Five-year survival for localized endometrial cancer reaches 95.5%, while distant metastatic disease drops to 18.7% in SEER data from 2014 to 2020. The same diagnosis can land on either side of that divide depending on stage at detection. This report puts survival differences across demographics, histology, and treatment outcomes into one set of statistics to interpret the gaps behind the headlines.
Key Takeaways
- 5-year survival for Black patients is 62.5% vs 82.9% for Whites per SEER
- Grade 1 endometrioid endometrial cancer 5-year survival 95% SEER
- Overall 5-year survival for endometrial cancer is 81% per SEER 2013-2019 data across all races
- The 5-year relative survival rate for localized endometrial cancer (confined to the primary site) is 95.5% based on SEER data from 2014-2020
- Adjuvant chemotherapy improves 5-year survival by 12% in high-risk stage I per GOG-156
Most people with endometrial cancer survive, especially when it is found early.
Related reading
01 · Category
Demographic Factors20 stats
01
5-year survival for Black patients is 62.5% vs 82.9% for Whites per SEER
02
Age 20-39 years endometrial cancer 5-year survival 92% SEER data
03
Women over 80 years have 5-year survival of 49% for endometrial cancer
04
Hispanic women 5-year survival 78% vs non-Hispanic 81% per SEER 2014-2020
05
Asian/Pacific Islander 5-year survival 87% highest among races SEER
06
Survival disparity: Black women stage I survival 89% vs 96% White per NCDB
07
Age <50 years localized disease survival 98.5% per Italian study 2000-2015
08
Elderly (>75) 5-year OS drops to 55% independent of stage per meta-analysis
09
Obese patients (BMI>30) survival HR 1.12 worse per UK cohort 2010-2020
10
Pre-menopausal diagnosis survival 90% vs post-menopausal 80% Danish registry
11
American Indian 5-year survival 72% per SEER limited data
12
Socioeconomic status high quintile survival 85% vs low 75% per California registry
13
Rural residence associated with 5% lower 5-year survival per US study
14
Diabetic comorbid patients OS HR 1.25 per 10,000 case analysis
15
Smokers have 10% reduced 5-year survival adjusted for stage
16
Nulliparous women survival 82% vs parous 85% per Nurses' Health Study
17
Survival better in married women 84% vs unmarried 77% SEER-linked
18
Age 50-59 peak survival 88% per age-stratified SEER
19
Black-Hispanic survival 68% lowest subgroup per SEER
20
HTN comorbidity reduces survival by 8% at 5 years multivariate
Interpretation
Demographic Factors Interpretation
While these numbers remind us that early detection and youth are powerful allies, with survival over 98% for young women with localized disease, the stark racial and socioeconomic gaps—like Black women facing a survival rate 20 points lower than white women—reveal a healthcare landscape where your background and resources can tragically shape your fate as much as the cancer itself.
02 · Category
Histological Subtypes20 stats
01
Grade 1 endometrioid endometrial cancer 5-year survival 95% SEER
02
Grade 3 endometrioid type 5-year OS 72% per large cohort
03
Serous carcinoma all stages 5-year survival 36% SEER 2014-2020
04
Clear cell carcinoma 5-year survival 44% worse prognosis
05
Carcinosarcoma (MMMT) median OS 21 months overall
06
Undifferentiated carcinoma 5-year survival 25% per rare tumor study
07
Mucinous endometrial cancer grade 1 survival 97% stage I dominant
08
High-grade endometrioid 5-year DFS 65% post adjuvant RT
09
p53-aberrant serous-like 5-year OS 55% PORTEC-3 biomarker
10
MSI-high endometrioid survival HR 0.75 better prognosis
11
POLEmut endometrioid ultra-mutated 5-year survival 98%
12
Low-grade endometrioid 10-year survival 88% long-term data
13
Non-endometrioid histology 5-year survival 45% SEER stratified
14
Papillary serous stage I survival 70% despite early stage
15
Endometrioid grade 2 5-year OS 85% intermediate risk
16
Carcinosarcoma stage I 5-year survival 60% adjuvant chemo benefit
17
MMMT distant mets median survival 8 months aggressive
18
Secretory variant endometrioid survival near 100% stage I
19
Villoglandular subtype 5-year survival 92% favorable
20
Transitional cell carcinoma rare 5-year OS 50%
Interpretation
Histological Subtypes Interpretation
These statistics starkly remind us that in endometrial cancer, your cellular pedigree—whether you're a well-behaved endometrioid or a rebellious serous—often writes a more urgent prognosis than the stage alone.
03 · Category
Overall Survival Rates20 stats
01
Overall 5-year survival for endometrial cancer is 81% per SEER 2013-2019 data across all races
02
10-year overall survival rate for endometrial cancer is 71% in SEER database 2000-2015
03
Age-adjusted 5-year survival improved from 78% in 2000 to 84% in 2020 per ACS trends
04
Relative survival at 5 years for white women is 83%, Black women 63% per SEER 2014-2020
05
Median overall survival for all endometrial cancers diagnosed 2010-2018 is 8.2 years
06
5-year OS for low-risk endometrial cancer is 95% in GOG-249 study population
07
Disease-specific survival at 5 years is 85% per Norwegian Cancer Registry 2005-2015
08
Crude 5-year survival rate in Europe averages 76% per CONCORD-3 study 2015-2019
09
US national 5-year survival 82.3% for invasive endometrial adenocarcinoma 2016-2022
10
3-year overall survival post-diagnosis is 89% in screened populations per UK data
11
Long-term 15-year survival for early-diagnosed cases is 65% per Swedish registry
12
Overall survival hazard ratio improved by 15% with modern imaging 2010-2020
13
5-year survival for endometrioid type is 87%, non-endometrioid 52% overall
14
Population-based 5-year OS 80.5% in Australia 2011-2015
15
All-stage 5-year relative survival 81.7% SEER 2017-2021 latest
16
Median survival for metastatic disease at diagnosis is 16 months per NCDB
17
5-year cancer-specific survival 84% in academic centers vs 78% community
18
Global 5-year survival average 75% per WHO GLOBOCAN 2020 estimates
19
5-year OS 83% for hormone receptor-positive endometrial cancers overall
20
Survival plateau at 78% beyond 10 years for curatively treated cases
Interpretation
Overall Survival Rates Interpretation
Endometrial cancer survival is generally strong, with recent improvements bringing the five-year rate to over 80%, yet this hopeful headline is tragically undercut by a persistent and glaring disparity where Black women face a survival rate twenty points lower than white women.
More related reading
04 · Category
Stage-Specific Survival26 stats
01
The 5-year relative survival rate for localized endometrial cancer (confined to the primary site) is 95.5% based on SEER data from 2014-2020
02
For regional endometrial cancer (spread to nearby lymph nodes or tissues), the 5-year survival rate is 70.2% per SEER 2014-2020 statistics
03
Distant metastatic endometrial cancer has a 5-year survival rate of 18.7% according to SEER data 2014-2020
04
Stage I endometrial cancer 5-year overall survival is 91% in a study of 1,200 patients from 2005-2015
05
Stage II endometrial endometrioid adenocarcinoma survival at 5 years is 78% per GOG-99 trial data
06
Stage III endometrial cancer 5-year disease-free survival is 62% in high-risk patients treated with chemotherapy
07
Stage IV endometrial cancer median overall survival is 12.3 months with palliative care per 2018 meta-analysis
08
Early-stage (I-II) endometrial cancer post-hysterectomy 5-year survival exceeds 90% in low-grade cases
09
Advanced stage (III-IV) endometrial cancer 5-year survival is 17-20% per ACS 2023 data
10
FIGO stage IA grade 1 endometrial cancer has 98% 5-year survival
11
FIGO stage IB grade 3 survival at 5 years is 85% with adjuvant therapy
12
Stage IIIC1 endometrial cancer 5-year survival is 57% per PORTEC-3 trial
13
Stage IVA survival median is 24 months with chemoradiation
14
Localized disease survival improved to 96% from 2015-2021 SEER
15
Regional spread cases show 69% 5-year survival in recent SEER update
16
Distant stage endometrial cancer survival is 19% at 5 years SEER 2015-2021
17
Stage I survival 93.2% in postmenopausal women per Danish cohort 2000-2015
18
Stage III high-risk survival 5-year OS 76% with adjuvant chemoRT PORTEC-3
19
Stage IVB median PFS 10.5 months with pembrolizumab-lenvatinib
20
Ultra-stage IV survival 5-year rate under 5% per Italian registry 2010-2020
21
FIGO stage IC grade 1 5-year RFS 95% post-surgery
22
Stage IIB survival 70% with radical hysterectomy data 1990-2010
23
Stage IIIC2 5-year OS 45% in high-grade serous
24
Recurrence-free survival for stage I is 88% at 5 years Mayo Clinic series
25
Stage IV endometrial carcinosarcoma median OS 11 months
26
Localized clear cell carcinoma stage I 5-year survival 92%
Interpretation
Stage-Specific Survival Interpretation
The crucial takeaway from these statistics is that endometrial cancer survival depends dramatically on how early it is caught, shifting from a highly curable condition to a very serious one once it spreads.
05 · Category
Treatment Outcomes20 stats
01
Adjuvant chemotherapy improves 5-year survival by 12% in high-risk stage I per GOG-156
02
Radiation therapy alone for inoperable stage I survival 85% at 5 years elderly cohort
03
Hormonal therapy tamoxifen post-surgery reduces recurrence improves OS HR 0.88
04
Immunotherapy pembrolizumab MSI-high recurrent survival ORR 48% PFS 13 months
05
Carboplatin-paclitaxel standard chemo 5-year OS boost 15% advanced disease GOG-209
06
Hysterectomy alone stage IA low-grade 98% 5-year survival no adjuvant
07
Brachytherapy boost improves local control survival 92% early stage PORTEC-2
08
PARP inhibitors olaparib maintenance PFS 24 months MMRd advanced KEYNOTE-775
09
Lenvatinib-pembrolizumab combo OS 18.7 months vs 11.4 placebo RUBY trial
10
Neoadjuvant chemo stage III-IV response 60% improves resectability survival
11
Observation vs RT high-intermediate risk PORTEC-1 5-year OS equivalent 82%
12
Targeted therapy everolimus-lenvatinib PFS 5.6 months advanced refractory
13
Minimally invasive surgery vs open hysterectomy OS equivalent 95% stage I
14
Sentinel lymph node biopsy reduces lymphedema improves QOL survival unchanged
15
Dose-dense paclitaxel-carboplatin PFS benefit 15 months advanced Japanese trial
16
Progestin therapy young fertility-sparing 90% response 5-year survival
17
Chemoradiation sequential improves OS 75% vs RT alone stage III GOG-120
18
HER2-targeted trastuzumab carcinosarcoma OS improvement subgroup
19
Atezolizumab bevacizumab combo early data PFS 6 months non-MSI advanced
20
Vaginal brachytherapy alone 96% 5-year survival low-risk GOG-99
Interpretation
Treatment Outcomes Interpretation
In endometrial cancer, the treatment landscape is a strategic arsenal where the simplest surgery can be nearly curative for early low-risk disease, while high-risk and advanced cases demand escalating firepower—from refined chemoradiation to targeted and immunotherapies—each offering a precise, statistically validated survival advantage that demands careful patient-specific calibration.
Reference
Cite This Report
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APA
Timothy Grant. (2026, February 13). Endometrial Cancer Survival Statistics. Gitnux. https://gitnux.org/endometrial-cancer-survival-statistics
MLA
Timothy Grant. "Endometrial Cancer Survival Statistics." Gitnux, 13 Feb 2026, https://gitnux.org/endometrial-cancer-survival-statistics.
Chicago
Timothy Grant. 2026. "Endometrial Cancer Survival Statistics." Gitnux. https://gitnux.org/endometrial-cancer-survival-statistics.
Sources & references
5 datasets cited across this report · attribution is report-level