Key Takeaways
- The average adult human brain weighs about 1,300 to 1,400 grams, roughly 2% of total body weight.
- The cerebral cortex, the outer layer of the brain, has a surface area of about 2,500 square centimeters when unfolded.
- The human brain is composed of approximately 73-83% water by weight.
- The human brain contains approximately 86 billion neurons.
- Glial cells outnumber neurons by a ratio of about 1:1 in the human brain.
- There are roughly 85 billion neurons in the cerebral cortex alone.
- The brain uses 20% of body's oxygen despite 2% mass.
- Neurons transmit signals at speeds up to 120 m/s in myelinated axons.
- Short-term memory holds 7 ± 2 items for 20-30 seconds.
- The fetal brain forms 250,000 neurons per minute during peak.
- Synaptogenesis peaks at 1 quadrillion synapses by age 3.
- Brain volume triples from birth to age 3, reaching 80% adult size.
- Alzheimer's affects 10% over 65, 33% over 85.
- Stroke incidence: 795,000 cases/year in US, brain damage primary.
- Parkinson's disease: 1% population over 60, dopamine neurons lost 50-80%.
The human brain is a compact yet complex organ packed with billions of neurons.
Anatomy
- The average adult human brain weighs about 1,300 to 1,400 grams, roughly 2% of total body weight.
- The cerebral cortex, the outer layer of the brain, has a surface area of about 2,500 square centimeters when unfolded.
- The human brain is composed of approximately 73-83% water by weight.
- The brainstem, which connects the brain to the spinal cord, measures about 7-8 cm in length.
- The frontal lobe occupies about 35% of the total cerebral cortex volume.
- The human brain contains around 1,000-2,000 km of blood vessels.
- The thickness of the cerebral cortex averages 2.5 mm, ranging from 1-4.5 mm across regions.
- The occipital lobe, responsible for vision, comprises about 18% of the neocortex.
- The brain's gray matter makes up 40% of its volume, white matter 60%.
- The corpus callosum, connecting hemispheres, is about 10 cm long and contains over 200 million axons.
- The average brain volume is 1,134 cm³ in women and 1,260 cm³ in men.
- The pineal gland weighs about 0.1 grams and is 5-8 mm in size.
- The hypothalamus weighs around 4 grams and regulates homeostasis.
- The cerebellum accounts for 10% of brain volume but 50% of neurons.
- The temporal lobe volume is approximately 15-20% of the cerebral hemispheres.
- The brain's meninges consist of three layers: dura, arachnoid, and pia mater.
- Ventricles hold about 25 ml of cerebrospinal fluid in adults.
- The falx cerebri divides the cerebral hemispheres longitudinally.
- The insula is buried within the lateral sulcus, measuring 5-7 cm deep.
- The brain stem includes midbrain (2 cm), pons (2.5 cm), and medulla (3 cm).
- The parietal lobe covers about 25% of the cortex surface.
- The amygdala is almond-shaped, about 1.5 cm long.
- The hippocampus volume averages 3-4 cm³ per side.
- The thalamus relays 99% of sensory information to cortex.
- The basal ganglia occupy 5-10% of brain volume.
- The sulci and gyri increase cortical surface area by 2-3 times.
- The human brain has 12 cranial nerves originating from it.
- The choroid plexus produces 500 ml of CSF daily.
- The limbic system includes structures totaling about 5% brain volume.
- The average adult brain length is 15-17 cm, width 14 cm, height 9 cm.
Anatomy Interpretation
Cellular Composition
- The human brain contains approximately 86 billion neurons.
- Glial cells outnumber neurons by a ratio of about 1:1 in the human brain.
- There are roughly 85 billion neurons in the cerebral cortex alone.
- The cerebellum holds about 69 billion neurons, 80% of brain's total.
- Each cortical pyramidal neuron receives 7,000-10,000 synaptic inputs.
- The brain has over 100 trillion synapses in total.
- Astrocytes, a type of glia, number about 40-50 billion in the cortex.
- Oligodendrocytes produce myelin, insulating 10-50 axons each.
- Microglia constitute 10-15% of brain cells, acting as immune cells.
- Purkinje cells in cerebellum have up to 200,000 dendritic spines.
- Granule cells in cerebellum number 50 billion, smallest neurons.
- Synaptic vesicles per terminal: 100-1,000, releasing neurotransmitters.
- Neocortical neurons average 30 meters of dendrites per neuron.
- The brain produces 100 billion new synapses during early development.
- Ependymal cells line ventricles, numbering in millions.
- Schwann cells myelinate peripheral axons, absent in CNS.
- Basket cells inhibit Purkinje cells via 1-2 synapses each.
- Neurons fire action potentials at 1-100 Hz rates typically.
- GABAergic interneurons comprise 20% of cortical neurons.
- Dopaminergic neurons in substantia nigra: about 400,000.
- Serotonergic neurons in raphe nuclei: around 250,000.
- Cholinergic neurons in basal forebrain: 100,000-200,000.
- Axons can extend up to 1 meter in length in the brain.
Cellular Composition Interpretation
Development
- The fetal brain forms 250,000 neurons per minute during peak.
- Synaptogenesis peaks at 1 quadrillion synapses by age 3.
- Brain volume triples from birth to age 3, reaching 80% adult size.
- Myelination completes 90% by age 3, full by 25 years.
- Critical period for language ends around age 7-12.
- Prefrontal cortex thins 1% per year from adolescence to 30.
- Hippocampus volume increases 20% from childhood to adulthood.
- Infant brain uses 65% of resting energy at birth, drops to 43% by age 5.
- Synapse pruning eliminates 50% excess by adolescence.
- Visual cortex sensitive period: birth to 8 years.
- Brain lateralization completes by age 10 for most functions.
- Adolescent brain reward sensitivity peaks at 15, risk-taking high.
- Adult neurogenesis rate: 1,400 new hippocampal neurons daily.
- Cortical gray matter peaks at 11-12 years, then declines.
- Sleep needs drop from 16 hours newborn to 10 hours age 5.
- Mirror neuron system develops by 12 months for imitation.
- Thalamic inputs wire cortex in first 6 months post-birth.
- Brainstem reflexes mature by 3-6 months.
- Executive function improves 300% from age 3 to adulthood.
- Cerebellum grows 5x volume in first year.
- Attachment shapes amygdala by age 2.
- Brain entropy peaks at age 10, stabilizes later.
- Pubertal hormones remodel 10% prefrontal connections.
- Lifespan brain shrinkage: 5 ml/year after 40.
Development Interpretation
Diseases
- Alzheimer's affects 10% over 65, 33% over 85.
- Stroke incidence: 795,000 cases/year in US, brain damage primary.
- Parkinson's disease: 1% population over 60, dopamine neurons lost 50-80%.
- Epilepsy: 50 million worldwide, 1 in 26 lifetime risk.
- Brain tumors: 23/100,000 incidence, gliomas 30% malignant.
- Traumatic brain injury: 69 million global/year, 50% severe cognitive impact.
- Multiple sclerosis: 2.8 million worldwide, demyelination key.
- Depression: 280 million affected, shrinks hippocampus 10-15%.
- Schizophrenia: 1% lifetime risk, dopamine hypothesis central.
- Migraine: 15% population, cortical spreading depression trigger.
- Autism spectrum: 1 in 54 children, brain overgrowth early.
- ADHD: 5-7% children, prefrontal hypoactivity.
- ALS: 2/100,000 incidence, motor neurons degenerate 100%.
- Huntington's: 5-10/100,000, striatal neuron loss progressive.
- Brain aneurysm rupture: 10% mortality, 50,000 US/year.
- Encephalitis: 10-15/100,000/year viral, inflammation widespread.
- Meningitis bacterial: 1.2 million cases/year global, 20% fatality.
- Prion diseases like CJD: 1/million/year, 100% fatal rapid.
- Glioblastoma: median survival 15 months post-diagnosis.
- Concussion recovery: 80% within 7-10 days, chronic 10-20%.
- Hydrocephalus: 1/1,000 births, ventricle enlargement.
- Narcolepsy: 50/100,000, orexin neurons 90% lost.
- Frontotemporal dementia: 15-22/100,000 over 45.
- Wernicke-Korsakoff: thiamine deficiency, 1-2% alcoholics.
- Creutzfeldt-Jakob disease incubation 10-40 years prions.
- Brain abscess: 2,000-3,000 US/year, 10-20% mortality.
Diseases Interpretation
Functions
- The brain uses 20% of body's oxygen despite 2% mass.
- Neurons transmit signals at speeds up to 120 m/s in myelinated axons.
- Short-term memory holds 7 ± 2 items for 20-30 seconds.
- The brain processes visual information 60,000 times faster than text.
- Hippocampus can store about 2.5 petabytes of memories over lifetime.
- Brain consumes 20-25 watts of power continuously.
- Reaction time to visual stimulus averages 250 ms.
- The fovea processes 50% of visual cortex activity despite 1% retina.
- Working memory capacity peaks at 4±1 chunks in adults.
- Brain waves in alpha state: 8-12 Hz during relaxation.
- Language areas (Broca/Wernicke) activate in 200-400 ms for speech.
- Mirror neurons fire both during action and observation.
- Default mode network active during mind-wandering, 60-80% wake time.
- Brain plasticity allows 1-10% synapse strengthening per LTP event.
- Olfactory bulb processes 10,000 odors distinguishable.
- Pain signals processed in 100-200 ms via spinothalamic tract.
- REM sleep occupies 20-25% of total sleep time in adults.
- Brain's reward system releases 10x dopamine on drugs vs. food.
- Spatial navigation uses 1% of cortex for grid cells.
- Emotional memory recall 2-3x stronger than neutral.
- Auditory cortex processes 40 Hz gamma for speech rhythm.
- Motor cortex maps body with homunculus, hand 30% area.
- Consciousness correlates with 40 Hz gamma synchrony.
- Brain filters 99% of sensory input subconsciously.
- Episodic memory degrades 20% per decade after 30.
- Prefrontal cortex matures at 25, enabling impulse control.
- Brain solves insight problems via right hemisphere alpha waves.
- Neurogenesis adds 700 new neurons daily in adult hippocampus.
Functions Interpretation
Sources & References
- Reference 1ENen.wikipedia.orgVisit source
- Reference 2BRAINFACTSbrainfacts.orgVisit source
- Reference 3NCBIncbi.nlm.nih.govVisit source
- Reference 4MYmy.clevelandclinic.orgVisit source
- Reference 5SCIENCEDIRECTsciencedirect.comVisit source
- Reference 6FRONTIERSINfrontiersin.orgVisit source
- Reference 7PNASpnas.orgVisit source
- Reference 8BRITANNICAbritannica.comVisit source
- Reference 9NATUREnature.comVisit source
- Reference 10KENHUBkenhub.comVisit source
- Reference 11RADIOPAEDIAradiopaedia.orgVisit source
- Reference 12TEACHMEANATOMYteachmeanatomy.infoVisit source
- Reference 13NEUROSCIENTIFICALLYCHALLENGEDneuroscientificallychallenged.comVisit source
- Reference 14HOPKINSMEDICINEhopkinsmedicine.orgVisit source
- Reference 15SIMPLYPSYCHOLOGYsimplypsychology.orgVisit source
- Reference 16JOURNALSjournals.plos.orgVisit source
- Reference 17JNEUROSCIjneurosci.orgVisit source
- Reference 18CELLcell.comVisit source
- Reference 19SCIENTIFICAMERICANscientificamerican.comVisit source
- Reference 20CVRLcvrl.orgVisit source
- Reference 21SLEEPFOUNDATIONsleepfoundation.orgVisit source
- Reference 22NOBELPRIZEnobelprize.orgVisit source
- Reference 23NIMHnimh.nih.govVisit source
- Reference 24SCIENCEscience.orgVisit source
- Reference 25ANNUALREVIEWSannualreviews.orgVisit source
- Reference 26ALZalz.orgVisit source
- Reference 27CDCcdc.govVisit source
- Reference 28PARKINSONparkinson.orgVisit source
- Reference 29WHOwho.intVisit source
- Reference 30CANCERcancer.govVisit source
- Reference 31NATIONALMSSOCIETYnationalmssociety.orgVisit source
- Reference 32ALSals.orgVisit source
- Reference 33HUNTINGTONhuntington.orgVisit source
- Reference 34BAFOUNDbafound.orgVisit source
- Reference 35CANCERcancer.orgVisit source
- Reference 36NINDSninds.nih.govVisit source
- Reference 37NIAAAniaaa.nih.govVisit source






