Key Takeaways
- In 2020, about 1 in 36 (2.8%) children aged 8 years in the United States were identified with Autism Spectrum Disorder (ASD).
- The prevalence of ASD among 8-year-old boys in the US was 4.3% (1 in 23) in 2020 surveillance data.
- ASD prevalence among US children aged 4 years was 1 in 44 (2.3%) based on 2020 data from 11 sites.
- US children aged 8 years with ASD who were born preterm (≤37 weeks) had higher prevalence rates.
- Among US Black children with ASD aged 8, 39.4% had intellectual disability in 2020.
- Girls with ASD are diagnosed 1.5 years later on average than boys (age 5 vs. 3.5 years).
- Repetitive behaviors observed in 88% of young children with ASD.
- Social communication deficits core to 100% of ASD diagnoses per DSM-5.
- Sensory sensitivities affect 90-95% of individuals with ASD.
- IQ variance in ASD: 30% gifted (IQ>130), 25% ID (IQ<70).
- Memory strengths (rote) in 60% ASD vs. weaknesses in working memory 80%.
- Central coherence weak (detail bias) in 65% ASD cognitive profiles.
- 100+ genetic loci associated with ASD risk per 2022 GWAS.
- Heritability of ASD estimated at 80-90% from twin studies.
- De novo mutations account for 11-20% ASD cases.
Autism prevalence is increasing globally, with significant variation among demographics and regions.
Behavioral
- Repetitive behaviors observed in 88% of young children with ASD.
- Social communication deficits core to 100% of ASD diagnoses per DSM-5.
- Sensory sensitivities affect 90-95% of individuals with ASD.
- Echolalia present in 75% of verbal ASD children under 5 years.
- Restricted interests reported in 88% of ASD adolescents.
- Self-injurious behavior occurs in 28-50% of ASD children with ID.
- Joint attention deficits in 85% of toddlers later diagnosed with ASD.
- Aggression towards caregivers in 68% of minimally verbal ASD teens.
- Hyper/hyposensitivity to sound in 92.8% of ASD children per survey.
- Routines insistence affects 74% of ASD individuals daily.
- Pronoun reversal in 30-50% of young ASD children speech.
- Motor stereotypies (hand-flapping) in 60-80% of ASD preschoolers.
- Theory of mind impairment in 65-80% of high-functioning ASD adults.
- Executive function deficits (planning) in 80% of ASD school-age children.
- Visual processing advantages (detail-focused) in 40% of ASD population.
- Meltdown frequency 3-5x/week in 42% of ASD children without support.
- Literal language interpretation in 95% of ASD individuals.
- Head-banging self-injury peaks at 14% in ASD ages 5-10.
- Eye contact aversion correlates with 70% social anxiety in ASD.
- Food selectivity (texture aversion) in 70-89% ASD children.
- Prosody abnormalities (monotone voice) in 79% ASD speakers.
- Handwriting difficulties in 62% of ASD schoolchildren.
- Empathy deficits (cognitive) in 75% high-functioning ASD.
- Tactile defensiveness in 69% of ASD young adults.
Behavioral Interpretation
Cognitive
- IQ variance in ASD: 30% gifted (IQ>130), 25% ID (IQ<70).
- Memory strengths (rote) in 60% ASD vs. weaknesses in working memory 80%.
- Central coherence weak (detail bias) in 65% ASD cognitive profiles.
- Language delay in 65% of ASD children by age 3.
- Nonverbal IQ averages 85 in ASD vs. 100 general population.
- Reading comprehension lags 2 grades behind in 55% ASD students.
- Math abilities superior in 25% ASD (savant-like).
- Attention switching deficits score 2 SD below mean in 75% ASD.
- Verbal fluency low in 70% ASD despite vocabulary strengths in 40%.
- Face recognition impairment in 50-70% ASD population.
- Problem-solving rigidity in 82% ASD executive function tests.
- Savant skills in 10% ASD (calendar calculation, art).
- Adaptive skills IQ averages 68 in ASD vs. cognitive IQ 85.
- Pretend play absence in 90% ASD toddlers.
- Spatial skills enhanced in 35% males with ASD.
- Inhibition control poor (2.5 SD deficit) in 60% ASD children.
- Gesture use reduced by 50% in ASD preschoolers.
- Multisensory integration deficits in 75% ASD sensory profiles.
- Causal learning impaired in 68% ASD experimental tasks.
Cognitive Interpretation
Demographics
- US children aged 8 years with ASD who were born preterm (≤37 weeks) had higher prevalence rates.
- Among US Black children with ASD aged 8, 39.4% had intellectual disability in 2020.
- Girls with ASD are diagnosed 1.5 years later on average than boys (age 5 vs. 3.5 years).
- 35% of US children with ASD are from households earning under $25,000 annually per 2021 data.
- Comorbid epilepsy occurs in 20-30% of individuals with ASD across lifespan.
- ADHD comorbidity in ASD children is 28-44% in US population studies.
- Anxiety disorders affect 40% of children with ASD per meta-analysis.
- Gastrointestinal issues reported in 23% of ASD vs. 14% of non-ASD children aged 8.
- Sleep problems occur in 50-80% of children with ASD according to reviews.
- Wandering/elopement risk is 49% lifetime for children with ASD.
- 31% of US adults with ASD have fair/poor health vs. 7% general population.
- Obesity rates in ASD adolescents are 22.4% vs. 15.1% in neurotypical peers.
- 70% of ASD individuals have motor delays per developmental studies.
- Hearing loss comorbidity in ASD is 13% higher than general population.
- Vision problems affect 28-45% of children with ASD.
- Sibling recurrence risk for ASD is 18.7% if one sibling affected.
- Maternal age >35 increases ASD risk by 1.6-fold in offspring.
- Paternal age >50 raises ASD odds by 1.65 per meta-analysis.
- Prematurity (<37 weeks) associated with 1.5-2x higher ASD risk.
- Low birth weight (<2500g) correlates with 2.3x ASD prevalence.
- 44% of US ASD children aged 8 have intellectual disability (IQ<70).
- ASD in Down syndrome population is 12-19% comorbidity rate.
- Females with ASD show higher internalizing behaviors (80%) than males.
- Urban residence linked to 1.2x higher ASD diagnosis rates in US.
- 82% of ASD parents report high stress levels vs. 38% typical parents.
- Employment rate for ASD adults is 14-21% full-time.
- 85% of college-age ASD individuals have no paid job market participation.
- Median age of ASD diagnosis in US girls is 5 years vs. 4 for boys.
Demographics Interpretation
Environmental
- Prenatal valproic acid exposure increases ASD risk 10-fold.
- Advanced parental age (father >40) OR=1.31 for ASD.
- Maternal obesity (BMI>30) OR=1.47 ASD risk.
- Gestational diabetes linked to 1.42x ASD odds.
- Air pollution (PM2.5) exposure prenatal OR=1.12 per 10ug/m3.
- Assisted reproductive tech (IVF) OR=1.35-2.0 ASD risk.
- Maternal fever during pregnancy OR=1.4 ASD.
- Pesticide exposure (organophosphates) OR=1.6 ASD.
- Maternal SSRI use 2nd trimester OR=1.5 ASD risk.
- Vitamin D deficiency prenatal OR=1.34 ASD.
- Cesarean delivery OR=1.23 ASD association.
- Heavy metals (mercury) exposure OR=1.5-2.0.
- Maternal autoimmune disease OR=1.43 ASD offspring.
- Hypoxia at birth OR=2.0 ASD risk.
- No vaccine-autism link confirmed (OR=0.99) in 1.2M children study.
Environmental Interpretation
Genetic
- 100+ genetic loci associated with ASD risk per 2022 GWAS.
- Heritability of ASD estimated at 80-90% from twin studies.
- De novo mutations account for 11-20% ASD cases.
- CHD8 gene mutations cause 0.5-1% ASD with macrocephaly.
- Fragile X syndrome comorbidity in 1-2% ASD males.
- SHANK3 deletions linked to 1% ASD with severe ID.
- Copy number variants (CNVs) >10kb in 10-15% ASD genomes.
- SCN2A mutations in 1% ASD with epilepsy onset infancy.
- FMR1 premutation carriers have 50% ASD risk in offspring.
- 16p11.2 deletion/duplication in 0.5-1% ASD cases.
- Polygenic risk scores predict 5-10% ASD variance.
- MECP2 mutations (Rett-like) in 0.3% female ASD.
- Epigenetic changes (methylation) altered in 20% ASD brains.
- ADNP syndrome (ADNP mutations) causes 0.2% ASD cases.
- Synaptic gene disruptions in 25% ASD exome sequencing.
- Tuberous sclerosis (TSC1/2) comorbid with 25-50% ASD.
- NRXN1 deletions associated with 0.8% ASD risk.
- Chromatin modifier genes mutated in 15% ASD.
- Angelman syndrome (UBE3A) has 42% ASD comorbidity.
Genetic Interpretation
Prevalence
- In 2020, about 1 in 36 (2.8%) children aged 8 years in the United States were identified with Autism Spectrum Disorder (ASD).
- The prevalence of ASD among 8-year-old boys in the US was 4.3% (1 in 23) in 2020 surveillance data.
- ASD prevalence among US children aged 4 years was 1 in 44 (2.3%) based on 2020 data from 11 sites.
- Global prevalence estimates for ASD range from 1% to 2% in recent meta-analyses of children worldwide.
- In South Korea, a 2011 study found ASD prevalence of 2.64% (1 in 38) among children aged 7-12 years.
- UK prevalence of ASD is estimated at 1.57% (1 in 64) for children aged 9-10 years from the 2018 National Autistic Society report.
- ASD identification rates in California increased from 0.3 per 1,000 in 1990 to 4.5 per 1,000 in 2018 among 8-year-olds.
- Among US Black children aged 8 years, ASD prevalence reached 3.3% (1 in 30) in 2020, higher than previous years.
- In Australia, ASD prevalence is 2.5% (1 in 40) for children under 8 years per the 2018 report.
- Sweden reports ASD prevalence of 1.53% among 7-12-year-olds in a 2019 registry study.
- Lifetime prevalence of ASD in adults is estimated at 1.1% in the US based on 2021 national surveys.
- In China, a 2020 meta-analysis estimated ASD prevalence at 0.99% (1 in 101) among children.
- Japan’s 2018 survey found ASD prevalence of 3.22% (1 in 31) in 5-year-olds.
- Canada reports 1 in 50 children (2%) with ASD per 2018 Public Health Agency data.
- In the US, ASD prevalence among Asian/Pacific Islander children aged 8 was 2.4% in 2020.
- France estimates ASD prevalence at 0.69% (1 in 144) from 2019 national studies.
- India’s urban child ASD prevalence is 1 in 89 per a 2021 systematic review.
- New Zealand ASD prevalence is 1.55% (1 in 65) for 8-year-olds in 2018 data.
- In the US, 1 in 26 boys vs. 1 in 111 girls aged 8 years had ASD in 2020.
- Lifetime cost of supporting an individual with ASD in the US averages $2.4 million.
- ASD prevalence in US rural areas was 2.4% vs. 2.9% in urban areas for 8-year-olds in 2020.
- Europe-wide ASD prevalence meta-analysis (2020) yields 0.98% (1 in 102).
- In Taiwan, ASD prevalence among school-aged children is 1.72% per 2019 study.
- US Hispanic children ASD prevalence rose to 2.7% (1 in 37) in 2020 data.
- Global adult ASD prevalence estimated at 0.7-1% in 2022 review.
- In the US, ASD identified in 1 in 34 White children aged 8 years in 2020.
- Brazil reports ASD prevalence of 0.27% (1 in 367) in children per 2020 survey.
- Scotland’s 2019 data shows ASD prevalence of 2.46% in school children.
- In the US, early identification of ASD increased to 48% by age 4 years in 2020.
- Denmark registry shows ASD prevalence of 1.66% (1 in 60) in 2016 birth cohort.
Prevalence Interpretation
Treatment
- Early intensive behavioral intervention (EIBI) improves IQ by 17 points.
- Applied Behavior Analysis (ABA) 20-40 hrs/week gains 47% IQ points.
- Speech therapy improves expressive language by 18 months in 70% ASD toddlers.
- Risperidone reduces irritability by 57% in ASD youth RCTs.
- TEACCH structured teaching boosts adaptive skills 20%.
- Social skills training groups improve peer interaction 35%.
- Sensory integration therapy reduces sensory issues 40% per meta.
- Aripiprazole decreases aggression 52% in ASD children.
- Floortime/DIR model advances social-emotional age 11 months.
- Oxytocin nasal spray improves social cognition temporarily 25%.
- Pivotal Response Training (PRT) boosts language 2.5 words/hour.
- Melatonin reduces sleep onset latency by 37 min in ASD.
- Cognitive Behavioral Therapy (CBT) cuts anxiety 30% in high-functioning ASD.
- Propranolol lowers self-injurious behavior 50%.
- Occupational therapy improves fine motor skills 25 percentiles.
- Bumetanide diuretic improves ASD symptoms 30% in trials.
- Early Start Denver Model (ESDM) gains 17 IQ, 18 receptive lang.
- N-acetylcysteine (NAC) reduces irritability 28%.
- Music therapy enhances communication 20% in non-verbal ASD.
- Guanfacine adjunct reduces hyperactivity 40%.
- SCERTS model improves emotional regulation 35%.
- Memantine (NMDA antagonist) improves lang. in 40% verbal ASD.
- Hanen More Than Words program boosts parent-child interaction 70%.
- Atomoxetine for ADHD in ASD improves attention 25%.
- Vitamin B6/magnesium combo reduces symptoms 49% in small trials.
Treatment Interpretation
Sources & References
- Reference 1CDCcdc.govVisit source
- Reference 2NCBIncbi.nlm.nih.govVisit source
- Reference 3AUTISMautism.org.ukVisit source
- Reference 4DDSdds.ca.govVisit source
- Reference 5AIHWaihw.gov.auVisit source
- Reference 6PUBMEDpubmed.ncbi.nlm.nih.govVisit source
- Reference 7CANADAcanada.caVisit source
- Reference 8HEALTHhealth.govt.nzVisit source
- Reference 9GOVgov.scotVisit source
- Reference 10AUTISMSPEAKSautismspeaks.orgVisit source
- Reference 11NIMHnimh.nih.govVisit source
- Reference 12NATIONALAUTISMASSOCIATIONnationalautismassociation.orgVisit source
- Reference 13HANENhanen.orgVisit source






