Pregnancy after 46 is often imagined as rare, but the numbers show a much more complex reality, from higher twin rates to major shifts in maternal and neonatal risk. For example, U.S. C section rates for mothers aged 50 and up reached 47.5% in 2022, while the odds of several complications climb steadily with age. Let’s connect these statistics so you can see exactly what changes, when it changes, and what it means for outcomes.
Key Takeaways
- The average age of mothers giving birth in the United States was 30.8 years in 2022
- Rates of multiple births are higher among older mothers; CDC reports that the share of twins+ among births increases with maternal age (2022 vital statistics)
- In the U.S., C-section rates for mothers aged 50+ were 47.5% in 2022 (CDC NCHS data brief)
- NIPT screening coverage increased to 81% of pregnancies in private insurance plans studied in 2022 (industry utilization study)
- US maternal mortality rate was 36.7 per 100,000 live births for ages 50 and older (2016–2019)
- At advanced maternal age (≥40), risk of gestational diabetes increases; the absolute risk reported for 41–45 years was 2.5× that of 20–29 in large population data (meta-analysis context, 2012)
- Risk of preeclampsia increases with age; pooled relative risk for women aged ≥40 compared with <30 was 1.7 (meta-analysis, 2015)
- A 2018 systematic review estimated that live birth after miscarriage-free clinical pregnancy drops with age, with ~1% probability of live birth from an embryo transfer context at age 44–45 (systematic review synthesis)
- In IVF, the odds of achieving a live birth decline with age; pooled analysis shows a monotonic decline beginning in the late 30s (systematic review, 2019)
- Maternal age is a significant risk factor for neural tube defects; risk rises with age in large registry studies (meta-analysis, 2016)
- In Europe, the proportion of women treated with IVF who are aged 40+ is reported around one-quarter in recent European ART surveillance summaries (ESHRE surveillance, 2020)
- The global fertility services market size was $4.3 billion in 2024 (forecast from a market research firm using public licensing data)
- The global infertility treatment market was $18.9 billion in 2023 (market research estimate)
- The assisted reproductive technology market was valued at $25.0 billion in 2023 (market research estimate)
- A claims study estimated that maternity episode costs increased by ~35% for women aged 45–54 compared with women aged 25–29 (2021)
At 46, pregnancy is possible, but risks like preeclampsia and stillbirth rise notably with age.
Related reading
01 · Category
Demographics1 stats
01
The average age of mothers giving birth in the United States was 30.8 years in 2022
Interpretation
Demographics Interpretation
In the Demographics snapshot of Pregnancy at 46, the average maternal age in the United States reached 30.8 years in 2022, underscoring that people are giving birth later on average, which is a key context for understanding pregnancies at advanced ages.
More related reading
02 · Category
Care Utilization4 stats
01
Rates of multiple births are higher among older mothers; CDC reports that the share of twins+ among births increases with maternal age (2022 vital statistics)
02
In the U.S., C-section rates for mothers aged 50+ were 47.5% in 2022 (CDC NCHS data brief)
03
NIPT screening coverage increased to 81% of pregnancies in private insurance plans studied in 2022 (industry utilization study)
04
In a large Swedish registry, women aged ≥45 had a substantially higher rate of cesarean birth than younger groups; cesarean rates increased with age (registry study, 2018)
Interpretation
Care Utilization Interpretation
Care utilization appears to rise sharply with maternal age, with cesarean delivery reaching 47.5% for U.S. mothers 50+ in 2022 and registry data showing cesarean rates increase with age, while higher twin rates and broader NIPT use (81% in private insurance in 2022) suggest more intensive medical monitoring around older pregnancies.
03 · Category
Health Risks10 stats
01
US maternal mortality rate was 36.7 per 100,000 live births for ages 50 and older (2016–2019)
02
At advanced maternal age (≥40), risk of gestational diabetes increases; the absolute risk reported for 41–45 years was 2.5× that of 20–29 in large population data (meta-analysis context, 2012)
03
Risk of preeclampsia increases with age; pooled relative risk for women aged ≥40 compared with <30 was 1.7 (meta-analysis, 2015)
04
Risk of Down syndrome at birth for maternal age 35 is about 1 in 350
05
In a U.S. cohort, the rate of placenta accreta increased from 0.03% in ages 25–29 to 0.3% in ages 45–49
06
A 2020 U.S. study reported that women aged 45–54 had higher odds of preeclampsia compared with women aged 20–34
07
Advanced maternal age is associated with higher risk of stillbirth; a 2019 systematic review reports stillbirth risk increases after age 40 (pooled estimates)
08
A 2021 meta-analysis reported that odds of placenta previa increase with maternal age, with elevated risk after age 40 (meta-analysis)
09
A 2019 population study found increased risk of gestational hypertension for mothers aged 45+ compared with 25–29 (registry data)
10
A 2018 systematic review found that the risk of preterm birth increases with maternal age, with higher odds for women ≥40 (systematic review)
Interpretation
Health Risks Interpretation
From the Health Risks data, pregnancy at 46 carries steadily rising medical risk with age, such as gestational diabetes reaching 2.5 times the 20 to 29 absolute risk at ages 41 to 45 and preeclampsia showing a pooled relative risk of 1.7 for women aged 40 and older compared with under 30.
More related reading
04 · Category
Fertility & Outcomes3 stats
01
A 2018 systematic review estimated that live birth after miscarriage-free clinical pregnancy drops with age, with ~1% probability of live birth from an embryo transfer context at age 44–45 (systematic review synthesis)
02
In IVF, the odds of achieving a live birth decline with age; pooled analysis shows a monotonic decline beginning in the late 30s (systematic review, 2019)
03
Maternal age is a significant risk factor for neural tube defects; risk rises with age in large registry studies (meta-analysis, 2016)
Interpretation
Fertility & Outcomes Interpretation
For the Fertility & Outcomes category, the key trend is that fertility and successful outcomes clearly worsen with age, dropping to about a 1% probability of live birth in an embryo transfer context at ages 44 to 45.
More related reading
05 · Category
Industry Trends1 stats
01
In Europe, the proportion of women treated with IVF who are aged 40+ is reported around one-quarter in recent European ART surveillance summaries (ESHRE surveillance, 2020)
Interpretation
Industry Trends Interpretation
Industry Trends data show that in Europe around one-quarter of women receiving IVF are aged 40 or older, indicating a significant and growing older age presence within assisted reproduction services.
06 · Category
Market Size4 stats
01
The global fertility services market size was $4.3 billion in 2024 (forecast from a market research firm using public licensing data)
02
The global infertility treatment market was $18.9 billion in 2023 (market research estimate)
03
The assisted reproductive technology market was valued at $25.0 billion in 2023 (market research estimate)
04
The genetic testing market for prenatal screening was $10.8 billion in 2022 (market research estimate)
Interpretation
Market Size Interpretation
The market size for Pregnancy at 46 is already large and concentrated, with infertility treatment at $18.9 billion in 2023 and assisted reproductive technology at $25.0 billion in 2023, underscoring that demand for fertility services grows well beyond basic support even before adding prenatal genetic screening at $10.8 billion in 2022.
More related reading
07 · Category
Cost Analysis2 stats
01
A claims study estimated that maternity episode costs increased by ~35% for women aged 45–54 compared with women aged 25–29 (2021)
02
$600per patient is the typical price range for a prenatal NIPT test in the U.S. in cash-pay pricing datasets (2023 pricing analysis)
Interpretation
Cost Analysis Interpretation
Cost analysis shows maternity episode expenses jumped by about 35% for women aged 45 to 54 versus those aged 25 to 29 in 2021, while prenatal NIPT tests in the U.S. commonly cost around $600 per patient on cash pay pricing in 2023.
Reference
Cite This Report
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APA
Lars Eriksen. (2026, February 13). Pregnancy At 46 Statistics. Gitnux. https://gitnux.org/pregnancy-at-46-statistics
MLA
Lars Eriksen. "Pregnancy At 46 Statistics." Gitnux, 13 Feb 2026, https://gitnux.org/pregnancy-at-46-statistics.
Chicago
Lars Eriksen. 2026. "Pregnancy At 46 Statistics." Gitnux. https://gitnux.org/pregnancy-at-46-statistics.
Sources & references
25 datasets cited across this report · attribution is report-level
+12 additional datasets cited (not shown individually)