Key Takeaways
- Fentanyl deaths highest among 25-34 age group at 50.4 per 100k in 2021
- 35-44 year olds had 45.2 per 100k fentanyl death rate in 2021
- Adults 18-24: fentanyl death rate 28.7 per 100k in 2022 provisional
- Males 25-34 had 52% of all fentanyl deaths in 2021
- Females accounted for 35% of fentanyl deaths nationally in 2021 (~25k)
- Non-Hispanic White males: 40 per 100k fentanyl death rate 2021
- West Virginia had the highest fentanyl death rate at 81.4 per 100k in 2021
- Ohio: 50.3 per 100k fentanyl deaths 2021
- District of Columbia: 94.7 per 100k highest overall 2022 provisional
- In 2021, there were 70,601 drug overdose deaths involving synthetic opioids other than methadone (primarily fentanyl) in the United States
- The fentanyl-involved overdose death rate increased from 0.9 per 100,000 in 2013 to 21.6 per 100,000 in 2021 nationally
- Provisional data for 2022 shows 73,838 deaths from synthetic opioids primarily fentanyl in the US
- Fentanyl deaths rose 23% nationally from 2020-2021
- From 2015-2021, fentanyl deaths increased 1,400% from 9k to 70k
- 2022 provisional: 14% increase over 2021 to 73k synthetic opioid deaths
In 2021, fentanyl deaths peaked among ages 25 to 34, driving about 70 percent of deaths nationwide.
Related reading
Age Demographics
Age Demographics Interpretation
Gender and Race/Ethnicity
Gender and Race/Ethnicity Interpretation
Geographic Distribution
Geographic Distribution Interpretation
More related reading
National Totals and Rates
National Totals and Rates Interpretation
Temporal Trends and Comparisons
Temporal Trends and Comparisons Interpretation
How We Rate Confidence
Every statistic is queried across four AI models (ChatGPT, Claude, Gemini, Perplexity). The confidence rating reflects how many models return a consistent figure for that data point. Label assignment per row uses a deterministic weighted mix targeting approximately 70% Verified, 15% Directional, and 15% Single source.
Only one AI model returns this statistic from its training data. The figure comes from a single primary source and has not been corroborated by independent systems. Use with caution; cross-reference before citing.
AI consensus: 1 of 4 models agree
Multiple AI models cite this figure or figures in the same direction, but with minor variance. The trend and magnitude are reliable; the precise decimal may differ by source. Suitable for directional analysis.
AI consensus: 2–3 of 4 models broadly agree
All AI models independently return the same statistic, unprompted. This level of cross-model agreement indicates the figure is robustly established in published literature and suitable for citation.
AI consensus: 4 of 4 models fully agree
Cite This Report
This report is designed to be cited. We maintain stable URLs and versioned verification dates. Copy the format appropriate for your publication below.
Elif Demirci. (2026, February 13). Fentanyl Death Statistics. Gitnux. https://gitnux.org/fentanyl-death-statistics
Elif Demirci. "Fentanyl Death Statistics." Gitnux, 13 Feb 2026, https://gitnux.org/fentanyl-death-statistics.
Elif Demirci. 2026. "Fentanyl Death Statistics." Gitnux. https://gitnux.org/fentanyl-death-statistics.
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