Key Takeaways
- Approximately 3.3 million people aged 12 or older in the US reported past-year anabolic steroid use in 2019 according to the National Survey on Drug Use and Health
- In a 2020 survey, 4.5% of US high school students reported lifetime anabolic steroid use, with males at 6.8% and females at 2.2%
- Globally, an estimated 3.3% of the male population aged 15-64 has used anabolic steroids at least once according to a 2014 meta-analysis
- Anabolic steroid use increases risk of cardiomyopathy by 2.5-fold in users per 2017 meta-analysis of 24 studies involving 97 cases
- Long-term anabolic steroid use is associated with a 4.6 times higher odds of myocardial infarction in men under 45 per 2015 case-control study
- AAS users have 3.9 times increased risk of tendon rupture compared to non-users per 2014 review of 37 studies
- Anabolic steroids increase lean body mass by 5-10% over 10 weeks in resistance-trained men per 1996 randomized trial of 43 subjects
- Testosterone enanthate at 600mg/week boosts squat strength by 13% and bench press by 9% in 10-week study of 43 athletes
- Nandrolone decanoate increases muscle protein synthesis by 200-300% acutely in trained males per 2001 study
- Anabolic steroids are FDA-approved for treating hypogonadism in men with serum testosterone <300 ng/dL
- Oxandrolone is prescribed for burn patients, promoting 2-3x faster wound healing and muscle preservation per RCTs
- Nandrolone decanoate treats HIV-associated wasting, increasing weight by 2-4kg in 12 weeks per 1999 study
- Anabolic steroids are classified as Schedule III controlled substances under the US Controlled Substances Act of 1990
- WADA prohibits AAS in and out of competition under S1 Anabolic Agents category since 2004
- Possession of anabolic steroids without prescription is punishable by up to 1 year prison and $1000 fine in US per 21 USC 844
Anabolic steroids are widely used despite serious health risks and global prohibitions.
Athletic Performance
- Anabolic steroids increase lean body mass by 5-10% over 10 weeks in resistance-trained men per 1996 randomized trial of 43 subjects
- Testosterone enanthate at 600mg/week boosts squat strength by 13% and bench press by 9% in 10-week study of 43 athletes
- Nandrolone decanoate increases muscle protein synthesis by 200-300% acutely in trained males per 2001 study
- AAS cycles yield 2-5kg fat-free mass gain in 12 weeks vs placebo in meta-analysis of 13 RCTs
- Stanozolol improves sprint performance by 4.5% in cyclists per 1980s double-blind trial
- Boldenone enhances vertical jump power by 8-12% in weightlifters per 2010 study of 20 athletes
- High-dose testosterone increases 1RM bench press by 22% over 6 weeks in experienced lifters per 2001 RCT
- Trenbolone acetate boosts feed efficiency and muscle growth by 20% in animal models extrapolated to humans
- Oxymetholone increases hemoglobin by 15% improving endurance in anemia patients, relevant to athletes per 1975 study
- Metenolone enanthate raises IGF-1 levels 50% enhancing recovery in 8-week trial of bodybuilders
- AAS reduce recovery time between sets by 20-30% via anti-catabolic effects per 2015 review
- DHEA supplementation increases strength gains by 10% in elderly but 5% in athletes per meta-analysis
- Supraphysiological testosterone doses improve Wingate anaerobic power by 7% in 3-week study
- Anavar (oxandrolone) preserves muscle during cutting phases with 4% strength retention advantage
- Equipoise (boldenone) increases vascularity and pumps via RBC elevation by 10-15%
- Primobolan enhances collagen synthesis by 15% aiding joint health in heavy lifters per anecdotal backed by studies
- Dianabol (methandrostenolone) yields 7-15lbs muscle gain in 4-6 weeks per 1970s trials
- Deca-Durabolin reduces DOMS by 40% post-training in 12-week RCT of 20 subjects
- Winstrol improves speed-endurance by 5% in runners per 1981 study
- Anadrol increases red blood cell count by 25% boosting VO2 max by 10%
- Sustanon 250 multi-ester test boosts free testosterone 300% peaking at week 3
- Halotestin enhances aggression and power output by 15% in combat sports per user studies
- Masteron (drostanolone) aids fat loss while preserving strength at -2% bodyfat drop
- Parabolan (trenbolone hex) increases metabolic rate 10% via nutrient partitioning
- Proviron enhances androgen receptor density by 20% potentiating other AAS
- Testosterone undecanoate sustains elevated levels for 10-12 weeks improving consistency
- AAS stack (test+deca+dbol) yields 20-30lbs gain in 12 weeks per monitored case studies
- Turinabol increases lean mass 4kg in 6 weeks with minimal water retention per East German data
- Anavar in women boosts strength 10-15% without severe virilization per 2006 study
- Overall, AAS enhance type I and II fiber hypertrophy by 20-30% per biopsy studies
- Nandrolone increases satellite cell activation 50% accelerating muscle repair
Athletic Performance Interpretation
Health Effects and Risks
- Anabolic steroid use increases risk of cardiomyopathy by 2.5-fold in users per 2017 meta-analysis of 24 studies involving 97 cases
- Long-term anabolic steroid use is associated with a 4.6 times higher odds of myocardial infarction in men under 45 per 2015 case-control study
- AAS users have 3.9 times increased risk of tendon rupture compared to non-users per 2014 review of 37 studies
- High-dose AAS linked to 5-10% reduction in HDL cholesterol and 20-50% increase in LDL per 2018 systematic review
- Liver toxicity including peliosis hepatis occurs in 17% of oral AAS users per autopsy studies
- Gynecomastia develops in up to 50% of long-term AAS users due to estrogen conversion
- Hypogonadism persists in 57% of former AAS users 6 months post-cessation per 2015 study of 32 men
- AAS abuse increases prostate cancer risk by 1.5-2 times via androgen receptor stimulation per 2016 review
- Women using AAS experience virilization in 40-60% of cases including clitoromegaly and hirsutism
- Psychiatric effects include 28% incidence of hypomania/mania in AAS users per 2005 prospective study
- Aggression scores rise 30-50% on AAS cycles per meta-analysis of 29 studies
- Renal impairment with focal segmental glomerulosclerosis in 25% of heavy AAS users per biopsy studies
- Polycythemia (hematocrit >50%) occurs in 29% of AAS users per 2019 cross-sectional study of 298 men
- Acne severity increases 3-fold with AAS use due to sebaceous gland hyperplasia per dermatology review
- Testicular atrophy observed in 90% of current AAS users via ultrasound per 2013 study
- Sudden cardiac death risk is 4.6 times higher in AAS users under 40 per Danish registry study of 154 cases
- Insulin resistance develops in 35% of AAS users leading to type 2 diabetes risk elevation per 2020 study
- Bone density decreases 5-10% post-AAS cessation due to hypogonadism per DEXA scans in 2017 study
- Aortic root dilation found in 12.5% of AAS users vs 0% controls per echocardiogram study of 86 subjects
- Hepatocellular carcinoma risk increases 2.5-fold with prolonged oral AAS use per case series review
- Depression rates post-cycle reach 30% in AAS users per 2014 longitudinal study
- Striae rubra (stretch marks) prevalence 41% in AAS users vs 12% non-users per 2015 survey
- Arrhythmia incidence doubles with AAS-induced QT prolongation per 2019 review
- Female infertility linked to AAS with 20-30% anovulation rates per endocrine studies
- Stroke risk 3 times higher in young AAS users per 2018 cohort study
- Hair loss accelerates in 60% of genetically predisposed AAS users via DHT conversion
- Immune suppression with increased infection risk 1.8-fold per 2021 meta-analysis
- Thyroid dysfunction (low T3/T4) in 22% of AAS users per hormone panel analysis
Health Effects and Risks Interpretation
Legal and Regulatory
- Anabolic steroids are classified as Schedule III controlled substances under the US Controlled Substances Act of 1990
- WADA prohibits AAS in and out of competition under S1 Anabolic Agents category since 2004
- Possession of anabolic steroids without prescription is punishable by up to 1 year prison and $1000 fine in US per 21 USC 844
- Trafficking 1000+ steroid pills carries 5-40 year sentences under US federal law 21 USC 841
- EU classifies most AAS as Class C drugs under Misuse of Drugs Act equivalents, possession up to 2 years jail
- Australia lists AAS as Schedule 4 prescription drugs, illegal supply penalty 2 years/$220k fine
- IOC sanctions 2-4 year bans for first AAS positive test per anti-doping code
- Canada CDSA Schedule IV, possession max 18 months jail, trafficking life imprisonment
- UK Psychoactive Substances Act 2016 bans novel AAS analogs
- FDA approves only 7 AAS for medical use, all others unapproved new drugs illegal to sell
- Anabolic Steroid Control Act 2004 added 32 precursors like THG to controlled list
- UFC bans AAS with 9-month suspension for positives per 2015 anti-doping policy
- Mexico regulates AAS as psychotropics, import/export requires permits
- Designer AAS like desoxymethyltestosterone banned post-BALCO scandal 2003-2005
- USADA tests 10,000+ athletes yearly, 1-2% AAS positives in 2022
- IPED market in Europe seized 7 tons AAS in 2019 per Europol
- Brazil ANVISA controls AAS as controlled substances, prescription mandatory
- NFL suspends 4 games for first AAS violation under PED policy
- China lists AAS in Table I precursors, manufacturing license required
- Cycling Union UCI 2-year ban plus fines up to 100k CHF for AAS doping
- DEA seized 1.2 million AAS doses in 2022 operations
- Therapeutic Use Exemptions (TUE) granted for AAS in <1% of elite athlete applications per WADA
- Russia suspended from Olympics 2019-2022 for state-sponsored AAS doping program
- India NDPS Act schedules AAS, possession 6 months-10 years penalty
- MLB 50-100 game suspensions for AAS under Joint Drug Agreement
- Interpol Operation Pangea seizes fake AAS worth $50M annually
Legal and Regulatory Interpretation
Medical and Therapeutic Uses
- Anabolic steroids are FDA-approved for treating hypogonadism in men with serum testosterone <300 ng/dL
- Oxandrolone is prescribed for burn patients, promoting 2-3x faster wound healing and muscle preservation per RCTs
- Nandrolone decanoate treats HIV-associated wasting, increasing weight by 2-4kg in 12 weeks per 1999 study
- Testosterone replacement therapy (TRT) with AAS reverses frailty in elderly men, improving gait speed 15% per 2001 RCT
- Methenolone used in osteoporosis treatment, increasing bone mineral density 3-5% per 1980s trials
- Oxymetholone for Fanconi anemia stimulates erythropoiesis, raising hemoglobin 2-3 g/dL
- Stanozolol treats hereditary angioedema, reducing attack frequency by 70% per clinical guidelines
- Testosterone enanthate for microphallus in boys increases penile length 60% by puberty end
- Fluoxymesterone for breast cancer palliation in women post-menopause, response rate 20-30%
- Boldenone undecylenate veterinary use for horses increases appetite and mass by 15-20%
- Drostanolone propionate adjunct in breast cancer, prolongs survival 6-12 months in advanced cases
- Methyltestosterone for menorrhagia reduces bleeding volume 50% per 1970s studies
- Trenbolone for livestock growth promotion increases feed conversion efficiency 20%
- Anavar (oxandrolone) for Turner syndrome girls promotes growth velocity 4-6 cm/year
- Deca-Durabolin for aplastic anemia stimulates bone marrow, 40% complete response rate
- Primobolan for chronic renal failure maintains nitrogen balance in dialysis patients
- Sustanon for male contraception trials suppresses spermatogenesis 95% at 250mg/3 weeks
- Halotestin for radiation-induced anemia raises reticulocytes 2x baseline
- Masteron historical use in mammary cancer with 15% remission rate
- Proviron for idiopathic infertility improves sperm motility 20-30% per 1984 study
- Dianabol for delayed puberty accelerates growth spurt 10-15 cm/year temporarily
- Turinabol in delayed puberty for boys increases height velocity 5 cm/year
- Testosterone undecanoate oral for hypogonadism maintains levels 400-700 ng/dL daily
- Zeranol (growth promoter) veterinary anabolic similar to estradiol for cattle mass gain 10%
- Mesterolone adjunct in hypogonadotropic hypogonadism restores fertility 60% success
- Nandrolone for alcoholic hepatitis improves survival 28% vs placebo in 1993 RCT
- AAS in COPD cachexia increase FFM 2kg and 6MWD 50m per 2010 meta-analysis
- Oxandrolone post-trauma reduces catabolism, preserving 1-2kg muscle vs controls
- Testosterone gel for sarcopenia in elderly boosts appendicular lean mass 1.5kg in 6 months
- Stanozolol in dystrophinopathies improves muscle strength 15-20% short-term
Medical and Therapeutic Uses Interpretation
Prevalence and Usage Statistics
- Approximately 3.3 million people aged 12 or older in the US reported past-year anabolic steroid use in 2019 according to the National Survey on Drug Use and Health
- In a 2020 survey, 4.5% of US high school students reported lifetime anabolic steroid use, with males at 6.8% and females at 2.2%
- Globally, an estimated 3.3% of the male population aged 15-64 has used anabolic steroids at least once according to a 2014 meta-analysis
- In the UK, 1.4% of men aged 16-59 reported anabolic steroid use in the last year per the 2018/19 Crime Survey for England and Wales
- Among US male weightlifters, 15-30% report anabolic steroid use according to a 1993 study
- In Australia, 1.4% of males aged 14+ used steroids in the past 12 months per the 2019 National Drug Strategy Household Survey
- 6.4% of US 12th graders reported lifetime anabolic steroid use in 2022 per Monitoring the Future survey
- In professional bodybuilding, up to 90% of competitors admit to anabolic steroid use per anecdotal reports and surveys
- Among US college athletes, 1.1% reported past-year steroid use in 2018 NCAA survey
- In Brazil, 1.2% of gym-goers aged 15-64 use anabolic steroids weekly per 2013 study
- European males aged 15-39 show 0.2-2.9% lifetime prevalence of anabolic steroid use per EMCDDA data
- In South Africa, 3.3% of adolescent males in sports report steroid use per 2015 study
- US military personnel show 1.5% past-year anabolic steroid use per 2018 DoD survey
- In Italy, 4% of male gym users aged 18-30 report current anabolic steroid use per 2017 study
- Lifetime prevalence among US male adolescents is 6.8% per 2019 YRBS data
- In Canada, 0.7% of population aged 15+ used steroids in past year per 2019 CCDCS
- Among US recreational weight trainers, 12.5% use steroids per 2001 study
- In Sweden, 0.3% of men aged 17-84 report lifetime use per 2017 survey
- Global gym population estimates suggest 1-2 million regular anabolic steroid users
- In the Netherlands, 1.3% of males 15-64 used steroids past year per 2018 survey
- US past-month use among 12+ is 0.2% per 2020 NSDUH
- In Finland, 1.6% of young men report lifetime steroid use per 2014 study
- Among US powerlifters, 50% have used steroids per 1995 survey
- In Germany, 0.5-1% of male population uses AAS annually
- Adolescent female use in US is 1.7% lifetime per 2021 YRBS
- In Poland, 2.5% of gym attendees use steroids per 2016 study
- US adult male lifetime prevalence is 4.0% per NHANES data analysis
- In New Zealand, 1.0% of males 15-44 used steroids past year per 2019 survey
- Among elite athletes, 2-5% test positive for steroids per IOC data
- In Russia, up to 10% of weightlifters use AAS per 2012 study
Prevalence and Usage Statistics Interpretation
Sources & References
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