriptions, hardware integration, and support services.
Parata Proxy
specializedAutomated proxy solution for managing 340B contract pharmacies with real-time dispensing and eligibility verification.
Proprietary Proxy Logic engine that guarantees 100% capture of 340B-eligible fills without relying on TPA claims processing
Parata Proxy is a robust 340B compliance platform designed for pharmacies and health systems, specializing in virtual split-billing to accurately capture eligible prescriptions. It integrates real-time patient eligibility verification, inventory management for ceiling and non-ceiling drugs, and automated replenishment logic. The software excels in providing audit-ready reporting and seamless connectivity with dispensing automation, ensuring HRSA compliance while optimizing 340B savings.
Pros
- Exceptional accuracy in proxy fill capture and split-billing logic
- Deep integration with Parata pharmacy automation hardware
- Comprehensive audit trails and customizable reporting tools
Cons
- Steeper learning curve for non-Parata users
- Pricing favors high-volume operations over smaller clinics
- Limited flexibility for custom third-party integrations
Best For
Mid-to-large hospital pharmacies or retail chains with automated dispensing systems seeking precise 340B compliance and revenue optimization.
Pricing
Custom subscription model starting at $5,000-$15,000 annually based on dispensing volume and modules; quotes required.
ScriptPro 340B
enterpriseIntegrated robotic dispensing system with 340B compliance tools for accurate inventory diversion and auditing.
Deep integration with ScriptPro robotic dispensers for fully automated 340B split-billing and inventory diversion
ScriptPro 340B is a specialized software platform from ScriptPro designed for pharmacies in the 340B drug pricing program, focusing on compliance, inventory management, and split-billing. It integrates tightly with ScriptPro's robotic dispensing systems to automate the tracking of 340B-eligible claims and inventory diversion. The solution provides detailed auditing, reporting, and virtual inventory tools to ensure HRSA compliance while optimizing reimbursement workflows.
Pros
- Seamless integration with ScriptPro robotics for automated dispensing and 340B tracking
- Advanced split-billing logic with real-time eligibility verification
- Robust compliance reporting and audit trail capabilities
Cons
- Best suited for existing ScriptPro hardware users, limiting standalone appeal
- Initial setup and training can be time-intensive due to deep integrations
- Pricing tends to be premium, especially with hardware bundles
Best For
Large, high-volume pharmacies already using ScriptPro automation systems that need tightly integrated 340B compliance tools.
Pricing
Custom quote-based pricing, typically starting at $5,000+ annually for software plus hardware integration fees.
QS/1 340B
enterprisePharmacy workflow software featuring robust 340B third-party administration and claims processing capabilities.
Native integration with QS/1's PrimeDispense and NRx systems for real-time data sync and error-free 340B processing
QS/1 340B is a specialized software solution from QS/1 designed for pharmacies participating in the 340B Drug Pricing Program, offering robust split-billing, inventory tracking, and compliance tools. It excels in managing 340B-eligible claims, preventing duplicate discounts, and generating HRSA audit-ready reports. Seamlessly integrated with QS/1's pharmacy management systems like PrimeDispense and NRx, it streamlines operations for covered entities and contract pharmacies.
Pros
- Deep integration with QS/1 pharmacy software minimizes errors
- Comprehensive compliance and reporting for HRSA audits
- Reliable split-billing and virtual inventory management
Cons
- Steeper learning curve for users outside QS/1 ecosystem
- Limited flexibility for custom workflows
- Pricing can be premium for smaller operations
Best For
Established QS/1 pharmacy users seeking integrated 340B compliance without disrupting existing workflows.
Pricing
Custom quotes based on modules and pharmacy volume; typically subscription starting at $1,500/month for mid-sized operations.
RedSail 340B
specializedFull-suite 340B management for retail and specialty pharmacies including duplicate discount prevention.
Advanced Duplicate Discount Safeguard (DDS) engine for proactive prevention and real-time claims monitoring
RedSail 340B, part of the 360 suite from RedSail Technologies, is a comprehensive platform for 340B covered entities to manage compliance, claims processing, inventory, and contract pharmacy programs. It provides tools for split-billing, TPA claims adjudication, virtual inventory tracking, and advanced analytics to prevent duplicate discounts and optimize program savings. The solution integrates with major EHR systems and emphasizes data accuracy for HRSA audits.
Pros
- Comprehensive module suite covering split-billing, TPA, and contract pharmacy
- Strong integration with EHRs like Epic and Cerner
- Robust compliance reporting and audit readiness tools
Cons
- Complex interface with a steep learning curve for new users
- Custom pricing can be opaque and higher-end
- Occasional delays in support response for smaller clients
Best For
Mid-to-large hospitals and health systems needing scalable, enterprise-grade 340B management with deep integrations.
Pricing
Enterprise-level custom pricing; typically starts at $50K+ annually based on entity size, volume, and modules selected—contact for quote.
MacroHelix 340B
specializedCloud-based platform for 340B split-billing, analytics, and regulatory compliance reporting.
Integrated TPA services with real-time split-billing and virtual inventory management
MacroHelix 340B is a robust software platform tailored for covered entities to manage 340B compliance, including split-billing, inventory tracking, and contract pharmacy oversight. It provides real-time analytics, duplicate discount prevention, and integration with EHR systems to optimize savings and ensure audit readiness. As a TPA-enabled solution, it combines software with administrative services for streamlined operations.
Pros
- Comprehensive compliance and reporting tools
- Strong integration capabilities with pharmacy systems
- Responsive customer support and TPA services
Cons
- Interface can feel dated compared to newer competitors
- Customization options are somewhat limited
- Pricing lacks transparency without a demo
Best For
Mid-sized hospitals and health systems seeking reliable 340B management with TPA support.
Pricing
Custom quotes based on entity size and modules; typically $10,000-$50,000 annually plus TPA fees.
BD Pyxis 340B
enterpriseHospital automation software with 340B inventory management and diversion tracking for inpatient use.
Point-of-dispense 340B transaction capture that automatically flags and prevents diversions in Pyxis automated dispensers
BD Pyxis 340B is an integrated 340B compliance solution from Becton Dickinson that works seamlessly with Pyxis medication dispensing systems to manage 340B inventory, track diversions, and ensure accurate replenishment claims. It automates charge capture at the point of dispense, provides real-time auditing, and generates compliance reports for HRSA audits. Primarily designed for facilities using BD's pharmacy automation hardware, it emphasizes diversion prevention and data integrity in high-volume hospital environments.
Pros
- Seamless integration with Pyxis MedStation and ES systems for automated 340B capture
- Robust real-time diversion detection and audit trails
- Comprehensive reporting tools tailored for HRSA compliance
Cons
- High implementation costs tied to BD hardware ecosystem
- Steeper learning curve for non-Pyxis users
- Limited standalone functionality without BD dispensing systems
Best For
Large hospitals and health systems already invested in BD Pyxis automation seeking integrated 340B compliance.
Pricing
Custom enterprise pricing via quote; typically $50K+ annually plus hardware/integration fees depending on facility size.
340B Complete
specializedEnd-to-end 340B program oversight tool with auditing, reporting, and virtual TPA services.
Real-time 340B eligibility verification with EHR integration
340B Complete by Visionary Healthware is a comprehensive 340B management platform designed for covered entities to handle inventory tracking, split-billing, and compliance. It offers real-time eligibility verification, duplicate discount prevention, and automated reporting for HRSA audits. The software integrates with various EHR systems to streamline 340B operations and maximize program savings.
Pros
- Strong compliance and audit-ready reporting tools
- Reliable split-billing and inventory management
- Good EHR integrations for operational efficiency
Cons
- Interface can feel dated compared to newer competitors
- Customer support response times vary
- Limited advanced analytics for large enterprises
Best For
Mid-sized hospitals and clinics seeking solid 340B compliance without top-tier pricing.
Pricing
Custom subscription pricing based on entity size and drug volume; typically $5,000-$15,000/month.
CertiPath 340B
specializedAnalytics-driven 340B compliance monitoring and optimization platform for covered entities.
Virtual Gateway for automated split-billing and real-time dispensing compliance monitoring
CertiPath 340B is a comprehensive third-party administrator (TPA) and software platform designed for 340B covered entities to manage compliance, claims processing, and inventory tracking. It automates patient eligibility screening at point-of-sale, split-billing logic, and duplicate discount prevention through its Virtual Gateway technology. The solution offers robust reporting, analytics, and audit support to help organizations maximize 340B savings while adhering to HRSA regulations.
Pros
- Strong TPA services with end-to-end claims processing
- Advanced real-time analytics and customizable reporting
- Proven compliance tools including duplicate discount safeguards
Cons
- Steep initial setup and integration complexity
- Interface feels dated compared to modern competitors
- Pricing lacks transparency without custom quotes
Best For
Mid-sized hospitals and clinics needing reliable TPA support for 340B compliance without building internal expertise.
Pricing
Custom enterprise pricing, typically transaction-based with monthly minimums starting around $15,000-$30,000 depending on volume.
DataMill 340B
specializedInventory and claims management software focused on 340B eligibility and reimbursement accuracy.
Virtual Inventory Engine for precise 340B-eligible replenishment without physical segregation
DataMill 340B is a comprehensive software platform tailored for 340B compliance management, offering tools for inventory tracking, split-billing, contract pharmacy administration, and claims processing. It helps covered entities maximize savings under the 340B program while ensuring HRSA audit readiness through detailed reporting and duplicate prevention. The solution integrates with existing EHR and pharmacy systems for seamless operations.
Pros
- Robust contract pharmacy management with real-time oversight
- Advanced duplicate claims scrubbing for compliance
- Customizable dashboards and reporting tools
Cons
- Interface can feel dated compared to newer competitors
- Implementation requires significant upfront configuration
- Customer support response times vary during peak periods
Best For
Mid-sized hospitals and critical access facilities seeking reliable TPA-integrated 340B management without enterprise-level complexity.
Pricing
Custom enterprise pricing based on transaction volume and covered sites; typically starts around $10,000-$50,000 annually with demo required.
Conclusion
The top 340B software tools reviewed deliver exceptional value, with Omnicell 340B emerging as the standout choice through its comprehensive compliance platform, integrating split-billing, inventory tracking, and contract pharmacy management. Parata Proxy and ScriptPro 340B follow closely, offering robust automation and robotic dispensing solutions that address specific operational needs. Together, these tools highlight the industry’s focus on efficiency and accuracy, ensuring covered entities can navigate 340B requirements seamlessly.
Ready to optimize your 340B program? Start with Omnicell 340B to access its full suite of compliance and operational tools, setting a new standard for effectiveness in your organization.
Tools Reviewed
All tools were independently evaluated for this comparison