Top 10 Best Manufacturing Quality Management Software of 2026

MasterControl is a comprehensive Quality Management System (QMS) software tailored for regulated manufacturing industries like life sciences, medical devices, and pharmaceuticals. It automates key processes including document control, CAPA, change management, audit management, training, and non-conformance tracking to ensure compliance with FDA 21 CFR Part 11, ISO 13485, and other standards. The platform's connected quality processes enable seamless data flow across modules, reducing manual errors and accelerating time-to-market while minimizing compliance risks.

ETQ Reliance is a cloud-based Quality Management System (QMS) designed specifically for manufacturing industries to manage end-to-end quality processes including audits, CAPA, nonconformances, supplier management, and customer complaints. It excels in ensuring compliance with standards like ISO 9001, IATF 16949, and FDA regulations through configurable workflows and real-time analytics. The platform's no-code environment allows manufacturers to tailor solutions to complex, industry-specific needs without custom development.

ComplianceQuest is a cloud-based Enterprise Quality Management System (EQMS) built natively on the Salesforce platform, designed to streamline quality processes for manufacturing and regulated industries. It offers modules for CAPA, audits, complaints, non-conformance, supplier management, document control, and training, ensuring compliance with standards like ISO 9001, IATF 16949, and FDA regulations. The software leverages AI for predictive analytics and root cause analysis, providing end-to-end traceability and real-time insights to improve manufacturing quality.

PTC Arena is a cloud-based SaaS platform from PTC focused on supplier collaboration and product lifecycle management for manufacturers. It enables secure sharing of BOMs, engineering changes, and quality data with suppliers, featuring tools for non-conformance management, CAPA workflows, audits, and compliance tracking. Integrated with PTC's ecosystem like Windchill and Creo, it streamlines manufacturing quality processes across global supply chains.

Qualio is a cloud-based electronic Quality Management System (eQMS) tailored for life sciences and biotech manufacturers, streamlining quality processes like document control, CAPA, audits, training, and supplier management. It ensures compliance with regulations such as FDA 21 CFR Part 11, ISO 13485, and EU MDR through automated workflows and electronic signatures. Designed for modern teams, it reduces administrative burden in regulated manufacturing environments.

AssurX is an enterprise-quality management system (EQMS) tailored for manufacturing and regulated industries, providing tools for CAPA, audits, complaints, non-conformances, supplier management, and training to ensure compliance with standards like ISO 9001, FDA 21 CFR Part 11, and IATF 16949. It features configurable workflows, real-time dashboards, and integrations with ERP systems like SAP and Oracle to streamline quality processes and reduce risks. The platform emphasizes predictive analytics and automation to drive continuous improvement in manufacturing quality control.

Plex is a cloud-based Manufacturing Execution System (MES) and ERP platform tailored for discrete and process manufacturers, offering integrated quality management tools for planning, inspections, audits, and corrective actions. It provides real-time traceability, statistical process control, and compliance reporting to minimize defects and ensure regulatory adherence. The system unifies quality data with production operations for proactive issue resolution and continuous improvement.

DELMIAworks, formerly IQMS, is a comprehensive ERP platform designed for manufacturers, with robust Quality Management modules that handle inspections, SPC, non-conformances, and compliance tracking. It provides real-time quality data collection from the shop floor, integrating seamlessly with production, inventory, and supply chain processes to prevent defects and ensure regulatory adherence. This solution excels in discrete, repetitive, and process manufacturing environments seeking end-to-end visibility.

Epicor Kinetic is a cloud-native ERP platform designed for manufacturers, offering integrated Quality Management modules for end-to-end quality control. It supports inspection planning, non-conformance tracking, corrective actions (CAPA), and compliance with standards like ISO 9001 and IATF 16949. The system leverages real-time data from production to drive quality improvements and reduce defects across the supply chain.

QAD Quality Management is a robust module within the QAD Adaptive ERP platform, tailored for manufacturing industries to manage quality processes end-to-end. It supports incoming inspections, in-process monitoring, supplier quality management, corrective and preventive actions (CAPA), and compliance with standards like ISO 9001 and IATF 16949. The solution provides real-time analytics and digital workflows to drive continuous improvement and reduce defects in discrete and process manufacturing environments.