Key Takeaways
- In 2021, heart disease accounted for 1 in every 5 deaths among U.S. men, with an age-adjusted death rate of 208.3 per 100,000 men
- Men have a 50% higher risk of dying from heart disease compared to women before age 60, with lifetime risk for men at 49%
- Approximately 1 in 4 male deaths in the U.S. is due to coronary heart disease, totaling over 180,000 male deaths annually
- In 2020, prostate cancer was the second most common cancer in men worldwide, with 1.4 million new cases
- U.S. men have a 1 in 8 lifetime risk of prostate cancer diagnosis
- Lung cancer kills more men annually (127,000 in U.S.) than prostate, colorectal, and pancreatic cancers combined
- Men die from suicide 3.7 times more often than women, with 39,000 male suicides in U.S. 2021
- 1 in 10 men experience depression, but only 50% receive treatment vs. 65% women
- Anxiety disorders affect 11.1% of U.S. men annually, linked to 2x heart disease risk
- Erectile dysfunction affects 30 million U.S. men, rising to 50% over age 70
- Benign prostatic hyperplasia (BPH) prevalence 50% in men 51-60, 90% over 80
- Prostate cancer screening (PSA) detects 80% early, but 20% overdiagnosis risk
- Type 2 diabetes affects 13.0% U.S. men aged 18+, 90% undiagnosed initially
- Obesity prevalence 43.0% U.S. adult men, BMI >=30
- Metabolic syndrome in 34% U.S. men over 40, increases diabetes risk 5x
Heart disease is the leading cause of death for American men, significantly more so than for women.
Cardiovascular Health
- In 2021, heart disease accounted for 1 in every 5 deaths among U.S. men, with an age-adjusted death rate of 208.3 per 100,000 men
- Men have a 50% higher risk of dying from heart disease compared to women before age 60, with lifetime risk for men at 49%
- Approximately 1 in 4 male deaths in the U.S. is due to coronary heart disease, totaling over 180,000 male deaths annually
- African American men have the highest prevalence of hypertension at 57.1% compared to 45.3% in white men aged 18+
- Smoking causes about 20% of cardiovascular deaths in men, with 480,000 total tobacco-related deaths yearly including heart disease
- Men aged 45-64 have a stroke incidence rate of 300 per 100,000, higher than women in the same age group
- Lifetime risk of developing atrial fibrillation for men is 1 in 4, increasing stroke risk by 5-fold
- In Europe, cardiovascular disease mortality in men is 220 per 100,000, 1.5 times higher than in women
- Physical inactivity contributes to 6% of coronary heart disease cases in men under 40
- Men with type 2 diabetes have a 2-4 times higher risk of heart disease compared to non-diabetic men
- Cholesterol levels above 240 mg/dL increase heart disease risk by 2x in men over 45
- Sudden cardiac arrest occurs in men at a rate of 95 per 100,000 annually, with 90% outside hospitals
- Abdominal obesity (waist >40 inches) in men raises cardiovascular risk by 2.5 times
- Aspirin use reduces heart attack risk by 22% in high-risk men aged 40-59
- Men with family history of early heart disease have 2x risk before age 55
- Alcohol consumption >14 drinks/week increases cardiomyopathy risk by 1.5x in men
- Sleep apnea affects 13% of men over 30, increasing heart failure risk by 2-3x
- Stress-related hypertension affects 30% of working men, leading to 50% higher CVD events
- Omega-3 intake reduces sudden cardiac death by 45% in men post-heart attack
- Erectile dysfunction precedes CVD diagnosis by 3 years in 70% of men
Cardiovascular Health Interpretation
Mental Health
- Men die from suicide 3.7 times more often than women, with 39,000 male suicides in U.S. 2021
- 1 in 10 men experience depression, but only 50% receive treatment vs. 65% women
- Anxiety disorders affect 11.1% of U.S. men annually, linked to 2x heart disease risk
- PTSD prevalence in men is 6%, higher in veterans at 12%
- Substance use disorder rates: 15% men vs. 8% women lifetime
- Bipolar disorder affects 2.8% of men, with higher suicide risk (15-20%)
- Schizophrenia incidence 1.4x higher in men, onset earlier at age 18-25
- Loneliness in men over 50 increases depression risk by 25%
- Work stress contributes to 50% of male anxiety cases, leading to 30% higher absenteeism
- ADHD persists into adulthood in 50% of diagnosed boys, affecting 4.4% men
- Gambling addiction affects 3-5% men vs. 1% women
- Sleep disorders linked to 40% higher depression rates in men
- Social isolation raises suicide risk 2.5x in elderly men
- Antidepressant use in men increased 63% from 2000-2015
- Childhood trauma triples adult mental illness risk in men
- Men veterans suicide rate 1.5x civilians, 20 per day U.S.
- In 2021, suicide accounted for 14.1% of all deaths among U.S. men aged 25-34
- Globally, 75% of suicides are men, rate 2x women
- In Australia, men comprise 84% of suicides despite 51% population
- U.S. male veterans suicide rate 29.0 per 100,000 vs. 17.8 civilian men
- Depression screening positive in 8.4% U.S. men aged 18+
- Men with depression 2x likely to develop substance use disorder
- Globally, male depression underdiagnosis 50% higher due to stigma
- In UK, male suicide peak age 45-49 at 25.3 per 100,000
- Bipolar I disorder men equal women but earlier onset, higher violence risk
- OCD affects 2.1% U.S. men lifetime, compulsive behaviors dominant
Mental Health Interpretation
Metabolic Health
- Type 2 diabetes affects 13.0% U.S. men aged 18+, 90% undiagnosed initially
- Obesity prevalence 43.0% U.S. adult men, BMI >=30
- Metabolic syndrome in 34% U.S. men over 40, increases diabetes risk 5x
- Prediabetes in 38% U.S. men 18+, converts to T2D at 10%/year untreated
- NAFLD prevalence 40% obese men, progresses to cirrhosis 20%
- Gout attacks affect 4 million U.S. men, uric acid >7 mg/dL
- Insulin resistance doubles hypertension risk in overweight men
- Abdominal obesity (waist 40+ inches) in 54% U.S. men, visceral fat CVD link
- Gestational diabetes fathers increase offspring risk 2x via genetics
- Vitamin D deficiency (<20 ng/mL) in 42% obese men, worsens insulin sensitivity
- Fructose intake >25% calories triples fatty liver risk in men
- Sleep <6 hours/night raises obesity risk 45% in men
- Sedentary behavior >8 hours/day increases T2D risk 1.8x independent of exercise
- Protein intake <0.8g/kg bodyweight slows muscle preservation in diabetic men
- Binge drinking (>=5 drinks) weekly raises metabolic syndrome 1.5x
- Statin use in high-cholesterol men reduces CVD events 25%
- In 2022, 38.4 million U.S. men over 18 have diabetes or prediabetes
- Hispanic men have 13.4% diabetes prevalence vs. 11.1% non-Hispanic white
- Men diabetes 2x kidney failure risk, 45% cases
- Waist-to-height ratio >0.5 metabolic syndrome 80% men
- Fiber <25g/day triples T2D risk men
Metabolic Health Interpretation
Oncology
- In 2020, prostate cancer was the second most common cancer in men worldwide, with 1.4 million new cases
- U.S. men have a 1 in 8 lifetime risk of prostate cancer diagnosis
- Lung cancer kills more men annually (127,000 in U.S.) than prostate, colorectal, and pancreatic cancers combined
- Testicular cancer incidence in U.S. men aged 15-44 is 5.9 per 100,000, highest among young men
- Colorectal cancer screening detects 90% of cases early in men over 50, reducing mortality by 30%
- Skin cancer (melanoma) mortality in men is 2.3 times higher than women due to later diagnosis
- Bladder cancer is diagnosed in 81,000 U.S. men yearly, 75% of cases
- Oral cavity cancer risk in men is 2x higher from tobacco and alcohol, 50,000 cases/year U.S.
- Kidney cancer incidence in men is 2x that of women, 44,000 cases in U.S. men 2023
- Liver cancer deaths in U.S. men exceed 15,000 annually, linked to hepatitis and alcohol
- Pancreatic cancer 5-year survival in men is 11%, with 30,000 male deaths/year U.S.
- Brain cancer (glioblastoma) affects men 1.6x more, median survival 15 months
- Leukemia incidence in U.S. men over 65 is 25 per 100,000
- Non-Hodgkin lymphoma in men has 40,000 new cases/year U.S., 1.2x women
- HPV-related oropharyngeal cancer in U.S. men rose 63% from 1999-2014
- Esophageal cancer mortality in men is 4x women, 16,500 U.S. male deaths/year
- Thyroid cancer aggressiveness in men leads to 2x mortality rate vs. women
- Multiple myeloma incidence in African American men is 2.4x white men
- Stomach cancer in U.S. men: 13,000 cases/year, higher in Hispanics/Asians
- In 2020, colorectal cancer incidence 73 per 100,000 U.S. men
- Lifetime risk of melanoma in white men 3%, black men 0.1%
- Penile cancer rare, 2,080 U.S. cases 2023, HPV-linked 60%
- In Europe, prostate cancer mortality 21.8 per 100,000 men
- Testicular cancer survival 95% 5-year U.S. men
- Lung cancer 5-year survival 25% men, smoking 85% cases
- In Canada, male cancer deaths 41% all causes
Oncology Interpretation
Urological Health
- Erectile dysfunction affects 30 million U.S. men, rising to 50% over age 70
- Benign prostatic hyperplasia (BPH) prevalence 50% in men 51-60, 90% over 80
- Prostate cancer screening (PSA) detects 80% early, but 20% overdiagnosis risk
- Chronic prostatitis affects 10-15% men lifetime
- Kidney stones incidence 12% in men vs. 6% women lifetime
- Peyronie's disease (penile curvature) in 3-9% men over 40
- Varicocele affects 15% men, linked to 40% infertility cases
- Hydrocele prevalence 1% adult men, higher post-surgery
- Urethral stricture from injury affects 0.6% men, recurrence 10-30%
- Male infertility contributes 40-50% couples, low sperm count 90% cases
- Testicular torsion peak age 12-18, 65% left side
- Epididymitis incidence 600,000 U.S. men/year, mostly bacterial
- Hypospadias congenital rate 1 in 250 male births
- Bladder cancer recurrence 50-70% in 5 years post-treatment men
- Premature ejaculation affects 20-30% sexually active men
- Low testosterone (<300 ng/dL) in 2.1% young men, 40% over 45
- Hypogonadism symptomatic in 2.4 million U.S. men
- PSA levels >4 ng/mL in 15% men over 50 prompt biopsy
- Urinary incontinence 11% community men, 30% nursing home
- Sperm quality declined 50% since 1973 in Western men
- Prostate biopsy detects cancer in 40% elevated PSA men
- Testosterone therapy raises hematocrit >54% in 10% men, thrombosis risk
- Fournier's gangrene mortality 20-40% men diabetics
- Phimosis treated circumcision 1% adult men
Urological Health Interpretation
Sources & References
- Reference 1CDCcdc.govVisit source
- Reference 2AHAJOURNALSahajournals.orgVisit source
- Reference 3HEARTheart.orgVisit source
- Reference 4ESCARDIOescardio.orgVisit source
- Reference 5WHOwho.intVisit source
- Reference 6DIABETESdiabetes.orgVisit source
- Reference 7NHLBInhlbi.nih.govVisit source
- Reference 8NIDDKniddk.nih.govVisit source
- Reference 9USPREVENTIVESERVICESTASKFORCEuspreventiveservicestaskforce.orgVisit source
- Reference 10NIAAAniaaa.nih.govVisit source
- Reference 11SLEEPFOUNDATIONsleepfoundation.orgVisit source
- Reference 12APAapa.orgVisit source
- Reference 13MAYOCLINICmayoclinic.orgVisit source
- Reference 14CANCERcancer.orgVisit source
- Reference 15SKINCANCERskincancer.orgVisit source
- Reference 16CANCERcancer.govVisit source
- Reference 17THYROIDthyroid.orgVisit source
- Reference 18NIMHnimh.nih.govVisit source
- Reference 19ADAAadaa.orgVisit source
- Reference 20PTSDptsd.va.govVisit source
- Reference 21NIDAnida.nih.govVisit source
- Reference 22NCRGncrg.orgVisit source
- Reference 23NCBIncbi.nlm.nih.govVisit source
- Reference 24VAva.govVisit source
- Reference 25AUANETauanet.orgVisit source
- Reference 26NICHDnichd.nih.govVisit source
- Reference 27ENDOCRINEendocrine.orgVisit source
- Reference 28DIABETESJOURNALSdiabetesjournals.orgVisit source
- Reference 29ODSods.od.nih.govVisit source
- Reference 30AIHWaihw.gov.auVisit source
- Reference 31SAMHSAsamhsa.govVisit source
- Reference 32THELANCETthelancet.comVisit source
- Reference 33ONSons.gov.ukVisit source
- Reference 34SEERseer.cancer.govVisit source
- Reference 35ECISecis.jrc.ec.europa.euVisit source
- Reference 36CANCERcancer.caVisit source
- Reference 37ACADEMICacademic.oup.comVisit source
- Reference 38KIDNEYkidney.orgVisit source
- Reference 39HSPHhsph.harvard.eduVisit source
- Reference 40FDAfda.govVisit source






