Key Takeaways
- In 2022, women and girls accounted for 53.3% of all people living with HIV globally, totaling approximately 20.5 million women
- Globally, adolescent girls and young women aged 15-24 comprised 75% of new HIV infections among adolescents in 2022
- In sub-Saharan Africa, women represent 63% of adults living with HIV, with prevalence rates up to 25% in some countries like Eswatini
- Female sex workers in sub-Saharan Africa have HIV prevalence of 36.5%
- Women in serodiscordant couples have 10% annual HIV acquisition risk without PrEP
- Intimate partner violence increases HIV risk in women by 1.5 times globally
- Globally, PrEP uptake among women is only 5% despite 30% eligibility
- Mother-to-child transmission reduced to <5% with ART prophylaxis in 90% coverage areas
- Female condoms prevent 94% of HIV transmission in trials
- In 2022, 82% of women living with HIV knew their status globally
- Only 65% of diagnosed women are on ART worldwide
- Viral suppression among women on ART is 88%, slightly lower than men at 90%
- Women living with HIV lose 25.5 million healthy years annually due to disability
- HIV+ women face 40% higher unemployment rates globally
- In sub-Saharan Africa, HIV orphans 15 million children, mostly motherless
Despite global progress, women still bear a disproportionate burden of the HIV epidemic worldwide.
Epidemiology
- In 2022, women and girls accounted for 53.3% of all people living with HIV globally, totaling approximately 20.5 million women
- Globally, adolescent girls and young women aged 15-24 comprised 75% of new HIV infections among adolescents in 2022
- In sub-Saharan Africa, women represent 63% of adults living with HIV, with prevalence rates up to 25% in some countries like Eswatini
- In Eastern Europe and Central Asia, new HIV diagnoses among women increased by 28% from 2010 to 2022
- In Latin America, women accounted for 32% of new HIV infections in 2022, with Brazil reporting 45,000 women living with HIV
- In Western and Central Africa, HIV prevalence among women aged 15-49 is 1.8%, twice that of men at 0.9%
- In South Asia, women represent 40% of people living with HIV, with India having over 300,000 women affected
- In 2021, 1.3 million women aged 15+ became newly infected with HIV globally
- Eastern and Southern Africa saw 670,000 new HIV infections among women in 2022
- In the US, women accounted for 18% of new HIV diagnoses in 2021, with Black women at 50% of those cases
- Globally, 620,000 women died from AIDS-related illnesses in 2022
- In Middle East and North Africa, HIV prevalence among women is 0.2%, but rising among key populations
- In 2022, 10.1 million women in Eastern and Southern Africa were living with HIV
- Caribbean women have HIV prevalence of 1.5%, higher than men in some islands like Haiti at 2.1%
- In Western Europe, migrant women from high-prevalence areas account for 40% of female HIV cases
- Globally, women aged 25-34 have the highest HIV prevalence at 1.4%
- In South Africa, 4.6 million women live with HIV, representing 60% of total cases
- In Nigeria, 1.1 million women aged 15-49 have HIV, prevalence 1.6%
- In Zimbabwe, women comprise 55% of PLHIV, with 870,000 affected
- In Kenya, HIV prevalence among women is 4.5% vs 3.3% for men
- Globally, vertical transmission accounts for 8% of new pediatric HIV cases from mother-to-child
- In India, 40% of HIV-positive pregnant women transmit to infants without intervention
- In Uganda, 140,000 women living with HIV gave birth in 2022
- In Mozambique, women aged 15-24 have 5x higher HIV incidence than men
- In Malawi, 10.8% of women aged 15-49 are HIV-positive
- In Botswana, 25% of women aged 15-49 live with HIV
- In Namibia, women account for 58% of PLHIV, total 170,000 women
- In Zambia, HIV prevalence in women is 11.1%
- In Lesotho, 23.5% of women aged 15-49 have HIV, highest globally
Epidemiology Interpretation
Prevention
- Globally, PrEP uptake among women is only 5% despite 30% eligibility
- Mother-to-child transmission reduced to <5% with ART prophylaxis in 90% coverage areas
- Female condoms prevent 94% of HIV transmission in trials
- Dapivirine vaginal ring reduces HIV risk by 35% in women aged 25+
- Voluntary medical male circumcision reduces heterosexual transmission to women by 60%
- PMTCT Option B+ prevents 75% of new child infections globally
- HIV self-testing kits increase testing by 40% among women in low-resource settings
- Microbicide gels like tenofovir reduce risk by 39% in high-adherence groups
- Condom promotion programs reduce HIV incidence by 20% in women
- PrEP for serodiscordant couples prevents 96% of transmissions to women
- HPV vaccination reduces cervical cancer risk in HIV+ women by 80%
- Community-based DREAMS program reduced new infections in AGYW by 25%
- Post-exposure prophylaxis (PEP) within 72 hours prevents 80% HIV acquisition in women
- Treatment as prevention (TasP) reduces community transmission by 50% when 70% virally suppressed
- Dual HIV/syphilis testing in ANC reaches 80% of pregnant women in some countries
- Long-acting cabotegravir (CAB-LA) prevents 89% of infections vs oral PrEP in women
- Education on U=U reduces stigma, increasing testing by 30% among women
- Multipurpose prevention technologies (MPTs) in trials show 50% adherence boost
- Screen-and-treat for cervical dysplasia prevents HIV progression complications
- Partner notification services increase partner testing by 60% for female index cases
- Globally, only 48% of HIV+ pregnant women access ART for PMTCT
- In South Africa, DREAMS reached 1.5 million AGYW, averting 50,000 infections
- VMMC coverage at 60% reduces female incidence by 30% in modeled scenarios
Prevention Interpretation
Risk Factors
- Female sex workers in sub-Saharan Africa have HIV prevalence of 36.5%
- Women in serodiscordant couples have 10% annual HIV acquisition risk without PrEP
- Intimate partner violence increases HIV risk in women by 1.5 times globally
- Women with bacterial vaginosis have 60% higher HIV acquisition risk
- HSV-2 infection doubles HIV risk in women, prevalence 50% in high-HIV areas
- Unprotected vaginal sex transmits HIV from man to woman at 0.08% per act
- Women using hormonal contraceptives have 20-50% increased HIV risk in some studies
- Early sexual debut before 15 increases lifetime HIV risk by 3x for women
- Women with multiple partners have 4x higher HIV incidence
- Low socioeconomic status correlates with 2.5x HIV prevalence in women
- Alcohol use during sex increases HIV risk by 50% in women
- Women with untreated STIs have 4-fold HIV transmission risk
- Postpartum women have 2x higher HIV acquisition risk due to immune changes
- In discordant couples, female condom reduces HIV risk by 94%
- Women engaging in transactional sex have HIV prevalence 10x general population
- Cervical ectopy increases HIV susceptibility by 2.5x in young women
- Malnutrition weakens vaginal mucosa, raising HIV risk by 30%
- Women with FGM type III have 50% higher HIV risk
- Smoking tobacco alters vaginal microbiome, increasing HIV risk 1.5x
- Pregnant women have thinned vaginal epithelium, 2x HIV risk
- Women with diabetes have impaired immunity, 1.8x HIV prevalence
- Lack of male circumcision increases HIV transmission to women by 60%
- High viral load in partners (>50,000 copies/ml) raises per-act risk to 0.2%
- Women in polygamous marriages have 3x HIV risk
- Oral contraceptive use with DMPA doubles HIV risk in observational data
Risk Factors Interpretation
Socioeconomic Impact
- Women living with HIV lose 25.5 million healthy years annually due to disability
- HIV+ women face 40% higher unemployment rates globally
- In sub-Saharan Africa, HIV orphans 15 million children, mostly motherless
- Women with HIV spend 2x more on healthcare, impoverishing 10% of households
- Gender-based violence affects 45% of HIV+ women, exacerbating poverty
- HIV reduces women's life expectancy by 10 years in high-prevalence areas
- In US, HIV+ women have 50% higher poverty rates at 25%
- Widow inheritance practices increase HIV spread, affecting 20% women in rural Kenya
- HIV+ mothers contribute to 30% school dropout among girls due to caregiving
- Economic cost of HIV in women totals $100 billion annually in lost productivity
- Stigma leads to 35% job discrimination against HIV+ women
- In South Africa, HIV+ women households 2x likely to be food insecure
- Mental health disorders affect 60% of HIV+ women, reducing workforce participation
- Property disinheritance affects 25% HIV+ widows in sub-Saharan Africa
- HIV care burdens women with 70% of unpaid caregiving time
- In India, HIV+ women face 30% divorce rate post-diagnosis
- Global AIDS fund invests $2 billion yearly, but women programs only 20%
Socioeconomic Impact Interpretation
Treatment Access
- In 2022, 82% of women living with HIV knew their status globally
- Only 65% of diagnosed women are on ART worldwide
- Viral suppression among women on ART is 88%, slightly lower than men at 90%
- In low-income countries, women face 20% stockouts of ARVs annually
- Pregnant women on ART have 95% PMTCT success if started early
- In US, Black women have lowest ART retention at 70% after 1 year
- Globally, 75% of women on ART are virally suppressed
- Adolescent girls on ART have 50% higher loss to follow-up than adults
- In sub-Saharan Africa, 85% of HIV+ women access ANC testing, but only 70% start ART
- Long-acting injectables like CAB-LA improve adherence to 90% in women trials
- Stigma causes 30% dropout from care among newly diagnosed women
- In Eastern Europe, only 55% of women on ART achieve viral suppression
- Differentiated service delivery retains 85% of stable women in community models
- In India, 80% of HIV+ women on ART, but TB co-infection reduces suppression to 70%
- Multi-month dispensing increases retention by 25% for women
- Only 40% of women with HIV/hepatitis C co-infection access DAAs
- In Brazil, 95% of diagnosed women on ART with 92% suppression
- Transportation barriers prevent 25% of rural women from ART adherence
- Peer support programs boost viral suppression to 95% in women groups
- In Nigeria, only 62% of HIV+ women on ART
Treatment Access Interpretation
Sources & References
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