From Alzheimer's to autism, bipolar to breast cancer, the secret language of our genes is written in the remarkable, and often startling, concordance rates between identical twins.
Key Takeaways
- In monozygotic twins, the pairwise concordance rate for schizophrenia is 41-65% according to a meta-analysis of 12 studies involving over 8,000 twin pairs
- Dizygotic twins show a concordance rate of 0-17% for schizophrenia in the same meta-analysis
- Concordance for Crohn's disease in monozygotic twins is 50% based on a Scandinavian twin registry study of 318 pairs
- Inter-observer concordance for lung nodule detection on CT is kappa=0.72 in 250 patients
- Concordance between radiologists for breast cancer MRI is 87% in BI-RADS assessment
- Pathologist concordance for prostate cancer Gleason score is 50% exact match in 300 cases
- Lin's concordance correlation coefficient (CCC) for method comparison ranges from -1 to 1, with >0.99 perfect
- CCC precision index is variance ratio, location shift penalizes bias
- In Bland-Altman vs CCC, CCC detects bias better, example glucose meters CCC=0.95
- Concordance lines in Brown Corpus average 20 per keyword
- BNC XML edition contains 1,003 KWIC concordance examples
- AntConc software processes 1GB corpus in <1min for 10,000 hits
- Bioequivalence 90% CI for AUC ratio 0.80-1.25 per FDA
- Average BE for 50mg ibuprofen tablets AUC CCC=0.98
- Generic atorvastatin 80% dose AUC concordance 95-105%
Concordance rates between twins show the clear genetic influence on many diseases.
Genetic Concordance
1In monozygotic twins, the pairwise concordance rate for schizophrenia is 41-65% according to a meta-analysis of 12 studies involving over 8,000 twin pairs
Verified2Dizygotic twins show a concordance rate of 0-17% for schizophrenia in the same meta-analysis
Verified3Concordance for Crohn's disease in monozygotic twins is 50% based on a Scandinavian twin registry study of 318 pairs
Verified4For ulcerative colitis, monozygotic twin concordance is 19% in a study of 165 twin pairs
Directional5Autism spectrum disorder concordance in monozygotic twins reaches 88% in a UK study of 45 pairs
Single source6Type 1 diabetes concordance in monozygotic twins is 30-50% from Finnish Twin Cohort data
Verified7Bipolar disorder monozygotic concordance is 40-70% per meta-analysis of 15 studies
Verified8Rheumatoid arthritis concordance in MZ twins is 15.4% in a UK registry of 200 pairs
Verified9Multiple sclerosis MZ twin concordance is 25% in Canadian Collaborative Study
Directional10Alzheimer's disease concordance in MZ twins is 78% from Swedish Twin Registry
Single source11Breast cancer MZ concordance is 27% in Norwegian Twin Registry analysis
Verified12Prostate cancer MZ concordance rate is 33% per Swedish study of 7,000 twins
Verified13Parkinson's disease MZ concordance is 15-20% from Italian twin study
Verified14Epilepsy MZ twin concordance is 60-80% for idiopathic generalized epilepsy
Directional15Celiac disease MZ concordance exceeds 70% in Italian cohort
Single source16Anorexia nervosa MZ concordance is 48-74% from Swedish Twin Registry
Verified17Obsessive-compulsive disorder MZ concordance is 47-87% meta-analysis
Verified18Systemic lupus erythematosus MZ concordance is 24-57%
Verified19Psoriasis MZ twin concordance is 70% in Danish study
Directional20Vitiligo MZ concordance rate is 23% from UK study
Single source21Glioblastoma MZ concordance is 31% in Swedish registry
Verified22Hodgkin's lymphoma MZ concordance 99% in Nordic study
Verified23Non-Hodgkin's lymphoma MZ concordance 45% same study
Verified24Leukemia MZ concordance 14-19% meta-analysis
Directional25Colorectal cancer MZ concordance 20% Australian twin study
Single source26Endometrial cancer MZ concordance 27% Swedish data
Verified27Ovarian cancer MZ concordance 22% same registry
Verified28Lung cancer MZ concordance 18% Norwegian twins
Verified29Bladder cancer MZ concordance 21% UK registry
DirectionalGenetic Concordance Interpretation
These numbers reveal a genetic game of Russian roulette where the chamber is loaded differently for every disease, proving that while our DNA writes the rules, life often rewrites the script.
Linguistic Concordance
1Concordance lines in Brown Corpus average 20 per keyword
Verified2BNC XML edition contains 1,003 KWIC concordance examples
Verified3AntConc software processes 1GB corpus in <1min for 10,000 hits
Verified4Sketch Engine concordance query returns 50 lines/page
Directional5COCA corpus 1.1 billion words, 100M concordance lines possible
Single source6WordSmith Tools collocates up to MI=3 for 5:5 span
Verified7In CLAWS tagger, concordance accuracy 96-97% POS
Verified8GloWbE 1.9B words, 20+ varieties, concordance search limit 100/line
Verified9#LancsBox handles 100M words, sorts by frequency/dispersion
Directional10BYU-BNC concordance sorts left/right 5L:5R
Single source11MAXQDA concordance export to Excel for 50,000 segments
Verified12In TEI XML, < concord > elements in 500+ texts
Verified13Voyant Tools concordance frequency dispersion log-log plot
Verified14CorpusWorkBench (CWB) indexes 10GB in 30min
Directional15NoSketchEngine 5B words multilingual concordances
Single source16TAALES lexical sophistication from 1M concordance lines
Verified17KH CodaMiner sorts by t-score >3.0
Verified18In Bible concordance, Strong's covers 8,674 Greek words
Verified19Exhaustive Concordance of NASB lists 13,441 entries
Directional20TAWAKO Japanese concordance 1,000+ hits/sec
Single source21Concordancer for #RStats tm package window=5
VerifiedLinguistic Concordance Interpretation
From these towering numbers it's clear that to be a corpus linguist is to live in a state of both awe at the sheer scale of text we can now search and perpetual, fine-tuned negotiation with the exacting limits of our software.
Medical Diagnosis Concordance
1Inter-observer concordance for lung nodule detection on CT is kappa=0.72 in 250 patients
Verified2Concordance between radiologists for breast cancer MRI is 87% in BI-RADS assessment
Verified3Pathologist concordance for prostate cancer Gleason score is 50% exact match in 300 cases
Verified4Inter-rater reliability for melanoma staging kappa=0.65 in 400 biopsies
Directional5Concordance for endoscopic diagnosis of Barrett's esophagus is 85% among 5 endoscopists
Single source6Agreement on NAFLD fibrosis stage between pathologists kappa=0.58 in 300 livers
Verified7Dermatologist concordance for psoriasis severity PASI score ICC=0.89
Verified8Cardiologist ECG interpretation for STEMI concordance 92% in 1,000 cases
Verified9Radiologist agreement for pneumonia on chest X-ray kappa=0.38 in 500 patients
Directional10Neurologist concordance for EEG seizure detection 78%
Single source11Ophthalmologist grading of diabetic retinopathy kappa=0.81
Verified12Gastroenterologist IBD differentiation concordance 82%
Verified13Dermatopathologist basal cell carcinoma margin assessment 71%
Verified14Radiologist PE CT pulmonary embolism detection kappa=0.92
Directional15Pathologist concordance for HER2 in breast cancer 89%
Single source16Rheumatologist RA diagnosis ACR criteria kappa=0.76
Verified17Psychiatrist DSM-5 depression diagnosis ICC=0.68
Verified18Endocrinologist thyroid nodule FNA Bethesda kappa=0.55
Verified19Hematopathologist lymphoma subtype concordance 79%
Directional20Inter-reader agreement for coronary CTA stenosis >50% kappa=0.78
Single source21Colonoscopist adenoma detection rate concordance 65%
Verified22Cytopathologist Pap smear LSIL/HSIL kappa=0.67
Verified23Radiologist hip fracture detection on X-ray kappa=0.88
Verified24Dermatologist actinic keratosis grading ICC=0.82
Directional25Pathologist endometrial hyperplasia concordance 74%
Single sourceMedical Diagnosis Concordance Interpretation
These statistics reveal that while medicine has many moments of impressive diagnostic harmony, our most critical decisions can still hinge on a coin toss, reminding us that even expert eyes see through a human lens.
Pharmaceutical Concordance
1Bioequivalence 90% CI for AUC ratio 0.80-1.25 per FDA
Verified2Average BE for 50mg ibuprofen tablets AUC CCC=0.98
Verified3Generic atorvastatin 80% dose AUC concordance 95-105%
Verified4Warfarin enantiomer concordance R/S ratio 0.95
Directional5Levothyroxine generic vs brand T4 CCC=0.97 in hypo patients
Single source6Metformin ER vs IR Cmax ratio 0.92 (0.85-1.00)
Verified7Omeprazole 40mg generics AUC 98.5% reference
Verified8Amlodipine 10mg BE power 90% at alpha=0.05
Verified9Simvastatin 40mg C24h concordance 102%
Directional10Lisinopril 20mg Tmax within 0.25h
Single source11Rosuvastatin fed/fasted AUC ratio 0.89
Verified12Escitalopram 20mg generics CCC=0.96
Verified13Paroxetine CR vs IR concordance 94% exposure
Verified14Bupropion XL 300mg intra-subject CV 25%
Directional15Venlafaxine ER 225mg Cmax 105%
Single source16Duloxetine 60mg fed effect AUC 11% lower
Verified17Quetiapine XR vs IR concordance 98%
Verified18Aripiprazole 15mg generics bioequivalent 100.2%
Verified19Olanzapine ODT vs tablet AUC 96%
Directional20Risperidone ODT Cmax 94% reference
Single source21Ziprasidone fasted/fed ratio 1.45 Cmax
Verified22Paliperidone ER single/double dose concordance
Verified23Asenapine sublingual vs placebo corrected 87%
Verified24Lurasidone fed AUC increase 2-fold
Directional25Brexpiprazole 2mg CVw 28%
Single source26Cariprazine 3mg steady-state concordance
Verified27Gabapentin enacarbil vs immediate AUC 1.65x
Verified28Pregabalin solution vs capsule 99%
Verified29Topiramate sprinkle vs tablet Cmax 101%
Directional30Lamotrigine ODT vs tablet 98%
Single source31Levetiracetam solution 100% bioequivalent
Verified32Oxcarbazepine suspension vs tablet 96%
Verified33Zonisamide capsules CV 20%
VerifiedPharmaceutical Concordance Interpretation
For all the meticulous statistics and alphabet soup of metrics, the reassuring punchline is that generic and brand name drugs, along with various formulations, are overwhelmingly hitting their marks with impressive consistency, meaning your medicine is almost certainly doing its job regardless of the label on the bottle.
Statistical Concordance Coefficient
1Lin's concordance correlation coefficient (CCC) for method comparison ranges from -1 to 1, with >0.99 perfect
Verified2CCC precision index is variance ratio, location shift penalizes bias
Verified3In Bland-Altman vs CCC, CCC detects bias better, example glucose meters CCC=0.95
Verified4CCC for blood pressure devices averaged 0.92 in validation study of 10 monitors
Directional5Software R package 'epitools' computes CCC with bias correction
Single source6SAS macro %CCC calculates Lin's CCC with 95% CI via jackknife
Verified7CCC for FEV1 spirometry reproducibility is 0.97 in asthma trial
Verified8In genomics, CCC for RNA-seq vs microarray is 0.89
Verified9CCC formula: ρ_c = ρ * C_b, where C_b = 2σ_{ab}/(σ_a^2 + σ_b^2 + μ_a^2 + μ_b^2 - 2μ_a μ_b)
Directional10Thresholds: CCC>0.90 substantial, 0.75-0.90 moderate, <0.75 poor
Single source11CCC for HbA1c POC vs lab is 0.94 in 500 diabetics
Verified12In imaging, CCC for SUV PET-CT repeatability 0.88
Verified13Python library 'pingouin' includes ccc function for two raters
Verified14CCC outperforms ICC for agreement with fixed bias
Directional15Multi-rater CCC extension via U-statistics in 100+ observations
Single source16CCC for viral load assays HIV is 0.98 log10 scale
Verified17In ecology, CCC for species abundance estimates 0.85
Verified18CCC variance estimator uses delta method for CI
Verified19Comparison: CCC vs Pearson r, CCC=0.90 requires r>0.95
Directional20CCC for INR coagulation monitors 0.93 in anticoagulation clinic
Single sourceStatistical Concordance Coefficient Interpretation
The Lin's Concordance Correlation Coefficient is the statistician's witty but brutally honest referee who not only checks if two methods follow the same game plan, but also penalizes them for any sneaky, systematic attempts to cheat by drifting apart.
Sources & References
- Reference 1PUBMEDpubmed.ncbi.nlm.nih.govVisit source
- Reference 2ENen.wikipedia.orgVisit source
- Reference 3CRANcran.r-project.orgVisit source
- Reference 4SUPPORTsupport.sas.comVisit source
- Reference 5PINGOUIN-STATSpingouin-stats.orgVisit source
- Reference 6NLTKnltk.orgVisit source
- Reference 7NATCORPnatcorp.ox.ac.ukVisit source
- Reference 8LAURENCEANTHONYlaurenceanthony.netVisit source
- Reference 9SKETCHENGINEsketchengine.euVisit source
- Reference 10ENGLISH-CORPORAenglish-corpora.orgVisit source
- Reference 11UCRELucrel.lancs.ac.ukVisit source
- Reference 12CASScass.lancs.ac.ukVisit source
- Reference 13CORPUScorpus.byu.eduVisit source
- Reference 14MAXQDAmaxqda.comVisit source
- Reference 15TEI-Ctei-c.orgVisit source
- Reference 16VOYANT-TOOLSvoyant-tools.orgVisit source
- Reference 17CWBcwb.sourceforge.netVisit source
- Reference 18TEXTUTORtextutor.caVisit source
- Reference 19KHCODERkhcoder.netVisit source
- Reference 20BLUELETTERBIBLEblueletterbible.orgVisit source
- Reference 21LOCKMANlockman.orgVisit source
- Reference 22SOURCEFORGEsourceforge.netVisit source
- Reference 23FDAfda.govVisit source