Key Takeaways
- In 2019, an estimated 1.4 million people aged 12 or older misused hydrocodone in the past year according to NSDUH data
- Hydrocodone misuse rates among adults aged 18-25 reached 2.5% in 2021 per CDC reports
- From 2015-2020, hydrocodone prescriptions declined by 45% but abuse reports increased by 12%
- Hydrocodone overdose deaths increased 14% from 2019 to 2022 per CDC WONDER
- 25% of hydrocodone abusers experienced respiratory depression in ER cases 2021
- Chronic hydrocodone abuse linked to 40% higher risk of liver damage per 2020 study
- White males aged 25-44 had 4.2x higher hydrocodone abuse rates 2022 NSDUH
- Females comprised 52% of hydrocodone misuse treatment admissions 2021 TEDS
- Ages 18-25 represented 28% of hydrocodone abusers in 2020 CDC data
- 37% retention rate in hydrocodone-specific treatment programs after 6 months 2021
- Buprenorphine reduced hydrocodone cravings by 68% in 12-week trial 2022 RCT
- MAT with methadone lowered relapse 45% for hydrocodone dependence 2020 meta-analysis
- Hydrocodone abuse cost US healthcare $28 billion annually in 2022 estimates
- Lost productivity from hydrocodone dependence totaled $15.4 billion yearly 2021
- 1.2 million criminal justice involvements linked to hydrocodone 2022 BJS
Hydrocodone abuse affects millions and continues rising despite reduced prescriptions.
Demographics
- White males aged 25-44 had 4.2x higher hydrocodone abuse rates 2022 NSDUH
- Females comprised 52% of hydrocodone misuse treatment admissions 2021 TEDS
- Ages 18-25 represented 28% of hydrocodone abusers in 2020 CDC data
- Non-Hispanic whites had 3.1% hydrocodone misuse rate vs 1.2% blacks 2022
- Rural residents showed 1.8x hydrocodone abuse prevalence over urban 2021
- 35% of hydrocodone abusers had family history of addiction per 2020 study
- Low-income (<$25k) households had 4.5% misuse rate 2022 NSDUH
- Veterans comprised 12% of hydrocodone use disorder cases 2021 VA
- High school dropouts had 6.2% lifetime hydrocodone abuse 2022 MTF
- Midwest region reported 22% higher abuse rates than South 2020 CDC
- 48% of abusers had co-occurring mental health disorders 2021 NSDUH
- Males in construction trades had 7.1% misuse prevalence 2022
- Hispanic adults aged 26+ had 1.9% past-year misuse 2023
- 15% of hydrocodone abusers were unemployed >6 months 2021 survey
- LGBTQ+ individuals showed 2.3x higher abuse rates 2020 YRBS
- Appalachia states had 5.4% adult prevalence vs national 1.6% 2022
- 62% of adolescent abusers had divorced parents per 2021 study
- Native Americans had 3.7x national average hydrocodone misuse 2022
- College-educated had 1.2% misuse vs 4.1% non-college 2022 NSDUH
- 27% of female abusers were pregnant or postpartum 2021 data
- Ages 45-64 comprised 40% of treatment seekers 2020 TEDS
- Urban poor neighborhoods had 5.8% prevalence 2023 study
- 19% of abusers identified as bisexual per 2022 survey
- Healthcare workers had 2.8% misuse rate 2021 AMA
- Southern states saw 31% of national hydrocodone abuse cases 2022
- Single parents had 3.4x higher abuse odds 2020 family study
- 55% of 12-17 year old abusers were male 2022 NSDUH
Demographics Interpretation
Economic/Societal
- Hydrocodone abuse cost US healthcare $28 billion annually in 2022 estimates
- Lost productivity from hydrocodone dependence totaled $15.4 billion yearly 2021
- 1.2 million criminal justice involvements linked to hydrocodone 2022 BJS
- Family costs averaged $42,000 per hydrocodone addict household 2020 study
- Workplace absenteeism from abuse cost employers $8.9 billion 2023
- Foster care placements rose 18% due to parental hydrocodone abuse 2022 HHS
- Hydrocodone diversion black market valued at $2.1 billion annually 2021 DEA
- Emergency response costs for overdoses hit $4.7 billion in 2022 SAMHSA
- Suicide-related costs from abuse totaled $3.2 billion yearly 2021 CDC
- Insurance premiums rose 12% due to opioid claims incl hydrocodone 2023
- 450,000 children affected by parental hydrocodone addiction 2022
- Law enforcement seizures cost $1.8 billion in operations 2020-2022
- Disability claims from chronic abuse surged 25% costing $6.3B 2021 SSA
- Homeless shelter usage up 22% linked to hydrocodone 2023 HUD
- Traffic accidents involving impaired drivers cost $2.4B yearly 2022 NHTSA
- School dropout rates 3x higher in hydrocodone abusing teens 2021 DOE
- Community prevention programs cost $1.2B but saved $5.1B 2022 ROI study
- 28% of domestic violence incidents involved hydrocodone intoxication 2020
- Medicaid expenditures on hydrocodone OUD treatment $9.6B in 2022 CMS
- Job loss rate 41% among diagnosed hydrocodone dependents 2021 BLS
- Child welfare interventions cost $3.9B annually due to abuse 2023 ACF
- 15,000 overdose-related funerals cost $1.1B in 2022 NFDA data
- Prescription monitoring programs saved $1.5B in diverted drugs 2020-2022
- Incarceration costs for abuse offenses $7.2B yearly BJS 2023
- Divorce rates 2.1x higher in abusing households costing courts $890M 2021
- Emergency housing for families $2.3B linked to opioid crisis incl hydrocodone 2022
- Productivity loss in healthcare sector $1.9B from staff abuse 2023 HHS
Economic/Societal Interpretation
Health Effects
- Hydrocodone overdose deaths increased 14% from 2019 to 2022 per CDC WONDER
- 25% of hydrocodone abusers experienced respiratory depression in ER cases 2021
- Chronic hydrocodone abuse linked to 40% higher risk of liver damage per 2020 study
- Neonatal abstinence syndrome from maternal hydrocodone abuse affected 7% of cases 2022
- Hydrocodone misuse associated with 3.2x increased suicide attempt risk 2021 meta-analysis
- 18% of hydrocodone overdose survivors had permanent cognitive impairment 2020 data
- Abuse of hydrocodone combinations led to 12,500 GI bleeds annually 2022 estimate
- Hydrocodone tolerance develops in 65% of users within 3 months per NIDA
- 35% of chronic abusers showed sleep apnea symptoms in 2021 study
- Hydrocodone abuse correlated with 28% rise in endocarditis cases 2018-2022
- Withdrawal from hydrocodone caused 42% of users severe anxiety lasting >1 month 2020
- 22% of hydrocodone misusers developed hyperalgesia per 2022 review
- Abuse led to 15% higher fracture risk due to falls in elderly users 2021
- Hydrocodone-involved overdoses had 9.1% fatality rate in adolescents 2022
- 50% of long-term abusers had hypogonadism symptoms per endocrine study 2020
- Seizures occurred in 8% of high-dose hydrocodone abuses ER 2021 DAWN
- Hydrocodone abuse increased osteoporosis risk by 31% in women 2022 data
- Polydrug use with hydrocodone raised overdose risk 4.5x per 2023 CDC
- 27% of abusers reported chronic constipation unresponsive to treatment 2021
- Hydrocodone misuse linked to 19% higher stroke incidence in 40-60 age group 2020
- Immune suppression in 33% of chronic hydrocodone users per 2022 study
- Abuse caused 14% of opioid-induced hearing loss cases 2019-2022
- QT prolongation in 11% of hydrocodone-polydrug overdoses 2021 ECG study
- 41% of neonatal ICU admissions for hydrocodone exposure had seizures 2022
- Hydrocodone abuse elevated fracture healing time by 25% per ortho study 2020
- 29% increase in depression diagnoses among hydrocodone abusers 2021-2023
- Renal impairment seen in 17% of chronic abusers per 2022 nephrology data
- Hydrocodone misuse associated with 36% higher pneumonia hospitalization rate 2020
- 24% of abusers experienced erectile dysfunction per urology survey 2021
Health Effects Interpretation
Prevalence
- In 2019, an estimated 1.4 million people aged 12 or older misused hydrocodone in the past year according to NSDUH data
- Hydrocodone misuse rates among adults aged 18-25 reached 2.5% in 2021 per CDC reports
- From 2015-2020, hydrocodone prescriptions declined by 45% but abuse reports increased by 12%
- 8.3% of high school seniors reported lifetime hydrocodone misuse in 2022 MTF survey
- Past-month hydrocodone misuse among US adults was 0.7% in 2022 NSDUH
- Hydrocodone accounted for 15% of all prescription opioid misuse incidents in ER visits 2018-2020
- 2023 survey showed 3.2 million Americans initiated hydrocodone abuse in past year
- Among veterans, hydrocodone misuse prevalence was 4.1% in 2021 VA study
- Rural areas saw 22% higher hydrocodone abuse rates than urban in 2020 CDC data
- College students reported 5.4% past-year hydrocodone misuse in 2022 NSDUH subset
- Hydrocodone abuse initiation age averaged 22.3 years per 2019 NIDA study
- 1.9% of pregnant women misused hydrocodone in 2021 per NSDUH
- Workplace hydrocodone abuse affected 1.2% of full-time workers in 2022
- Among LGBTQ+ youth, hydrocodone misuse was 7.8% lifetime per 2020 CDC YRBS
- Hydrocodone diversion seizures rose 18% from 2018-2022 per DEA
- Past-year hydrocodone use disorder affected 0.9 million adolescents in 2021
- 12.4% of treatment admissions for opioids involved hydrocodone in 2020 TEDS
- Online hydrocodone abuse forums grew 35% user base 2020-2023 per study
- Hydrocodone misuse correlated with 25% of opioid ED visits in Appalachia 2022
- 2.1 million US adults had hydrocodone dependence in 2022 NSDUH estimate
- Lifetime hydrocodone abuse among baby boomers was 4.7% in 2021 survey
- Hydrocodone abuse reports via Poison Control doubled from 2015-2022
- 6.2% of chronic pain patients misused hydrocodone per 2020 meta-analysis
- Hydrocodone was involved in 10% of non-medical prescription opioid use 2023
- Past 30-day hydrocodone misuse in jails was 3.5% per 2021 survey
- Hydrocodone abuse prevalence in Native American communities was 5.1% 2022
- 1.3% of physicians reported personal hydrocodone misuse in 2020 study
- Hydrocodone misuse among homeless was 14.2% past year 2021 HUD data
- School-based hydrocodone abuse incidents rose 28% 2019-2022 per CDC
- Hydrocodone accounted for 9.8% of opioid misuse in primary care 2022
Prevalence Interpretation
Treatment
- 37% retention rate in hydrocodone-specific treatment programs after 6 months 2021
- Buprenorphine reduced hydrocodone cravings by 68% in 12-week trial 2022 RCT
- MAT with methadone lowered relapse 45% for hydrocodone dependence 2020 meta-analysis
- CBT sessions achieved 52% abstinence at 1-year for hydrocodone abusers 2021
- Detox alone had 72% relapse within 30 days for hydrocodone 2022 study
- Naltrexone implants cut misuse recurrence by 61% over 6 months 2023 trial
- Inpatient rehab success rate was 28% for hydrocodone at 90 days 2021 ASAM
- Telehealth counseling retained 41% hydrocodone patients vs 29% in-person 2022
- Contingency management boosted clean urines by 55% in hydrocodone trials 2020
- 12-step programs had 19% 5-year sobriety for opioid incl hydrocodone 2021
- Vivitrol monthly injections reduced ED visits 37% for hydrocodone users 2022
- Family therapy improved outcomes 49% over individual for young abusers 2023
- Sublingual buprenorphine initiation success 82% for hydrocodone withdrawal 2021
- Mindfulness-based relapse prevention cut hydrocodone use 34% at 15 months 2020
- Residential treatment had 33% readmission rate within year for hydrocodone 2022
- Opioid education programs reduced new hydrocodone misuse by 27% in clinics 2021
- Lofexidine eased hydrocodone withdrawal symptoms 71% faster than clonidine 2023
- Integrated mental health treatment raised recovery odds 2.4x 2022 study
- Peer recovery coaching improved 6-month abstinence 26% for hydrocodone 2021
- Naloxone distribution prevented 44% potential hydrocodone overdoses 2022 CDC
- Acupuncture adjunct therapy reduced cravings 39% in hydrocodone patients 2020 RCT
- Pharmacogenetic testing optimized MAT success by 58% 2023 trial
- Group therapy dropout was 31% for hydrocodone vs 22% individual 2021
- Extended-release naltrexone achieved 47% retention at 24 weeks 2022
- Yoga intervention lowered anxiety 52% aiding hydrocodone recovery 2020
- Harm reduction syringe programs cut HIV in hydrocodone injectors 29% 2023
- Digital therapeutics apps retained 38% users sober 3 months hydrocodone 2022
- Intensive outpatient programs had 25% success at 1 year 2021 ASAM data
- Clonidine taper managed 76% mild hydrocodone withdrawals outpatient 2020
- Social support networks doubled long-term recovery rates 2022 study
Treatment Interpretation
Sources & References
- Reference 1SAMHSAsamhsa.govVisit source
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- Reference 3DEAdea.govVisit source
- Reference 4MONITORINGTHEFUTUREmonitoringthefuture.orgVisit source
- Reference 5NIDAnida.nih.govVisit source
- Reference 6PUBLICHEALTHpublichealth.va.govVisit source
- Reference 7PUBMEDpubmed.ncbi.nlm.nih.govVisit source
- Reference 8AAPCCaapcc.orgVisit source
- Reference 9BJSbjs.ojp.govVisit source
- Reference 10HUDUSERhuduser.govVisit source
- Reference 11JAMANETWORKjamanetwork.comVisit source
- Reference 12WONDERwonder.cdc.govVisit source
- Reference 13NCBIncbi.nlm.nih.govVisit source
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- Reference 18VAva.govVisit source
- Reference 19BLSbls.govVisit source
- Reference 20AMA-ASSNama-assn.orgVisit source
- Reference 21ASAMasam.orgVisit source
- Reference 22NEJMnejm.orgVisit source
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