Top 10 Best Server Antivirus Software of 2026

CrowdStrike Falcon is a cloud-native endpoint detection and response (EDR) platform that delivers next-generation antivirus protection specifically tailored for servers, using AI-driven behavioral analysis to prevent, detect, and respond to sophisticated threats in real-time. It deploys a lightweight agent that monitors server workloads across Windows, Linux, and other environments, providing unified visibility and automated remediation without heavy resource overhead. As a leader in independent tests like MITRE ATT&CK Evaluations, it excels in stopping advanced persistent threats (APTs) that traditional signature-based AV misses.

Sophos Intercept X for Server is a next-generation antivirus solution tailored for Windows, Linux, and cloud servers, providing multi-layered protection against malware, ransomware, exploits, and zero-day threats. It leverages deep learning AI, behavioral analysis, and exploit prevention technologies to deliver real-time threat detection and response with minimal performance impact. Managed through the intuitive Sophos Central cloud console, it supports physical, virtual, and hybrid environments for comprehensive server security.

SentinelOne Singularity is an AI-powered extended detection and response (XDR) platform that delivers advanced antivirus, endpoint detection, and automated threat response specifically optimized for servers across on-premises, cloud, and hybrid environments. It leverages behavioral AI and machine learning to detect zero-day threats, ransomware, and sophisticated attacks without relying on traditional signatures. The platform provides deep visibility through its patented Storyline technology, enabling rapid investigation and autonomous remediation on Windows, Linux, and Unix servers.

Bitdefender GravityZone is a cloud-managed enterprise security platform that delivers advanced antivirus and endpoint protection specifically tailored for servers in physical, virtual, and cloud environments. It provides real-time malware scanning, ransomware remediation, vulnerability assessments, and patch management through a unified console. The solution excels in multi-platform support, including Windows and Linux servers, with machine learning-driven threat detection for proactive defense.

Microsoft Defender for Endpoint is an enterprise-grade endpoint detection and response (EDR) solution with built-in antivirus capabilities tailored for servers, including Windows Server, Linux, and cloud instances. It delivers real-time malware protection, behavioral analysis, cloud-delivered updates, and advanced threat hunting using AI-driven Microsoft threat intelligence. The platform integrates deeply with Microsoft ecosystems like Azure, Microsoft 365, and Intune for centralized management and automated response.

ESET Server Security is a lightweight antivirus solution designed specifically for Windows and Linux servers, providing real-time protection against malware, ransomware, exploits, and rootkits. It features advanced scanning technologies like multi-threaded heuristic analysis and idle-state scanning to minimize performance impact on critical server environments. The software integrates seamlessly with ESET PROTECT for centralized management, policy deployment, and reporting across enterprise networks.

Trend Micro Deep Security is a robust security platform tailored for protecting servers, virtual machines, and cloud workloads against malware, exploits, and advanced threats. It combines real-time antivirus and anti-malware scanning with intrusion prevention, firewall, integrity monitoring, and vulnerability management in a single agent-based or agentless deployment. Managed via a centralized console, it excels in hybrid and multi-cloud environments, providing scalable protection for enterprise infrastructures.

Kaspersky Endpoint Security is a robust antivirus solution tailored for protecting servers against malware, ransomware, and advanced persistent threats. It provides real-time scanning, behavioral detection, vulnerability assessments, and centralized management via Kaspersky Security Center, supporting Windows Server, Linux, and virtual environments. Designed for enterprise use, it minimizes performance impact while offering features like file encryption rollback and adaptive anomaly control.

Malwarebytes Endpoint Protection is a cloud-managed cybersecurity solution that provides real-time malware detection, ransomware protection, and exploit mitigation for endpoints including Windows and Linux servers. It uses a lightweight agent with advanced remediation tools and integrates with the Nebula console for centralized management and reporting. While effective against known and zero-day threats, it focuses more on traditional antivirus capabilities rather than full-spectrum EDR for complex server environments.

ClamAV is a free, open-source antivirus engine designed for detecting trojans, viruses, malware, and other threats, primarily targeting Unix-like server environments. It offers a command-line scanner (clamscan), a multi-threaded daemon (clamd) for on-demand and on-access scanning, and freshclam for signature database updates. Commonly integrated with mail servers like Postfix and Amavis for email scanning, it provides lightweight protection suitable for servers without heavy resource demands.