Key Takeaways
- In the United States, approximately 20.1 million adults aged 18 and older have coronary heart disease (CHD)
- Globally, cardiovascular diseases (CVDs) account for 17.9 million deaths annually, with ischemic heart disease (a form of CHD) being the leading cause at 8.9 million deaths
- The age-adjusted prevalence of CHD in US adults is 6.7% overall, rising to 24.0% in those aged 65 and older
- Smoking increases CHD risk by 2-4 times
- High blood pressure contributes to 50% of all CHD cases globally
- Diabetes doubles the risk of CHD, with 65% of diabetics dying from heart disease or stroke
- In the US, CHD caused 382,897 deaths in 2022, accounting for 1 in 5 deaths
- Globally, ischemic heart disease mortality is 16% of all deaths, or 9 million annually
- Post-myocardial infarction 1-year mortality is 10-15% in developed countries
- US spends $219 billion annually on CHD
- Global CVD economic burden $1 trillion/year, half from CHD
- Lost productivity from CHD: $101 billion/year in US
CHD is a widespread global health crisis affecting millions worldwide.
Economic and Social Impact
- US spends $219 billion annually on CHD
- Global CVD economic burden $1 trillion/year, half from CHD
- Lost productivity from CHD: $101 billion/year in US
- CABG costs average $123,000 per patient in US
- PCI procedure costs $20,000-$50,000
- Medicare CHD spending $80 billion/year
- Work absenteeism from CHD: 5.5 million lost days/year UK
- Informal caregiving for CHD patients costs $30 billion/year US
- Disability claims from CHD: 20% of all cardiovascular
- Hospitalizations for CHD: 1.2 million/year US, costing $75 billion
- Low-income CHD patients have 2x higher hospitalization rates
- Gender pay gap widens post-CHD by 10-20% for women
- CHD reduces life expectancy by 5-10 years
- Social isolation increases CHD hospitalization by 68%
- Employer costs for employee CHD: $1,500 higher annually
- Global CHD productivity losses $3.7 trillion 2011-2030
- Nursing home admissions post-CHD double costs by $50,000/year
- Racial disparities: Black CHD costs 25% higher per case
- Telemedicine for CHD saves $2,000 per patient annually
- Smoking-related CHD costs $184 billion/year US
- Obesity-attributable CHD costs $192 billion/year globally
- Cardiac rehab ROI: $2.33 saved per $1 spent
- Statins prevent $13,000 cost per MI avoided
- Aspirin therapy saves $20-40 per patient/year
Economic and Social Impact Interpretation
Mortality and Morbidity
- In the US, CHD caused 382,897 deaths in 2022, accounting for 1 in 5 deaths
- Globally, ischemic heart disease mortality is 16% of all deaths, or 9 million annually
- Post-myocardial infarction 1-year mortality is 10-15% in developed countries
- US men have age-adjusted CHD death rate of 90.9 per 100,000, women 55.8
- In low-income countries, CHD mortality is rising 2% per year
- Heart failure post-CHD affects 6.2 million US adults, with 50% 5-year mortality
- Recurrent MI occurs in 10-20% within 1 year post-event
- CHD patients have 2-4 times higher stroke risk
- In-hospital mortality for STEMI is 5-10%, NSTEMI 3-5%
- Black Americans have 30% higher CHD mortality than Whites
- Global disability-adjusted life years (DALYs) from ischemic heart disease: 182 million
- 5-year survival post-CHD diagnosis is 80-90% with treatment
- Women with CHD have 50% higher mortality post-MI than men
- Rural US CHD mortality 20% higher than urban
- Untreated hypertension leads to 50% CHD mortality increase
- Sudden cardiac death accounts for 50% of CHD deaths
- Post-CABG 10-year mortality is 20-30%
- Diabetes doubles CHD mortality risk
- Age 75+ has CHD mortality rate >500 per 100,000
- Global CHD years of life lost (YLL): 197 million annually
- PCI in-hospital mortality <1% for elective, 2-3% urgent
- Chronic total occlusion increases annual mortality by 2-3%
- Multi-vessel disease mortality 2x single-vessel
- Smoking cessation reduces CHD mortality by 36% in 5 years
- Left ventricular ejection fraction <35% post-MI: 20-40% 1-year mortality
- Atrial fibrillation in CHD patients doubles mortality risk
- PCI vs medical therapy mortality similar at 5 years (16.7% vs 18.2%)
- CABG 30-day mortality 2-3%
- STEMI door-to-balloon time >90 min increases mortality by 40%
- Aspirin reduces vascular mortality by 23% in CHD patients
- Statin therapy lowers CHD mortality by 20-30%
- Beta-blockers post-MI reduce mortality by 23%
- ACE inhibitors reduce mortality by 20% in post-MI patients
- Primary PCI for STEMI reduces mortality to 3-5% vs 7-10% thrombolysis
- Cardiac rehab reduces mortality by 20-30% post-event
- ICD implantation reduces sudden death by 30% in high-risk CHD
- CABG vs PCI: 5-year mortality 13.7% vs 19.4% in diabetes
- Radial access PCI reduces mortality by 50% vs femoral
- Optimal medical therapy alone: 2.4% annual mortality
Mortality and Morbidity Interpretation
Prevalence and Incidence
- In the United States, approximately 20.1 million adults aged 18 and older have coronary heart disease (CHD)
- Globally, cardiovascular diseases (CVDs) account for 17.9 million deaths annually, with ischemic heart disease (a form of CHD) being the leading cause at 8.9 million deaths
- The age-adjusted prevalence of CHD in US adults is 6.7% overall, rising to 24.0% in those aged 65 and older
- In Europe, the incidence of acute myocardial infarction (key CHD event) is 1.29 million cases per year
- Among US men, CHD prevalence is 7.8%, compared to 5.8% in women
- In India, CHD prevalence in urban populations is 7-13%, doubling every decade after age 40
- UK has about 2.3 million people living with CHD
- In Australia, 1 in 20 adults (over 500,000) have CHD
- China reports over 11 million CHD patients, with incidence increasing by 8.4% annually
- In the US, non-Hispanic Black adults have a CHD prevalence of 6.1%, higher than non-Hispanic White at 6.5% when adjusted
- Brazil's CHD prevalence is around 4.5% in adults over 40
- In Japan, CHD incidence is lower at 100 per 100,000 person-years compared to Western countries
- South Africa shows CHD prevalence of 8.6% in urban black populations
- Canada reports 1.6 million adults with diagnosed ischemic heart disease
- In Germany, over 2.3 million people suffer from CHD
- Mexico's CHD prevalence is 3.4% in adults, rising with urbanization
- Russia has high CHD incidence at 500-600 per 100,000 annually
- In Saudi Arabia, CHD prevalence among adults is 9.6%
- New Zealand Maori have CHD prevalence 1.5 times higher than Europeans
- In Sweden, CHD affects 4% of the population
- Turkey reports CHD prevalence of 4.1% in adults over 40
- In the US, rural areas have 20% higher CHD prevalence than urban
- Egypt shows 10.1% CHD prevalence in urban areas
- In France, 3.5 million people have CHD
- Nigeria's urban CHD prevalence is 8.3%
- In Italy, CHD incidence is 200 per 100,000
- US Hispanics have CHD prevalence of 5.9%
- In Poland, 2.5% of adults have diagnosed CHD
- Vietnam reports rising CHD incidence to 150 per 100,000
- In the US, CHD prevalence increases from 1.2% in 18-44 year olds to 18.2% in 75+
Prevalence and Incidence Interpretation
Risk Factors
- Smoking increases CHD risk by 2-4 times
- High blood pressure contributes to 50% of all CHD cases globally
- Diabetes doubles the risk of CHD, with 65% of diabetics dying from heart disease or stroke
- Obesity raises CHD risk by 50-100% in adults
- High LDL cholesterol levels increase CHD risk by 3-fold when above 190 mg/dL
- Physical inactivity accounts for 6% of the global CHD burden
- Family history doubles CHD risk if first-degree relative affected before age 60
- Men have 50% higher CHD risk than premenopausal women
- Chronic kidney disease increases CHD risk 10-50 times
- Air pollution (PM2.5) exposure raises CHD risk by 10-20% per 10 ug/m3 increase
- Excessive alcohol (>14 drinks/week) increases CHD risk by 20%
- Low socioeconomic status triples CHD risk due to multiple factors
- Hyperhomocysteinemia (>15 umol/L) associated with 2.5-fold CHD risk
- Shift work increases CHD risk by 40%
- Depression raises CHD risk by 30-64%
- HIV infection increases CHD risk 1.5-2 times due to inflammation
- Psoriasis patients have 50% higher CHD risk
- Rheumatoid arthritis doubles CHD risk
- Sleep apnea increases CHD risk by 30-140%
- High stress (job strain) linked to 20% higher CHD risk
- Oral contraceptive use in smokers over 35 increases CHD risk 4-fold
- Gout associated with 1.6-2.3 times higher CHD risk
- High triglycerides (>200 mg/dL) raise CHD risk by 30%
- Sedentary behavior >8 hours/day increases CHD risk by 147%
- Erectile dysfunction predicts CHD risk with 44% event rate in 2 years
- Metabolic syndrome increases CHD risk 2-3 fold
- Non-alcoholic fatty liver disease raises CHD risk by 64%
- Chronic obstructive pulmonary disease (COPD) doubles CHD risk
- Polycystic ovary syndrome (PCOS) increases CHD risk 2-7 fold
- Inflammatory bowel disease elevates CHD risk by 20-50%
Risk Factors Interpretation
Sources & References
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- Reference 2WHOwho.intVisit source
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