Endometrial cancer survival outcomes are a lot more uneven than many people expect, and the latest figures available for 2025 help show why. For example, the gap between living years for early versus advanced disease is stark, and that difference matters for planning and hope. If you have ever wondered how stage, treatment type, and timing can shift survival, you will want the full breakdown behind those headline percentages.
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Demographic Factors
15-year survival for Black patients is 62.5% vs 82.9% for Whites per SEER
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2Age 20-39 years endometrial cancer 5-year survival 92% SEER data
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3Women over 80 years have 5-year survival of 49% for endometrial cancer
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4Hispanic women 5-year survival 78% vs non-Hispanic 81% per SEER 2014-2020
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5Asian/Pacific Islander 5-year survival 87% highest among races SEER
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6Survival disparity: Black women stage I survival 89% vs 96% White per NCDB
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7Age <50 years localized disease survival 98.5% per Italian study 2000-2015
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8Elderly (>75) 5-year OS drops to 55% independent of stage per meta-analysis
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9Obese patients (BMI>30) survival HR 1.12 worse per UK cohort 2010-2020
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10Pre-menopausal diagnosis survival 90% vs post-menopausal 80% Danish registry
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11American Indian 5-year survival 72% per SEER limited data
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12Socioeconomic status high quintile survival 85% vs low 75% per California registry
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13Rural residence associated with 5% lower 5-year survival per US study
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14Diabetic comorbid patients OS HR 1.25 per 10,000 case analysis
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15Smokers have 10% reduced 5-year survival adjusted for stage
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16Nulliparous women survival 82% vs parous 85% per Nurses' Health Study
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17Survival better in married women 84% vs unmarried 77% SEER-linked
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18Age 50-59 peak survival 88% per age-stratified SEER
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19Black-Hispanic survival 68% lowest subgroup per SEER
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20HTN comorbidity reduces survival by 8% at 5 years multivariate
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Demographic Factors Interpretation
While these numbers remind us that early detection and youth are powerful allies, with survival over 98% for young women with localized disease, the stark racial and socioeconomic gaps—like Black women facing a survival rate 20 points lower than white women—reveal a healthcare landscape where your background and resources can tragically shape your fate as much as the cancer itself.
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Histological Subtypes
1Grade 1 endometrioid endometrial cancer 5-year survival 95% SEER
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2Grade 3 endometrioid type 5-year OS 72% per large cohort
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3Serous carcinoma all stages 5-year survival 36% SEER 2014-2020
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4Clear cell carcinoma 5-year survival 44% worse prognosis
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5Carcinosarcoma (MMMT) median OS 21 months overall
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6Undifferentiated carcinoma 5-year survival 25% per rare tumor study
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7Mucinous endometrial cancer grade 1 survival 97% stage I dominant
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8High-grade endometrioid 5-year DFS 65% post adjuvant RT
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9p53-aberrant serous-like 5-year OS 55% PORTEC-3 biomarker
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10MSI-high endometrioid survival HR 0.75 better prognosis
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11POLEmut endometrioid ultra-mutated 5-year survival 98%
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12Low-grade endometrioid 10-year survival 88% long-term data
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13Non-endometrioid histology 5-year survival 45% SEER stratified
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14Papillary serous stage I survival 70% despite early stage
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15Endometrioid grade 2 5-year OS 85% intermediate risk
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16Carcinosarcoma stage I 5-year survival 60% adjuvant chemo benefit
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17MMMT distant mets median survival 8 months aggressive
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18Secretory variant endometrioid survival near 100% stage I
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19Villoglandular subtype 5-year survival 92% favorable
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20Transitional cell carcinoma rare 5-year OS 50%
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Histological Subtypes Interpretation
These statistics starkly remind us that in endometrial cancer, your cellular pedigree—whether you're a well-behaved endometrioid or a rebellious serous—often writes a more urgent prognosis than the stage alone.
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Overall Survival Rates
1Overall 5-year survival for endometrial cancer is 81% per SEER 2013-2019 data across all races
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210-year overall survival rate for endometrial cancer is 71% in SEER database 2000-2015
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3Age-adjusted 5-year survival improved from 78% in 2000 to 84% in 2020 per ACS trends
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4Relative survival at 5 years for white women is 83%, Black women 63% per SEER 2014-2020
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5Median overall survival for all endometrial cancers diagnosed 2010-2018 is 8.2 years
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65-year OS for low-risk endometrial cancer is 95% in GOG-249 study population
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7Disease-specific survival at 5 years is 85% per Norwegian Cancer Registry 2005-2015
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8Crude 5-year survival rate in Europe averages 76% per CONCORD-3 study 2015-2019
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9US national 5-year survival 82.3% for invasive endometrial adenocarcinoma 2016-2022
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103-year overall survival post-diagnosis is 89% in screened populations per UK data
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11Long-term 15-year survival for early-diagnosed cases is 65% per Swedish registry
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12Overall survival hazard ratio improved by 15% with modern imaging 2010-2020
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135-year survival for endometrioid type is 87%, non-endometrioid 52% overall
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14Population-based 5-year OS 80.5% in Australia 2011-2015
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15All-stage 5-year relative survival 81.7% SEER 2017-2021 latest
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16Median survival for metastatic disease at diagnosis is 16 months per NCDB
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175-year cancer-specific survival 84% in academic centers vs 78% community
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18Global 5-year survival average 75% per WHO GLOBOCAN 2020 estimates
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195-year OS 83% for hormone receptor-positive endometrial cancers overall
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20Survival plateau at 78% beyond 10 years for curatively treated cases
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Overall Survival Rates Interpretation
Endometrial cancer survival is generally strong, with recent improvements bringing the five-year rate to over 80%, yet this hopeful headline is tragically undercut by a persistent and glaring disparity where Black women face a survival rate twenty points lower than white women.
More related reading
Stage-Specific Survival
1The 5-year relative survival rate for localized endometrial cancer (confined to the primary site) is 95.5% based on SEER data from 2014-2020
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2For regional endometrial cancer (spread to nearby lymph nodes or tissues), the 5-year survival rate is 70.2% per SEER 2014-2020 statistics
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3Distant metastatic endometrial cancer has a 5-year survival rate of 18.7% according to SEER data 2014-2020
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4Stage I endometrial cancer 5-year overall survival is 91% in a study of 1,200 patients from 2005-2015
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5Stage II endometrial endometrioid adenocarcinoma survival at 5 years is 78% per GOG-99 trial data
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6Stage III endometrial cancer 5-year disease-free survival is 62% in high-risk patients treated with chemotherapy
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7Stage IV endometrial cancer median overall survival is 12.3 months with palliative care per 2018 meta-analysis
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8Early-stage (I-II) endometrial cancer post-hysterectomy 5-year survival exceeds 90% in low-grade cases
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9Advanced stage (III-IV) endometrial cancer 5-year survival is 17-20% per ACS 2023 data
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10FIGO stage IA grade 1 endometrial cancer has 98% 5-year survival
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11FIGO stage IB grade 3 survival at 5 years is 85% with adjuvant therapy
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12Stage IIIC1 endometrial cancer 5-year survival is 57% per PORTEC-3 trial
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13Stage IVA survival median is 24 months with chemoradiation
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14Localized disease survival improved to 96% from 2015-2021 SEER
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15Regional spread cases show 69% 5-year survival in recent SEER update
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16Distant stage endometrial cancer survival is 19% at 5 years SEER 2015-2021
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17Stage I survival 93.2% in postmenopausal women per Danish cohort 2000-2015
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18Stage III high-risk survival 5-year OS 76% with adjuvant chemoRT PORTEC-3
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19Stage IVB median PFS 10.5 months with pembrolizumab-lenvatinib
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20Ultra-stage IV survival 5-year rate under 5% per Italian registry 2010-2020
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21FIGO stage IC grade 1 5-year RFS 95% post-surgery
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22Stage IIB survival 70% with radical hysterectomy data 1990-2010
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23Stage IIIC2 5-year OS 45% in high-grade serous
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24Recurrence-free survival for stage I is 88% at 5 years Mayo Clinic series
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25Stage IV endometrial carcinosarcoma median OS 11 months
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26Localized clear cell carcinoma stage I 5-year survival 92%
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Stage-Specific Survival Interpretation
The crucial takeaway from these statistics is that endometrial cancer survival depends dramatically on how early it is caught, shifting from a highly curable condition to a very serious one once it spreads.
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Treatment Outcomes
1Adjuvant chemotherapy improves 5-year survival by 12% in high-risk stage I per GOG-156
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2Radiation therapy alone for inoperable stage I survival 85% at 5 years elderly cohort
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3Hormonal therapy tamoxifen post-surgery reduces recurrence improves OS HR 0.88
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4Immunotherapy pembrolizumab MSI-high recurrent survival ORR 48% PFS 13 months
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5Carboplatin-paclitaxel standard chemo 5-year OS boost 15% advanced disease GOG-209
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6Hysterectomy alone stage IA low-grade 98% 5-year survival no adjuvant
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7Brachytherapy boost improves local control survival 92% early stage PORTEC-2
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8PARP inhibitors olaparib maintenance PFS 24 months MMRd advanced KEYNOTE-775
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9Lenvatinib-pembrolizumab combo OS 18.7 months vs 11.4 placebo RUBY trial
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10Neoadjuvant chemo stage III-IV response 60% improves resectability survival
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11Observation vs RT high-intermediate risk PORTEC-1 5-year OS equivalent 82%
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12Targeted therapy everolimus-lenvatinib PFS 5.6 months advanced refractory
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13Minimally invasive surgery vs open hysterectomy OS equivalent 95% stage I
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14Sentinel lymph node biopsy reduces lymphedema improves QOL survival unchanged
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15Dose-dense paclitaxel-carboplatin PFS benefit 15 months advanced Japanese trial
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16Progestin therapy young fertility-sparing 90% response 5-year survival
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17Chemoradiation sequential improves OS 75% vs RT alone stage III GOG-120
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18HER2-targeted trastuzumab carcinosarcoma OS improvement subgroup
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19Atezolizumab bevacizumab combo early data PFS 6 months non-MSI advanced
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20Vaginal brachytherapy alone 96% 5-year survival low-risk GOG-99
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Treatment Outcomes Interpretation
In endometrial cancer, the treatment landscape is a strategic arsenal where the simplest surgery can be nearly curative for early low-risk disease, while high-risk and advanced cases demand escalating firepower—from refined chemoradiation to targeted and immunotherapies—each offering a precise, statistically validated survival advantage that demands careful patient-specific calibration.
How We Rate Confidence
Models
Every statistic is queried across four AI models (ChatGPT, Claude, Gemini, Perplexity). The confidence rating reflects how many models return a consistent figure for that data point. Label assignment per row uses a deterministic weighted mix targeting approximately 70% Verified, 15% Directional, and 15% Single source.
Single source
Only one AI model returns this statistic from its training data. The figure comes from a single primary source and has not been corroborated by independent systems. Use with caution; cross-reference before citing.
AI consensus: 1 of 4 models agree
Directional
Multiple AI models cite this figure or figures in the same direction, but with minor variance. The trend and magnitude are reliable; the precise decimal may differ by source. Suitable for directional analysis.
AI consensus: 2–3 of 4 models broadly agree
Verified
All AI models independently return the same statistic, unprompted. This level of cross-model agreement indicates the figure is robustly established in published literature and suitable for citation.
AI consensus: 4 of 4 models fully agree
Models
Cite This Report
This report is designed to be cited. We maintain stable URLs and versioned verification dates. Copy the format appropriate for your publication below.
APA
Timothy Grant. (2026, February 13). Endometrial Cancer Survival Statistics. Gitnux. https://gitnux.org/endometrial-cancer-survival-statistics
MLA
Timothy Grant. "Endometrial Cancer Survival Statistics." Gitnux, 13 Feb 2026, https://gitnux.org/endometrial-cancer-survival-statistics.
Chicago
Timothy Grant. 2026. "Endometrial Cancer Survival Statistics." Gitnux. https://gitnux.org/endometrial-cancer-survival-statistics.
Sources & References
- Reference 1SEERseer.cancer.gov
seer.cancer.gov
- Reference 2PUBMEDpubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
- Reference 3CANCERcancer.org
cancer.org
- Reference 4CANCERcancer.gov
cancer.gov
- Reference 5GCOgco.iarc.who.int
gco.iarc.who.int