Top 10 Best Laboratory Billing Software of 2026

XIFIN is a premier revenue cycle management (RCM) platform designed specifically for clinical laboratories, pathology groups, and diagnostics providers. It automates complex laboratory billing processes, including claims submission, denial management, and patient collections, while leveraging AI for predictive analytics and optimization. The solution excels in handling high-volume, multi-specialty lab billing with compliance to payer rules and supports anatomic pathology, molecular diagnostics, and reference labs.

SCC Soft Computer's laboratory billing software is integrated within their SoftLab LIS platform, providing end-to-end revenue cycle management for clinical laboratories. It automates charge capture from test orders, handles claims scrubbing, EDI submissions, and denial management while ensuring compliance with HIPAA and payer regulations. The solution excels in high-volume environments by linking lab workflows directly to billing for accuracy and efficiency.

Orchard Software provides a comprehensive Laboratory Information System (LIS) with a robust integrated billing module tailored for clinical, anatomic pathology, and reference laboratories. It automates the entire revenue cycle, including charge capture, CPT/ICDM coding, electronic claims submission to multiple payers, ERA posting, denial management, and AR tracking. The system ensures compliance with HIPAA, CLIA, and payer-specific rules while integrating seamlessly with EHRs, practice management systems, and lab instruments.

Psyche Systems offers Thoroughbred Billing, a specialized laboratory billing software integrated within their LIS platform, designed for clinical labs to automate charge capture, claims processing, and revenue cycle management. It handles complex lab-specific billing rules, including CPT coding, modifiers, and payer-specific requirements for Medicare, Medicaid, and commercial insurers. The solution emphasizes compliance, denial management, and AR optimization to improve lab financial performance.

Cerner Millennium is a comprehensive enterprise EHR platform from Oracle Health (formerly Cerner) that includes robust laboratory billing modules integrated with its clinical laboratory information system (LIS). It automates lab charge capture, coding (CPT, ICD-10), claims scrubbing, and revenue cycle management, ensuring compliance with payer requirements and reducing denials. Ideal for high-volume labs within large health systems, it supports real-time eligibility verification and analytics for billing optimization.

Epic Beaker is a robust laboratory information system (LIS) from Epic Systems, designed to manage end-to-end lab workflows including order management, testing, result reporting, and integrated billing for clinical, anatomic, and molecular laboratories. It excels in seamless integration with Epic's electronic health record (EHR) and revenue cycle management, automating charge capture, coding, and claims submission. Primarily targeted at large healthcare enterprises, Beaker ensures compliance with regulatory standards like HIPAA and supports high-volume lab operations.

LabVantage is a robust Laboratory Information Management System (LIMS) with integrated billing capabilities designed for laboratories handling clinical, research, and testing workflows. It automates invoicing by linking test orders, results, and financial transactions, supporting complex pricing rules, insurance claims, and revenue cycle management. The software excels in providing traceability from sample intake to billing, reducing errors and improving compliance in regulated environments.

LabWare is a comprehensive Laboratory Information Management System (LIMS) that includes integrated billing modules for managing laboratory invoicing, client accounts, and financial reporting. It automates billing based on sample testing workflows, test pricing, and approval processes, making it suitable for labs requiring end-to-end operations. While not a standalone billing solution, its billing capabilities are tightly coupled with core LIMS functions like sample tracking and instrument integration.

STARLIMS is a comprehensive Laboratory Information Management System (LIMS) from Abbott Informatics that includes a robust billing module designed for clinical, research, and testing laboratories. It automates billing processes such as charge capture, insurance claims, patient invoicing, and revenue cycle management, all integrated seamlessly with core lab workflows like sample tracking and reporting. This makes it suitable for labs needing end-to-end operations rather than standalone billing tools.

athenahealth's athenaOne platform offers comprehensive revenue cycle management (RCM) capabilities tailored for healthcare providers, including specialized laboratory billing features like automated claims submission, eligibility verification, and denial management. It integrates seamlessly with EHR functionalities to handle lab-specific CPT/HCPCS coding, payment posting, and AR tracking. Designed for scalability, it supports labs from small practices to large enterprises with cloud-based access and real-time analytics.