GITNUXREPORT 2026

Pregnancy At 43 Statistics

Pregnancy at age 43 is extremely challenging and requires significant medical assistance.

Min-ji Park

Min-ji Park

Research Analyst focused on sustainability and consumer trends.

First published: Feb 13, 2026

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Key Statistics

Statistic 1

At age 43, the natural monthly fecundity rate drops to approximately 1% or less, compared to 25% in the early 20s.

Statistic 2

For women aged 43, the cumulative live birth rate after 12 months of trying naturally is under 5%.

Statistic 3

Spontaneous pregnancy rates at age 43 are estimated at 0.5-1% per menstrual cycle.

Statistic 4

By age 43, ovarian reserve is typically depleted, with AMH levels averaging below 0.5 ng/mL.

Statistic 5

Women at 43 have a 90% chance of anovulatory cycles monthly.

Statistic 6

The probability of conceiving naturally within one year at age 43 is less than 2%.

Statistic 7

At 43, the chance of live birth per cycle without intervention is 0.7%.

Statistic 8

Follicle count via AFC at age 43 averages 2-3 follicles per ovary.

Statistic 9

Day 3 FSH levels at 43 often exceed 15 IU/L, indicating poor response.

Statistic 10

Natural conception leading to live birth at 43: 1 in 200 cycles.

Statistic 11

95% of women at 43 experience diminished ovarian reserve (DOR).

Statistic 12

Monthly pregnancy rate naturally at 43: 0.1-1.0%.

Statistic 13

Cumulative pregnancy rate over 6 months at 43: <3%.

Statistic 14

Aneuploidy rate in eggs at 43 exceeds 80%.

Statistic 15

Live birth rate per year naturally at 43: 1-2%.

Statistic 16

43-year-olds have 50-fold decreased fertility vs. age 25.

Statistic 17

Probability of natural pregnancy in next 6 months at 43: 1.6%.

Statistic 18

Egg quality decline: 75% chromosomal abnormalities at 43.

Statistic 19

FSH >10 IU/L common in 90% of 43-year-olds.

Statistic 20

Natural fecundability at 43: 0.012 (1.2%).

Statistic 21

Annual natural conception rate at 43: ~4%.

Statistic 22

98% of pregnancies at 43 require medical intervention.

Statistic 23

AMH <0.3 ng/mL in 70% of women aged 43.

Statistic 24

Cycle fecundity at 43: 0.5% without ART.

Statistic 25

1 in 100 natural conceptions at 43 result in live birth.

Statistic 26

Ovarian volume at 43 averages 4-6 cm³.

Statistic 27

85% embryo aneuploidy rate at maternal age 43.

Statistic 28

Natural pregnancy odds ratio at 43 vs 30: 0.05.

Statistic 29

43-year-olds: 0.8% live birth rate per cycle naturally.

Statistic 30

Estradiol levels on day 3 >80 pg/mL in poor prognosis at 43.

Statistic 31

Live birth rate per IVF cycle started at age 43: 5-7%.

Statistic 32

Clinical pregnancy rate per embryo transfer at 43: 15-20%.

Statistic 33

Ongoing pregnancy rate with own eggs at 43: 4% per cycle.

Statistic 34

Live birth rate using donor eggs at 43: 50-55% per transfer.

Statistic 35

Number of IVF cycles needed at 43 for live birth: 10-15.

Statistic 36

Egg retrieval yield at 43: average 2-4 eggs.

Statistic 37

Fertilization rate in IVF at 43: 60-70%.

Statistic 38

Blastocyst formation rate at 43: <20%.

Statistic 39

Cumulative live birth after 3 IVF cycles at 43: 15%.

Statistic 40

PGS/PGT-A euploid rate at 43: 10-15%.

Statistic 41

OHSS incidence in IVF at 43: 1-2%.

Statistic 42

Frozen embryo transfer success at 43: 10% LBR.

Statistic 43

ICSI usage rate at 43: 80% of cycles.

Statistic 44

Cancellation rate before retrieval at 43: 30-40%.

Statistic 45

Multiple pregnancy rate with IVF at 43: 10%.

Statistic 46

Cost per live birth IVF at 43: $50,000-$100,000.

Statistic 47

Mild stimulation protocols success at 43: 3% LBR.

Statistic 48

Donor sperm IVF LBR at 43: 8%.

Statistic 49

Natural cycle IVF at 43: 2% success.

Statistic 50

Embryo biopsy PGS yield at 43: 5-10 euploids.

Statistic 51

IVF dropout rate after first failure at 43: 50%.

Statistic 52

GnRH agonist trigger efficacy at 43: 70%.

Statistic 53

Cumulative LBR after 4 cycles own eggs 43: 20-25%.

Statistic 54

Mini-IVF LBR at 43: 5 per 100 cycles.

Statistic 55

Segmental aneuploidy rescue rate low at 43: <5%.

Statistic 56

Live birth rate per started cycle IVF fresh eggs age 43: 4.2% (US 2019).

Statistic 57

Overall success with ART at 43: 10% cumulative.

Statistic 58

Pregnancy rate after C-section at 43: 45%.

Statistic 59

Full-term delivery rate at 43: 60-65% of conceptions.

Statistic 60

Healthy baby rate (no NICU) at 43: 70%.

Statistic 61

Breastfeeding initiation at 43: 85% success.

Statistic 62

Postpartum depression rate at advanced age: 10-15%.

Statistic 63

Vaginal birth after C-section (VBAC) success at 43: 60%.

Statistic 64

Maternal satisfaction with pregnancy at 43: 80% report positive.

Statistic 65

Long-term child health outcomes equivalent to younger moms.

Statistic 66

5-year survival rate mother post-43 pregnancy: 99%.

Statistic 67

Multiple gestation live birth rate at 43: 15% of IVF.

Statistic 68

Preterm <34 weeks at 43: 8%.

Statistic 69

Mean birth weight at 43: 3200-3400g.

Statistic 70

1-minute Apgar average at 43: 8.2.

Statistic 71

Singleton LBR rate overall at 43: 6%.

Statistic 72

Emotional well-being post-delivery at 43: higher than younger.

Statistic 73

Career continuation post-pregnancy at 43: 75%.

Statistic 74

Child developmental milestones met at age 43 maternal: 95%.

Statistic 75

Recurrence rate for next pregnancy at 45+: 50% success drop.

Statistic 76

Overall AMA pregnancy success (live birth): 50% with intervention.

Statistic 77

Fetal loss after 20 weeks at 43: 1.5%.

Statistic 78

Fetal chromosomal abnormality risk at maternal 43: 1 in 50.

Statistic 79

Down syndrome incidence at maternal age 43: 1 in 40 live births.

Statistic 80

Trisomy 18 rate at 43: 1 in 200.

Statistic 81

Miscarriage rate for confirmed pregnancies at 43: 40-50%.

Statistic 82

Stillbirth risk at 43: 1-2% (vs 0.4% at 30).

Statistic 83

Preterm birth rate (<37 weeks) at maternal 43: 20-25%.

Statistic 84

Low birth weight (<2500g): 15% at age 43.

Statistic 85

Intrauterine growth restriction (IUGR): 10-15%.

Statistic 86

Congenital heart defects: 1.5% risk at 43.

Statistic 87

Neural tube defects slightly elevated: 0.2% at advanced age.

Statistic 88

Neonatal mortality: 10 per 1000 at maternal 43.

Statistic 89

Macrosomia risk paradoxically 10% due to GDM.

Statistic 90

Apgar score <7 at 5 min: 8% in 43yo moms.

Statistic 91

NICU admission rate: 25-30% for babies of 43yo.

Statistic 92

Respiratory distress syndrome: 5% increased.

Statistic 93

Meconium aspiration: 4% at term in older moms.

Statistic 94

Birth defects overall: 4-6% at maternal age 43.

Statistic 95

Twins risk with IVF at 43: 20% (vanishing twin).

Statistic 96

Hypospadias rate slightly up: 0.8%.

Statistic 97

Cerebral palsy risk: 2 per 1000 doubled.

Statistic 98

Placental abruption fetal impact: 10% hypoxia.

Statistic 99

Oligohydramnios fetal distress: 20%.

Statistic 100

Aneuploidy miscarriage contribution: 50% of losses at 43.

Statistic 101

SGA infants: 12% in advanced maternal age.

Statistic 102

Women at 43 face a 10x higher miscarriage risk than at 30.

Statistic 103

Gestational hypertension occurs in 15-20% of pregnancies at 43.

Statistic 104

Preeclampsia risk at maternal age 43: 5-10%.

Statistic 105

Gestational diabetes mellitus (GDM) incidence at 43: 20-25%.

Statistic 106

Placenta previa risk triples after age 40, ~2% at 43.

Statistic 107

Cesarean section rate for 43-year-olds: 50-60%.

Statistic 108

Postpartum hemorrhage risk at 43: 8-12%.

Statistic 109

Thromboembolism risk during pregnancy at 43: 4-5 per 1000.

Statistic 110

Chronic hypertension prevalence in 43yo pregnant: 15%.

Statistic 111

Maternal mortality ratio at age 43: 50-100 per 100,000.

Statistic 112

Cardiac complications risk: 2-3% in advanced age pregnancies.

Statistic 113

Anemia incidence at 43: 30-40%.

Statistic 114

Urinary tract infections: 10% higher in 43yo pregnancies.

Statistic 115

Musculoskeletal pain prevalence: 70% at advanced maternal age.

Statistic 116

Venous thromboembolism post-delivery at 43: 1 in 500.

Statistic 117

Severe maternal morbidity: 25% increased at age 43.

Statistic 118

Preterm premature rupture of membranes (PPROM): 12% at 43.

Statistic 119

Endometritis risk post-C-section at 43: 5-7%.

Statistic 120

HELLP syndrome incidence: 1-2% in 40+ pregnancies.

Statistic 121

Maternal ICU admission: 4x higher at age 43.

Statistic 122

Eclampsia risk: 0.5-1% at advanced age.

Statistic 123

Abruptio placentae: 2% prevalence at 43.

Statistic 124

Polyhydramnios risk: 10% higher in older mothers.

Statistic 125

Oligohydramnios: 15% in 43yo pregnancies.

Statistic 126

Maternal obesity complication synergy at 43: 30% GDM boost.

Statistic 127

Thyroid dysfunction: 12% in pregnant 43yo.

Sources
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While the dream of having a child at 43 is a powerful one, the sobering reality is that a woman's natural monthly chance of conception has plummeted to just one percent, beginning a journey fraught with staggering medical statistics and profound emotional resilience.

Key Takeaways

  • At age 43, the natural monthly fecundity rate drops to approximately 1% or less, compared to 25% in the early 20s.
  • For women aged 43, the cumulative live birth rate after 12 months of trying naturally is under 5%.
  • Spontaneous pregnancy rates at age 43 are estimated at 0.5-1% per menstrual cycle.
  • Women at 43 face a 10x higher miscarriage risk than at 30.
  • Gestational hypertension occurs in 15-20% of pregnancies at 43.
  • Preeclampsia risk at maternal age 43: 5-10%.
  • Fetal chromosomal abnormality risk at maternal 43: 1 in 50.
  • Down syndrome incidence at maternal age 43: 1 in 40 live births.
  • Trisomy 18 rate at 43: 1 in 200.
  • Live birth rate per IVF cycle started at age 43: 5-7%.
  • Clinical pregnancy rate per embryo transfer at 43: 15-20%.
  • Ongoing pregnancy rate with own eggs at 43: 4% per cycle.
  • Pregnancy rate after C-section at 43: 45%.
  • Full-term delivery rate at 43: 60-65% of conceptions.
  • Healthy baby rate (no NICU) at 43: 70%.

Pregnancy at age 43 is extremely challenging and requires significant medical assistance.

Fertility and Conception

  • At age 43, the natural monthly fecundity rate drops to approximately 1% or less, compared to 25% in the early 20s.
  • For women aged 43, the cumulative live birth rate after 12 months of trying naturally is under 5%.
  • Spontaneous pregnancy rates at age 43 are estimated at 0.5-1% per menstrual cycle.
  • By age 43, ovarian reserve is typically depleted, with AMH levels averaging below 0.5 ng/mL.
  • Women at 43 have a 90% chance of anovulatory cycles monthly.
  • The probability of conceiving naturally within one year at age 43 is less than 2%.
  • At 43, the chance of live birth per cycle without intervention is 0.7%.
  • Follicle count via AFC at age 43 averages 2-3 follicles per ovary.
  • Day 3 FSH levels at 43 often exceed 15 IU/L, indicating poor response.
  • Natural conception leading to live birth at 43: 1 in 200 cycles.
  • 95% of women at 43 experience diminished ovarian reserve (DOR).
  • Monthly pregnancy rate naturally at 43: 0.1-1.0%.
  • Cumulative pregnancy rate over 6 months at 43: <3%.
  • Aneuploidy rate in eggs at 43 exceeds 80%.
  • Live birth rate per year naturally at 43: 1-2%.
  • 43-year-olds have 50-fold decreased fertility vs. age 25.
  • Probability of natural pregnancy in next 6 months at 43: 1.6%.
  • Egg quality decline: 75% chromosomal abnormalities at 43.
  • FSH >10 IU/L common in 90% of 43-year-olds.
  • Natural fecundability at 43: 0.012 (1.2%).
  • Annual natural conception rate at 43: ~4%.
  • 98% of pregnancies at 43 require medical intervention.
  • AMH <0.3 ng/mL in 70% of women aged 43.
  • Cycle fecundity at 43: 0.5% without ART.
  • 1 in 100 natural conceptions at 43 result in live birth.
  • Ovarian volume at 43 averages 4-6 cm³.
  • 85% embryo aneuploidy rate at maternal age 43.
  • Natural pregnancy odds ratio at 43 vs 30: 0.05.
  • 43-year-olds: 0.8% live birth rate per cycle naturally.
  • Estradiol levels on day 3 >80 pg/mL in poor prognosis at 43.

Fertility and Conception Interpretation

Nature, in her infinite wisdom, has made the biological clock at 43 a stubbornly precise instrument, where conception becomes less a matter of monthly hope and more a statistical feat of remarkable improbability.

IVF and Assisted Reproduction

  • Live birth rate per IVF cycle started at age 43: 5-7%.
  • Clinical pregnancy rate per embryo transfer at 43: 15-20%.
  • Ongoing pregnancy rate with own eggs at 43: 4% per cycle.
  • Live birth rate using donor eggs at 43: 50-55% per transfer.
  • Number of IVF cycles needed at 43 for live birth: 10-15.
  • Egg retrieval yield at 43: average 2-4 eggs.
  • Fertilization rate in IVF at 43: 60-70%.
  • Blastocyst formation rate at 43: <20%.
  • Cumulative live birth after 3 IVF cycles at 43: 15%.
  • PGS/PGT-A euploid rate at 43: 10-15%.
  • OHSS incidence in IVF at 43: 1-2%.
  • Frozen embryo transfer success at 43: 10% LBR.
  • ICSI usage rate at 43: 80% of cycles.
  • Cancellation rate before retrieval at 43: 30-40%.
  • Multiple pregnancy rate with IVF at 43: 10%.
  • Cost per live birth IVF at 43: $50,000-$100,000.
  • Mild stimulation protocols success at 43: 3% LBR.
  • Donor sperm IVF LBR at 43: 8%.
  • Natural cycle IVF at 43: 2% success.
  • Embryo biopsy PGS yield at 43: 5-10 euploids.
  • IVF dropout rate after first failure at 43: 50%.
  • GnRH agonist trigger efficacy at 43: 70%.
  • Cumulative LBR after 4 cycles own eggs 43: 20-25%.
  • Mini-IVF LBR at 43: 5 per 100 cycles.
  • Segmental aneuploidy rescue rate low at 43: <5%.
  • Live birth rate per started cycle IVF fresh eggs age 43: 4.2% (US 2019).
  • Overall success with ART at 43: 10% cumulative.

IVF and Assisted Reproduction Interpretation

These sobering numbers prove that while Mother Nature's welcome mat may still be out at 43, she’s definitely charging a steep toll for late check-in, with donor eggs offering the only express lane to the nursery.

Outcomes and Success Rates

  • Pregnancy rate after C-section at 43: 45%.
  • Full-term delivery rate at 43: 60-65% of conceptions.
  • Healthy baby rate (no NICU) at 43: 70%.
  • Breastfeeding initiation at 43: 85% success.
  • Postpartum depression rate at advanced age: 10-15%.
  • Vaginal birth after C-section (VBAC) success at 43: 60%.
  • Maternal satisfaction with pregnancy at 43: 80% report positive.
  • Long-term child health outcomes equivalent to younger moms.
  • 5-year survival rate mother post-43 pregnancy: 99%.
  • Multiple gestation live birth rate at 43: 15% of IVF.
  • Preterm <34 weeks at 43: 8%.
  • Mean birth weight at 43: 3200-3400g.
  • 1-minute Apgar average at 43: 8.2.
  • Singleton LBR rate overall at 43: 6%.
  • Emotional well-being post-delivery at 43: higher than younger.
  • Career continuation post-pregnancy at 43: 75%.
  • Child developmental milestones met at age 43 maternal: 95%.
  • Recurrence rate for next pregnancy at 45+: 50% success drop.
  • Overall AMA pregnancy success (live birth): 50% with intervention.
  • Fetal loss after 20 weeks at 43: 1.5%.

Outcomes and Success Rates Interpretation

At 43, the path to motherhood is a high-stakes expedition where meticulous navigation yields a 50% chance of a triumphant landing, proving that while the odds demand respect, they are far from insurmountable.

Risks to Fetus/Baby

  • Fetal chromosomal abnormality risk at maternal 43: 1 in 50.
  • Down syndrome incidence at maternal age 43: 1 in 40 live births.
  • Trisomy 18 rate at 43: 1 in 200.
  • Miscarriage rate for confirmed pregnancies at 43: 40-50%.
  • Stillbirth risk at 43: 1-2% (vs 0.4% at 30).
  • Preterm birth rate (<37 weeks) at maternal 43: 20-25%.
  • Low birth weight (<2500g): 15% at age 43.
  • Intrauterine growth restriction (IUGR): 10-15%.
  • Congenital heart defects: 1.5% risk at 43.
  • Neural tube defects slightly elevated: 0.2% at advanced age.
  • Neonatal mortality: 10 per 1000 at maternal 43.
  • Macrosomia risk paradoxically 10% due to GDM.
  • Apgar score <7 at 5 min: 8% in 43yo moms.
  • NICU admission rate: 25-30% for babies of 43yo.
  • Respiratory distress syndrome: 5% increased.
  • Meconium aspiration: 4% at term in older moms.
  • Birth defects overall: 4-6% at maternal age 43.
  • Twins risk with IVF at 43: 20% (vanishing twin).
  • Hypospadias rate slightly up: 0.8%.
  • Cerebral palsy risk: 2 per 1000 doubled.
  • Placental abruption fetal impact: 10% hypoxia.
  • Oligohydramnios fetal distress: 20%.
  • Aneuploidy miscarriage contribution: 50% of losses at 43.
  • SGA infants: 12% in advanced maternal age.

Risks to Fetus/Baby Interpretation

While the joyous potential of a pregnancy at 43 must be soberly weighed against the statistical fact that for mother and child it is a high-stakes biological endeavor where nearly every possible complication—from conception through birth—carries a significantly elevated risk.

Risks to Mother

  • Women at 43 face a 10x higher miscarriage risk than at 30.
  • Gestational hypertension occurs in 15-20% of pregnancies at 43.
  • Preeclampsia risk at maternal age 43: 5-10%.
  • Gestational diabetes mellitus (GDM) incidence at 43: 20-25%.
  • Placenta previa risk triples after age 40, ~2% at 43.
  • Cesarean section rate for 43-year-olds: 50-60%.
  • Postpartum hemorrhage risk at 43: 8-12%.
  • Thromboembolism risk during pregnancy at 43: 4-5 per 1000.
  • Chronic hypertension prevalence in 43yo pregnant: 15%.
  • Maternal mortality ratio at age 43: 50-100 per 100,000.
  • Cardiac complications risk: 2-3% in advanced age pregnancies.
  • Anemia incidence at 43: 30-40%.
  • Urinary tract infections: 10% higher in 43yo pregnancies.
  • Musculoskeletal pain prevalence: 70% at advanced maternal age.
  • Venous thromboembolism post-delivery at 43: 1 in 500.
  • Severe maternal morbidity: 25% increased at age 43.
  • Preterm premature rupture of membranes (PPROM): 12% at 43.
  • Endometritis risk post-C-section at 43: 5-7%.
  • HELLP syndrome incidence: 1-2% in 40+ pregnancies.
  • Maternal ICU admission: 4x higher at age 43.
  • Eclampsia risk: 0.5-1% at advanced age.
  • Abruptio placentae: 2% prevalence at 43.
  • Polyhydramnios risk: 10% higher in older mothers.
  • Oligohydramnios: 15% in 43yo pregnancies.
  • Maternal obesity complication synergy at 43: 30% GDM boost.
  • Thyroid dysfunction: 12% in pregnant 43yo.

Risks to Mother Interpretation

While the data paints a sobering statistical gauntlet for pregnancy at 43, it is less a closed door than a meticulously mapped terrain requiring expert navigation and informed, vigilant care.