Key Takeaways
- Globally, cardiovascular diseases (CVDs) cause 17.9 million deaths annually, accounting for 32% of all global deaths, with 85% due to heart attacks and strokes.
- In the US, heart disease is the leading cause of death, killing about 695,000 people in 2021, or one in every five deaths.
- High blood pressure affects 1.28 billion adults aged 30-79 worldwide, with two-thirds living in low- and middle-income countries.
- COPD affects 384 million people globally, causing 3 million deaths yearly or 5% of all deaths.
- Asthma impacts 262 million people worldwide, leading to 455,000 deaths in 2019.
- Pneumonia is the single largest infectious cause of death in children under 5, killing 740,180 in 2019.
- Global osteoporosis affects 200 million women, with 9 million fractures yearly.
- US adults with arthritis: 53 million (23%), limiting 8 million daily activities.
- Low back pain affects 619 million globally, projected to 843 million by 2050.
- Global obesity tripled since 1975, 1.9 billion overweight, 650 million obese in 2016.
- US adult obesity rate 42.4% in 2017-2020, severe obesity 9.2%.
- Type 2 diabetes affects 462 million adults globally, projected 700 million by 2045.
- Global adults insufficiently active: 27%, 1.4 billion.
- US adults meeting aerobic + muscle guidelines: 23.2%.
- Sedentary time >8 hours/day raises mortality risk 15%.
Cardiovascular diseases are the world's leading cause of death, killing millions annually.
Cardiovascular Health
- Globally, cardiovascular diseases (CVDs) cause 17.9 million deaths annually, accounting for 32% of all global deaths, with 85% due to heart attacks and strokes.
- In the US, heart disease is the leading cause of death, killing about 695,000 people in 2021, or one in every five deaths.
- High blood pressure affects 1.28 billion adults aged 30-79 worldwide, with two-thirds living in low- and middle-income countries.
- Stroke kills 6.55 million people annually worldwide, and is the second leading cause of death.
- Atrial fibrillation prevalence is estimated at 2-3% in adults over 65, increasing stroke risk by 5-fold.
- Coronary heart disease affects 18.2 million US adults, with 805,000 experiencing a new or recurrent heart attack yearly.
- Smoking causes about 1.8 million deaths yearly from CVDs globally.
- Physical inactivity contributes to 6% of coronary heart disease cases worldwide.
- Diabetes doubles the risk of cardiovascular disease, affecting 422 million adults globally.
- LDL cholesterol levels above 190 mg/dL increase heart disease risk by 10-fold in some populations.
- Heart failure affects 6.2 million US adults aged 20+, with prevalence rising to 9.5% in those 65+.
- Globally, 1 in 100 people over 65 have peripheral artery disease, causing leg pain and amputation risk.
- Rheumatic heart disease kills 288,000 people yearly, mostly in low-income countries.
- US adults with hypertension: 47%, but only 1 in 4 have it under control.
- Endothelial dysfunction precedes atherosclerosis, with 50% of CVD events linked to it.
- Chronic kidney disease increases CVD mortality risk by 10-50 times.
- Air pollution causes 4.2 million premature deaths yearly from stroke, heart disease, etc.
- Women have 20-30% higher lifetime risk of stroke than men in high-income countries.
- Sudden cardiac death occurs in 350,000-450,000 US cases yearly, mostly from ventricular arrhythmias.
- Obesity raises heart failure risk by 35% per 5-unit BMI increase.
- Alcohol consumption above 14g/day increases hypertension risk by 20%.
- South Asians have 2-4 times higher coronary artery calcium score progression.
- Wearable ECG detects atrial fibrillation with 98.1% sensitivity in clinical trials.
- Framingham Risk Score predicts 10-year CVD risk with C-statistic of 0.76 in men, 0.79 in women.
- Statins reduce major vascular events by 21% per 1 mmol/L LDL reduction.
- Aspirin reduces nonfatal MI by 34% in secondary prevention.
- Cardiac rehab post-MI reduces mortality by 20-30%.
- Mediterranean diet lowers CVD events by 30% in high-risk individuals.
- Yoga reduces systolic BP by 5 mmHg on average in hypertensives.
- Global prevalence of hypertension in adults is 30-45%.
Cardiovascular Health Interpretation
Exercise and Fitness
- Global adults insufficiently active: 27%, 1.4 billion.
- US adults meeting aerobic + muscle guidelines: 23.2%.
- Sedentary time >8 hours/day raises mortality risk 15%.
- Resistance training 2x/week reduces all-cause mortality 40%.
- 150 min moderate aerobic exercise/week cuts CVD risk 14%.
- HIIT improves VO2max by 5-10% more than MICT in meta-analyses.
- Walking 10,000 steps/day linked to 46% lower premature mortality.
- Yoga reduces chronic low back pain by 60% short-term.
- Strength training increases muscle mass 1-2kg in 12 weeks untrained.
- Exercise adherence drops to 50% after 6 months in programs.
- Children <1h screen time/day, 60 min activity recommended.
- Balance training reduces falls 24% in elderly.
- Cycling commuters have 15% lower cancer, 24% lower CVD risk.
- Sleep 7-9 hours/night optimizes exercise recovery.
- Fitness trackers improve activity by 1,200 steps/day initially.
- Tai Chi improves knee OA pain by 24 points on VAS.
- VO2max declines 1%/year after 30, 50% faster if inactive.
- Group exercise boosts adherence 20-30% vs solo.
- Acute exercise increases BDNF 20-30%, aiding neuroplasticity.
- Cancer survivors exercising meet guidelines 37% vs 53% general pop.
Exercise and Fitness Interpretation
Infectious and Chronic Diseases
- Global cancer burden: 20 million new cases, 10 million deaths in 2022.
- HIV causes 630,000 deaths in 2022, 39 million living with it.
- TB incidence 10.6 million new cases in 2022, 1.3 million deaths.
- Malaria kills 608,000 yearly, mostly African children under 5.
- Chronic kidney disease 7th leading cause of death globally, 3.1 million deaths.
- Alzheimer's/dementia affects 55 million, 10 million new cases yearly.
- Liver cirrhosis from alcohol kills 500,000 yearly.
- US opioid overdose deaths 81,806 in 2022.
- Hepatitis B chronic 296 million, causing 1.1 million deaths yearly.
- Parkinson's 8.5 million globally, incidence rising 160% since 1990.
- Chronic liver disease kills 2 million yearly, 50% alcohol-related.
- Multiple sclerosis prevalence 2.8 million worldwide.
- Sepsis affects 49 million yearly, 11 million deaths (20%).
- Influenza pandemics historically kill 290k-650k respiratory deaths yearly.
- COVID-19 cumulative 7 million deaths reported, excess 15-20 million.
- Rheumatoid arthritis increases mortality 1.5-2-fold vs general pop.
- Vaccination prevents 2-3 million deaths yearly from vaccine-preventable diseases.
- Antimicrobial resistance causes 1.27 million deaths directly in 2019.
- Dengue 400 million infections yearly, 40,000 deaths.
- Chlamydia 129 million new cases yearly globally.
- Non-communicable diseases cause 41 million deaths yearly, 74% global deaths.
Infectious and Chronic Diseases Interpretation
Metabolic and Nutritional Health
- Global obesity tripled since 1975, 1.9 billion overweight, 650 million obese in 2016.
- US adult obesity rate 42.4% in 2017-2020, severe obesity 9.2%.
- Type 2 diabetes affects 462 million adults globally, projected 700 million by 2045.
- Vitamin D deficiency prevalent in 40-100% by region, linked to metabolic syndrome.
- Iron deficiency anemia affects 1.92 billion people, 40% women of reproductive age.
- Iodine deficiency causes 2 billion at risk, impairing child development.
- Sodium intake exceeds 2g/day in 99% global population, raising BP.
- Fruit/veg <5 servings/day in 77% world population.
- US sugar-sweetened beverage intake averages 145 kcal/day adults.
- Malnutrition causes 45% under-5 deaths, 149 million stunted.
- Omega-3 deficiency common, linked to 8% CVD deaths.
- Protein intake <0.8g/kg ideal body weight risks sarcopenia in elderly.
- Fiber intake averages 15g/day vs recommended 25-30g.
- Calcium intake <1000mg/day in 90% US women over 50.
- Mediterranean diet adherence reduces T2D risk by 52%.
- Intermittent fasting improves insulin sensitivity by 20-31%.
- Bariatric surgery leads to 50-70% excess weight loss, remitting T2D in 60-80%.
- Plant-based diets lower BMI by 1.7 kg/m² on average.
- Folate deficiency in 20% global population, raising neural tube defects.
Metabolic and Nutritional Health Interpretation
Musculoskeletal Health
- Global osteoporosis affects 200 million women, with 9 million fractures yearly.
- US adults with arthritis: 53 million (23%), limiting 8 million daily activities.
- Low back pain affects 619 million globally, projected to 843 million by 2050.
- Rheumatoid arthritis prevalence 0.5-1% worldwide, 3:1 female:male ratio.
- Osteoarthritis knee prevalence 16% in US adults 45+, rising to 30% at 65+.
- Sarcopenia affects 10% community-dwelling older adults, up to 50% in long-term care.
- Gout prevalence 3.9% US adults, 5.9 million cases.
- Fibromyalgia impacts 2-8% population, 80-90% women.
- US hip fractures: 300,000 yearly, 90% in 65+.
- Ankylosing spondylitis prevalence 0.1-1.4%, higher in males.
- Plantar fasciitis incidence 10 per 1,000 yearly, peak 40-60 years.
- Rotator cuff tears in asymptomatic 40+: 20-54% prevalence on MRI.
- Psoriatic arthritis affects 30% of psoriasis patients, prevalence 0.1-1%.
- Juvenile idiopathic arthritis incidence 16 per 100,000 children under 16.
- Bone density loss: 1-2% yearly post-menopause without treatment.
- Carpal tunnel syndrome lifetime risk 10% women, 3% men.
- Physical activity halves hip fracture risk in older women.
- Weight-bearing exercise increases bone mineral density by 1-3% yearly.
- Vitamin D deficiency (<20 ng/mL) in 42% US population, linked to falls.
- Methotrexate reduces RA radiographic progression by 70%.
- Hip replacement lasts 15-20 years in 80-90% cases.
- Grip strength predicts mortality, with 1kg loss raising risk 16% in men.
Musculoskeletal Health Interpretation
Respiratory Health
- COPD affects 384 million people globally, causing 3 million deaths yearly or 5% of all deaths.
- Asthma impacts 262 million people worldwide, leading to 455,000 deaths in 2019.
- Pneumonia is the single largest infectious cause of death in children under 5, killing 740,180 in 2019.
- US adults with current asthma: 8.4% or 24.9 million, with 11.5 deaths per million.
- Smoking causes 80-90% of COPD deaths, with 1.8 billion tobacco users globally.
- Air pollution leads to 6.7 million premature deaths yearly, 25% from respiratory diseases.
- Idiopathic pulmonary fibrosis prevalence is 13-20 per 100,000, median survival 3-5 years post-diagnosis.
- Sleep apnea affects 936 million adults aged 30-69 globally, with 425 million having moderate-severe OSA.
- Cystic fibrosis impacts 70,000-100,000 people worldwide, with median survival now 50+ years.
- Tuberculosis causes 1.3 million deaths yearly, with 10 million new cases.
- US COPD prevalence: 6.4% adults or 16 million, higher in current smokers (12.1%).
- Interstitial lung disease includes 200+ disorders, with incidence 30 per 100,000 yearly.
- Bronchiectasis prevalence 70 per 100,000 in Europe, rising with age.
- Pulmonary embolism incidence 60-70 per 100,000 yearly in US, mortality 10-30% if untreated.
- Lung cancer kills 1.8 million yearly, 85% linked to smoking.
- Influenza causes 290,000-650,000 respiratory deaths yearly globally.
- RSV leads to 33,000 deaths yearly in US adults 65+.
- Sarcoidosis prevalence 10-40 per 100,000, more common in women and African Americans.
- Pulmonary hypertension prevalence 15-50 per million, with group 1 PAH at 5-15 per million.
- Inhaler misuse occurs in 50-90% of asthma/COPD patients, worsening control.
- Oxygen therapy reduces mortality by 40% in severe COPD exacerbations.
- Pulmonary rehab improves 6-minute walk distance by 45 meters on average.
- Smoking cessation reduces lung cancer risk by 50% after 10 years.
- Long COVID respiratory symptoms persist in 20-30% of cases 12 months post-infection.
- Peak expiratory flow variability >20% indicates poor asthma control.
Respiratory Health Interpretation
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