Key Takeaways
- The lifetime prevalence of Antisocial Personality Disorder (ASPD) in the United States is approximately 3.7% in men and 1.6% in women based on the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)
- Globally, the pooled prevalence of ASPD from 24 studies is 3.0% (95% CI: 2.4-3.7%), with higher rates in high-income countries at 3.7%
- In prison populations, ASPD prevalence reaches 47-64% among male inmates according to a systematic review of 62 surveys
- Childhood conduct disorder predicts 40-50% of adult ASPD cases, per meta-analysis of 23 studies
- Heritability of ASPD is 40-50% from twin studies like the Finnish Twin Cohort
- Low socioeconomic status increases ASPD risk by 2-3 fold, per UK Biobank data
- A core symptom of ASPD is failure to conform to social norms with respect to lawful behaviors, as indicated by repeatedly performing acts that are grounds for arrest, per DSM-5 criteria
- Deceitfulness, indicated by repeated lying, use of aliases, or conning others for personal profit or pleasure, is present in 80-90% of ASPD cases
- Impulsivity or failure to plan ahead affects 70-85% of individuals with ASPD, per clinical validation studies
- 92% lifetime ASPD-substance use disorder comorbidity, NESARC odds ratio 13.0 (95% CI 11.2-15.2)
- ASPD-alcohol dependence OR=7.2, highest among PDs, National Comorbidity Survey Replication
- 52% ASPD in opioid-dependent patients, vs 3% general pop
- Pharmacotherapy shows small effect size 0.2-0.4 for ASPD aggression, meta-analysis 9 RCTs
- CBT for ASPD core features effect size d=0.45 (95% CI 0.15-0.75), 12 studies meta
- Contingency management reduces ASPD substance use relapse by 50%
ASPD is more common in men, prison populations, and those with substance abuse issues.






