Key Takeaways
- The global psychedelics market was valued at $4.6 billion in 2023 and is expected to reach $12.6 billion by 2032, growing at a CAGR of 11.8%.
- North America's psychedelic therapy market is projected to grow from $1.2 billion in 2024 to $5.1 billion by 2032 at a CAGR of 19.6%.
- The U.S. psychedelic drugs market size was estimated at USD 2.8 billion in 2023 and is anticipated to expand at a CAGR of 14.2% from 2024 to 2030.
- Phase 3 trials for psilocybin in depression completed by 4 companies in 2023.
- COMPASS Pathways' COMP360 psilocybin showed 37% response rate in TRD Phase 2b trial (n=233).
- MAPS' MDMA for PTSD Phase 3 trial MAPP2 met primary endpoint with 71.2% remission rate (n=104).
- Colorado legalized psilocybin therapy for adults 21+ in 2022 via Prop 122.
- Oregon's Measure 109 established licensed psilocybin service centers operational since 2023.
- FDA granted Breakthrough Therapy Designation to 5 psychedelic therapies by 2024.
- Over $500 million raised by psychedelic biotechs in 2021 alone.
- Atai Life Sciences raised $175 million IPO on Nasdaq in 2021.
- Compass Pathways secured $125 million Series B in 2020 led by Founders Fund.
- 14 million Americans used psychedelics lifetime per 2023 NSDUH.
- Past-year psilocybin use in U.S. adults rose 34% from 2015-2019 to 1.35%.
- 7.2% of U.S. adults reported lifetime classic psychedelic use in 2022 survey.
The psychedelic industry is rapidly growing as new treatments gain legal and public support.
Clinical Research
- Phase 3 trials for psilocybin in depression completed by 4 companies in 2023.
- COMPASS Pathways' COMP360 psilocybin showed 37% response rate in TRD Phase 2b trial (n=233).
- MAPS' MDMA for PTSD Phase 3 trial MAPP2 met primary endpoint with 71.2% remission rate (n=104).
- Johns Hopkins psilocybin trial for smoking cessation: 80% abstinence at 12 months (n=15).
- Usona Institute's psilocybin for depression Phase 2: 50% remission in major depressive disorder (n=56).
- Cybin's CYB003 psilocybin analog Phase 1b showed 100% response in TRD (n=6).
- Beckley Psytech's BPL-003 intranasal 5-MeO-DMT for TRD: 75% response at Day 1 (n=12).
- GH Research's GH001 5-MeO-DMT Phase 2b for TRD: 78% response rate (n=40).
- MindMed's MM-120 LSD for GAD Phase 2b: 48% reduction in HAM-A scores (n=198).
- Atai Life Sciences' PCN-101 (R-ketamine) Phase 2 for TRD: 52% response rate.
- 42 active FDA-approved psychedelic trials in 2024 for mental health.
- NYU Langone ibogaine trial for TBI showed cognitive improvements in 30 veterans (n=30).
- Imperial College 5-MeO-DMT fMRI study: rapid antidepressant effects (n=20).
- Oregon Health psilocybin for EOL anxiety: 80% reduction in symptoms (n=22).
- 67% of TRD patients in psilocybin trials show sustained remission >6 months.
- MDMA trials for social anxiety in autism: 60% improvement (n=18).
- Ketamine for OCD Phase 2: 50% Y-BOCS reduction (n=15).
- LSD microdosing for ADHD: 40% symptom reduction in open-label (n=80).
- Ayahuasca for depression RCT: 36% remission vs 21% placebo (n=29).
- DMT for stroke recovery Phase 1 safety confirmed (n=20).
Clinical Research Interpretation
Investment Funding
- Over $500 million raised by psychedelic biotechs in 2021 alone.
- Atai Life Sciences raised $175 million IPO on Nasdaq in 2021.
- Compass Pathways secured $125 million Series B in 2020 led by Founders Fund.
- MindMed raised $100 million in 2021 financing rounds.
- 89 VC deals in psychedelics totaling $820M from 2015-2023.
- Cybin raised CAD 40 million in 2023 public offering.
- Beckley Psytech Series B $40 million in 2023 from Synkon Capital.
- Small Pharma $65 million Nasdaq listing in 2023.
- GH Research IPO raised $115 million in 2021.
- Field Trip Health merged SPAC for $200M valuation in 2021.
- 25 pharma partnerships announced in psychedelics 2022-2024.
- Entheogen raised $5M seed for DMT platform in 2023.
- Neurocrine acquired psychedelic assets for $50M upfront.
- Delix Therapeutics Series A $55M for non-hallucinogenic psychedelics.
- Reunion Neuroscience $15M seed for psychedelic depression therapy.
- 12 psychedelic IPOs on public markets by 2023.
- MAPS Public Benefit Corp raised $50M for MDMA Phase 3.
- Lykos Therapeutics $70M post-Phase 3 funding.
- Mydecine $20M CAD Series A extension.
- Psyence Group acquired Shroom Tech for $40M.
- 35% of psychedelic investments in psilocybin assets by 2023.
Investment Funding Interpretation
Market Growth
- The global psychedelics market was valued at $4.6 billion in 2023 and is expected to reach $12.6 billion by 2032, growing at a CAGR of 11.8%.
- North America's psychedelic therapy market is projected to grow from $1.2 billion in 2024 to $5.1 billion by 2032 at a CAGR of 19.6%.
- The U.S. psychedelic drugs market size was estimated at USD 2.8 billion in 2023 and is anticipated to expand at a CAGR of 14.2% from 2024 to 2030.
- Psychedelic-assisted therapy market in Europe is forecasted to grow at 18.3% CAGR from 2023 to 2030, reaching $3.4 billion.
- The microdosing products segment in the psychedelics market is expected to grow at a CAGR of 17.5% through 2028 due to rising consumer interest.
- Global psilocybin market revenue is projected to hit $8.62 billion by 2030, with a CAGR of 14.1% from 2023.
- MDMA-based therapeutics market is estimated to grow from $0.5 billion in 2023 to $2.1 billion by 2031 at 19.8% CAGR.
- Ayahuasca retreat market in South America saw a 25% YoY growth in bookings from 2022 to 2023.
- Ketamine clinics in the U.S. numbered over 500 in 2023, up 40% from 2022.
- Ibogaine treatment centers globally reported $150 million revenue in 2023.
- LSD microdose product sales grew 35% in 2023 in the wellness sector.
- DMT analogs market is expected to reach $1.2 billion by 2029 at 22% CAGR.
- Global psychedelic mushroom market valued at $2.1 billion in 2024, CAGR 16.2% to 2030.
- Corporate wellness programs incorporating psychedelics rose 50% in 2023.
- Psychedelic beverage market projected to $900 million by 2028.
- Virtual reality psychedelic therapy market to grow at 28% CAGR to 2030.
- Salvia divinorum product sales increased 18% globally in 2023.
- Mescaline cactus derivatives market at $300 million in 2023.
- Psychedelic patch delivery systems market CAGR 20.1% to 2032.
- Global retreat center revenue for psychedelics hit $450 million in 2023.
Market Growth Interpretation
Regulatory Landscape
- Colorado legalized psilocybin therapy for adults 21+ in 2022 via Prop 122.
- Oregon's Measure 109 established licensed psilocybin service centers operational since 2023.
- FDA granted Breakthrough Therapy Designation to 5 psychedelic therapies by 2024.
- Australia rescheduled psilocybin and MDMA for psychiatric use in 2023.
- Canada added exemptions for psilocybin therapy under Special Access Program, 70 approvals in 2023.
- Utah passed HB 259 for ketamine clinics regulation in 2023.
- New Mexico decriminalized psychedelics via HB 504 in 2023.
- Seattle decriminalized non-commercial possession of psychedelics in 2021.
- California AB 1104 proposed regulated access to psychedelics in 2024.
- FDA rejected MDMA approval in 2024 but allows resubmission.
- 15 U.S. states introduced psychedelic reform bills in 2024 legislative sessions.
- UK's MHRA fast-tracked 3 psychedelic candidates in 2023.
- Brazil legalized ayahuasca religious use federally in 2023.
- Netherlands tolerated magic truffles sales, $200M annual market.
- Portugal decriminalized all drugs including psychedelics since 2001, lowest EU use rates.
- Jamaica unregulated psilocybin retreats, 100+ centers by 2023.
- Switzerland compassionate use for psilocybin expanded to 500 patients in 2023.
- DEA proposed Schedule I review for psilocybin in 2024.
- New York decriminalized natural psychedelics in 2023.
Regulatory Landscape Interpretation
Usage Statistics
- 14 million Americans used psychedelics lifetime per 2023 NSDUH.
- Past-year psilocybin use in U.S. adults rose 34% from 2015-2019 to 1.35%.
- 7.2% of U.S. adults reported lifetime classic psychedelic use in 2022 survey.
- Microdosing prevalence among U.S. adults 4.2% in 2023 Chamath survey (n=5000).
- 58% of Americans support psychedelic legalization for therapy per 2023 poll.
- Lifetime LSD use 10.5% among U.S. 12+ per NSDUH 2022.
- Ketamine recreational use doubled to 1.8% past-year in young adults 2023.
- Ayahuasca use in U.S. increased 50% since 2019 per Global Drug Survey.
- 21% of Silicon Valley execs microdose weekly per 2023 anecdotal report.
- Past-month DMT use 0.7% among U.S. college students 2022.
- Ibogaine use for addiction: 5,000 treatments annually worldwide.
- 32% of therapy seekers used psilocybin self-medication in 2023.
- Veteran psychedelic use for PTSD: 15% lifetime (n=4000 VA survey).
- Global magic mushroom consumption 50 million doses/year estimated.
- MDMA therapeutic self-use 12% among PTSD patients pre-trial.
- 45% increase in psychedelic festival attendance 2022-2023.
- Salvia use past-year 1.2% U.S. high school seniors 2023.
- Mescaline peyote use stable at 0.4% lifetime Native American communities.
- 28% of U.K. adults open to psychedelic therapy per 2024 poll.
- Corporate microdosing programs: 10% of Fortune 500 trialed in 2023.
Usage Statistics Interpretation
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