Top 10 Best Quality Improvement Software of 2026

Minitab is a premier statistical software package designed specifically for quality improvement, enabling professionals to analyze data, monitor processes, and drive continuous improvement initiatives like Six Sigma and Lean. It provides an extensive array of tools including statistical process control (SPC) charts, design of experiments (DOE), capability analysis, and regression modeling. With its intuitive interface and built-in quality roadmaps, Minitab streamlines complex analyses for manufacturing, healthcare, and service industries, helping users reduce variation and enhance process efficiency.

JMP, developed by SAS Institute, is a powerful statistical software platform focused on interactive data visualization, analysis, and modeling tailored for scientists and engineers. It offers robust quality improvement tools including statistical process control (SPC) charts, process capability analysis, design of experiments (DOE), Gage R&R, and Pareto analysis. JMP enables dynamic exploration of data through its drag-and-drop interface, making it ideal for identifying trends, root causes, and optimization opportunities in manufacturing and R&D environments.

MasterControl is a robust enterprise quality management system (QMS) software tailored for highly regulated industries like life sciences, medical devices, and manufacturing. It offers modules for document control, CAPA (Corrective and Preventive Actions), audit management, training, complaints, and supplier quality to ensure compliance with FDA 21 CFR Part 11, ISO 13485, and other standards. The platform automates quality processes, provides real-time visibility, and supports risk-based decision-making to drive continuous improvement.

ETQ Reliance is a cloud-based Quality Management System (QMS) that empowers organizations to manage quality processes such as CAPA, audits, complaints, supplier management, and document control. It emphasizes configurability with a no-code platform, enabling drag-and-drop workflow customization to fit specific business needs. The software supports compliance in regulated industries like manufacturing, life sciences, and automotive through robust analytics and real-time insights for continuous improvement.

QI Macros is a powerful Microsoft Excel add-in designed for quality improvement professionals, offering over 300 pre-built statistical charts, templates, and dashboards for Lean Six Sigma analysis. It automates the creation of control charts, histograms, Pareto diagrams, fishbone diagrams, and process capability studies directly within Excel. The software simplifies data analysis, reducing the need for advanced statistical expertise while supporting SPC, root cause analysis, and reporting.

Qualio is a cloud-based electronic Quality Management System (eQMS) tailored for life sciences companies, automating key quality processes like document control, training management, CAPA, non-conformances, audits, and supplier management. It ensures compliance with regulations such as FDA 21 CFR Part 11, ISO 13485, and EU Annex 11 through validated, audit-ready workflows. Qualio promotes continuous quality improvement by enabling real-time collaboration, risk-based decision-making, and data-driven insights across teams.

ComplianceQuest is a comprehensive Quality Management System (QMS) built natively on the Salesforce platform, enabling organizations in regulated industries like manufacturing, life sciences, and automotive to streamline compliance, quality processes, and continuous improvement. It provides end-to-end modules for CAPA, audits, complaints, document control, training management, supplier quality, and non-conformances, all integrated seamlessly with Salesforce CRM for a 360-degree view of quality and customer data. The platform supports mobile access, AI-driven insights, and customizable workflows to drive proactive quality improvements.

Intellect (intellect.com) is a comprehensive cloud-based Quality Management System (QMS) platform designed to drive continuous quality improvement in regulated industries like manufacturing, healthcare, and aerospace. It provides configurable modules for CAPA, audits, document control, risk management, supplier quality, and training, enabling compliance with standards such as ISO 9001, FDA 21 CFR Part 11, and IATF 16949. The software leverages automation, analytics, and mobile accessibility to streamline processes and foster data-driven decision-making for enhanced operational efficiency.

AssurX is a robust Quality Management System (QMS) platform tailored for regulated industries like life sciences, manufacturing, and medical devices. It centralizes processes such as incident reporting, CAPA, audits, complaints, supplier management, and training to ensure compliance with FDA, ISO, and other standards. The software offers configurable workflows, real-time analytics, and risk-based quality intelligence to drive continuous improvement and reduce compliance risks.

Greenlight Guru is a cloud-based electronic Quality Management System (eQMS) tailored specifically for medical device companies to ensure compliance with standards like FDA 21 CFR Part 820, ISO 13485, and EU MDR. It provides integrated modules for document control, design controls, risk management, CAPA, audits, training, and change management, helping teams maintain an audit-ready state. The platform accelerates product development by streamlining quality processes while minimizing regulatory risks.