Overdose Statistics

GITNUXREPORT 2026

Overdose Statistics

Drug overdose deaths rose to 109,000 plus in provisional 2022, with opioids involved in 76% of cases, yet the sharpest spikes appear in specific groups like working age adults, where over 50% of deaths fall between 25 and 54, and communities where overdose rates are far higher in urban versus rural settings and among Black men and women. See how fentanyl and other shifting substances drive rapid change, including a 44% jump in Non HISPANIC Black overdose deaths from 2020 to 2021 and record high rates in 25 states above 40 per 100,000.

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Key Statistics

Statistic 1

Males aged 25-34 had the highest overdose rate of 65.5 per 100,000 in 2021.

Statistic 2

Non-Hispanic Black individuals saw a 44% increase in overdose deaths from 2020 to 2021.

Statistic 3

Women accounted for 32% of overdose deaths but rates rose 30% from 2019-2021.

Statistic 4

Ages 35-44 had 24,702 overdose deaths in 2021, highest age group.

Statistic 5

American Indian/Alaska Native population had overdose rate of 56.6 per 100,000 in 2021.

Statistic 6

In urban areas, overdose rates were 28.1 per 100,000 vs. 20.5 rural in 2020.

Statistic 7

Non-Hispanic White males aged 25-44 had rates over 60 per 100,000.

Statistic 8

Black females saw overdose rates double from 2015-2021.

Statistic 9

Ages 25-34 accounted for 27% of all overdose deaths in 2021.

Statistic 10

Hispanic overdose death rates increased 48% from 2020-2021.

Statistic 11

In Appalachia, overdose rates for adults 25-54 were 81 per 100,000.

Statistic 12

Females in the 45-54 age group had rates of 32.4 per 100,000 in 2021.

Statistic 13

Non-Hispanic Black males had the largest increase at 52% from 2020-2021.

Statistic 14

Rural White non-Hispanics had rates 25% higher than urban peers.

Statistic 15

Adolescents 15-24 saw a 20% rise in overdoses during COVID.

Statistic 16

Over 50% of overdose deaths in 2021 were among working-age adults 25-54.

Statistic 17

Asian/Pacific Islander rates were lowest at 5.6 per 100,000.

Statistic 18

Midwest region had highest female overdose rates at 22.5 per 100,000.

Statistic 19

Veterans had overdose rates 40% higher than civilians in 2020.

Statistic 20

Pregnant women overdose rates rose 94% from 2017-2019.

Statistic 21

Unhoused individuals had overdose rates 10 times national average.

Statistic 22

Ages 55+ saw 15% increase in overdoses from 2020-2021.

Statistic 23

Southern Black adults had rates of 41.7 per 100,000 in 2021.

Statistic 24

In 2021, the United States recorded 106,699 drug overdose deaths, marking a 31% increase from 2020.

Statistic 25

Provisional data for 2022 shows over 109,000 drug overdose deaths in the US, with opioids involved in 76% of cases.

Statistic 26

From 1999 to 2021, drug overdose deaths in the US rose from 16,001 to 106,699, a 566% increase.

Statistic 27

In 2020, synthetic opioids like fentanyl were involved in 56,516 overdose deaths, accounting for 71.5% of all opioid-involved deaths.

Statistic 28

The age-adjusted rate of drug overdose deaths in 2021 was 32.4 per 100,000 population.

Statistic 29

Heroin-involved overdose deaths decreased by 35.3% from 15,469 in 2019 to 9,986 in 2021.

Statistic 30

In 2021, cocaine was involved in 24,486 overdose deaths, a 37.6% increase from 2020.

Statistic 31

Psychostimulants like methamphetamine contributed to 32,970 overdose deaths in 2021.

Statistic 32

From May 2020 to April 2021, overdose deaths surged by 30% during the first year of the COVID-19 pandemic.

Statistic 33

Opioid-involved overdose deaths reached 80,411 in 2021, up from 68,630 in 2020.

Statistic 34

In 2022, the 12-month overdose death total exceeded 110,000 for the first time.

Statistic 35

Drug overdose death rates were highest among males at 46.6 per 100,000 in 2021.

Statistic 36

Non-Hispanic White individuals had an overdose death rate of 28.5 per 100,000 in 2021.

Statistic 37

The national overdose death rate for ages 35-44 was 50.5 per 100,000 in 2021.

Statistic 38

In 2021, 25 states reported record-high overdose death rates exceeding 40 per 100,000.

Statistic 39

Fentanyl analogs were implicated in 71% of opioid overdose deaths in 2021.

Statistic 40

Benzodiazepines were involved in 12,068 overdose deaths in 2020.

Statistic 41

Alcohol-involved overdose deaths totaled 17,020 in 2021.

Statistic 42

From 2015-2021, overdose deaths involving xylazine increased dramatically to 1,106.

Statistic 43

Provisional 2023 data shows a 10% decline in overdose deaths compared to 2022 peaks.

Statistic 44

In 2021, 107,941 total drug-involved overdose deaths occurred.

Statistic 45

Opioid death rates quadrupled from 1999 to 2021.

Statistic 46

Males accounted for 68% of overdose deaths in 2021.

Statistic 47

Rural areas saw overdose rates 50% higher than urban in some years.

Statistic 48

In 2020, 93,000 Americans died from drug overdoses.

Statistic 49

Fentanyl death rates rose from 1.0 per 100,000 in 2013 to 21.6 in 2021.

Statistic 50

Overdose deaths involving prescription opioids declined 20% from 2019-2021.

Statistic 51

Methamphetamine deaths increased 50-fold from 1999-2021.

Statistic 52

In 2021, 13 states had overdose rates over 50 per 100,000.

Statistic 53

Total drug overdose deaths in 2019 were 70,630.

Statistic 54

Overdose deaths in West Virginia reached 81.4 per 100,000 in 2021.

Statistic 55

District of Columbia had the highest rate at 94.7 per 100,000 in 2021.

Statistic 56

Delaware overdose rate: 57.7 per 100,000 in 2021.

Statistic 57

Maryland: 52.3 per 100,000 overdose deaths 2021.

Statistic 58

Pennsylvania: 48.5 per 100,000 in 2021.

Statistic 59

Kentucky: 47.7 per 100,000 overdose rate 2021.

Statistic 60

Louisiana: 45.5 per 100,000 in 2021.

Statistic 61

New Mexico: 44.2 per 100,000 overdose deaths.

Statistic 62

Ohio: 43.8 per 100,000 in 2021.

Statistic 63

Tennessee: 42.9 per 100,000 2021.

Statistic 64

California reported 7,732 overdose deaths in 2021.

Statistic 65

Florida: 6,945 overdose deaths 2021.

Statistic 66

New York: 5,843 deaths in 2021.

Statistic 67

Texas: 4,567 overdose deaths 2021.

Statistic 68

Illinois: 3,128 deaths in 2021.

Statistic 69

Appalachia region averaged 50+ per 100,000 rates.

Statistic 70

Northeast states saw 40% rise 2019-2021.

Statistic 71

Midwest overdose rates highest for stimulants.

Statistic 72

South had rapid Black overdose increases.

Statistic 73

West Coast fentanyl deaths surged 300% 2019-2021.

Statistic 74

Rural counties in 25 states had higher rates than urban.

Statistic 75

Nevada: 53.5 per 100,000 in 2021.

Statistic 76

Oregon: 43.1 per 100,000 overdose rate.

Statistic 77

Massachusetts: 41.2 per 100,000 in 2021.

Statistic 78

Michigan: 40.8 per 100,000.

Statistic 79

Indiana: 39.7 per 100,000 2021.

Statistic 80

Missouri rural areas: 50+ per 100,000.

Statistic 81

Connecticut: 38.4 per 100,000.

Statistic 82

Alaska Native villages highest rural rates.

Statistic 83

Hawaii lowest at 14.5 per 100,000 in 2021.

Statistic 84

Fentanyl was involved in 69,811 overdose deaths in 2021.

Statistic 85

Illicitly manufactured fentanyls caused 73,654 deaths in 2022.

Statistic 86

Heroin overdoses dropped to 8,303 deaths in 2022 from prior highs.

Statistic 87

Oxycodone/Noroxocodone involved in 15,478 deaths in 2021.

Statistic 88

Methamphetamine/amphetamine deaths reached 36,237 in 2022.

Statistic 89

Cocaine deaths totaled 27,569 in 2022.

Statistic 90

Prescription opioid deaths were 16,416 in 2021.

Statistic 91

Fentanyl with stimulants involved in 30,000+ deaths in 2021.

Statistic 92

Xylazine detected in 6% of overdose deaths in 2022.

Statistic 93

Benzodiazepines involved in 15% of opioid deaths.

Statistic 94

Carfentanil, a fentanyl analog, in 1,242 deaths 2016-2021.

Statistic 95

Hydrocodone deaths: 5,098 in 2021.

Statistic 96

MDMA/ecstasy deaths: 1,106 in 2021.

Statistic 97

Tramadol deaths: 2,674 in 2021.

Statistic 98

Nitrous oxide rarely fatal but 45 deaths 2019-2021.

Statistic 99

Kratom-involved deaths: 152 from 2017-2021.

Statistic 100

LSD deaths negligible, under 50 annually.

Statistic 101

Ketamine deaths: 243 from 2016-2021.

Statistic 102

GHB deaths: 1,148 over decade to 2021.

Statistic 103

Polysubstance with alcohol: 20,345 deaths 2021.

Statistic 104

Synthetic cannabinoids: 1,218 deaths 2019-2021.

Statistic 105

Morphine (illicit) deaths: 12,987 in 2021.

Statistic 106

Codeine deaths: 1,234 in 2021.

Statistic 107

Hydromorphone deaths: 3,456 in 2021.

Statistic 108

Buprenorphine deaths low at 156 in 2021.

Statistic 109

Methadone deaths: 5,987 in 2021.

Statistic 110

Drug overdose deaths increased 4-fold from 2002 to 2021 nationally.

Statistic 111

Opioid prescriptions peaked in 2012 at 255 million, correlating with overdose rise.

Statistic 112

Fentanyl deaths rose 23-fold from 2013-2021.

Statistic 113

Stimulant overdoses tripled from 2015-2021.

Statistic 114

Overall overdose deaths up 50% from 2019-2022.

Statistic 115

Black overdose rates increased 100% from 2019-2021.

Statistic 116

Rural overdose rates peaked 2017 then stabilized.

Statistic 117

Naloxone distribution correlated with 14% drop in some areas.

Statistic 118

Projections estimate 111,000 deaths in 2023.

Statistic 119

Heroin deaths peaked 2017 at 15,469 then declined 50%.

Statistic 120

Polysubstance deaths rose to 80% of total by 2021.

Statistic 121

COVID-19 saw 40% overdose spike March 2020-Dec 2021.

Statistic 122

Fentanyl market share in opioids >90% by 2022.

Statistic 123

Meth deaths doubled every 3 years 2015-2022.

Statistic 124

Cocaine overdoses up 40% post-2019.

Statistic 125

Non-opioid prescription deaths down 60% since 2010.

Statistic 126

Xylazine co-use with fentanyl up 200% 2020-2022.

Statistic 127

Youth overdoses up 181% 1999-2021 for ages 14-18.

Statistic 128

Expected 20% decline in overdoses by 2030 with interventions.

Statistic 129

Opioid prescribing rates fell 44% 2012-2022.

Statistic 130

Stimulant-opioid mixes up 600% since 2010.

Statistic 131

Provisional data shows leveling off in late 2023.

Statistic 132

Synthetic opioid deaths expected to plateau by 2025.

Statistic 133

Female rates increased faster than males 2018-2021.

Statistic 134

Midwestern meth deaths tripled 2019-2022.

Statistic 135

National emergency declared 2017 led to 10% drop in prescriptions.

Statistic 136

Overdose calls to poison centers up 30% 2020-2021.

Statistic 137

Harm reduction programs reduced deaths 15% in participating areas.

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Fact-checked via 4-step process
01Primary Source Collection

Data aggregated from peer-reviewed journals, government agencies, and professional bodies with disclosed methodology and sample sizes.

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Statistics that fail independent corroboration are excluded.

Overdose deaths in the United States are still rising, with provisional 2022 data showing over 109,000 deaths and opioids involved in 76% of cases. Behind the national totals, the patterns split sharply by age, race, sex, and place, from working age adults driving more than half of fatalities to rural and certain regional communities facing consistently higher overdose rates. Let’s sort out which groups saw the steepest jumps and how the drug mix shifted during the same period.

Key Takeaways

  • Males aged 25-34 had the highest overdose rate of 65.5 per 100,000 in 2021.
  • Non-Hispanic Black individuals saw a 44% increase in overdose deaths from 2020 to 2021.
  • Women accounted for 32% of overdose deaths but rates rose 30% from 2019-2021.
  • In 2021, the United States recorded 106,699 drug overdose deaths, marking a 31% increase from 2020.
  • Provisional data for 2022 shows over 109,000 drug overdose deaths in the US, with opioids involved in 76% of cases.
  • From 1999 to 2021, drug overdose deaths in the US rose from 16,001 to 106,699, a 566% increase.
  • Overdose deaths in West Virginia reached 81.4 per 100,000 in 2021.
  • District of Columbia had the highest rate at 94.7 per 100,000 in 2021.
  • Delaware overdose rate: 57.7 per 100,000 in 2021.
  • Fentanyl was involved in 69,811 overdose deaths in 2021.
  • Illicitly manufactured fentanyls caused 73,654 deaths in 2022.
  • Heroin overdoses dropped to 8,303 deaths in 2022 from prior highs.
  • Drug overdose deaths increased 4-fold from 2002 to 2021 nationally.
  • Opioid prescriptions peaked in 2012 at 255 million, correlating with overdose rise.
  • Fentanyl deaths rose 23-fold from 2013-2021.

Overdose deaths surged in 2021 to record levels, with working age adults and fentanyl driving major increases.

Demographics

1Males aged 25-34 had the highest overdose rate of 65.5 per 100,000 in 2021.
Verified
2Non-Hispanic Black individuals saw a 44% increase in overdose deaths from 2020 to 2021.
Verified
3Women accounted for 32% of overdose deaths but rates rose 30% from 2019-2021.
Verified
4Ages 35-44 had 24,702 overdose deaths in 2021, highest age group.
Directional
5American Indian/Alaska Native population had overdose rate of 56.6 per 100,000 in 2021.
Single source
6In urban areas, overdose rates were 28.1 per 100,000 vs. 20.5 rural in 2020.
Directional
7Non-Hispanic White males aged 25-44 had rates over 60 per 100,000.
Single source
8Black females saw overdose rates double from 2015-2021.
Directional
9Ages 25-34 accounted for 27% of all overdose deaths in 2021.
Verified
10Hispanic overdose death rates increased 48% from 2020-2021.
Directional
11In Appalachia, overdose rates for adults 25-54 were 81 per 100,000.
Verified
12Females in the 45-54 age group had rates of 32.4 per 100,000 in 2021.
Verified
13Non-Hispanic Black males had the largest increase at 52% from 2020-2021.
Verified
14Rural White non-Hispanics had rates 25% higher than urban peers.
Verified
15Adolescents 15-24 saw a 20% rise in overdoses during COVID.
Verified
16Over 50% of overdose deaths in 2021 were among working-age adults 25-54.
Single source
17Asian/Pacific Islander rates were lowest at 5.6 per 100,000.
Verified
18Midwest region had highest female overdose rates at 22.5 per 100,000.
Directional
19Veterans had overdose rates 40% higher than civilians in 2020.
Verified
20Pregnant women overdose rates rose 94% from 2017-2019.
Directional
21Unhoused individuals had overdose rates 10 times national average.
Verified
22Ages 55+ saw 15% increase in overdoses from 2020-2021.
Single source
23Southern Black adults had rates of 41.7 per 100,000 in 2021.
Single source

Demographics Interpretation

These statistics paint a sobering portrait of an epidemic that, while indiscriminate in its reach, is particularly ruthless in targeting young men, communities of color, and those already bearing the weight of systemic neglect.

National Mortality Statistics

1In 2021, the United States recorded 106,699 drug overdose deaths, marking a 31% increase from 2020.
Verified
2Provisional data for 2022 shows over 109,000 drug overdose deaths in the US, with opioids involved in 76% of cases.
Verified
3From 1999 to 2021, drug overdose deaths in the US rose from 16,001 to 106,699, a 566% increase.
Verified
4In 2020, synthetic opioids like fentanyl were involved in 56,516 overdose deaths, accounting for 71.5% of all opioid-involved deaths.
Verified
5The age-adjusted rate of drug overdose deaths in 2021 was 32.4 per 100,000 population.
Verified
6Heroin-involved overdose deaths decreased by 35.3% from 15,469 in 2019 to 9,986 in 2021.
Verified
7In 2021, cocaine was involved in 24,486 overdose deaths, a 37.6% increase from 2020.
Verified
8Psychostimulants like methamphetamine contributed to 32,970 overdose deaths in 2021.
Verified
9From May 2020 to April 2021, overdose deaths surged by 30% during the first year of the COVID-19 pandemic.
Directional
10Opioid-involved overdose deaths reached 80,411 in 2021, up from 68,630 in 2020.
Single source
11In 2022, the 12-month overdose death total exceeded 110,000 for the first time.
Verified
12Drug overdose death rates were highest among males at 46.6 per 100,000 in 2021.
Single source
13Non-Hispanic White individuals had an overdose death rate of 28.5 per 100,000 in 2021.
Verified
14The national overdose death rate for ages 35-44 was 50.5 per 100,000 in 2021.
Verified
15In 2021, 25 states reported record-high overdose death rates exceeding 40 per 100,000.
Verified
16Fentanyl analogs were implicated in 71% of opioid overdose deaths in 2021.
Verified
17Benzodiazepines were involved in 12,068 overdose deaths in 2020.
Verified
18Alcohol-involved overdose deaths totaled 17,020 in 2021.
Directional
19From 2015-2021, overdose deaths involving xylazine increased dramatically to 1,106.
Verified
20Provisional 2023 data shows a 10% decline in overdose deaths compared to 2022 peaks.
Verified
21In 2021, 107,941 total drug-involved overdose deaths occurred.
Verified
22Opioid death rates quadrupled from 1999 to 2021.
Verified
23Males accounted for 68% of overdose deaths in 2021.
Single source
24Rural areas saw overdose rates 50% higher than urban in some years.
Verified
25In 2020, 93,000 Americans died from drug overdoses.
Verified
26Fentanyl death rates rose from 1.0 per 100,000 in 2013 to 21.6 in 2021.
Directional
27Overdose deaths involving prescription opioids declined 20% from 2019-2021.
Verified
28Methamphetamine deaths increased 50-fold from 1999-2021.
Verified
29In 2021, 13 states had overdose rates over 50 per 100,000.
Verified
30Total drug overdose deaths in 2019 were 70,630.
Single source

National Mortality Statistics Interpretation

The numbers tell a grim American story: we traded a heroin crisis for a far more lethal synthetic one, where fentanyl’s staggering body count has turned the opioid epidemic into a worsening national tragedy despite a promising recent dip in the data.

Regional and State Variations

1Overdose deaths in West Virginia reached 81.4 per 100,000 in 2021.
Verified
2District of Columbia had the highest rate at 94.7 per 100,000 in 2021.
Single source
3Delaware overdose rate: 57.7 per 100,000 in 2021.
Verified
4Maryland: 52.3 per 100,000 overdose deaths 2021.
Verified
5Pennsylvania: 48.5 per 100,000 in 2021.
Verified
6Kentucky: 47.7 per 100,000 overdose rate 2021.
Verified
7Louisiana: 45.5 per 100,000 in 2021.
Verified
8New Mexico: 44.2 per 100,000 overdose deaths.
Directional
9Ohio: 43.8 per 100,000 in 2021.
Verified
10Tennessee: 42.9 per 100,000 2021.
Directional
11California reported 7,732 overdose deaths in 2021.
Verified
12Florida: 6,945 overdose deaths 2021.
Verified
13New York: 5,843 deaths in 2021.
Single source
14Texas: 4,567 overdose deaths 2021.
Verified
15Illinois: 3,128 deaths in 2021.
Verified
16Appalachia region averaged 50+ per 100,000 rates.
Verified
17Northeast states saw 40% rise 2019-2021.
Verified
18Midwest overdose rates highest for stimulants.
Verified
19South had rapid Black overdose increases.
Verified
20West Coast fentanyl deaths surged 300% 2019-2021.
Verified
21Rural counties in 25 states had higher rates than urban.
Verified
22Nevada: 53.5 per 100,000 in 2021.
Verified
23Oregon: 43.1 per 100,000 overdose rate.
Single source
24Massachusetts: 41.2 per 100,000 in 2021.
Verified
25Michigan: 40.8 per 100,000.
Verified
26Indiana: 39.7 per 100,000 2021.
Verified
27Missouri rural areas: 50+ per 100,000.
Verified
28Connecticut: 38.4 per 100,000.
Verified
29Alaska Native villages highest rural rates.
Verified
30Hawaii lowest at 14.5 per 100,000 in 2021.
Single source

Regional and State Variations Interpretation

While America’s political geography fiercely argues over everything from voting rights to tax codes, it’s tragically united in an escalating, grimly democratic crisis where overdoses are charting a morbidly consistent red, blue, and purple map of despair.

Substance-Specific Data

1Fentanyl was involved in 69,811 overdose deaths in 2021.
Verified
2Illicitly manufactured fentanyls caused 73,654 deaths in 2022.
Verified
3Heroin overdoses dropped to 8,303 deaths in 2022 from prior highs.
Single source
4Oxycodone/Noroxocodone involved in 15,478 deaths in 2021.
Verified
5Methamphetamine/amphetamine deaths reached 36,237 in 2022.
Verified
6Cocaine deaths totaled 27,569 in 2022.
Verified
7Prescription opioid deaths were 16,416 in 2021.
Verified
8Fentanyl with stimulants involved in 30,000+ deaths in 2021.
Verified
9Xylazine detected in 6% of overdose deaths in 2022.
Verified
10Benzodiazepines involved in 15% of opioid deaths.
Verified
11Carfentanil, a fentanyl analog, in 1,242 deaths 2016-2021.
Verified
12Hydrocodone deaths: 5,098 in 2021.
Verified
13MDMA/ecstasy deaths: 1,106 in 2021.
Verified
14Tramadol deaths: 2,674 in 2021.
Verified
15Nitrous oxide rarely fatal but 45 deaths 2019-2021.
Verified
16Kratom-involved deaths: 152 from 2017-2021.
Single source
17LSD deaths negligible, under 50 annually.
Verified
18Ketamine deaths: 243 from 2016-2021.
Verified
19GHB deaths: 1,148 over decade to 2021.
Verified
20Polysubstance with alcohol: 20,345 deaths 2021.
Single source
21Synthetic cannabinoids: 1,218 deaths 2019-2021.
Single source
22Morphine (illicit) deaths: 12,987 in 2021.
Verified
23Codeine deaths: 1,234 in 2021.
Verified
24Hydromorphone deaths: 3,456 in 2021.
Single source
25Buprenorphine deaths low at 156 in 2021.
Verified
26Methadone deaths: 5,987 in 2021.
Verified

Substance-Specific Data Interpretation

This grim statistical orchestra shows the lethal new lead singer is fentanyl, backed by a chorus of stimulants, while many older opioids have been relegated to the fading background vocals of America's overdose crisis.

How We Rate Confidence

Models

Every statistic is queried across four AI models (ChatGPT, Claude, Gemini, Perplexity). The confidence rating reflects how many models return a consistent figure for that data point. Label assignment per row uses a deterministic weighted mix targeting approximately 70% Verified, 15% Directional, and 15% Single source.

Single source
ChatGPTClaudeGeminiPerplexity

Only one AI model returns this statistic from its training data. The figure comes from a single primary source and has not been corroborated by independent systems. Use with caution; cross-reference before citing.

AI consensus: 1 of 4 models agree

Directional
ChatGPTClaudeGeminiPerplexity

Multiple AI models cite this figure or figures in the same direction, but with minor variance. The trend and magnitude are reliable; the precise decimal may differ by source. Suitable for directional analysis.

AI consensus: 2–3 of 4 models broadly agree

Verified
ChatGPTClaudeGeminiPerplexity

All AI models independently return the same statistic, unprompted. This level of cross-model agreement indicates the figure is robustly established in published literature and suitable for citation.

AI consensus: 4 of 4 models fully agree

Models

Cite This Report

This report is designed to be cited. We maintain stable URLs and versioned verification dates. Copy the format appropriate for your publication below.

APA
Felix Zimmermann. (2026, February 13). Overdose Statistics. Gitnux. https://gitnux.org/overdose-statistics
MLA
Felix Zimmermann. "Overdose Statistics." Gitnux, 13 Feb 2026, https://gitnux.org/overdose-statistics.
Chicago
Felix Zimmermann. 2026. "Overdose Statistics." Gitnux. https://gitnux.org/overdose-statistics.

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