GITNUX MARKETDATA REPORT 2024
Zoloft Elimination Half-Life Statistics
The elimination half-life of Zoloft (sertraline) is approximately 26 hours.
In this post, we explore a comprehensive overview of the statistics related to Zoloft (Sertraline) pharmacokinetics and metabolism. From the drug’s elimination half-life to its metabolites and therapeutic efficacy timelines, we delve into key insights that shed light on the dynamics of Zoloft within the human body.
Statistic 1
"The elimination half-life for Zoloft (Sertraline) is approximately 26 hours."
Statistic 2
"Steady-state concentrations of sertraline are reached within a week on once daily dosing."
Statistic 3
"Most of the drug (about 98%) is protein bound in the human plasma."
Statistic 4
"The half-life of desmethylsertraline, a Zoloft metabolite, is approximately 62-104 hours."
Statistic 5
"Zoloft's terminal half-life ranges from 22 to 36 hours."
Statistic 6
"The total clearance of sertraline was approximately 0.6 L/hr/kg following oral administration."
Statistic 7
"Zoloft is metabolized extensively by the liver, primarily to N-desmethylsertraline."
Statistic 8
"Within a dose range of 50 to 200 mg/day, the kinetics of sertraline are dose proportional."
Statistic 9
"Around 40-45% of Sertraline is left unchanged in the urine."
Statistic 10
"The full therapeutic effect of Zoloft may not be achieved for a few weeks."
Statistic 11
"Peak plasma concentrations of Zoloft are reached about 4.5 to 8.4 hours after dosing."
Statistic 12
"Zoloft may take as long as 12 weeks to demonstrate therapeutic efficacy."
Statistic 13
"Sertraline exhibits a sex- and age-dependent half-life. In men, the half-life is around 26 hours, while in women it is approximately 33 hours."
Statistic 14
"In elderly individuals, sertraline half-life is longer (41 hours) due to decreased metabolism."
Statistic 15
"Among poor metabolizers, Zoloft has a half-life of about 56 hours."
Statistic 16
"The half-life of Zoloft can be extended to 34-43 hours for the elderly people over the age of 65."
Statistic 17
"Zoloft's steady state levels are achieved after about 1 week of once daily dosing."
Statistic 18
"The pharmacokinetics of sertraline exhibit significant interindividual variability."
Statistic 19
"None of the sertraline metabolites demonstrate significant activity at serotonergic, dopaminergic, cholinergic, or histaminergic receptors in vitro."
Statistic 20
"N-desmethylsertraline has an elimination half-life of 62 to 104 hours in plasma."
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