Top 10 Best Endpoint Security Software of 2026

CrowdStrike Falcon is a cloud-native endpoint detection and response (EDR) platform that delivers next-generation antivirus, threat prevention, detection, and response capabilities through a single, lightweight agent. Leveraging AI, machine learning, and behavioral analysis, it identifies and stops sophisticated attacks in real-time across endpoints, workloads, and cloud environments. Falcon also includes managed detection services like Falcon OverWatch for expert threat hunting, making it a comprehensive solution for enterprise security.

Microsoft Defender for Endpoint is a cloud-delivered endpoint security platform that protects devices across Windows, macOS, Linux, Android, and iOS with next-generation antivirus, endpoint detection and response (EDR), and attack surface reduction rules. It leverages AI-driven behavioral analysis and integrates deeply with the Microsoft 365 security stack for unified threat intelligence and automated response. Designed for enterprises, it helps organizations reduce risk through vulnerability management, secure configuration assessment, and cross-endpoint correlation.

SentinelOne Singularity is a comprehensive AI-powered endpoint protection platform (EPP/EDR/XDR) designed to detect, prevent, and respond to advanced threats autonomously. It leverages behavioral AI engines for real-time threat hunting, automated remediation, and one-click rollback to restore systems without data loss. The platform provides unified visibility across endpoints, cloud workloads, and identities through its intuitive Storyline interface and Purple AI assistant for accelerated investigations.

Palo Alto Networks Cortex XDR is a comprehensive Extended Detection and Response (XDR) platform that unifies endpoint protection, behavioral analytics, and threat intelligence to prevent, detect, and respond to sophisticated cyberattacks. It leverages Precision AI and machine learning to analyze endpoint, network, and cloud data in real-time, providing autonomous prevention and remediation capabilities. Ideal for enterprise environments, it integrates seamlessly with Palo Alto's broader security ecosystem for enhanced visibility and faster incident response.

Trend Micro Apex One is a comprehensive endpoint protection platform (EPP) designed for enterprises, combining next-generation antivirus (NGAV), endpoint detection and response (EDR), and advanced threat prevention capabilities. It leverages AI-powered behavioral analysis, machine learning, and sandboxing to defend against malware, ransomware, zero-day exploits, and advanced persistent threats. The solution includes centralized management via Apex Central console, vulnerability shielding, application control, and USB device security, making it scalable for large deployments.

Sophos Intercept X is a next-generation endpoint detection and response (EDR) solution that leverages deep learning AI for real-time malware detection, exploit prevention, and ransomware protection. It defends against advanced threats like fileless attacks, zero-days, and tamper-proof malware through behavioral analysis and CryptoGuard technology. Integrated with Sophos XDR, it provides centralized management and managed detection services for comprehensive endpoint security.

Bitdefender GravityZone is a cloud-based endpoint detection and response (EDR) platform designed for businesses, offering multi-layered protection including antivirus, anti-ransomware, behavioral analysis, and patch management. It provides centralized management through an intuitive console, supporting Windows, macOS, Linux, and virtual environments. The solution excels in risk analytics and network threat defense, making it suitable for mid-sized to enterprise organizations seeking scalable security.

Cisco Secure Endpoint is an advanced endpoint detection and response (EDR) platform that combines next-generation antivirus (NGAV), behavioral analysis, and machine learning to protect against malware, ransomware, and zero-day threats. Leveraging Cisco Talos threat intelligence, it enables real-time threat detection, automated response, and retrospective analysis via a cloud-managed console. The solution excels in exploit prevention and integrates deeply with Cisco's broader security ecosystem, including SecureX for streamlined operations.

McAfee Endpoint Security is a comprehensive enterprise-grade endpoint protection platform that delivers multi-layered defense including antivirus, anti-malware, firewall, web control, and exploit prevention. It leverages machine learning, behavioral analysis, and signature-based detection to combat advanced persistent threats, ransomware, and zero-day attacks. Centralized management via ePolicy Orchestrator (ePO) or cloud consoles enables efficient deployment and policy enforcement across large networks.

ESET Endpoint Security is a robust endpoint protection platform designed for businesses, offering multi-layered defense against malware, ransomware, exploits, and network attacks. It combines signature-based detection, machine learning, behavioral analysis, and a two-way firewall, with tools for device control and web filtering. Centralized management via ESET PROTECT enables efficient deployment and monitoring across Windows, macOS, Linux, and mobile devices.